DEPRESSION, ANXIETY

This study tests a smartphone app called Aviva that delivers a type of therapy (Brief Cognitive Behavioral Therapy) to service members who have had recent suicidal thoughts or attempts. The goal is to see if the app reduces suicidal thinking and behavior better than standard care…

This study aims to create a short, simple questionnaire that doctors can use during routine check-ups to quickly screen childhood cancer survivors for anxiety and depression. About 545 participants aged 6 to 25 who have finished intensive cancer treatment and are in remission wil…

This study tests whether a special toolkit of proven mental health techniques can help prevent depression, anxiety, and stress in active-duty airmen. About 5,500 service members and their behavioral health technicians will take part. The toolkit gives technicians better training …

This study is testing a mobile health toolkit called mWEL to help teachers and caregivers in Uganda manage stress and prevent depression and anxiety. The app screens for mental health issues, gives personalized feedback, and offers coping strategies. Researchers will enroll 1,180…

This study tests a program called TENDAI4PrEP, which uses problem-solving techniques to help pregnant women in Zimbabwe take PrEP, a daily pill that prevents HIV. The program also involves their partners and healthcare providers. Researchers will enroll 132 HIV-negative pregnant …

This study tests whether adding magnesium vitamin B6 to usual treatment can reduce depression, anxiety, and stress in people experiencing their first episode of bipolar I disorder. Forty adults aged 18-50 will take either the supplement or a placebo three times daily for four wee…

This phase 2 trial at MD Anderson Cancer Center is testing whether psilocybin-assisted psychotherapy can safely help ease depression and anxiety in 30 adults with advanced cancer who are on maintenance therapy. Participants receive either psilocybin or a placebo (niacin) along wi…

This study tests an internet-based cognitive behavioural therapy (ICBT) program designed specifically for Canadian public safety personnel (like police, firefighters, and paramedics) who have symptoms of depression, anxiety, or posttraumatic stress. Participants choose their leve…

This study tests a sleep health program for teens aged 10-19 who recently had a concussion. The goal is to see if better sleep helps symptoms go away faster and improves sleep quality, mood, and school engagement. Participants will be randomly assigned to the sleep program or sta…

This study aims to train psychotherapists to deliver personalized, evidence-based therapies to cancer patients and their caregivers who are experiencing high levels of distress. Therapists will choose from treatments like cognitive behavioral therapy and mindfulness-based stress …

This study is testing whether adding small amounts of human coaching, email reminders, or text messages to a meditation app can help people with depression and anxiety feel better. About 688 adults with elevated symptoms will use the Healthy Minds Program app for four weeks. Rese…

This study is testing whether cognitive behavioral therapy (CBT) can help children aged 4 to 17 who struggle with severe irritability, anxiety, or mood disorders. Researchers will track changes in irritability and overall functioning using clinician and parent reports. The goal i…

This study tests whether high-dose aerobic exercise (over 150 minutes per week at a safe intensity) helps teens aged 13–18 recover faster from a concussion compared to standard care. Researchers will track symptom resolution, brain inflammation markers, and changes in anxiety and…

This study is testing whether a type of talk therapy called acceptance and commitment therapy (ACT) can help Black teenagers and young adults with sickle cell disease feel less stressed, anxious, and depressed. About 66 youth and their parents will join group therapy sessions and…

This study is testing a self-help workbook designed to help people in prison manage anxiety and depression. About 96 adults with moderate to severe symptoms will use the workbook for 8 weeks and be followed for 13 weeks total. The goal is to see if the workbook is practical, acce…

This study tests whether a web-based program can improve quality of life for people who survived a cardiac arrest outside the hospital. The program includes educational sessions, brain games, and tips on physical activity and nutrition. Researchers will enroll 106 survivors and m…

This study tests whether a culturally adapted skills training program called START NOW can reduce depression and anxiety in teen refugees. About 80 participants aged 14-18 will be randomly assigned to either the training or standard care. The goal is to see if the program helps t…

This study tests whether a smartphone app called Safe Haven can help college students feel less depressed, anxious, or stressed. About 68 undergraduates will either use the app plus standard campus care, or just standard care alone. The app includes daily mood tracking, weekly ch…

This study tests a stepped-care program to help pregnant women and new mothers who have depression or anxiety. About 3,000 women in Kenya will be screened and offered treatment that increases in intensity as needed. The goal is to improve mood and quality of life.

This study tests a short online course called 'Things You Do' that teaches five simple actions to improve emotional well-being. Researchers want to see if this single-session lesson helps adults in Canada manage symptoms of depression and anxiety. About 50 people who are already …

This study in Arviat, Nunavut, is testing whether eating more traditional country foods like caribou and fish, along with participating in Elder-led cultural workshops, can help reduce symptoms of depression and anxiety in Inuit adults. Forty participants will receive weekly food…

This study is testing a digital cognitive behavioral therapy program (SilverCloud) in Spanish, with added support from a peer coach, for Latino adults in San Francisco with depression or anxiety. 213 participants will either use the program on their own or with weekly check-ins f…

This study tests a smartphone app called Orbi, which uses cognitive behavioural therapy (CBT) to help people with long-term physical conditions cope with depression and anxiety. 60 participants will either use the app plus usual charity support, or charity support alone, then swi…

This early-phase trial is testing whether a generative AI chatbot called Therabot-CALM is usable and acceptable for people with cannabis use disorder who also have anxiety or depression. Fifteen participants will use the app for 4 weeks and give feedback through interviews and su…

This study tests whether a brief, self-guided computer program can alter how people with anxiety and intolerance of uncertainty make decisions when outcomes are unclear. Researchers will measure changes in brain activity and decision-making before and after the 30-minute session.…

This study tests a community-wide program in Harlem that trains health workers and coordinates services to help Black and Latino adults with depression or anxiety. About 700 participants from low-income housing or primary care clinics will be involved. The goal is to see if this …

This study is testing a mobile app called Wysa for Chronic Pain, designed to support people aged 45 and older who have chronic pain along with depression or anxiety. Researchers want to see if personalized in-app notifications can encourage people to use the app more often. Parti…

This study looks at how a 7-week online mindfulness program affects emotions, thoughts, and behaviors in 500 adults with anxiety or depression. Participants fill out weekly questionnaires to track changes. The goal is to understand which skills improve first and lead to emotional…

This study is testing a digital platform and teacher training program to reduce suicidal thoughts and behaviors among Colombian youth aged 14-19. About 228 teens from three schools in Bogota will use the platform, which includes self-help tools, safety planning, and links to coun…

This study uses transcranial magnetic stimulation (TMS) to map brain circuits in 180 adults with depression, OCD, anxiety, or schizophrenia. Participants receive accelerated TMS over two days while completing behavioral tests and questionnaires. The goal is to understand which br…

This study will observe 40 adults in Italy receiving EMDR therapy for depressive symptoms. Researchers want to find out which factors—like personal beliefs, anxiety, or the therapist-patient relationship—influence how well the therapy works. The goal is to better understand how t…

This study works with clinics in Massachusetts to help people in underserved communities manage weight, get cancer screenings, and improve mental health. It includes 3,600 adults who speak English or Spanish and have obesity, are due for colorectal or cervical cancer screening, o…

This study uses brain imaging and a single dose of the anti-anxiety drug lorazepam to understand how people with both depression and anxiety disorders process threats differently than those with depression alone. About 165 adults will complete two sessions involving startle tests…