DEPRESSION IN ADULTS

This study looks at whether an online depression treatment program can improve how the body uses insulin to control blood sugar in people with HIV who are on HIV medication. Researchers will compare the online therapy to standard depression education. The goal is to see if treati…

This small pilot study is testing whether a brief, culturally adapted form of behavioral activation therapy is acceptable and practical for adults with depression in a primary care setting. The study will enroll 12 participants and their healthcare providers to gather feedback on…

This study is testing a type of talk therapy called acceptance and commitment therapy (ACT) for people with mild dementia and their care partners. The goal is to see if the therapy is practical and helpful for reducing symptoms like depression, anxiety, and grief. About 100 pairs…

This study tests whether personalized music playlists can help adults reduce stress, anxiety, and depression. 2000 participants will either receive custom playlists or no music intervention. The goal is to see if music can be a simple, non-drug tool for improving emotional well-b…

This study looks at two different ways to reach out to lung cancer patients who may need help with anxiety or depression. The goal is to see which method gets more people to start and stay in a telehealth counseling program. About 30 adults being treated for lung cancer at Penn M…

This study tests two minimally invasive procedures—cryoablation (freezing) and radiofrequency ablation (heating)—to control severe chest pain after combat-related chest injuries. About 50 adults in Ukraine will be randomly assigned to one of the two treatments. The goal is to see…

This study tests whether a new drug called CYB003 can safely reduce symptoms of major depression. About 330 adults with moderate to severe depression will receive either CYB003 or a placebo. The goal is to see if CYB003 improves mood and daily function better than a placebo.

This study compares two minimally invasive procedures—cryoablation (freezing) and radiofrequency ablation (heating)—to treat nerve pain caused by combat injuries in Ukraine. Fifty adults with moderate to severe pain from neuromas will be randomly assigned to one treatment. The go…

This study tests whether heated yoga, sauna sessions, or a mindfulness app can reduce symptoms of depression. Researchers will enroll 120 adults aged 18-65 with at least moderate depression. Participants will be assigned to one of the three approaches and monitored for changes in…