New study tests if GP-pharmacist teamwork can help patients quit antidepressants safely

NCT ID NCT07398053

Not yet recruiting Symptom relief Sponsor: University Ghent Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a new approach where general practitioners and pharmacists work together to help adults who have been taking antidepressants for a long time but are feeling stable. The goal is to see if this teamwork helps more people safely stop their medication without their depression coming back. The study will compare this new approach to usual care over two years in GP practices across Belgium.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: structured GP-pharmacist collaboration (behavioural intervention)
What this could lead to: If it works, this could provide a safe, supportive way for many people to stop long-term antidepressants without their depression returning.
What could go wrong: This is a relatively small trial (324 people) testing a behavioural approach, not a drug. Success depends on patient and doctor willingness, and results may not apply to everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Depression depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANTIDEPRESSANT DEPRESCRIBING DEPRESSION DISORDER DISCONTINUATION PRIMARY CARE

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Other studies related to the condition(s) this trial covers.