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Can talking therapy ease the double burden of sickle cell and racism?

NCT ID NCT05685368

Recruiting now Symptom relief Sponsor: Children's Hospital Los Angeles Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is testing whether a type of talk therapy called acceptance and commitment therapy (ACT) can help Black teenagers and young adults with sickle cell disease feel less stressed, anxious, and depressed. About 66 youth and their parents will join group therapy sessions and fill out surveys before, after, and three months later. The goal is to see if this approach is practical and helpful for coping with race-related stress and preparing for adult healthcare.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
acceptance and commitment therapy (ACT) group sessions
What this could lead to
If this works, it could provide a practical, community-based therapy to help young people with sickle cell disease manage race-related stress and improve their mental health and readiness for adult care.
What could go wrong
This is a small, early-phase study with only 66 participants, so results may not apply to everyone. The therapy is behavioral, so benefits depend on individual engagement, and there is no control group to compare against.

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Conditions

The condition(s) this trial relates to.

anxiety disorder Depression Fractures, Stress sickle cell disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DEPRESSION, ANXIETY QUALITY OF LIFE RACE-RELATED STRESS STRESS REACTION

Contacts and locations

Locations

  • Children's Hospital Los Angeles

    RECRUITING

    Los Angeles, California, 90027, United States

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