Brain zapping gets personal: a new approach to treating depression and anxiety
NCT ID NCT07766291
First seen Aug 14, 2026 · Last updated Aug 14, 2026
Summary
This trial is testing whether a personalized form of brain stimulation, called accelerated intermittent theta-burst stimulation (iTBS), can improve symptoms of depression and anxiety in people with treatment-resistant depression. The approach uses brain imaging to target specific neural circuits linked to each person's symptoms. Participants will receive either personalized or standard stimulation, and researchers will measure changes in mood and anxiety levels to see if the personalized approach works better.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Personalized, accelerated intermittent theta-burst stimulation (iTBS) using a transcranial magnetic stimulation (TMS) device
- What this could lead to
- If successful, this could lead to more personalized brain stimulation treatments that effectively reduce both depression and anxiety symptoms in people who haven't responded to standard therapies.
- What could go wrong
- This is a small, early-stage trial (36 participants) focused on measuring brain changes, not a proven treatment. Results may not generalize, and TMS can cause side effects like headache or scalp discomfort.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for DEPRESSION DISORDER are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
National University Hospital, Singapore
Singapore, Singapore
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Faith-Based therapy aims to heal trauma in young women
- Brain zaps tuned to your wiring: a new hope for depression?
- Could simple home workouts ease depression in afghan women?
- Antidepressants may rewire how the brain perceives control
- What makes young doctors burn out or stay? a major study follows residents for answers
- Can a phone app lift depression? 1,500 volunteers test a meditation program