DEPRESSION DISORDER

This trial investigates whether the Healthy Minds Program, a mobile meditation training app, can reduce symptoms of depression in adults. About 1,500 participants with elevated depressive symptoms will complete a 4-week well-being program using the app. Researchers will measure c…

This study tests whether a tailored online support group (VOCALE LBD) can reduce depression in family caregivers of people with Lewy body dementia (LBD). LBD caregivers often face high stress and depression rates. The 8-week program brings small groups together online to discuss …

This study will test a behavioral activation therapy program delivered via telehealth for Spanish-speaking adults with depression living in rural areas of Montana and New Mexico. The goal is to see if the program improves depressive symptoms and keeps people engaged in mental hea…

This study tests a non-drug treatment called transcranial electrical stimulation (tES) for people who have both depression and chronic pain. 240 adults will receive one of four types of brain stimulation or a fake treatment for two weeks. Researchers will check if it reduces pain…

This study tests whether a dietary supplement called GynMDD, taken alongside weekly supportive therapy, can improve symptoms of mild to moderate depression more than therapy plus a placebo. 168 adults aged 18 to 65 will take either the supplement or a placebo daily for 8 weeks, c…

This study tests a new approach where general practitioners and pharmacists work together to help adults who have been taking antidepressants for a long time but are feeling stable. The goal is to see if this teamwork helps more people safely stop their medication without their d…

This study tests if adding exercise and education to standard talk therapy helps people with depression feel better. About 112 adults will be split into two groups: one gets therapy alone, the other adds an 8-week program of guided exercise and learning sessions. Researchers will…

This observational study will test whether a 1-3 minute AI-powered facial scan can accurately measure vital signs like heart rate and blood pressure, as well as estimate blood sugar, cholesterol, and mental health status. Researchers will compare the scan results with standard me…

This study looks at how anxiety and depression influence shared decision-making in patients aged 65 and older with critical limb threatening ischaemia (CLTI), a severe form of leg artery disease. Researchers will interview patients, their carers, and healthcare staff to understan…