National University Hospital, Singapore

This study tests whether combining trastuzumab (a targeted antibody) with a patient's own modified immune cells (CAR T cells) is safe and feasible for people with HER2-positive advanced breast cancer or other solid tumors. The first part focuses on safety, and if successful, the …

This study tests whether a mouthpiece worn during sleep can improve heart health and quality of life in people with both heart failure and obstructive sleep apnea. The device, called a mandibular advancement device (MAD), keeps the airway open. 328 adults in Singapore will use ei…

This study looks at whether adding surgery after chemotherapy can help people with stage IV stomach cancer that has spread to the abdomen lining live longer. About 300 adults whose cancer responds well to initial treatment will be randomly assigned to either continue chemotherapy…

This study tests a drug called ivonescimab in 42 people with advanced nasopharyngeal cancer that has stopped responding to standard immunotherapy and chemotherapy. The goal is to see if the drug can shrink tumors or slow the cancer's growth. Participants will receive the drug int…

This study tests an online educational program designed to help people learn how to spot early signs of skin cancer. About 280 adults in Singapore will participate, and researchers will measure whether the program improves their ability to tell harmless skin growths from potentia…

This study tests whether letting patients complete monthly health surveys online can help schedule their dermatology appointments more flexibly, instead of fixed visits. About 250 adults with chronic skin conditions like eczema or psoriasis will be randomly assigned to either the…