National University Hospital, Singapore

This study is testing if taking a lower dose of the targeted lung cancer drug osimertinib every other day is still effective and possibly easier for patients to tolerate. It is for adults with a specific type of advanced lung cancer (EGFR-positive NSCLC) who have not had prior tr…

This early-stage study is testing whether two HIV medications (emtricitabine and Descovy) are safe for people with mild cognitive impairment, which often leads to Alzheimer's disease. Researchers want to see if these drugs, which block a specific enzyme, might help slow memory de…

This study is testing whether a dental mouthpiece is as good as a standard CPAP machine at improving memory and thinking skills in people with sleep apnea who also have mild memory problems and heart disease risk. Researchers will enroll 260 adults in Singapore to use one of the …

This study is testing if adding two newer drugs (pembrolizumab and bevacizumab) to standard chemotherapy before radiation is better for patients with advanced nasopharyngeal cancer. It will involve 50 adults with newly diagnosed, locally advanced cancer who have not yet started t…

This study compares two ways to treat extremely deep cavities that are close to the tooth's nerve. It tests whether a simpler procedure called a pulpotomy works as well as a full root canal treatment. Senior dental students will perform the treatments under supervision to see whi…

This study is testing if providing ready-to-eat meals helps people follow their pre-surgery diet better than the standard liquid meal shakes. Researchers will compare two groups of 70 people each, all preparing for weight loss surgery, to see which diet plan they stick to more cl…

This trial is testing if a drug called dupilumab can help children with a severe, recurring kidney condition called nephrotic syndrome. The main goal is to see if dupilumab injections can keep the disease in remission longer and allow kids to safely reduce their steroid medicatio…

This is a small pilot study to see if a supplement called myo-inositol can help improve health outcomes for babies born to mothers with Type 2 Diabetes. It will recruit 182 pregnant women in Singapore to test if taking the supplement alongside standard care leads to healthier bir…

This study is testing a new method to find personalized drug combinations for people whose aggressive brain tumor has returned. Researchers will grow small 3D models of a patient's tumor in the lab to test many different drug combinations and find the most effective one. The goal…

This small pilot study is testing a new, highly personalized approach to treating advanced breast or stomach cancer. For each of the 10 participants, scientists will first use lab tests on their own tumor cells to find the best drug combination. Then, an artificial intelligence (…

This study is testing if adding a common antibiotic called doxycycline to standard tuberculosis (TB) treatment can protect patients' lungs and heart from long-term damage. It will involve 150 adults with active TB who have just started treatment. The goal is to see if this extra …

This study is testing a new, sticker-like smart sensor to see if it can help doctors screen for pneumonia early in high-risk patients. It will be used on 70 hospitalized adults who have had a recent stroke or have kidney failure. The sensor listens to lung sounds daily and is com…

This study is testing a blood test as a first step before a CT scan for lung cancer screening. The goal is to see if the blood test can accurately identify people who are unlikely to have lung cancer, so they might avoid an unnecessary scan. This could reduce radiation exposure a…

This study is testing a new limb cooling system to see if it can prevent nerve damage, a common and painful side effect of chemotherapy. The research involves 80 cancer patients receiving paclitaxel chemotherapy. Participants will wear special cooling wraps on their arms and legs…

This study is testing if a non-invasive brain stimulation technique can help reduce the severity of chronic tinnitus, the perception of ringing or buzzing in the ears. 50 participants will receive 20 treatment sessions, a mix of real and sham (placebo) stimulation, to see if the …

This small pilot study is testing whether a combination of non-invasive electrical spinal stimulation and robot-assisted walking training can improve mobility and quality of life for people with chronic spinal cord injuries. Twelve participants will undergo two training phases: o…

This small pilot study is testing whether a combination of non-invasive electrical spinal cord stimulation and robotic arm/hand training can improve arm and hand function more than robotic training alone. It involves 6-8 people with chronic, incomplete spinal cord injuries in the…