Anxiety disorder

This study looks at whether treating obstructive sleep apnea (OSA) early with a positive airway pressure (PAP) device can improve outcomes for veterans with both PTSD and substance use disorder. About 194 veterans in a residential treatment program will either receive PAP therapy…

This study tests whether an 8-week home-based breathing exercise called Inspiratory Muscle Strength Training (IMST) can reduce dementia risk in adults aged 60-80. Researchers will measure changes in blood pressure, thinking skills, mood, and sleep quality. The goal is to see if t…

This pilot study will test a program that combines a trauma-focused therapy (STAIR) with peer-led HIV prevention (PrEP) support for transgender and nonbinary people who have experienced violence. The goal is to see if this combined approach is acceptable, feasible, and helps impr…

This study tests if deep brain stimulation (DBS) can help people with severe obsessive-compulsive disorder (OCD) that hasn't improved with other treatments. Ten participants will have a device implanted in their brain and be randomly assigned to receive real or sham stimulation. …

This Phase 3 trial evaluates the long-term safety and tolerability of an experimental drug called ITI-1284, taken under the tongue, for people with generalized anxiety disorder (GAD) who have not responded to previous treatments. Participants receive ITI-1284 either alone or alon…

This Phase 2 trial is testing whether HB-1, a tablet combining two blood pressure medications (telmisartan and verapamil), can safely reduce PTSD symptoms. About 200 adults aged 18-65 with PTSD will receive either HB-1 or a placebo daily for 12 weeks. The main goal is to see if H…

This phase 3 trial is testing whether an experimental oral medication called SEP-363856 (ulotaront) can reduce anxiety symptoms in adults with generalized anxiety disorder. Participants will receive one of two fixed doses of the drug or a placebo for 8 weeks. The main goal is to …

This trial tests whether Caplyta, a drug already used for other conditions, can reduce symptoms of social anxiety disorder in adults. Researchers will give 40 adults either Caplyta or a placebo every day for 8 weeks, with weekly clinic visits to track changes. The main question i…

This trial is testing whether an experimental oral medication called SEP-363856 (ulotaront) can reduce anxiety symptoms in adults with generalized anxiety disorder (GAD). About 384 participants will receive either the drug or a placebo daily for 8 weeks. The main goal is to see i…

This trial tests whether a structured group therapy, blending EMDR and sensorimotor techniques, can help adults with trauma-related symptoms in a primary care setting. Participants are randomly assigned to either this group intervention or usual care. The study measures changes i…

This trial tests whether a non-invasive brain stimulation technique called continuous theta burst stimulation (cTBS) can enhance the effects of standard anxiety medication in adults with generalized anxiety disorder. Participants are randomly assigned to receive cTBS targeting on…

This pilot study tests whether transcranial magnetic stimulation (TMS) is safe and tolerable for teenagers aged 13 to 17 with obsessive-compulsive disorder (OCD) who have not improved enough with standard treatments. Participants receive TMS sessions five days a week for three we…

This trial tests whether a daily synbiotic supplement, which combines prebiotics and beneficial bacteria, can improve gut health and mental well-being in people with obesity. Researchers will give 120 adults with a BMI between 30 and 40 either the supplement or a placebo for 12 w…

This trial tests whether a noninvasive technique called transcranial temporal interference stimulation (tTIS) can reduce symptoms in people with obsessive-compulsive disorder (OCD). The stimulation targets the nucleus accumbens, a deep brain region linked to OCD, using electric f…

This trial tests whether giving prolonged exposure therapy for PTSD in a massed format, with multiple sessions each week, works as well as the standard once-a-week schedule for veterans who are also in intensive outpatient treatment for substance use disorder. Researchers will co…

This trial tests whether an internet-based form of cognitive behavior therapy (CBT) can reduce symptoms of common mental disorders like anxiety, depression, and stress-related conditions in adults seeking primary care. About 500 participants will be randomly assigned to either th…

This study tests whether a computerized training program designed to improve response inhibition — the ability to stop an automatic action — can reduce symptoms in people with obsessive-compulsive disorder, trichotillomania (hair-pulling), or skin-picking disorder. Participants a…

This trial tests whether a 12-session healthy lifestyle program—focusing on physical activity, nutrition, sleep, and stress management—can lower cardiovascular risk in adults with posttraumatic stress disorder (PTSD). Participants are adults with PTSD symptoms who are also overwe…

This trial tests whether an artificial intelligence tool called StratCare can improve depression treatment by recommending personalized therapy paths. About 1,250 adults with depression will be split into two groups: one using StratCare to guide treatment choice, the other follow…

This study tests whether a 6-week digital mindfulness program, delivered through a mobile app, can help people with obsessive-compulsive disorder (OCD) manage their symptoms. The trial compares the digital therapy alone, standard medication alone, and a combination of both in 150…

This study tests whether combining a leadership alignment program with a champion strategy helps clinics in Malawi better integrate mental health care for anxiety and depression. About 1,080 adult patients who screen positive for these conditions will take part. The goal is to se…

This study tests whether adding a motivation-enhancing module and a shared decision-making session before standard PTSD treatment can reduce dropout and improve outcomes. Adults with PTSD at two clinics are randomly assigned to receive standard care, the motivation module plus st…

This phase 2 study tests whether the sleep medication suvorexant can reduce insomnia in 76 adults aged 21–65 who have both alcohol use disorder and posttraumatic stress disorder. Participants take either suvorexant or a placebo for 14 days while trying to stop drinking. The study…

This study tests whether using a person's genetic information to guide medication choices leads to better recovery for people with mood, anxiety, or psychotic disorders. Over 2,500 participants will receive either standard care or personalized medication advice based on their gen…

This study tests whether a drug called BXCL501, given as a film under the tongue, can reduce acute stress and prevent post-traumatic stress disorder (PTSD) in people who have been in a motor vehicle collision. One hundred adults who come to the emergency department within 72 hour…

This study tests a program called HARPP that combines proven treatments for PTSD and weight management into a single therapy for veterans. The goal is to see if this integrated approach leads to greater weight loss and PTSD symptom reduction compared to standard care. The study w…

This study tests a pharmacy-led program for low-income patients with multiple chronic conditions like diabetes, heart disease, and depression. After leaving the hospital, participants get their medications with no copay, delivery to their bedside and home, and help from a pharmac…

This study tests whether a trauma-focused group therapy (CPT-CJ) given in prison can reduce drug use, PTSD symptoms, and re-arrest after release. 640 incarcerated adults from about 10 prisons will either receive the group therapy or a self-help workbook. Researchers will also mea…

Researchers are testing an artificial intelligence algorithm called CAUD-PIN to see whether it can predict awakenings caused by trauma-related nightmares in military personnel and veterans with PTSD. Participants wear an EEG headband and a wrist sensor at home for 15 nights and p…

Researchers are testing an AI-powered clinical decision support system for primary care. Adult patients complete a self-report assessment before a routine visit, and the system turns their answers into a short Companion Brief for the treating clinician. A principal investigator r…

This study tests a radioactive tracer called 18F-AIPF-1026 that binds to monoamine oxidase A (MAO-A), an enzyme linked to depression, anxiety, and heart injury. About 200 adults with these conditions will receive a single injection of the tracer and then undergo PET/CT or MRI sca…

This study tests a simple talking therapy for heart surgery patients while they are still in the ICU. The therapy uses a visitor book with photos and family messages to help patients process stressful memories. Researchers hope this can prevent posttraumatic stress disorder (PTSD…

People who need emergency surgery after a traumatic event like a car crash or fall face a higher risk of developing post-traumatic stress disorder. This trial tests whether giving the sedative dexmedetomidine during surgery, with or without adding a non-invasive ear stimulation c…

This study tests a program called TENDAI4PrEP, which uses problem-solving techniques to help pregnant women in Zimbabwe take PrEP, a daily pill that prevents HIV. The program also involves their partners and healthcare providers. Researchers will enroll 132 HIV-negative pregnant …

This study tests whether a non-invasive brain stimulation technique called TMS, given within two weeks of a traumatic event, can prevent chronic PTSD. Researchers will measure changes in brain activity linked to fear and threat. The goal is to see if early intervention can reduce…

This study tests a mobile app called e-Perinatal designed to prevent depression and anxiety during and after pregnancy. The app offers personalized tips, mental health tracking, and a support button. Researchers will enroll 3,000 pregnant women across primary care centers in Spai…

This study tests whether a special toolkit of proven mental health techniques can help prevent depression, anxiety, and stress in active-duty airmen. About 5,500 service members and their behavioral health technicians will take part. The toolkit gives technicians better training …

This study tests whether reading special storybooks can teach kindergarteners coping skills to prevent emotional difficulties like anxiety. About 56 children in Singapore will participate. Researchers will measure changes in coping skills and anxiety levels to see if the program …

This study tests a program called Family Spirit Strengths (FSS) designed to help American Indian and Alaska Native mothers and caregivers cope with stress, build skills, and connect with their culture. About 188 participants will either receive FSS or a nutrition education progra…

This pilot study tests whether a breathing technique called cardiac coherence can prevent chronic PTSD in people who recently experienced a traumatic event. 44 participants with acute stress disorder will practice the breathing exercises for 3 months. The goal is to see if this s…

This study tests two school-based programs designed to help teenagers aged 13-19 sleep better. The goal is to see if improving sleep can prevent depression, anxiety, and daytime sleepiness. About 3000 students in Swedish high schools will take part, and their results will be comp…

This study tests whether a probiotic called Clostridium butyricum can help reduce anxiety and depression in people with functional dyspepsia (a common stomach disorder). 180 adults will receive either the probiotic or a placebo for 4 weeks, alongside standard stomach medication. …

Researchers are studying two online programs for parents going through divorce or separation. The study enrolls 96 parents in the United States who have a child aged 6 to 18 with a former partner and report mild to moderate distress. Parents are assigned to one of three groups: a…

This study tests a program called CommunityRx-Dementia, where trained peer mentors help caregivers of people with dementia. Over 12 months, caregivers get a personalized list of community resources, coaching, and supportive text messages. The goal is to reduce loneliness and help…

Researchers are testing whether daily virtual reality sessions can reduce anxiety and pain for people having hip or knee replacement surgery. Participants use a VR headset for 20 minutes a day starting about a week before surgery and continuing for 30 days after. The pilot study …

Researchers are testing whether a multisensory nature experience, using natural materials and a virtual natural setting, reduces anxiety, fear, and pain in hospitalized children aged 5 to 9 during venous blood sampling. The trial compares this approach with standard care and also…

Patients who need stitches for minor injuries often feel anxious and expect pain while they wait in the emergency department. Researchers at Gazi University are testing whether an AI-assisted education material, reviewed by clinicians and given during that wait, can lower anxiety…

This study tests whether adding a computer task called gaze-contingent music reward therapy (GCMRT) to standard cognitive behavioral therapy (CBT) helps reduce anxiety in children aged 8 to 17. In GCMRT, children look at faces on a screen while pleasant music plays or stops depen…

This study tests a virtual platform called MOVIN that helps pregnant and postpartum people with depression or anxiety. Participants get a care coordinator who recommends online treatments and works with their doctor. The goal is to see if this approach reduces symptoms better tha…

This study tests whether a computer-based working memory training program can help veterans with PTSD improve their ability to unlearn fear responses. 120 veterans will be randomly assigned to either the training or a sham version. The goal is to see if the training changes brain…

This study tests whether acupressure, a technique that applies gentle pressure to specific points on the body, can lower blood sugar and reduce anxiety in people aged 65 and older with diabetes. Forty-eight participants will receive either real acupressure or a sham version for 6…

This study tests a 10-session meditation practice combined with real-time brain feedback to help ease depression. Twenty-seven adults with moderate depression will participate. The goal is to see if this approach can improve mood and reduce symptoms.

This pilot study will test whether a 'Comfort Tote' filled with items like aromatherapy oils, stress balls, acupressure guides, and a journal can help teens aged 10-21 feel less pain, anxiety, and stress after scoliosis surgery. Half the participants will get a tote with therapeu…

Researchers at Northwestern University are testing a psychological program called PREPARE-GI for adults who have lasting stress from past medical experiences and are scheduled for complex gastrointestinal surgery. The program involves eight one-hour sessions with a licensed psych…

This study tests a handheld device called gammaCore that gently stimulates the vagus nerve in the neck, aiming to reduce PTSD symptoms. About 40 adults with PTSD will use the device at home for 12 weeks. Researchers will track symptom changes and safety to see if this approach co…

Researchers are studying how many sessions of MDMA-assisted therapy U.S. veterans with PTSD need to reduce their symptoms. Participants receive between one and five treatment cycles, each pairing an MDMA session with follow-up talk therapy. The trial measures changes in PTSD symp…

This study tests a 20-25 minute online program called Project EMPOWER-OCD for caregivers of people with OCD. The program teaches caregivers how to reduce accommodating behaviors that can accidentally make OCD worse. Researchers want to see if it lowers caregiver stress and improv…

This study explores whether a short, evidence-based therapy called Written Exposure Therapy (WET) can help pregnant and postpartum women who have PTSD and a history of substance misuse. Participants receive five weekly telehealth sessions where they write about a traumatic experi…

This study tests a prescription wrist device called NightWare that detects when a veteran with PTSD is having a nightmare and gently disrupts it without waking them. Researchers want to see if better sleep from fewer nightmares can also improve blood vessel and heart health. 125 …

Transgender and gender diverse adults smoke at higher rates than the general population, and stigma, discrimination, anxiety, and depression may make quitting harder. Researchers at Massachusetts General Hospital are adapting an existing smoking cessation program called QUIT, whi…

Researchers are studying a 16-session group programme that teaches Dialectical Behaviour Therapy (DBT) skills to people who struggle with emotional dysregulation. Participants attend weekly 2.5-hour sessions in small groups over about five to six months. The study includes adults…

This study tests a 13-week remote stress recovery program for people who had a heart attack before age 55 and still feel distressed. The program includes online sessions with a therapist, a workbook, and videos. The goal is to see if a larger trial is possible by checking how man…

This study tests two mind-body programs designed to reduce anxiety, depression, and emotional distress in cardiac arrest survivors and their caregivers. About 84 pairs (survivor and a family member or friend who helps them) will participate. The goal is to see if the programs are…

This study tests whether a small device that gently stimulates a nerve in the neck can reduce PTSD symptoms in veterans. 80 veterans will use the device at home twice a day for three months. Researchers will measure changes in brain activity, heart function, and PTSD symptoms com…

This study tests whether listening to short, guided mindfulness audio recordings before and after surgery for a broken arm or leg can help reduce pain, anxiety, and the need for opioid painkillers. Fifty adults will be randomly assigned to either the mindfulness group or a contro…

This trial tests two ways to bring nature to older adults stuck in the hospital for weeks: watching 360-degree nature videos through a virtual reality headset, or listening to audio guides that prompt them to imagine the same scenes. Both approaches use identical nature themes—me…

This study tests whether COMP360, a lab-made psilocybin, can reduce PTSD symptoms when given with professional support. About 300 adults with PTSD will receive either a high or low dose and be followed for 8 weeks. The goal is to see if the drug safely eases symptoms like flashba…

This study tests whether brief, online self-guided programs can help parents of children ages 2-7 better manage their child's anxiety. About 90 parents will be randomly assigned to one of three programs. The goal is to see if these programs reduce how much parents accommodate the…

This study tests a new drug called SPT-300 in 360 adults with major depressive disorder, with or without anxiety. Participants will receive either the drug or a placebo for 6 weeks to see if it reduces depression symptoms. The goal is to find a safe and effective new treatment op…

This study tests a new way to reduce fear in people with phobias (like spiders or snakes) without needing to consciously face what scares them. Using brain scans (fMRI), the method retrains the brain unconsciously, aiming to lower fear responses and make treatment less distressin…

This study tests whether two types of breathing exercises—pranayama and pursed-lip breathing—can reduce pain, anxiety, and improve vital signs in women after breast surgery. 126 participants will be randomly assigned to one of three groups: pranayama, pursed-lip breathing, or sta…

Researchers are testing a four-session compassion-based program for family caregivers of people recently diagnosed with lung cancer. The program teaches self-compassion and soothing breathing exercises. The trial compares the program with a single telephone support session. The t…

Researchers are testing whether Deep Brain Reorienting (DBR), a psychotherapy that targets brainstem-level survival responses, can reduce PTSD symptoms in military members and veterans. Participants receive eight sessions of about 50 minutes each, and the study compares their out…

This study tests an 8-week group program that combines mindfulness, gentle movement, breathing exercises, healthy eating tips, and art activities for adults aged 55 and older with mild-to-moderate depression or loneliness. The goal is to see if the program improves mood, reduces …

This study is testing a new social skills training program for Veterans with serious mental illness (like schizophrenia, bipolar disorder, or PTSD) who are looking for work. The program teaches skills to better understand social cues and handle workplace relationships. Researcher…

This study tests whether a dedicated 30-minute consultation with a healthcare professional before getting an implantable port (a small device under the skin for chemotherapy) can lower patient anxiety. About 150 adults scheduled for the procedure will either get standard care or …

This trial tests whether a device that sends mild electrical pulses to the ear — a method called transcutaneous auricular vagus nerve stimulation (taVNS) — can reduce symptoms of social anxiety disorder. About 100 adults with the condition will receive either real taVNS or a sham…

This study tests whether very short (4 or 8 sessions) psychological treatments can reduce symptoms of anxiety, depression, and stress-related physical complaints. About 184 adults with mild to moderate symptoms will be randomly assigned to group or individual therapy, or a relaxa…

This trial tests whether a combination of pain education, guided imagery, and paced breathing—called the STEIN Protocol—can help people undergoing awake cataract surgery need less pain and anxiety medication. Participants wear open-ear headphones that play audio prompts every few…

This study tests whether applying an ice pack or a warm gel pad to the drain site before removal can lower anxiety, improve comfort, and stabilize vital signs in patients recovering from open urological surgery. 120 adults will be randomly assigned to ice, warm gel, or standard c…

This Stanford study tests whether having a dream while under anesthesia can reduce PTSD symptoms. In a small Phase 2 trial, 42 adults with PTSD will receive either deep sedation to trigger dreaming or light sedation without dreaming. Researchers will compare changes in PTSD sever…

This study tests whether the psychedelic drug psilocybin, combined with talk therapy, can safely reduce PTSD symptoms in Georgia military veterans. 150 veterans will be randomly assigned to different therapy approaches to compare results. The goal is to see if this combination is…

Researchers in Pakistan are testing whether group-based positive psychotherapy and positive cognitive behavioral therapy can reduce psychological distress and improve coping and wellbeing among incarcerated individuals. The trial enrolls 180 people serving their first sentence wh…

Researchers test whether behavioral therapy for selective mutism works better when children also practice speaking in a virtual school at home using a VR headset. The trial enrolls 15 primary school children who do not speak in certain social situations, such as at school, despit…

Researchers are studying whether hyperbaric oxygen therapy changes thinking skills and post-concussion symptoms in current and former first responders who have a traumatic brain injury. About 54 adults will complete cognitive tests and questionnaires before and after receiving 40…

This study looks at two short counseling programs for veterans who have experienced intimate partner violence in the past year. One program offers up to 8 sessions covering topics like social support and health effects, while the other is a single session focused on safety and re…

This study tests a 6-week compassion-based program for teens (ages 12-18) with emotional disorders like depression or anxiety, together with their parents. The program includes weekly group sessions and home practice to build self-compassion and improve family communication. Rese…

This study tests whether listening to binaural beats or a patient's chosen music for 30 minutes after knee or hip replacement surgery can lower pain and anxiety. About 50 adults having these surgeries will take part. Researchers will measure pain and anxiety levels right after su…

Hospital workers exposed to trauma from war and terrorism often face anxiety, emotional distress, and acute stress symptoms. This study examines whether integrative medicine treatments such as acupuncture, touch and movement techniques, and mind-body practices can ease those symp…

Researchers are studying whether hyperbaric oxygen therapy changes blood markers of inflammation and brain injury in military veterans who have traumatic brain injury and persistent post-concussive symptoms. About 34 veterans receive 40 sessions in a pressurized chamber, breathin…

This study tests whether listening to your own choice of music during awake hand surgery lowers anxiety more than standardized relaxation music. 170 adults having hand surgery with only local anesthetic will be randomly assigned to one of the two music groups. Researchers will me…

Many people feel anxious before joint replacement surgery, and that anxiety can lead to more pain and more pain medication afterward. Researchers at Columbia University are testing whether letting patients listen to their own music through noise-cancelling headphones before hip o…

This study from Yale University will test whether 20 minutes of moderate cycling can reduce obsessive thoughts, compulsive urges, and improve thinking flexibility in adults with OCD. Fifty participants will be randomly assigned to either moderate or low-intensity cycling. Researc…

Researchers are testing whether telling riddles during cast application can reduce pain, fear, and anxiety in children aged 6 to 12. The study enrolls 68 children who need an upper or lower limb cast. Children are randomly assigned to either hear riddles during the procedure or r…

Breast biopsy can cause pain and anxiety, and those feelings may affect blood pressure and heart rate. Researchers are testing whether squeezing a stress ball during the procedure lowers pain and anxiety compared with standard care. The trial enrolls women having a first Tru-Cut …

Researchers are testing whether a daily 20-minute mandala coloring session, led by a nurse, lowers anxiety and improves how children view nurses during a hospital stay. The trial enrolls 64 children aged 8 to 11 who are patients in a pediatric clinic. Children in the coloring gro…

This study tests whether acceptance and commitment therapy (ACT) can help adults with religiously oriented obsessive-compulsive disorder (OCD). Ten participants will receive ACT and be assessed for changes in their OCD symptoms and avoidance behaviors. The goal is to see if this …

This study tests whether a virtual reality (VR) tour of the hospital and operating room can help children aged 3 to 12 feel less anxious and scared before elective surgery. Half of the 56 children will use a VR program called NixiKit, while the other half will receive the usual p…

Researchers are testing an 11-week online group program that combines mindfulness, cognitive-behavioral therapy, and exposure techniques for adults with obsessive-compulsive disorder. The study enrolls 42 outpatients in Italy and measures changes in OCD severity, depression, trea…

This study tests a brief group therapy called Acceptance and Commitment Therapy for insomnia (ACT-i) in 76 adults aged 18-59 with chronic insomnia and mild depression or anxiety. Participants are randomly assigned to either ACT-i or a general support group. The goal is to see if …

This study tests whether taking a daily probiotic supplement for 8 weeks can reduce stress and anxiety in healthy university students during exam time. Two hundred students will receive either the probiotic or a placebo. Researchers will measure changes in stress, anxiety, sleep …

This study tests an experimental drug called ITI-1284 for people with generalized anxiety disorder (GAD) whose current treatment isn't working well enough. About 705 adults will receive either ITI-1284 or a placebo added to their usual therapy. The goal is to see if the drug safe…

This study tests whether a daily tablet called ITI-1284, taken under the tongue, can help people with generalized anxiety disorder whose current treatments aren't working well enough. About 570 adults will receive either the drug or a placebo, and researchers will measure changes…

Researchers are testing the best order of two talk therapies for military personnel and veterans who have both PTSD and ringing in the ears, known as tinnitus, after a mild traumatic brain injury. Participants receive either Cognitive Processing Therapy for PTSD first, followed b…

This Phase 2 trial tests whether a single injection of RE104 can reduce anxiety symptoms in 64 adults with generalized anxiety disorder, compared to a placebo. Participants receive one dose and are followed for four weeks to measure changes in anxiety severity using a standard ra…

This study tests a mobile app called Maya that teaches cognitive behavioral therapy skills to adults who recently had a stroke and feel depressed or anxious. Ten participants will use the app for a few weeks to see if it is easy to use and helps improve their mood. The goal is to…

Researchers are testing whether TSND-201, a capsule form of methylone, can reduce PTSD symptom severity in adults. About 300 participants with a PTSD diagnosis lasting at least six months and prior treatment will take either one of two TSND-201 doses or a placebo once a week for …

This study will follow 120 people with chronic pain, nerve damage from chemotherapy, radiation side effects, or slow-healing wounds who are referred for ozone therapy. Researchers will track changes in quality of life, pain, and other symptoms over several months. The goal is to …

This study looks at whether combining psychotherapy with mind-body practices (like yoga or meditation) helps Veterans with PTSD function better in daily life. About 300 Veterans will be randomly assigned to different types of integrated care for 12 weeks. Researchers will track c…

This study tests whether special breathing exercises can help veterans and others with persistent post-concussion symptoms like headaches, dizziness, and memory trouble. The exercises aim to improve heart rate variability, a sign of how well the nervous system is working. 148 par…

Researchers test whether pre-cooling the mouth or giving a sweet-tasting solution, alone or with a numbing gel, reduces pain when children get dental anesthetic injections. The trial enrolls 224 children aged 7 to 11 who need dental work. In a first phase, children pick their fav…

This study tests a mobile app designed to help veterans with PTSD who struggle with anger. 150 veterans will be randomly assigned to use either the anger-reduction app or a health education app. The goal is to see if the anger app helps more veterans get their anger under control…

This study compares two ways of delivering a combined attention and strategy training program to veterans with mild traumatic brain injury and PTSD. One group receives the training in person, the other via telehealth. The goal is to see if remote delivery works just as well for i…

Researchers are testing whether a five-day program of drawing and reflective writing can reduce anxiety and improve mood in adolescents with type 1 diabetes. Fifty teens aged 9 to 18 who use an insulin pump take part, with half doing the art activities online and half receiving s…

This study is testing a therapy program called the Unified Protocol for Children (UP-C) and Adolescents (UP-A) to help young people aged 7-17 with anxiety, depression, or other emotional difficulties. The program involves up to 24 sessions with a therapist, either in groups or in…

This pilot study will test whether virtual reality (VR) or a combination of VR and hypnosis (Hypno-VR) can help reduce pain and anxiety during a diagnostic hysteroscopy, a common gynecological procedure. 45 adult patients will be randomly assigned to standard care, VR, or Hypno-V…

This early-phase study tests whether a sublingual form of dexmedetomidine (BXCL501) is safe and shows promise for treating alcohol use disorder in people who also have PTSD. Ten heavy drinkers with PTSD will take the drug and be monitored for changes in blood pressure, anxiety, a…

This study explores whether group drumming or music listening can improve pain, stress, and brain function in people with early Alzheimer's, mild dementia, or mild cognitive impairment, as well as their caregivers. Over 8 weeks, 60 participants will attend weekly sessions while r…

This study tests whether using a mobile app called the Safe and Sound Protocol (SSP) can help adults who are in treatment for substance use and have a history of trauma. About 100 participants will either use the active SSP or a sham version for up to 5 hours over a week, alongsi…

This study tests whether a 3-day program called Alliance180, which includes working with horses, can improve anxiety, depression, and overall well-being in adults who are or were US veterans, first responders, or frontline healthcare workers. Fifty participants will fill out ques…

This study tests a web-based program called webSTAIR, which teaches emotion regulation and relationship skills, for female veterans who have experienced military sexual trauma or intimate partner violence and also have a brain injury. The goal is to see if it helps them manage em…

This study tests whether a nature-based healing meditation program can help friends and family caregivers who are grieving the loss of a loved one to cancer. The program includes six audio meditation modules available online. Researchers will measure how feasible and acceptable t…

This pilot study tests whether a faster schedule of non-invasive magnetic brain stimulation, called accelerated intermittent theta burst stimulation (iTBS), is practical and safe for adults with both PTSD and major depression. Participants receive six short sessions per day for f…

Researchers test whether adding rectal ozone therapy to usual care can reduce numbness and tingling in people with chemotherapy-induced peripheral neuropathy. The trial enrolls 42 adults whose cancer is stable or in remission and who have had persistent numbness or tingling for a…

Researchers are testing whether playing video games can reduce anxiety in adolescents aged 11 to 15 with elevated anxiety symptoms. The trial compares an action game designed to boost attention control, a casual puzzle game, and no game at all. Teens play at home online for six w…

Researchers are testing whether an accelerated protocol of transcranial magnetic stimulation using the BTL-699-2 device can reduce anxiety symptoms in adults with generalized anxiety disorder. The trial enrolls 40 adults aged 22 and older who receive 16 stimulation sessions over …

This study tests whether buspirone, a medication used for anxiety, is safe and effective for autistic youth aged 7 to 17 who also have anxiety disorders. Researchers will measure changes in anxiety symptoms over 16 weeks. The goal is to see if this drug can ease anxiety in this s…

Researchers at Penn State are testing whether the BaSICS program reduces anxiety, depression, and suicide risk in 11- to 14-year-olds from low-income families who are waiting for mental health services. The program teaches coping skills, healthy identity development, and collecti…

This study tests whether giving coloring activities (nature scenes, geometric shapes, word searches, or free drawing) to adults waiting in the emergency department can lower their self-reported pain and anxiety. Researchers will measure changes using standard questionnaires. If e…

Researchers are testing a two-day group therapy program for military couples where one partner has PTSD. The program, called AIM-CBCT for PTSD, teaches couples skills to manage PTSD symptoms and improve their relationship. They compare it with a standard relationship education pr…

This trial tests whether cannabidiol (CBD) can reduce symptoms of post-traumatic stress disorder (PTSD) in adults. Participants take either CBD or a placebo for 8 weeks, and researchers measure changes in PTSD symptoms using standard clinical assessments. The study aims to see if…

This study tests whether a new drug called TSND-201 can safely reduce PTSD symptoms in adults. About 300 people with PTSD will receive either one of two doses of TSND-201 or a placebo once a week for 4 weeks, then be followed for 8 more weeks. The goal is to see if the drug helps…

This study tests a new type of talk therapy called Identity-Based Transdiagnostic Therapy (IBTT) for young adults with anxiety or depression. It compares IBTT to a well-known therapy called the Unified Protocol (CBT-based). The goal is to see if IBTT is more engaging and effectiv…

This study tests whether a simple injection of dextrose (sugar water) into the neck can reduce symptoms like anxiety, brain fog, and depression in people with PTSD who haven't improved after trying multiple medications and therapies. About 50 adults will receive either the dextro…

This study tests whether virtual reality (VR) can help healthcare workers and COVID-19 patients with posttraumatic stress disorder (PTSD). Participants will use VR headsets during 10 therapy sessions over 5 weeks to safely revisit and overcome traumatic memories. The goal is to s…

This early study tests whether a surgically implanted device that stimulates the vagus nerve can boost the effects of talk therapy for people with chronic PTSD. Twenty adults who have not gotten better with standard treatments will receive either active or sham stimulation alongs…

This study tests whether playing gentle sounds during deep sleep can improve thinking and emotional control in young adults (ages 18-25) with anxiety, depression, and sleep problems. Participants will spend two nights in a sleep lab, once with tones and once without, and complete…

This study tests a new version of a therapy called RTM-C for children aged 6-14 with PTSD. The treatment uses child-friendly language, games, and animated tools to help kids safely replay difficult memories and reduce fear. About 40 children and their parents will take part in up…

Researchers are testing whether ketamine infusions combined with mindfulness-based cognitive therapy improve quality of life more than mindfulness therapy alone in adults who have both chronic pain and posttraumatic stress disorder. The pilot study enrolls 30 veterans and civilia…

This study tests whether squeezing a stress ball during wound cleaning (debridement) helps reduce pain, distress, and changes in heart rate or blood pressure in people with diabetic foot ulcers. About 84 adults with type 2 diabetes will be randomly assigned to use a stress ball o…

This phase 2 trial tests whether low intensity focused ultrasound, aimed at a deep brain region called the amygdala, can ease PTSD symptoms in 60 veterans. The treatment is non-invasive and uses sound waves similar to diagnostic ultrasound. Researchers will measure symptom change…

This study tests whether a single injection of RE104 can reduce symptoms of depression or mixed depression and anxiety in people with adjustment disorder caused by a serious medical illness like cancer, ALS, multiple sclerosis, Parkinson's disease, or idiopathic pulmonary fibrosi…

This study will enroll 400 youth aged 8-18 with chronic medical conditions who have experienced trauma. Participants will first receive group therapy using either SPARCS or UP, two evidence-based talk therapies. Those who still need help after group therapy will then receive indi…

Researchers at San Diego State University are testing an 8-week online program that teaches intuitive eating principles to pregnant women with obesity. The program includes weekly video modules and workbook exercises, with optional office hours. The study will compare participant…

This trial tests whether adding personalized feedback makes an ultra-brief online program more effective for adults with depression and anxiety. The program, called Things You Do, teaches skills to increase healthy actions like meaningful activities, healthy thinking, and social …

Researchers are testing a computer-based program that aims to change how anxious children interpret ambiguous situations as threatening. The trial enrolls 72 youth ages 10 to 17 with generalized, separation, or social anxiety disorder. Participants are randomly assigned to either…

This study tests whether a therapist-guided online cognitive-behavior therapy program can help reduce obsessive-compulsive disorder (OCD) symptoms in children and teens with autism. About 220 participants will receive the online treatment or a comparison condition. The goal is to…

This study tests a program called Parenting STAIR Modular (PSTAIR-M) for military-connected mothers who have experienced trauma and have young children aged 2-10. The program helps mothers manage PTSD and depression symptoms while improving their parenting skills. Researchers wil…

This study tested a school-based program called Proud & Empowered, designed to help LGBTQ students cope with minority stress and improve mental health. About 228 high school students took part. The program was led by school counselors and social workers. The study was terminated …

This study compares two strategies for veterans struggling with Cognitive Processing Therapy (CPT) for PTSD: using CPT skills to work through challenges, or switching to a different therapy called Present Centered Therapy. The goal is to see which approach reduces dropout and imp…

This study tests whether involving a romantic partner in PTSD therapy helps veterans function better in daily life. About 420 post-9/11 veterans with PTSD and their partners will take part. The treatment, called Partnered PE, adds partner support to standard exposure therapy to i…

This phase 2 trial at MD Anderson Cancer Center is testing whether psilocybin-assisted psychotherapy can safely help ease depression and anxiety in 30 adults with advanced cancer who are on maintenance therapy. Participants receive either psilocybin or a placebo (niacin) along wi…

Researchers test whether an AI chatbot called Pai.ACT can help parents of young children with neurodevelopmental disorders like autism and ADHD. The chatbot delivers acceptance and commitment therapy, a type of talk therapy, and adapts its exercises to each parent's needs. The tr…

This study tests whether taking vitamin D daily for 8 weeks helps healthy adults keep their thinking, simple physical tasks, and mood steady during very stressful situations. 52 participants will take either vitamin D or a placebo, then perform tasks while wearing a belt that giv…

This small study will test whether giving a 15-20 minute massage during infusion therapy can reduce pain and anxiety in women with gynecologic cancer. Twenty-four participants will be randomly assigned to receive either a hand, foot, or neck/shoulder massage or simply talk with t…

This study tests a two-week intensive summer treatment program for 70 adolescents aged 12-18 with obsessive-compulsive disorder (OCD) in Iceland. The program uses daily cognitive-behavioral therapy with exposure and response prevention in a group setting. Researchers will measure…

This study will test whether Emotional Freedom Technique (a type of tapping) and music therapy can reduce stress, anxiety, and depression in women with a high-risk pregnancy due to early rupture of membranes. About 177 women will be randomly assigned to receive these therapies or…

Researchers are testing an internet-delivered form of acceptance and commitment therapy for people aged 15 to 24 who have PTSD and chronic pain. Participants work through online modules on trauma education, facing avoided memories and situations, mindfulness, and acceptance, with…

This study is testing whether adding small amounts of human coaching, email reminders, or text messages to a meditation app can help people with depression and anxiety feel better. About 688 adults with elevated symptoms will use the Healthy Minds Program app for four weeks. Rese…

This study tests whether a therapy called Sensory Motor Arousal Regulation Treatment (SMART) works better than standard care for youth aged 7-17 who have experienced trauma and struggle with self-regulation. The trial will involve 120 participants randomly assigned to SMART or us…

This trial tests whether two simple distractions — watching a betta fish or playing with a hand puppet — can lower pain, fear, and anxiety in children aged 5 to 7 during a blood draw. One group will use the fish, another the puppet, and a third will receive standard care. Researc…

This study tests if reading a personal narrative book, in addition to standard care, can help women of childbearing age manage anxiety, depression, and negative thinking before a hysterectomy. About 156 women will either receive standard information or also read a book. The goal …

This study tests an online, therapist-guided program to help cancer survivors who have anxiety, depression, or fear of cancer returning. About 400 adults in Sweden who finished cancer treatment at least 6 months ago will take part. The goal is to see which parts of the 10-week on…

This study tests whether an 8-week mindfulness program can reduce anxiety and depression in adults with mild emotional distress. Participants are randomly assigned to either mindfulness training or progressive muscle relaxation. Researchers use brain scans to see if mindfulness c…

This study tests a program that offers mental health screening, therapy, and follow-up to pregnant women who are in the hospital for medical complications. About 50 participants will receive brief counseling and symptom tracking during their stay and for three months after. The g…

This study tests whether a culturally adapted version of Dialectical Behavior Therapy skills training (DBT-A-ST) helps teens aged 12-18 with emotional disorders like depression, anxiety, or ADHD. Participants are randomly assigned to either the DBT group or a standard support gro…

This study tests a four-day intensive therapy called Bergen Four-Day Treatment (B4DT) for people with obsessive-compulsive disorder (OCD). About 35 patients will receive the therapy, which involves exposure and response prevention exercises over four days, followed by three month…

This study tests whether using a stress ball for 15 minutes before retrograde intrarenal surgery (a type of kidney stone procedure) can lower patients' anxiety and fear, and improve heart rate and blood pressure. Sixty-six adults scheduled for elective surgery will be randomly as…

This study tests a short, three-session online program designed to help caregivers of people with advanced prostate cancer manage their fear that the cancer will progress. The program teaches techniques like detached mindfulness to help caregivers relate to worrying thoughts in a…

This study tests an internet-based therapy program called the Sleep Course, designed to help public safety personnel (like police, firefighters, and paramedics) who have trouble sleeping. The program teaches skills to manage sleep difficulties and includes optional support from a…

This trial tests whether a four-week improv comedy program can reduce anxiety and improve mental well-being in Chinese young adults in Hong Kong who have mild-to-moderate anxiety but no diagnosed mental disorder. Participants attend weekly three-hour improv workshops and complete…

This early-stage study at Johns Hopkins is testing whether giving both psilocybin and MDMA together is safe and can help reduce PTSD symptoms in military veterans. Forty veterans with PTSD will receive the drugs in a controlled setting. The study tracks side effects, suicidal tho…

This study tests an 8-week program called MH-POWER designed to help autistic college students manage stress, anxiety, and depression. The program combines cognitive behavioral therapy, acceptance and commitment therapy, and habit formation through weekly group sessions and daily …

This study tests a special type of talk therapy called Multi-Modal Cognitive Processing Therapy (MMCPT) for people with posttraumatic stress disorder (PTSD). Sixty adults with PTSD will either receive 12 weekly therapy sessions or standard care. Researchers will track changes in …

This trial tests a program called Teachers Leading the Frontlines (Tealeaf) that trains elementary and middle school teachers in North Carolina to support students with mental health needs, such as depression, anxiety, and behavior challenges. Teachers learn to identify students …

This pilot study tests whether adding socialization support to Trauma-Focused Cognitive Behavioral Therapy (TF-CBT) helps reduce posttraumatic stress symptoms in youth aged 10-15 who have experienced child maltreatment. Participants receive the enhanced therapy, and researchers m…

This study at the University of Pennsylvania is testing whether personalized brain stimulation can reduce negative emotions in people with depression and anxiety. Researchers will use brain scans to map each participant's negative emotion patterns, then apply different types of t…

This study tests whether a single early meeting with a psycho-oncology counselor can reduce anxiety and depression and improve quality of life in people recently diagnosed with cancer. About 148 patients will be randomly assigned to either receive this counseling plus standard ca…

This study tests a digital therapy that combines unconscious exposure to trauma-related images with bilateral eye movements to reduce intrusive memories in people with PTSD. About 123 participants who experience at least 5 intrusive memories per week will be randomly assigned to …

This study tests a new approach to reduce intrusive memories in people with PTSD. Participants are briefly exposed to trauma cues without realizing it, then play Tetris. The idea is to disrupt memory reconsolidation without needing to consciously recall the trauma. The trial will…

This study tests a group program to help teens (ages 13-17.5) with Prader-Willi Syndrome and their families learn practical ways to handle irritability, meltdowns, and anxiety. Ten participants will attend weekly 90-minute sessions. The goal is to see if the program improves emot…

This trial investigates whether wearing a virtual reality headset showing calming nature scenes can lower pain and anxiety in adults undergoing ingrown toenail surgery under local anesthesia. Participants are randomly assigned to either receive standard care or wear the VR headse…

This study tests whether a sublingual tablet (TNX-102 SL) can reduce acute stress symptoms and prevent long-term PTSD in adults who come to the emergency room after a car crash. 180 participants will receive either the drug or a placebo for two weeks, starting in the ER. Research…

Researchers in Pakistan are testing whether Solution-Focused Therapy, a short talking therapy that focuses on goals and strengths, can reduce symptoms of generalized anxiety disorder in emerging adults. The study will enroll 50 people with mild to moderate anxiety and randomly as…

This study aims to help families with food insecurity and mothers with depression by providing resources like food, rent help, and mental health support. Researchers will enroll 2,000 caregivers of young children in the hospital to see if these services improve mother-child bondi…

This trial tests a program that screens cancer survivors for fear of recurrence and refers those who need help to psychological services. The program is being rolled out in cancer clinics in Hong Kong, with nurses trained to identify at-risk patients. Researchers will measure how…

This study tests whether high-dose aerobic exercise (over 150 minutes per week at a safe intensity) helps teens aged 13–18 recover faster from a concussion compared to standard care. Researchers will track symptom resolution, brain inflammation markers, and changes in anxiety and…

This trial tests a stepped-care program to help cancer survivors manage fear of their cancer returning. The program starts with an online intervention called eConquerFear, which teaches strategies to control worry and accept uncertainty. If needed, participants receive additional…

This study tests a new type of talk therapy for veterans and service members who have both PTSD and a mild or moderate traumatic brain injury. The therapy focuses on relaxation, stress management, and problem solving instead of asking patients to relive their trauma. The goal is …

This phase 2 trial tests whether ketamine-assisted psychotherapy (KAP) can safely ease PTSD and trauma symptoms in adults with severe burns covering more than 15% of their body. Twelve participants will receive two KAP sessions plus a preparatory talk therapy session. The main go…

This study explores whether an 8-week Brazilian Jiu-Jitsu (BJJ) program can help first responders—like police, firefighters, and EMS—manage trauma-related symptoms. Participants will attend beginner-friendly BJJ classes one to two times per week, while tracking their mood, stress…

This trial tests whether a therapy focused on trauma-related guilt and shame (TrIGR) works as well as standard prolonged exposure therapy for veterans with PTSD. About 158 U.S. veterans who served since 2001 and have PTSD with guilt symptoms will receive one of the two talk thera…

This study tests whether wearing light therapy glasses for one hour each morning can reduce obsessive-compulsive disorder (OCD) symptoms in young adults (ages 18–35) who go to bed at 1 a.m. or later. Participants wear the glasses daily for five weeks, track their sleep, and compl…

This study tests a program called Grow with Grit, where school nurses screen children aged 8-12 in rural Montana for anxiety using a standard questionnaire. Children who show signs of anxiety receive a brief, 3-5 minute coping-skills session during a regular nurse visit, along wi…

This study looks at whether a simple, non-needle ear acupressure technique can lower anxiety and pain in women having breast surgery after a first breast cancer diagnosis. About 66 women will either get standard care or standard care plus ear acupressure. The goal is to see if th…

This study tests whether combining virtual reality therapy with a mild brain stimulation technique can help veterans and civilians in Ukraine cope with PTSD. Participants attend 10 therapy sessions using VR goggles to safely face traumatic memories, with some also receiving a gen…

This study tests whether a new form of exposure therapy, called Expectancy Focused Exposure (EFE), can reduce anxiety symptoms and prevent fear from returning more effectively than traditional exposure therapy. Adults with anxiety disorders—such as social anxiety, panic disorder,…

This study looks at whether adding hypnosis or relaxation sessions to standard psychological care can lower anxiety in children, teens, and young adults who have finished treatment for pediatric cancer. About 558 participants aged 7 to 25 who are in remission and have anxiety wil…

This study tests whether a type of magnetic brain stimulation called iTBS can help people with PTSD. Researchers will give 140 adults either real or fake (sham) stimulation to see if it reduces symptoms like flashbacks and anxiety. The goal is to find a new, non-drug treatment op…

This study tests whether theatrical improvisation can help children and adolescents aged 8 to 17 who have elevated anxiety or depression. Participants are randomly assigned to one of three groups: improv combined with wellness techniques (like cognitive-behavioral skills), improv…

This trial tests whether a structured education session for family members of ICU patients about to receive a tracheostomy can lower their anxiety, boost their psychological well-being, and increase their satisfaction with care. Half of the participants get the structured program…

This trial tests whether listening to binaural beats — a type of sound that may gently nudge brain waves — can improve cognitive function in older adults with mild cognitive impairment living in nursing homes. Participants listen to old songs with or without embedded binaural bea…

This early-stage pilot study is testing whether psilocybin, a psychedelic compound, can be safely combined with trauma-focused psychotherapy for people with post-traumatic stress disorder (PTSD). Thirteen participants will receive two doses of psilocybin in a controlled setting, …

This trial tests whether a therapy that blends Exposure and Response Prevention (ERP) with Habit Reversal Training (HbRT) can reduce both obsessive-compulsive and tic symptoms in adults with Tourettic OCD — a subtype where OCD and tic disorders overlap. Standard treatments usuall…

This trial tests whether sertraline, a widely used antidepressant, can reduce anxiety in children and teens aged 8 to 17 with neurodevelopmental disorders such as autism, ADHD, Fragile X syndrome, and Tourette syndrome. Participants receive either sertraline or a placebo for seve…

This study tests whether a single 23-30 minute session of specially designed music or pink noise can reduce anxiety in adults with psoriasis. About 120 participants will listen at home using headphones. The goal is to see if audio therapy offers a quick, accessible way to manage …

This trial tests whether combining a video game exercise program (Nintendo Ring Fit Adventure) with Acceptance and Commitment Therapy (ACT) can reduce depression and anxiety in breast cancer survivors. About 120 participants will be randomly assigned to the combined program, ACT …

This study tests whether personalized music playlists can reduce stress, anxiety, and depression in adults. 2,000 participants will either receive music designed to match and gradually shift their mood, or no music. The goal is to see if this simple, non-invasive approach can imp…

This study tests whether psilocybin, the active ingredient in magic mushrooms, can safely help people with obsessive-compulsive disorder (OCD). Thirty adults with moderate to severe OCD who haven't improved with standard treatments will receive either a low, medium, or high dose …

This trial tests whether a culturally adapted, nurse-led program called COPE can improve the psychological wellbeing of primary caregivers of children with autism spectrum disorder in Pakistan. The program includes four weekly sessions focused on coping skills, emotional regulati…

This study tests whether two non-prescription therapies—inhaled essential oils and a wearable TENS device—can help adults with chronic nausea and anxiety. Participants use the essential oil products as needed for 12 weeks, then switch to the TENS device for another 12 weeks, whil…

This study follows 1,000 adults in Canada who are authorized to use medical cannabis for pain, sleep issues, anxiety, depression, or epilepsy. Researchers will track changes in symptoms using standard questionnaires over 24 weeks. The goal is to see how well medical cannabis work…

This study tests whether taking a daily probiotic supplement called Neuralli Mood for 90 days can help reduce stress, sleep problems, low mood, anxiety, and burnout in adults who experience these issues. Participants take two capsules each day and complete questionnaires before a…

This trial tests whether a support package for relatives of patients dying in the emergency department can lower the risk of prolonged grief disorder. The package includes a meeting with the healthcare team, written information on palliative care, proactive communication, a dedic…

This early-stage trial tests whether Floatation-REST — floating in a shallow, soundproof, light-free pool of Epsom salt water — can safely reduce post-traumatic stress symptoms and burnout in frontline healthcare workers and first responders. Fifteen participants will be randomly…

This trial investigates whether giving children aged 7 to 17 a sedative before general anesthesia improves their surgical experience. Participants receive either midazolam, dexmedetomidine, or a placebo before surgery. The study measures anxiety, pain, and overall satisfaction to…

This pilot study tests a program called Heartsight, which provides educational modules to caregivers of children who have had a cardiac arrest. The goal is to see if the program is feasible and acceptable, and whether it can reduce caregivers' uncertainty, anxiety, depression, an…

This study tests whether watching a virtual reality (VR) video before kidney stone surgery can lower anxiety, boost knowledge, and improve self-care. About 90 adults scheduled for surgery will be split into three groups: standard education, standard VR, or a special VR with built…

This trial tests a culturally tailored, peer-led program called SanaMente for rural Latino adults with chronic medical conditions and mild-to-moderate depression or anxiety. Over 6 to 8 weeks, trained bilingual peer mentors lead small group sessions focused on mental health, stre…

This study tests a 10-session LGBTQ-affirmative cognitive behavioral therapy (CBT) delivered via telehealth to sexual minority women who drink heavily and have anxiety or depression. Researchers will compare it to standard LGBTQ-affirmative therapy to see if it better reduces hea…

This study tests whether a 30-minute virtual reality session with nature scenes and music can reduce pain, anxiety, and improve comfort in people who just had hip replacement surgery. Participants choose from forest, beach, underwater, or outdoor footage. The goal is to see if VR…

This study tests whether a non-invasive brain stimulation technique called intermittent theta burst stimulation (iTBS) can reduce chronic PTSD symptoms in veterans. The stimulation is guided by functional MRI scans to target a specific brain region. Half of the 64 participants re…

This study tests whether giving children a sugary drink (maltodextrin) two hours before surgery can reduce their anxiety and improve recovery. Children aged 3 to 17 having day surgery will receive either the sugary drink or a plain drink like water or tea. Researchers will measur…

This study tests a group therapy program called the Unified Protocol for adults with emotional disorders such as anxiety, depression, and related conditions. The program teaches skills like emotional awareness, flexible thinking, and facing fears. Researchers want to see if it im…

This study tests whether a mobile app with short weekly exercises can help first-time parents manage emotions and reduce depression during pregnancy. About 572 expectant mothers and fathers in Singapore will use the app or receive standard care. Participants will also wear a Fitb…

This study explores whether a mobile app called FlowMD can help adults with mild anxiety. Participants use the app for 1-5 minutes of guided breathwork each day for four weeks. Surveys measure changes in anxiety levels and how easy the app is to use. The goal is to see if this ap…

This study tests whether sitting in front of a bright lightbox for 60 minutes each morning can improve sleep and overall well-being in veterans who have traumatic brain injury, post-traumatic stress disorder, and chronic pain together—known as the polytrauma clinical triad. The t…

This study tests whether a videoconference with a psychologist before anterior cruciate ligament (ACL) knee surgery can reduce pain afterward. It includes 126 anxious patients scheduled for first-time ACL reconstruction. The main goal is to compare pain levels the night after sur…

This pilot study is testing a device that sends a mild electrical current to the brain (tACS) to see if it can reduce anxiety and improve sleep in people with generalized anxiety disorder and chronic insomnia. Thirty adults will receive 20 sessions over four weeks. The goal is to…

This pilot study tests whether a peer support program can help young adults (ages 18-27) recently discharged from a psychiatric hospital. Participants get one-on-one and group meetings with trained Peer Support Specialists and recovery organizations, while a comparison group rece…

This pilot study tests a self-management program based on cognitive behavioral therapy to help people who survived acute respiratory failure and now struggle with anxiety. Sixty ICU survivors will either receive the program or usual care. The goal is to see if the program is prac…

This study tests whether using a genetic test to guide antidepressant dosing helps teens aged 12-17 with anxiety or depression. About 452 teens will be randomly assigned to either gene-guided dosing or standard dosing. The goal is to see if the genetic approach leads to more remi…

This study tests whether a non-invasive brain stimulation technique called tDCS can reduce pain in people with Complex Regional Pain Syndrome (CRPS). Thirty-two adults with active CRPS will receive either real or sham stimulation over several sessions. The goal is to see if this …

This study looks at whether using a weighted blanket during intravenous cancer treatment can help lower anxiety, stress, and depression, and improve comfort. About 152 adults with solid cancers who are starting their first IV therapy will be randomly assigned to receive either a …

This study tests a sleep health program for teens aged 10-19 who recently had a concussion. The goal is to see if better sleep helps symptoms go away faster and improves sleep quality, mood, and school engagement. Participants will be randomly assigned to the sleep program or sta…

This study tests a hybrid dialectical behavior therapy (DBT) program for veterans with PTSD who have already completed inpatient treatment. The goal is to reduce lingering symptoms and prevent relapse. About 24 veterans will take part, combining in-person skill groups with online…

This study tests whether using virtual reality (VR) goggles during a colposcopy can lower women's anxiety, stress, and pain. About 60 women scheduled for the procedure will either receive standard care or wear a VR headset showing calming content. The goal is to see if this simpl…

This study tests a 6-session program called BE-FIT that helps cardiac rehabilitation patients reduce anxiety about exercise. The program uses gradual exposure to feared sensations, prevents safety behaviors, and uses activity monitors for feedback. Researchers will enroll 146 adu…

This study looks at whether having a therapy dog present during a dental visit can lower stress in children. About 225 kids aged 4 to 8 will be randomly assigned to have a dental exam with or without a dog. Researchers will measure stress by tracking heart rate and testing saliva…

This study tests whether starting a structured exercise and education program within a month of a pulmonary embolism (a blood clot in the lungs) can prevent long-term problems like poor quality of life, shortness of breath, and reduced physical ability. About 160 hospitalized pat…

This study is testing a new type of talk therapy called Process-Based Therapy (PBT) for people with anxiety. Unlike standard treatments, PBT adapts techniques from different therapies to target each person's specific struggles. Ten adults with moderate-to-severe anxiety will try …

This study is testing a type of talk therapy for people who have both HIV and PTSD. The therapy helps people understand how trauma affects their emotions and relationships. The goal is to see if this therapy is helpful and acceptable for this group. About 20 adults with HIV and P…

This study tests whether hemp-derived CBD (with or without THC) can help older adults (60+) who use cannabis for pain, anxiety, depression, or sleep problems. Over 8 weeks, 385 participants will take either CBD+THC, CBD alone, or a placebo. The goal is to see if CBD can reduce sy…

This study tests whether having a trained peer mentor—someone who also has atrial fibrillation—can improve mental well-being in patients who are more vulnerable due to low income or education. About 290 participants will either receive usual care or be paired with a mentor for 16…

This study is testing whether a daily prebiotic fiber powder can reduce stress in healthy adults with mild to severe stress. Over 12 weeks, 120 participants will take either the fiber blend or a placebo. Researchers will measure stress levels, mood, and gut health changes.

This study compares group-based Acceptance and Commitment Therapy (ACT) to standard individual therapy for young people aged 16-25 with depression, anxiety, or stress. About 212 participants will be randomly assigned to either group ACT or individual therapy. The goal is to see i…

This study looks at whether a visual rehabilitation program can ease anxiety and depression in people with advanced age-related macular degeneration (AMD). Twenty-two participants will attend five group sessions over 60 days, learning skills like coin recognition, using voice ass…

This study tests an online program called My Wellbeing Guide for cancer patients who feel depressed or anxious. The program uses videos, activities, and written tips based on cognitive behavioral therapy over 7 weeks. About 6,500 participants will be randomly assigned to the prog…

This study tests whether a special kind of talk therapy, called Emotion-Focused Acceptance and Commitment Therapy (ACT), can reduce symptoms of Obsessive-Compulsive Disorder (OCD). About 36 adults with OCD will be randomly assigned to either ACT group therapy or a supportive grou…

This study tests whether a short, evidence-based therapy for PTSD (Written Exposure Therapy) can be effectively delivered by community health workers to pregnant women. The goal is to make treatment more accessible and reduce PTSD symptoms during pregnancy and after childbirth. A…

This early-stage trial tests whether giving psilocybin (the active ingredient in magic mushrooms) in a group setting is safe and feasible for people with PTSD. 36 participants, including veterans, first responders, and survivors of sexual violence, will receive two group dosing s…

This study tests whether watching augmented reality (AR) health education videos can help reduce anxiety and depression in women after breast cancer surgery. 60 female patients will be randomly assigned to receive either standard education alone or standard education plus AR vide…

This study tests if trauma-adapted yoga, added to usual care, can improve mental health and quality of life for 180 teens diagnosed with ADHD or PTSD. Participants will be randomly assigned to a yoga group or a waiting list. The study also explores if online yoga is a feasible op…

This study tests whether a structured emotional intelligence (EI) training program can improve mental health and reduce anxiety and depression among secondary school teachers and students in Dhaka, Bangladesh. The program teaches skills like self-awareness, self-management, socia…

This pilot study tests whether VA chaplains can deliver a program to help veterans struggling with moral injury—feelings of guilt, shame, and isolation after traumatic events. Twenty veterans receiving mental health care will take part in up to 12 chaplain-led sessions focused on…

This study tests a comfort program for children aged 5-10 in the pediatric intensive care unit (PICU). The program includes listening to their mother's voice, dimming lights, and using a weighted blanket, along with regular nursing care. Researchers want to see if this helps chil…

This study tests an accelerated form of transcranial magnetic stimulation (TMS) for people with obsessive-compulsive disorder (OCD) who haven't gotten better with standard treatments. Over 7 days, 30 participants will receive 28 sessions of brain stimulation targeting areas linke…

This study tests whether an AI-guided cognitive behavioral therapy program can reduce symptoms of mild depression and anxiety in adults. Over 10 weeks, 120 participants will either receive AI-guided therapy through a digital platform or standard care. The goal is to see if AI can…

This study tests whether EMDR, a therapy that uses guided eye movements, can help people with PTSD caused by a heart attack. Sixty adults who had a heart attack and developed PTSD will receive eight weekly EMDR sessions. The goal is to see if EMDR reduces PTSD symptoms and might …

This study tests whether AI-generated audio stories can help people with anxiety and fear of failure. Forty adults will listen to personalized scenarios based on childhood memories of criticism, with one version including a therapeutic twist where a supportive figure steps in. Th…

This study tests an online psychological program called MY-CHOICE for adults with ischemic heart disease who also have anxiety or depression. The program offers personalized online modules and therapist calls over 6-12 weeks. Researchers want to see if patients find it acceptable…

This study is testing whether a type of talk therapy called acceptance and commitment therapy (ACT) can help Black teenagers and young adults with sickle cell disease feel less stressed, anxious, and depressed. About 66 youth and their parents will join group therapy sessions and…

This study tests two types of social therapy for young adults (ages 18-30) with eating disorders or anxiety. One group gets educational sessions about brain function and social processing; the other adds interactive art tasks done in teams. Researchers will track changes in eatin…

This study tests whether a drug called pimavanserin can improve sleep in veterans with post-traumatic stress disorder (PTSD) who also have insomnia. About 60 veterans will receive either the drug or a placebo for 8 weeks. The goal is to see if it reduces insomnia severity and imp…

This study tests whether giving oxytocin nasal spray before couples therapy can help veterans with PTSD feel better and improve their relationships. About 240 veterans and their partners will take part. Half get oxytocin, half get a placebo, and all receive eight sessions of brie…

This study explores whether structured dog-assisted therapy can reduce pain, anxiety, and depression in people with fibromyalgia. Sixty adults with confirmed fibromyalgia will attend 10 sessions with a therapy dog and complete surveys on pain, mood, and daily function. Researcher…

This pilot study will put a portable transcranial magnetic stimulation (TMS) device into a van and test it at three locations in South Carolina. Thirty adults with treatment-resistant depression will receive five days of TMS. Researchers will check if this mobile approach is feas…

This study tests whether a 15-20 minute session in a specially designed sensory modulation room before kidney transplant surgery can reduce pain, anxiety, and sleep problems afterward. The room has dim lights, nature videos, calming music, and tactile objects like stress balls. R…

This study looks at whether a specific breathing technique called SKY breath meditation can help college students feel less stressed and anxious. About 53 students will be split into two groups: one learns the breathing method, the other does general yoga. Over 8 weeks, researche…

This study looks at whether a formal care support program, led by a specialized nurse, can reduce anxiety in people who have just been told they have acute leukemia. About 110 patients will be split into two groups: one gets the extra support, the other does not. Researchers will…

This study tests whether adding booster sessions and homework reminders to a short psychological program (PM+) can further reduce stress, PTSD, and other mental health problems in refugees and asylum seekers. About 1,200 participants in Switzerland will receive the enhanced suppo…

This study tests whether low or moderate doses of LSD can reduce anxiety, pain, and depression in people with advanced or terminal illnesses. Sixty participants will receive either two moderate doses or two very low (placebo-like) doses of LSD in a double-blind setup. The goal is…

This study tests whether adding a trauma-focused therapy called EMDR to usual care can help reduce trauma symptoms in people with schizophrenia spectrum disorders. Many people with these conditions have experienced trauma, which can make their illness worse, but trauma treatment …

This Stanford study tests how ketamine quickly reduces OCD symptoms by blocking opioid receptors with naltrexone. 150 adults with OCD who haven't responded to standard treatments will receive ketamine plus either naltrexone or a placebo. The goal is to see if the opioid system is…

This study is testing whether adopting and training a shelter dog can reduce PTSD symptoms and improve mental health in veterans. 120 veterans with self-reported PTSD or other mental health conditions will attend eight one-hour dog training sessions over 10 weeks. Researchers wil…

This study looks at whether taking ETAS® daily for 12 weeks can improve memory, mood, and brain activity in healthy adults aged 60 to 80 who have mild memory complaints. Participants will be randomly assigned to receive either ETAS® or a placebo, and will undergo memory tests, br…

This study tests two treatments for insomnia in veterans who also have PTSD. One is a brief behavioral therapy focused on sleep habits, and the other is a relaxation technique. Researchers want to see which one improves sleep and daily life more, and if benefits last over time. A…

This study tests a 7-session therapeutic song-writing program for young people aged 13 to 24 with mild to moderate depression. Participants are randomly assigned to either the song-writing program or a waitlist group. The goal is to see if the program improves depressive symptoms…

This study tests whether a proven sleep therapy (CBT-I) can improve how the brain regulates emotions, helping treat depression and anxiety. Researchers will use brain scans to see changes in emotion networks. 120 adults with insomnia and depression will participate. The goal is t…

This study tests whether gentle chest vibration or breath focus exercises can reduce symptoms of dissociation in people who have experienced trauma. Researchers will measure changes in brain activity and self-reported symptoms over 8 sessions. The goal is to understand if these s…

This study tests whether a program that improves how ICU staff care for patients can lower discomfort and reduce the risk of PTSD after leaving the hospital. About 1,242 adults who have been in the ICU for at least three days will take part. The program includes better communicat…

This study looks at whether adding three extra support visits after surgery can lower anxiety and improve quality of life for people with head and neck cancers. About 60 patients will take part. The goal is to see if more follow-up care helps patients cope better after their oper…

This study tests whether a web-based program can improve quality of life for people who survived a cardiac arrest outside the hospital. The program includes educational sessions, brain games, and tips on physical activity and nutrition. Researchers will enroll 106 survivors and m…

This study is testing whether adding a brief writing exercise (AWARE) to standard PTSD therapies like cognitive processing therapy (CPT) or prolonged exposure (PE) can improve patient-therapist communication and treatment outcomes. Researchers will enroll 54 adults with PTSD, fir…

This study compares two group therapies for university students aged 18-28 who have moderate anxiety and depression. One group receives Acceptance and Commitment Therapy (ACT), which teaches skills to accept difficult emotions and live according to personal values. The other grou…

This study tests a 4-week online cognitive-behavioral therapy (CBT) program for women with BRCA1/2 mutations who have finished cancer treatment and still worry a lot about cancer coming back. Researchers will compare those who get therapy right away to those on a waitlist, measur…

This study tests whether a 5-minute mindfulness-based breathing exercise, done just before spinal anesthesia, can reduce the common drop in blood pressure and ease anxiety in women having a planned C-section. Half of the 150 participants will do slow, guided breathing (about 6 br…

This study tests a program called Reminder-Focused Positive Psychiatry (RFPP) for teens aged 11-15 with PTSD. The program helps teens reframe traumatic memories in a positive way. Researchers will compare RFPP to a general support group to see if it reduces PTSD symptoms and impr…

This study tests an online program (eCBTi+) that teaches older adults with insomnia and memory concerns how to improve sleep, manage anxiety and low mood, and potentially protect brain health. About 275 people aged 60 and older will use the program or a control version for severa…

This study tests a 6-session psychoeducation program for people who have experienced sexual violence. The goal is to see if the program improves their quality of life, self-esteem, and mental well-being. Researchers will enroll 60 participants from a hospital clinic in France.

This study tests a brief guided self-help program called Self-Help Plus for university students who are behind on at least three exams and feeling distressed. The program teaches coping skills based on acceptance and commitment therapy. Researchers will measure changes in distres…

This study tests a special mental health program for people who have been in the ICU. It includes coaching, digital tools, and psychiatric support to help with anxiety, depression, and PTSD. The goal is to see if this program works better than usual care. About 150 adults who vis…

This study tests whether a daily drink containing inactivated lactic acid bacteria (a postbiotic called Humiome® Post LB) can reduce stress and improve memory in healthy adults aged 50 to 75. Over 3 months, 236 participants will take either the postbiotic or a placebo. The goal i…

This study looks at whether art therapy, delivered through virtual reality glasses or in person, can help reduce anxiety and improve sleep and well-being in people with colorectal cancer. 78 patients receiving chemotherapy will be randomly assigned to one of three groups: virtual…

This study tests a type of talk therapy called Acceptance and Commitment Therapy (ACT) for teenagers who have both social anxiety disorder and oppositional defiant disorder. The therapy aims to help teens become more flexible in their thinking and behavior. Researchers will measu…

This study tests a non-invasive brain stimulation technique called TMS for adults with obsessive-compulsive disorder (OCD) who did not improve enough with standard exposure therapy. 250 participants will receive either real or sham TMS combined with therapy for 5-7 weeks. The goa…

This pilot study tests a 12-week workshop called STEP-Home-SP for veterans who recently left military service. The workshop teaches emotional regulation and problem-solving skills to help with reintegration and reduce suicide risk. Researchers will enroll 120 veterans to see if t…

This study tests whether a computer-based program can reduce anxiety in older adults with mild cognitive impairment or early Alzheimer's disease, and also help their care partners feel less burdened. About 388 pairs (patient and care partner) will take part. The program involves …

This pilot study tests a new way to deliver trauma-focused therapy to teens with PTSD. It combines therapist-led video sessions with a mobile app for self-paced exercises. Researchers want to see if this blended approach is feasible and acceptable compared to standard therapy. Ab…

This study is testing whether listening to specially chosen music every day for 4 weeks can help reduce anxiety and depression in people who have recently had a stroke. About 132 participants will either receive the music therapy plus standard care, or standard care alone. The go…

This study tests whether adding a one-hour cognitive behavioral session focused on handling uncertainty to standard lethal means counseling helps active-duty service members store firearms more securely. One hundred participants who own unlocked, loaded guns will attend two sessi…

This pilot study tests a new 12-week group therapy program called BEAR-SI for women aged 18-75 who have experienced interpersonal trauma and currently have suicidal thoughts. The program combines psychological skills, education about trauma, and physical self-defense training. Th…

This study tests a simple, drug-free method called hypnotic communication to help patients feel calmer during a heart procedure (coronary angiography). About 306 adults will either receive this special calming talk from a nurse or standard care. The goal is to see if it reduces s…

This study tests whether listening to music through a special app (Music Care®) can calm anxiety as well as a gas mixture (EMONO) during a CT-guided injection for low back pain. The gas can cause nausea and dizziness, and the music app has no side effects. Researchers will compar…

This study tests whether a short writing therapy called Written Exposure Therapy (WET) can help veterans who have both posttraumatic stress disorder (PTSD) and a substance use disorder. About 170 veterans will complete five writing sessions about their trauma. The goal is to see …

This study tests a noninvasive technique called Energy Resonance by Skin Stimulation (ERCS) to reduce stress in patients recovering after an ICU stay. 38 adults in a post-ICU rehabilitation unit will receive two ERCS sessions a week apart. Researchers will measure stress levels b…

This study tests a new way to help veterans with PTSD stop smoking. It combines counseling, nicotine gum, and a noninvasive brain stimulation called TMS. Researchers want to see if this approach is practical and helps veterans stay smoke-free for at least 3 months. About 50 veter…

This study tests an online, 9-week program designed to help parents and caregivers of LGBTQ+ youth of color become more supportive and accepting. Researchers will enroll 180 youth (ages 14-25) and their caregivers to see if the program reduces depression, anxiety, drug use, and o…

This study is testing whether a brief, therapist-guided expressive writing program can reduce symptoms of depression and anxiety in sexual minority veterans. Participants will complete three writing sessions focused on minority stress. The goal is to see if this approach is feasi…

This study tests a drug called CORT108297, which blocks the stress hormone cortisol, as a short-term treatment for PTSD in veterans. Forty veterans with PTSD will take either the drug or a placebo daily for one week. The goal is to see if it reduces PTSD symptoms and to check its…

This study is testing whether transcranial magnetic stimulation (TMS) can reduce anxiety and depression in children and teens aged 6 to 18. About 120 participants will receive TMS treatment, and researchers will track symptom changes using questionnaires. The goal is to see if th…

This study tests a multi-sensory therapy called Heal, which uses calming sounds, gentle vibrations, and soft lighting to help detained youth (ages 12-18) manage their emotions before counseling sessions. The goal is to see if this brief, non-verbal intervention improves emotional…

This study tests whether a guided therapy using psilocybin (the active ingredient in magic mushrooms) can safely help US Veterans with PTSD. Fifteen participants will receive two psilocybin sessions combined with talk therapy. The goal is to reduce PTSD symptoms and improve long-…

This study looks at whether using a short-acting paralytic drug (succinylcholine) instead of a longer-acting one (rocuronium) can prevent patients from being awake while paralyzed during emergency breathing support. About 3,090 adults on ventilators in emergency departments will …

This study uses virtual reality to understand how people learn fear and safety. Participants already have a brain implant (RNS device) for epilepsy. They wear a VR headset while researchers measure brain activity, heart rate, and sweat. The goal is to better understand anxiety an…

This study aims to understand what happens in the brain when someone thinks about or attempts suicide. Researchers will use brain scans, sleep monitoring, blood tests, and questionnaires to compare four groups: people with recent suicidal thoughts or attempts, those with past sui…

This observational study asks whether a parent can accurately gauge the pain their child feels during a dental local anaesthetic. Children aged 6 to 15 and their parents each rate the child's pain on a 0-10 scale after the procedure. The goal is to see if parents can serve as rel…

This study talks one-on-one with 30 adults who are anxious about their upcoming elective surgery. The goal is to learn exactly what worries them, so doctors can create better support plans and possibly prevent long-term pain after the operation. Participants will answer questions…

This study uses eye-tracking technology to measure how people with bipolar disorder pay attention, respond to rewards, and control their thoughts. Researchers will compare different groups, including those with anxiety or substance use issues. The goal is to better understand the…

This study looks at how a stellate ganglion block injection affects sleep in U.S. service members and veterans with PTSD who are already receiving talk therapy. About 40 participants will wear an EEG headband for three nights before and three nights after the injection to measure…

This study looks at brain activity in teenagers aged 10 to 17 with ADHD, OCD, or no diagnosis. Researchers will use EEG, MRI, and MEG to measure brain signals while participants do computer tasks. The goal is to understand how the brain controls thinking and behavior, which may h…

This study aims to improve MRI imaging methods to better understand how mood and anxiety disorders affect the brain. Researchers will scan healthy volunteers and people with major depressive disorder while they perform tasks or view images. The goal is to refine these techniques …

Many women feel anxious in the first 12 weeks of pregnancy, yet most do not see a midwife or doctor until around 10 weeks. Researchers at Bournemouth University will survey and interview women who are pregnant or recently gave birth, along with midwives, doctors, and digital heal…

This study at the National Institute of Mental Health screens up to 16,000 people with mood or anxiety disorders, as well as healthy volunteers, to see if they can join other research studies. Participants undergo evaluations like psychiatric interviews, brain scans, and lab test…

Researchers are studying 150 former French military personnel diagnosed with PTSD to test whether trauma raises anger levels by harming social-cognitive abilities such as reading emotions, understanding others' minds, and feeling empathy. Participants complete questionnaires and …

This pilot study tests whether low-intensity focused ultrasound (LIFU) can safely target brain areas linked to obsessive-compulsive disorder (OCD). Ten adults with chronic OCD will receive single sessions of ultrasound to up to three brain regions. Researchers will measure change…

This study looks at anxiety levels in 100 living liver donors before and after their surgery. Participants will fill out questionnaires to measure their worry and stress. The goal is to better understand how anxiety affects recovery and to improve care for future donors.

This study tests whether a device called rTMS, which uses magnetic pulses to temporarily change brain activity, can alter how people with anxiety respond to fearful situations. Researchers will measure brain signals and reactions in 80 adults who recently started anxiety treatmen…

This observational study aims to understand why some people are more impulsive or compulsive than others. Researchers will use brain scans, genetic tests, and behavioral surveys in 1,100 participants aged 6 to 80, including those with ADHD, OCD, autism, and conduct disorder. The …

Chemotherapy often damages nerves, causing numbness and tingling that can force dose reductions. Researchers are studying stool samples from 42 adults with this nerve pain who are also receiving rectal ozone therapy or a placebo. The goal is to see whether gut bacteria differ bet…

This study looks at how exercise training impacts blood vessel function in people with PTSD or generalized anxiety disorder, compared to healthy individuals. Researchers want to understand if harmful substances called oxidants play a role in blood vessel damage. The study involve…

This study looks at how getting older and feeling stressed can change the way we remember places and find our way around. Researchers will have 85 adults aged 65 to 80 do a virtual navigation task while their brains are scanned. Some participants will be put under mild stress to …

Researchers at Yale University are studying whether brain imaging can show how people with obsessive-compulsive disorder respond to fluoxetine, a common antidepressant. The trial enrolls about 100 adults with OCD who take fluoxetine either right away or after a six-week placebo p…

This study is looking at whether test anxiety during final exams is linked to bowel problems and constipation in university students. About 200 students will fill out questionnaires about their anxiety and digestive health. The goal is to better understand how mental stress might…

This study looks at how the brains of children with anxiety disorders work differently from healthy children. Researchers will use brain scans and thinking tasks to track changes over a year, before and after standard treatments like therapy or medication. The goal is to find pat…

This study looks at whether short-term changes in the immune system can alter how people process information and experience fear. Researchers will give some participants a typhoid vaccine (which temporarily activates the immune system) and others a placebo. By measuring physical …

This study is looking for biological markers in the body that might predict how well people with treatment-resistant psychiatric disorders—like schizophrenia, depression, bipolar disorder, OCD, and catatonia—respond to new treatments. Researchers will collect blood, stool, cerebr…

Deep brain stimulation uses implanted electrodes to send electrical pulses to specific brain regions, and doctors are still working out how to tune it for each patient. This study records brain activity while adults with neurological or psychiatric conditions perform cognitive an…

This study looks at how exercise affects the way people with PTSD learn and remember emotional information. One hundred adults with PTSD from interpersonal violence will do either moderate or light cycling after recalling a traumatic memory. Researchers will measure anxiety, hear…

This study looks at how the brain processes threats in people with PTSD. Researchers will use a mild electrical current (tACS) to gently stimulate brain areas and measure changes in brain activity and anxiety. The goal is to understand the brain mechanisms behind PTSD, not to tes…

This study looks at how cannabidiol (CBD) influences stress in 160 people aged 18-25 who experienced early life trauma. Participants receive either CBD or a placebo, then undergo brain scans and stress tests. The goal is to understand the brain and hormone changes behind CBD's st…

Researchers are studying how attachment styles and social cognition relate to post-traumatic stress disorder in French military personnel. The trial compares military personnel with PTSD to those without it, looking at biological, psychological, and social factors that may contri…

This study looks at whether a trauma-informed approach can improve smoking cessation support for pregnant women, especially those from racial and ethnic minority groups. Researchers will interview clinicians and pregnant women to understand their needs and experiences. The goal i…

Researchers at Ariel University are studying how the level of food processing and nutritional quality affect how much people eat, how fast they eat, how full they feel, and their blood sugar. Forty adults in Israel with a body mass index between 20 and 40 will eat three laborator…

This study tests a stepped care program called the Trauma Resilience and Recovery Program (TRRP) for people hospitalized after a traumatic injury. It includes education, symptom tracking, and referrals to mental health services. Researchers will follow 350 participants for 12 mon…

Researchers at Yale University are using PET brain imaging with a radiotracer called Bavarostat to measure levels of an epigenetic marker, HDAC6, in people with PTSD, alcohol use disorder, or both. The study includes 150 adults aged 18 to 70 and compares them with control groups.…

This study aims to understand the brain mechanisms behind fear and anxiety in people with anxiety disorders like PTSD and GAD. Researchers will measure brain activity, heart rate, and skin responses while participants view fear-provoking images or use virtual reality. The study i…

This study looks at teenagers aged 12 to 17 who live in child welfare care. Researchers want to understand emotional dysregulation, which is trouble managing emotions, in those who have experienced trauma. They aim to see if this emotional difficulty can help tell apart complex p…

This study aims to build a comprehensive 'physiological brain atlas' by collecting electrical and other data from patients undergoing stereotactic brain surgery for conditions like Parkinson's disease, OCD, and epilepsy. The goal is to map this information onto a standard brain t…

This study tests whether a wrist-worn activity monitor can help doctors understand how people recover after leaving the intensive care unit (ICU). 40 adults who spent more than a week in the ICU will wear the device for two months at home and answer health questionnaires. The goa…

This study compares different ways to train mental health providers in Written Exposure Therapy (WET), an effective treatment for PTSD. Some providers attend a live workshop via video, while others use a self-paced web-based program or an AI-powered training tool called TherapyTr…

This study follows 436 women undergoing hysterectomy for non-cancerous reasons to see if certain pre-surgery assessments can predict who will develop chronic pain lasting months after the operation. Researchers measure pain sensitivity using a pressure device on the shoulders, an…

This study asks children aged 6-16, their parents, and clinicians to vote on the most important research topics in pediatric anesthesia and perioperative medicine. Over 1,000 participants in Switzerland will complete online surveys to create a ranked list of the top 10 priorities…

This trial compares an online training program (COPEWeb) to in-person training for behavioral health providers. The goal is to see if the online version is as effective at teaching providers to deliver a combined treatment for PTSD and substance use disorders. Providers will be r…

This study looks at how people with depression or anxiety respond to different types of psychotherapy—individual sessions or an online program. It aims to find clues that predict who benefits most from each approach. By understanding these factors, doctors may better match patien…

This study follows adults with a suspected bone or soft tissue tumor to see how their stress and anxiety levels change at three critical moments: before biopsy, after learning the diagnosis, and when treatment begins. Participants fill out standard questionnaires about anxiety, d…

This study uses transcranial magnetic stimulation (TMS) to map brain circuits in 180 adults with depression, OCD, anxiety, or schizophrenia. Participants receive accelerated TMS over two days while completing behavioral tests and questionnaires. The goal is to understand which br…

This study looks at whether a new strategy to detect and refer pregnant and postpartum women with depression or anxiety to mental health services works well in routine care. About 3000 women will take part. The goal is to see if early help is feasible and acceptable, and to test …

This study tests a new type of talk therapy called Process Based Therapy (PBT) for people with depression or anxiety. Instead of a one-size-fits-all plan, PBT uses daily mood check-ins from a smartphone app to help therapists tailor treatment to each person's changing needs. The …

This study looks at how common depression, anxiety, and behavior problems are in children with cystic fibrosis (CF) aged 18 months to 11 years. Researchers will use parent and child questionnaires to track these issues over time. The goal is to understand the mental health needs …

This study looks at how ongoing stress, anxiety, and poor sleep might affect the course of pancreatic cancer. Researchers will ask 320 participants to fill out simple questionnaires about their mental well-being and will also measure stress markers in leftover blood samples. The …

This study looks at how the brain processes emotions by using tiny electrical pulses in people with epilepsy who already have electrodes implanted for surgery. Researchers will measure brain activity and physical responses like sweat to understand how certain brain areas control …

This study tests whether having a general practitioner and pharmacist work together can help people aged 65 and older safely stop or reduce benzodiazepines (drugs for sleep or anxiety). These medications raise the risk of falls, confusion, and dementia in older adults. The trial …

This study is developing and testing a 12-week group education program called FEELS to help Black young adults (ages 18-35) who have experienced trauma better understand mental health and substance use. Participants will attend weekly sessions and complete surveys to see if their…

This study looks at how THC and CBD, two compounds found in cannabis, affect the body's stress response in people who are sleep-deprived and have higher-than-average anxiety. Sixty healthy volunteers will take either THC, CBD, both, or a placebo after a night of restricted sleep.…

This study looks at how the brain processes time and attention after losing a loved one to suicide, homicide, or accident. Researchers will measure brain waves in 61 adults who experienced such a loss recently. The goal is to find early signs that may lead to PTSD or depression, …

This study tests whether a 3-day training program called REFOCUS helps mental health teams provide care that supports personal recovery. About 760 people with severe mental disorders (like schizophrenia or bipolar disorder) will take part across 18 centers. Researchers will measu…

This study looks at whether a simple rating scale used by doctors right after a traumatic event can predict who will develop post-traumatic stress disorder (PTSD) later. Researchers will follow 241 adults who experienced a trauma in the last 48 hours, tracking their scores and ch…

This study is a large survey of up to 20,000 adults with conditions like depression, anxiety, or borderline personality disorder. Researchers will ask about medical history and symptoms to see who might qualify for future industry-sponsored clinical trials. The goal is to make it…

This study follows 35 men in residential rehab for severe substance use. They write weekly stories about their feelings and challenges, and fill out questionnaires every two weeks. Researchers use natural language processing to analyze the stories and look for patterns that might…

This study looks at whether asking new mothers a few questions within 48 hours of an unplanned C-section can predict who will develop post-traumatic stress disorder (PTSD) related to childbirth. Researchers will follow 420 women for three months, comparing early screening scores …

This study aims to understand why people with post-traumatic stress disorder (PTSD) have a higher risk of heart disease and high blood pressure. Researchers will measure nerve activity and test whether the drug losartan can lower high adrenaline levels during stress. The study in…

This study tests whether a phone-based check-in system can improve mental health outcomes for women who have experienced violence. Researchers will call some participants a few weeks after their forensic exam and offer support, while others receive standard care. The goal is to s…

This study looks at whether a child's genes can predict if they will have certain side effects from common antidepressants (SSRIs). Researchers will collect saliva samples from 120 children and young adults aged 6 to 24 with depression, anxiety, or OCD. The goal is to find geneti…

This study looks at whether giving low-income adults aged 40 and older free meal kits and nutrition education can improve their food security, diet quality, mental health, and heart health. About 120 participants will be split into two groups: one gets meal kits plus nutrition cl…

Researchers at the University of Pittsburgh are testing whether a short, non-invasive brain stimulation technique called continuous theta burst stimulation (cTBS) can alter emotional and physical responses to stress. Fifty-five healthy adults will receive both real and sham stimu…

This study looks at how a type of talk therapy called Cognitive Processing Therapy (CPT) changes brain circuits related to reward and pleasure in people with PTSD. Researchers will use brain scans to track these changes in 120 participants. The goal is to understand why some peop…

This observational study looks at how controlled sensory stimulation, such as music, changes brain activity in people with epilepsy and healthy volunteers. Researchers will measure brain networks and track anxiety and depression symptoms. The goal is to better understand brain fu…

This study is testing a new family-based program (Fam-AID) for teens aged 13-21 who are getting treatment for substance use and also have anxiety or depression. The program adds extra support for mental health and family involvement to their usual care. Researchers want to see if…

This study looks at how alcohol changes decision-making in people with PTSD, especially when they have to choose between reward and danger. Researchers will give participants either alcohol or a placebo and then scan their brains while they perform a task. The goal is to understa…

This study is looking at whether people with benign paroxysmal positional vertigo (BPPV) have differences in their autonomic nervous system compared to healthy people. Researchers will measure heart rate variability (HRV) in 104 participants (52 with BPPV and 52 matched controls)…

This study aims to validate a questionnaire that measures anxiety in cancer patients before surgery. Researchers will test the Italian version of the Surgical Anxiety Questionnaire (SAQ) with 180 adult patients. The goal is to better understand patients' fears and concerns so tha…

This study is testing whether a prebiotic called resistant potato starch can change the gut microbiome in 30 veterans who have both cirrhosis (liver scarring) and PTSD. Participants will take either the potato starch or a placebo (cellulose) for a period, and researchers will mea…

This study is gathering information from 4500 people who have or will have brain surgery for conditions like aneurysms, tumors, epilepsy, and Parkinson's disease. The goal is to find patterns that help doctors predict how well someone will recover. By standardizing how outcomes a…

This study looks at how growing up with a heart condition might increase the risk of post-traumatic stress disorder (PTSD). Researchers will survey 1,000 adults with congenital heart disease to find out which experiences—like past surgeries or bullying—are linked to PTSD. They wi…

This study looks at whether training nursing home staff in oral care can improve the oral health-related quality of life for elderly residents. About 99 residents aged 65 and older will have their oral health assessed before and 6 months after caregivers receive training. The goa…

This study is creating a shared database of children who have received deep brain stimulation (DBS) for movement disorders like dystonia, epilepsy, or Tourette syndrome. By pooling data from multiple hospitals, researchers hope to answer key questions about who benefits most and …

This study is testing whether a new blood test can help tell the difference between depression and schizophrenia, and whether it can show if a treatment is working. Researchers will take blood samples and do mental health check-ins with 500 adults over several visits. The goal is…

This study follows 100 men aged 30-75 who had a heart procedure called PCI (stent placement) to open blocked arteries. Researchers want to see how erectile function changes over 6 months, comparing those who had a heart attack to those with stable chest pain. Participants fill ou…

This study aims to understand why some people with social anxiety or body dysmorphic disorder respond fully to cognitive behavioral therapy while others do not. Researchers will use brain scans, thinking tests, and questionnaires to look for early signs of non-response. The study…

This study looks at how changes in preoperative care affect anxiety in 100 children with congenital heart disease who need surgery or catheterization. Researchers will measure stress levels using questionnaires and scales, and also get feedback from parents and care teams. The go…

This study looks at whether a single dose of estradiol (a hormone) can reduce the number of intrusive, unwanted memories that form after a traumatic event. Healthy female volunteers will watch a stressful film and then record any intrusive memories over the next four days. The go…

This study follows 21 adolescents aged 12 to 18 who have experienced trauma and are undergoing trauma-focused cognitive behavioral therapy (TF-CBT). Researchers will regularly measure their PTSD symptoms, along with anxiety and depression, to see how symptoms change over time. Th…

This study aims to validate French versions of two short screening questionnaires: the PHQ-4 for anxiety and depression, and the PC-PTSD-5 for post-traumatic stress disorder. Researchers will enroll 90 adults, both outpatients and hospitalized, to see if these tools work as well …

This study tests whether a special eye-tracking device (Gaize) can identify changes in eye movement patterns caused by long-term use of psychiatric medications. Researchers will observe 50 adults with conditions like ADHD, depression, or anxiety who have been on medication for ov…

This study is developing a platform called CAMERA that uses wristband sensors and smartphone data to predict anxiety and memory states in people with epilepsy. Researchers will monitor 40 patients in the hospital to see how brain, body, and behavior signals relate. The goal is to…

This study is testing a new questionnaire called PTSD-iMPACT to see how well it measures the ways PTSD can interfere with daily life in children and adolescents. Researchers will include 1,200 participants from Switzerland and Germany, both those with and without PTSD symptoms. T…

This study looks at how thinking skills (like memory and focus) are linked to sick leave in people with depression or anxiety. Researchers will give metacognitive therapy with a work focus to 200 patients at risk of sick leave. They want to see if the therapy improves symptoms an…

This study looks at anxiety levels in men with low-risk prostate cancer who are closely monitored instead of receiving immediate treatment, and also checks how their partners are doing. Researchers will use questionnaires to measure anxiety and find out what factors might predict…

This study looks at how a stay in the intensive care unit (ICU) affects a person's quality of life and risk of post-traumatic stress disorder (PTSD). Researchers will ask 40 adults who spent more than 48 hours in the ICU to fill out questionnaires about their experience and curre…