Could a daily supplement boost depression therapy?

NCT ID NCT07416747

Not yet recruiting Symptom relief Sponsor: Fondation FondaMental Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a dietary supplement called GynMDD, taken alongside weekly supportive therapy, can improve symptoms of mild to moderate depression more than therapy plus a placebo. 168 adults aged 18 to 65 will take either the supplement or a placebo daily for 8 weeks, complete mood and digestive questionnaires, and provide stool samples. The goal is to see if the supplement reduces depression scores and improves gut health.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: GynMDD (a dietary supplement containing L-glutamine, curcumin, and probiotic bacteria)
What this could lead to: If it works, this could offer a simple, natural add-on to therapy for people with mild to moderate depression, potentially improving mood and digestive health.
What could go wrong: This is an early-stage, small trial (168 people) testing a dietary supplement, not a drug. The supplement may show no extra benefit over placebo, and results may not apply to severe depression.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Depression depressive disorder major depressive disorder Psychological Well-Being

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DEPRESSION DEPRESSION DISORDER DEPRESSION IN ADULTS

Contacts and locations

Locations

Hôpital Albert Chenevier 40 rue de Mesly

Créteil, 94010, France

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