Can a simple mouthpiece outperform CPAP for brain fog in sleep apnea?

NCT ID NCT06983769

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a dental mouthpiece (MAD) works as well as a CPAP machine to improve thinking and memory in people with sleep apnea who also have mild memory problems. About 260 adults aged 45 and older will be randomly assigned to use either device for one year. Researchers will track changes in cognitive tests, blood pressure, and brain scans to see which treatment helps more.

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Conditions

The condition(s) this trial relates to.

Cognitive Dysfunction microcephaly 6, primary, autosomal recessive obstructive sleep apnea syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • National University Hospital

    RECRUITING

    Kent Ridge, Please Select, 267383, Singapore

    Contact Phone: •••-•••-•••• Email: •••••@•••••