DEPRESSION DISORDER

This Phase 3 study tests whether CYB003, a psilocin analog (related to the active ingredient in magic mushrooms), can safely reduce depression symptoms in 330 adults with major depressive disorder. Participants receive either one of two doses of CYB003 or a placebo, along with ps…

This study looks at whether a low dose of ketamine, given as an IV infusion, can quickly improve depressive symptoms in adults who have been in the intensive care unit (ICU) for at least 6 days. About 50 participants will receive either ketamine or a placebo on two days in a row.…

This study tests whether inhaling lavender essential oil for four weeks can reduce anxiety, stress, and depression in women waiting for IVF treatment. 120 women will be split into three groups: one using real lavender oil, one using a placebo scent, and one receiving no scent. Th…

This study tests whether a 6-week music program—including drumming and rhythm exercises—can reduce stress, anxiety, depression, and chronic pain in adults living in rural residential care facilities. Sixty participants will attend weekly hour-long sessions and complete surveys be…

This study tests whether adding virtual reality (VR) mindfulness sessions to standard treatment can help people with treatment-resistant depression feel better. Thirty adults who haven't responded to multiple antidepressants will either get usual care alone or usual care plus 8 V…

This study tests a multi-sensory therapy called Heal, which uses calming sounds, gentle vibrations, and soft lighting to help detained youth (ages 12-18) manage their emotions before counseling sessions. The goal is to see if this brief, non-verbal intervention improves emotional…

This study looks at whether eating nuts can help reduce symptoms of depression, anxiety, and stress, and improve memory and thinking skills in young adults. Researchers will enroll 135 university students aged 18 to 25 and measure changes in mood, cognitive function, and a brain-…

This study looks at whether reducing social media use and replacing that time with exercise, or practicing mindfulness, can help college students feel less anxious and depressed. About 300 students who use social media heavily will be split into three groups: one that does nothin…

This study compares heated yoga, sauna sessions, and a mindfulness app to see which best reduces symptoms of depression. Researchers at Massachusetts General Hospital are recruiting 120 adults aged 18-65 with moderate to severe depression. Participants will attend twice-weekly se…

This study looks at how loneliness impacts recovery from depression in 200 hospitalized patients. Researchers will track symptoms, social support, and collect blood, saliva, and stool samples at three points: start of treatment, discharge, and three months later. The goal is to u…