Could a pill replace CPAP for sleep apnea? large study tests three treatments Head-to-Head

NCT ID NCT07679282

Not yet recruiting Disease control Sponsor: Sairam Parthasarathy Source: ClinicalTrials.gov ↗

First seen Jul 01, 2026 · Last updated Aug 14, 2026 · Updated 3 times

Summary

This study compares three treatments for obstructive sleep apnea: positive airway pressure (CPAP), a dental device that moves the jaw forward, and a combination of two medications (atomoxetine and oxybutynin). About 2,400 adults with sleep apnea will be randomly assigned to one of these treatments for one year. Researchers will track quality of life, side effects, and how well each treatment controls apnea episodes to find which option works best and is easiest for people to stick with.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: atomoxetine-oxybutynin
What this could lead to: If this trial succeeds, it could show that a simple pill works as well as CPAP or a dental device for treating sleep apnea, offering a more convenient option for many patients.
What could go wrong: The medication combination is not yet approved for sleep apnea, and side effects may limit its use. The study is also large but results may not apply to everyone with the condition.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

obstructive sleep apnea syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OBSTRUCTIVE SLEEP APNEA (OSA)

Contacts and locations

Locations

Banner University Medical Center Tucson

Tucson, Arizona, 85719, United States
Stanford Medical Center

Redwood City, California, 94305, United States
University of Maryland Baltimore

Baltimore, Maryland, 21201, United States
University of Miami Miller School of Medicine

Miami, Florida, 33136, United States

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