OBSTRUCTIVE SLEEP APNEA (OSA)

This study compares three treatments for obstructive sleep apnea: positive airway pressure (CPAP), a dental device that moves the jaw forward, and a combination of two medications (atomoxetine and oxybutynin). About 2,400 adults with sleep apnea will be randomly assigned to one o…

This study compares two common treatments for moderate obstructive sleep apnea: a custom mouth device that moves the jaw forward (MAD) and a machine that blows air through a mask (CPAP). Researchers want to see how well each treatment improves breathing during sleep and reduces d…

This Phase 2 trial tests IHL-42X, a combination of two drugs (dronabinol and acetazolamide), in people with obstructive sleep apnea. The study aims to see if the drug can reduce the number of breathing pauses during sleep and improve daytime symptoms. Participants will receive di…

This study tests whether a high-flow nasal cannula (HFNC) — a soft tube that delivers warm, humidified air through the nose — works as well as the standard CPAP mask for children with moderate-to-severe obstructive sleep apnea. About 258 children aged 2 to 18 will use one of the …

This study tests an injection called GZR18 in 140 obese adults with moderate-to-severe obstructive sleep apnea who already use a breathing machine (PAP). The goal is to see if the drug improves breathing during sleep, reduces weight, and boosts quality of life compared to a place…

This study tests an injection called GZR18 in 140 obese adults with moderate to severe obstructive sleep apnea who cannot or will not use a CPAP machine. The goal is to see if the drug improves breathing during sleep and helps with weight loss over 52 weeks. Participants will rec…

This study tests whether a program that includes remote monitoring, couple therapy, and peer support can help African American patients with sleep apnea use their CPAP machine more consistently. The goal is to improve sleep and quality of life for both the patient and their bed p…

This study tests whether a Garmin smartwatch that shows health data can help people with moderate to severe sleep apnea use their CPAP machine more regularly. 80 adults who are new to CPAP will be split into two groups: one can see their wearable data, the other cannot. The main …

This study will test whether a smart mattress with built-in sensors can accurately diagnose obstructive sleep apnea (OSA) compared to the standard hospital sleep test (polysomnography). Researchers plan to enroll 500 people and have them sleep on the mattress while also undergoin…

This study compares two exercise approaches—short 'exercise snacks' spread throughout the day versus traditional aerobic exercise—in adults with moderate to severe obstructive sleep apnea. Researchers will measure sleep quality, daytime sleepiness, and physical function over 8 we…

This study looks at whether giving people with obstructive sleep apnea (OSA) access to their nightly oxygen levels can improve their experience with a mouthpiece device (MAD). About 120 adults with mild to severe OSA will either get standard care or also see their oximetry data t…

This study looks at people who have both sleep apnea and chronic insomnia. All 120 participants will receive standard CPAP therapy for sleep apnea. Half will also get a digital program to treat their insomnia starting at the same time as CPAP. The other half will follow usual car…

This study tests a 4-month personalized digital program (PASS) to help people with obstructive sleep apnea start and continue using positive airway pressure (PAP) therapy. Sixty overweight, inactive adults newly diagnosed with sleep apnea will be randomly assigned to either the P…

This study compares standard fentanyl pain medicine to an opioid-free mix of acetaminophen, ibuprofen, ketamine, and dexamethasone in 64 children aged 5-10 with mild to moderate sleep apnea undergoing tonsil surgery. The goal is to see if the opioid-free option controls pain just…

This study tests a new oral appliance called DPOA that gently and gradually moves the jaw forward during sleep to keep the airway open in people with mild to moderate obstructive sleep apnea. Forty adults aged 20 to 65 will be enrolled and monitored with sleep tests. The goal is …

This study tests a new software tool called Pressure Match that helps doctors set personalized minimum and maximum pressure levels on CPAP machines for people newly diagnosed with obstructive sleep apnea. The tool uses patient data like weight, gender, and severity of apnea to re…

This study tests whether myofunctional therapy—simple exercises for the tongue, face, and breathing muscles—can improve sleep in children aged 6-12 with obstructive sleep apnea. Half of the 174 participants will do these exercises for 24 weeks with remote coaching, while the othe…

This study looks at whether a quick, non-invasive breathing test called impulse oscillometry (IOS) can help doctors find the right pressure settings for sleep apnea machines. Currently, patients often need an overnight sleep study to determine the correct pressure. The study will…

This study will give a single dose of morphine or a placebo to 26 adults (some healthy, some with obstructive sleep apnea) during a sleep study night. Researchers will measure how much their breathing changes. The goal is to understand why opioids can dangerously slow breathing d…

This study will observe 55 adults with obstructive sleep apnea to see if the severity of their breathing pauses during sleep is linked to higher blood pressure in the lungs. Researchers will use echocardiography to measure lung artery pressure. The goal is to better understand th…

This study looks at whether treating obstructive sleep apnea with CPAP can change how certain immune cells (neutrophils) behave. Researchers will collect blood from 120 people — 80 with moderate-to-severe sleep apnea and 40 healthy controls — to measure immune cell activity and r…