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Heart failure breakthrough? fluid removal may ease sleep apnea

NCT ID NCT07601724

Knowledge-focused Sponsor: Itshak Amsalem Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This observational study looks at whether removing excess fluid from the body (diuresis) can reduce sleep apnea severity in adults hospitalized with heart failure. Fifty participants will wear a sleep monitor before and after fluid removal, and researchers will track changes in neck size and breathing patterns. The goal is to understand the link between fluid overload and obstructive sleep apnea.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could show that treating fluid overload improves sleep apnea in heart failure patients, pointing to a simple way to ease breathing during sleep.
What could go wrong
This is a small observational study, not a treatment trial. Results may not apply to all heart failure patients, and sleep apnea might not improve with fluid removal alone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 50 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2026

Expected to finish

Jun 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adults admitted with decompensated heart failure and clinical fluid overload, including both preserved and reduced ejection fraction. Participants will be recruited during hospitalization in a dedicated heart failure unit and followed prospectively with sleep monitoring and clinical assessments before and after achievement of clinical euvolemia.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults aged 18 years or older * Hospitalized with decompensated heart failure and clinical evidence of fluid overload * Diagnosis of heart failure (reduced or preserved ejection fraction) * Clinically indicated for diuretic therapy * Able to undergo sleep apnea assessment using the WatchPAT device * Able to provide informed consent Exclusion Criteria: * Known central sleep apnea as the predominant sleep-disordered breathing type * Current treatment with continuous positive airway pressure (CPAP) * Acute respiratory failure requiring mechanical ventilation * Conditions preventing proper use of the WatchPAT device (e.g., severe hand or finger injury) * Hemodynamic instability precluding participation * Pregnancy

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Conditions

The condition(s) this trial relates to.

congestive heart failure heart failure obstructive sleep apnea syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Heart failure Obstructive sleep apnea (OSA)

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

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Contacts and locations

Locations

  • Shaare Zedek Medical Center

    RECRUITING

    Jerusalem, Israel

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