DEPRESSION, ANXIETY

This study tests whether giving military behavioral health technicians a special toolkit of proven mental health techniques helps prevent depression, anxiety, and stress in active-duty airmen. About 5,500 airmen and their technicians will take part. The goal is to see if this app…

This study is testing a program called TENDAI4PrEP to help pregnant women in Zimbabwe take PrEP, a daily pill that prevents HIV. The program combines problem-solving support to address barriers like depression and anxiety. About 132 pregnant women at risk for HIV will participate…

This study tests a smartphone app called Aviva that delivers therapy to help prevent suicidal behaviors. It is for military members who have had recent suicidal thoughts or attempts. Participants will be randomly assigned to use Aviva or a standard safety plan app, and researcher…

This study tests a short online course called 'Things You Do' that teaches five simple actions to boost emotional wellbeing. Researchers want to see if a single session can help adults in Canada with depression or anxiety feel better. About 50 people will take the course and answ…

This study tests whether an internet-based program can help people who survived a cardiac arrest and now face problems with memory, mood, or daily life. About 106 participants will use a web app designed to improve their quality of life. The goal is to see if online support can e…

This study tests whether a smartphone app called Safe Haven can help college students feel less depressed, anxious, and stressed. About 68 undergraduates in Taiwan will either use the app plus standard campus care, or just standard care. The app includes daily mood tracking, week…

This study is testing whether a type of talk therapy called Acceptance and Commitment Therapy (ACT) can help Black teenagers and young adults with sickle cell disease cope with stress related to racism. About 30 participants aged 14-21 will take part in a 10-session group therapy…

This early-stage study is testing a generative AI chatbot called Therabot-CALM to see if it is acceptable and helpful for people who have cannabis use disorder along with anxiety or depression. Fifteen participants will use the app for four weeks and give feedback through intervi…

This study aims to find the best way to add small amounts of human or digital support to a meditation app for people with depression or anxiety. About 688 adults with elevated symptoms will use the Healthy Minds Program app and receive different levels of support. The goal is to …

This study will test a Spanish-language digital cognitive behavioral therapy program (SilverCloud) for 213 Latino adults in San Francisco with depression or anxiety. Participants will either use the program on their own or with support from a peer. The goal is to see if the progr…

This study trains psychotherapists to give personalized talk therapy to cancer patients and their caregivers who are feeling very distressed. Therapists learn to use proven methods like cognitive behavioral therapy and mindfulness to help with anxiety, depression, pain, fatigue, …

This study tests whether taking magnesium and vitamin B6 alongside standard treatment can reduce symptoms of depression, anxiety, and stress in people who have recently been diagnosed with bipolar I disorder. About 40 adults aged 18 to 50 with a first episode in the last 10 years…

This study looks at whether eating more traditional Inuit foods (like fish and game) and taking part in cultural activities can help reduce depression and anxiety in Inuit adults aged 18-65 in Arviat, Nunavut. About 40 participants will be followed for 12 weeks to see if their mo…

This study tests whether a smartphone app called Orbi can help people with long-term physical illnesses manage feelings of distress, anxiety, or depression. About 60 adults in the UK will either use the app plus usual charity support, or just charity support, then switch after 12…

This study tests a self-help workbook designed for people in prison who have moderate to severe anxiety or depression. About 96 adults will use the workbook for 8 weeks and be followed for 13 weeks total. The goal is to see if the workbook is helpful, easy to use, and improves me…

This study tests a stepped-care program to help pregnant women and new mothers who have depression or anxiety. About 2,970 women attending maternal and child health clinics in Kenya will take part. The program starts with screening and offers increasing levels of support based on…

This study tests whether a special sleep health program helps teens aged 10–19 recover faster from a concussion. About 54 participants will either receive the sleep program or standard sleep advice. The goal is to see if better sleep leads to quicker symptom relief, improved mood…

This study tests whether a higher amount of aerobic exercise, started within two weeks of a concussion, helps teenagers recover faster. Researchers will measure symptom relief, brain inflammation markers, and changes in anxiety or depression. The goal is to create better, more pr…

This study tests whether psilocybin (the active ingredient in magic mushrooms) combined with talk therapy can safely reduce depression and anxiety in people with advanced cancer. About 30 adults whose cancer has not responded fully to standard treatments will receive the therapy.…

This study tests whether a culturally adapted skills training program called START NOW can reduce depression and anxiety in adolescent refugees aged 14 to 18. About 80 participants will be randomly assigned to either the START NOW program or standard care. The goal is to see if t…

This study looks at what causes severe irritability in children and teens (ages 4-17) who have anxiety or mood disorders. It will test psychological treatments to help manage emotional and behavioral outbursts. The goal is to understand and improve these symptoms, not to cure the…

This study looks at what influences how well EMDR therapy works for people with depression. Researchers will track 40 patients and their therapists in Italy, measuring symptoms and personal beliefs over time. The goal is to identify which factors predict better outcomes, not to t…

This study aims to understand how different parts of the brain's prefrontal cortex control behaviors in people with major depression, obsessive-compulsive disorder, generalized anxiety disorder, or schizophrenia. Participants will receive transcranial magnetic stimulation (TMS) a…

This study aims to improve a mobile app called Wysa for Chronic Pain, which supports people aged 45 and older who have chronic pain along with depression or anxiety. Researchers will test different types of in-app notifications to see which ones encourage people to use the app mo…

This study aims to create a short, simple screening tool to help doctors quickly identify anxiety or depression in children, teens, and young adults who have survived childhood cancer. About 545 participants aged 6 to 25, who are at least 3 months past intensive cancer treatment …

This study is testing a mobile health toolkit called mWEL to help teachers and parents in Uganda better understand and manage their mental health. The toolkit provides self-help support, with optional help from community health workers. Researchers will measure changes in mental …

This study will test a digital platform and teacher training program to reduce suicidal thoughts and improve mental health in 228 Colombian youth aged 14-19. The platform offers self-help tools, safety planning, and counseling links, while teachers get training to spot warning si…

This study looks at how a 7-week online mindfulness program helps people with anxiety or depression. About 500 adults will fill out weekly surveys to track changes in emotions, thoughts, and behaviors. The goal is to understand which skills improve first and lead to emotional rel…

This study works with clinics in Massachusetts to offer proven programs for weight management, cancer screening, and mental health to adults in underserved areas. Researchers will track changes in body mass index, cancer screening rates, and mental health scores. The goal is to r…

This study looks at how people with anxiety or depression react to uncertain situations. Researchers will use a one-time mental exercise to see if it changes decision-making and brain activity. About 140 adults aged 25-60 who struggle with uncertainty will participate. The goal i…

This study looks at how the brain handles threats in people with depression, anxiety, or both. About 165 adults will take a single dose of an anti-anxiety drug or a placebo and then have their brain activity measured with MRI and eye-blink tests. The goal is to find differences i…