High-Dose exercise may speed concussion recovery in teens

NCT ID NCT05434130

Recruiting now Symptom relief Sponsor: University of Colorado, Denver Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether high-dose aerobic exercise (over 150 minutes per week at a safe intensity) helps teens aged 13–18 recover faster from a concussion compared to standard care. Researchers will track symptom resolution, brain inflammation markers, and changes in anxiety and depression. The goal is to create better rehabilitation guidelines for young athletes.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: high dose aerobic exercise
What this could lead to: If it works, this could lead to more precise exercise guidelines for teens recovering from concussion, potentially speeding up symptom relief and reducing long-term anxiety or depression.
What could go wrong: This is a Phase 2 trial with 216 participants, so results are still early. Exercise may not speed recovery for everyone, and some teens might find the high dose too difficult or risky.

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Conditions

The condition(s) this trial relates to.

anxiety disorder Brain Concussion Depression Inflammation inflammatory disease traumatic brain injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AEROBIC EXERCISE CONCUSSION, BRAIN DEPRESSION, ANXIETY INFLAMMATION TREATMENT

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••
Contact

Email: •••••@•••••

Locations

Boston Children's Hospital
RECRUITING

Boston, Massachusetts, 02115, United States
Spaulding Rehabilitation Hospital
RECRUITING

Cambridge, Massachusetts, 02138, United States
University of Colorado Denver
RECRUITING

Aurora, Colorado, 80045, United States

Contact Email: •••••@•••••

Contact Email: •••••@•••••

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