OBSTRUCTIVE SLEEP APNEA (OSA)

This study tests an injectable drug called GZR18 in 140 obese adults with moderate to severe obstructive sleep apnea who cannot or will not use a CPAP machine. The main goal is to see if the drug reduces breathing pauses during sleep and helps with weight loss over 52 weeks. It i…

This study tests an investigational drug called GZR18 in 140 obese adults with moderate-to-severe obstructive sleep apnea who already use a breathing machine (PAP). The goal is to see if the drug can reduce breathing pauses during sleep and help with weight loss. Participants wil…

This study tests whether a program that includes remote monitoring, couple therapy, and peer support can help African American patients with sleep apnea use their CPAP machine more regularly. The goal is to improve sleep and quality of life for both the patient and their bed part…

This study will test a smart mattress designed to diagnose obstructive sleep apnea (OSA) at home. Researchers will compare the mattress's measurements to standard sleep lab tests (polysomnography) in 500 people. The goal is to see if the mattress can accurately detect breathing p…

This study looks at whether a simple questionnaire given during a dental visit can identify children aged 8-13 who are at risk for sleep-disordered breathing (SDB), including obstructive sleep apnea. Kids will be grouped as low- or high-risk based on the questionnaire, then wear …

This study tests a personalized digital program called PASS to help people with obstructive sleep apnea start and stick with positive airway pressure (PAP) therapy. Sixty adults newly diagnosed with sleep apnea will either receive the PASS program (including motivational coaching…

This study looks at whether giving people with sleep apnea access to their nightly oxygen levels helps them feel better about using a mouthpiece device. About 120 adults with mild-to-moderate sleep apnea will either get standard care or also see their oxygen data on a phone app. …

This study tests whether myofunctional therapy—special exercises for the tongue, face, and breathing muscles—can help children aged 6 to 12 with obstructive sleep apnea. About 174 children will be split into two groups: one gets the therapy plus standard care, the other gets stan…

This study will test a special mouthpiece called a Dynamic Propulsion Oral Appliance (DPOA) in 40 adults with mild to moderate obstructive sleep apnea. Unlike standard mouthpieces that lock the jaw in one position, this device slowly and gently moves the lower jaw forward during …

This study looks at 120 adults aged 45-65 who have both sleep apnea and chronic insomnia. Everyone gets a CPAP machine, but half also start a digital insomnia program right away. The goal is to see if early insomnia treatment helps people use CPAP more and improves their overall …

This study looks at whether a combination of non-opioid pain medicines works as well as fentanyl for children aged 5-10 with mild to moderate sleep apnea who are having their tonsils removed. The goal is to see if the opioid-free approach causes fewer breathing problems and side …

This study tests whether wearing a smartwatch and seeing its data can help people with moderate to severe sleep apnea use their CPAP machine more often. About 80 adults who are new to CPAP will be split into two groups: one can see their wearable data anytime, the other cannot un…

This study looks at how short bursts of low oxygen (like those experienced in sleep apnea) affect certain immune cells called neutrophils. Researchers will collect blood from 120 people—80 with moderate-to-severe sleep apnea and 40 without—to measure immune activity and specific …

This study looks at how opioids change breathing during sleep in healthy people and those with obstructive sleep apnea. Researchers will give participants morphine or a placebo and measure their breathing. The goal is to understand the risks of opioid use during sleep, especially…

This study tests a new software tool called Pressure Match that helps doctors choose the right CPAP pressure settings for people newly diagnosed with obstructive sleep apnea (OSA). The tool uses data from thousands of patients to give personalized recommendations, aiming to reduc…

This study looks at whether a non-invasive lung function test called impulse oscillometry (IOS) can predict the correct pressure settings for sleep apnea therapy. About 92 adults with moderate-to-severe obstructive sleep apnea will take the test during the day and then have their…

This study will observe 55 adults with obstructive sleep apnea to see if the severity of their breathing pauses during sleep is linked to higher blood pressure in the lungs. Participants will have their sleep and heart function measured, but no new treatments are tested. The goal…