National University Hospital, Singapore

This Phase 3 trial tests whether adding doxycycline to standard tuberculosis treatment can reduce permanent lung damage and lower the risk of heart problems. Researchers will give 150 adults either doxycycline or a placebo for 8 weeks alongside their TB medication. The main goal …

This phase 2 trial tests whether adding the antibiotic doxycycline to standard treatment can reduce deaths and severe brain damage in adults with tuberculosis of the brain or its lining. About 200 participants will receive either doxycycline or a placebo for 8 weeks, alongside us…

This study tests a personalized CAR T-cell therapy for people with B-cell lymphoma that has come back or not responded to treatment. Patients' own immune cells are collected, modified to target cancer cells, and infused back. The trial has two phases: first to find the safest dos…

This pilot study tests whether adding transcutaneous spinal cord stimulation (tSCS) to robotic gait training (RGT) can improve trunk control and walking in people with chronic spinal cord injury. Twelve participants will first receive RGT alone, then RGT plus tSCS, and their prog…

This study tests whether taking myo-inositol (a natural supplement) during pregnancy can improve health outcomes for babies born to mothers with type 2 diabetes. About 182 pregnant women will take either myo-inositol plus folic acid or folic acid alone from early pregnancy until …

This study tests if dupilumab, a drug already used for allergies, can help children with severe nephrotic syndrome stay relapse-free longer. About 66 kids aged 6–18 will get either dupilumab or a placebo injection for 6 months, while slowly reducing their steroid dose. The goal i…

This study compares two treatments for extremely deep cavities that reach the tooth's nerve: a full pulpotomy (removing only the top part of the nerve) versus a standard root canal. About 93 people aged 12 and older with a deep cavity in a permanent tooth will be randomly assigne…

This study tests whether two HIV medications, emtricitabine and Descovy, are safe for people with mild cognitive impairment (MCI), a condition that can lead to Alzheimer's. Researchers think these drugs might slow disease progression by blocking a process linked to Alzheimer's. A…

This study tests whether a lower dose of the targeted therapy osimertinib can control advanced EGFR-positive non-small cell lung cancer while reducing side effects. About 58 adults with this specific genetic type of lung cancer will receive 80 mg every other day. Researchers will…

This phase 2 trial tests whether adding two immunotherapy drugs (pembrolizumab and bevacizumab) to standard chemotherapy (gemcitabine and cisplatin) works better for advanced nasopharyngeal cancer. About 50 participants will be randomly assigned to receive either the standard che…

This study tests two AI platforms to personalize cancer treatment for people with solid tumors like gastrointestinal or breast cancer. First, a platform called QPOP analyzes a patient's tumor sample to find the best drug combination. Then, another AI called CURATE.AI adjusts the …

This study is testing whether a blood test (liquid biopsy) can be used as a first step to screen for lung cancer in high-risk people, before deciding if they need a low-dose CT scan. The goal is to reduce unnecessary scans, radiation exposure, and healthcare costs. The study will…

This study is testing a new smart sensor that listens to chest sounds to help doctors screen for pneumonia in people who have had a stroke or are on dialysis for kidney failure. About 50 adults will take part, and the sensor's findings will be checked against chest X-rays. The go…

This study tests a special cooling and compression sleeve (Paxman Limb Cryocompression System) worn during chemotherapy to prevent nerve damage, a common side effect. About 200 cancer patients receiving weekly paclitaxel will use the device for up to 4 hours per session. Research…

This study tests whether a mobile app that provides psychological tools can improve quality of life for people with eczema, psoriasis, or chronic hives. Participants use the app over 32 weeks to learn coping strategies and wellness tips. The goal is to see if this digital approac…

This study tests whether early occupational therapy—focused on motivating activities and sleep routines—can reduce delirium (sudden confusion) in patients after heart bypass surgery. Researchers will compare the therapy to standard care in 300 adults. The goal is to see if this a…

This study tests whether a non-invasive brain stimulation technique called TMS can reduce the ringing or buzzing of chronic tinnitus. Fifty adults with tinnitus will receive 10 real and 10 fake (sham) treatments in random order, with a two-week break in between. An MRI scan is us…

This small pilot study tests whether adding a gentle electrical stimulation to the spinal cord (tSCS) can make robotic arm training more effective for people with chronic tetraplegia from a spinal cord injury. Six to eight adults with neck-level injuries will first receive roboti…

This study tests whether a dental mouthpiece (MAD) works as well as a CPAP machine to improve thinking and memory in people with sleep apnea who also have mild memory problems. About 260 adults aged 45 and older will be randomly assigned to use either device for one year. Researc…

This study compares two pre-surgery diets for people scheduled for bariatric surgery: ready-to-eat meals versus standard liquid meal replacements. The goal is to see which diet is easier to stick to, measured by blood ketone levels and meal logging. About 140 adults will particip…

This study tests an educational website designed to help people detect skin cancer early. About 280 participants in Singapore will use either a gain-framed or loss-framed version of the program, or no program at all. Researchers will measure how well participants can tell benign …

This study looks at whether a new way of organizing hospital care, called an Acute Medical Unit, can help older adults with sudden illnesses like infections or COPD get better faster and spend fewer days in the hospital. Researchers will compare 220 patients who receive this new …

This study tests a community-based program to screen and prevent decline in physical and mental abilities in 2500 older adults in Singapore. Participants will use digital tools to monitor their health, and those showing early signs of decline will get targeted support or referral…

This study tests a new way to choose drug combinations for people with recurrent high-grade astrocytic glioma, a type of aggressive brain cancer. Researchers take a sample of the tumor, grow it in the lab, and test many drug combinations to find the best one for that patient. The…