INFLAMMATION

This study is testing whether a daily probiotic/prebiotic supplement can help slow bone loss in women aged 60 and older. Researchers will compare the supplement against a placebo in 220 women over 18 months to see if it improves bone density and strength. The study focuses on die…

This study is testing if adding the antibiotic minocycline to standard antidepressants is a practical and acceptable approach for people who have both obesity and depression that hasn't responded to other treatments. Researchers want to see if participants can complete the 8-week…

This study is testing whether an 8-week online program called RiSE, which teaches stress management skills with a focus on coping with racism, can improve well-being and reduce body inflammation in African American women who are at risk for heart and metabolic diseases. Researche…

This study is testing if a diet where most calories come from beef can improve health markers better than a standard healthy diet. It will involve 56 adults who are overweight or have metabolic syndrome or pre-diabetes. Participants will follow one of the two diets for 5 weeks wh…

This study is testing whether a special computer-based 'brain training' program can help improve memory and thinking skills in older adults who have persistent cognitive problems after a viral infection like COVID-19. Researchers will compare the brain training program to other c…

This study is testing if a special blood filter called the HA380 can help critically ill patients who need machines to support their kidneys or lungs. The filter aims to remove harmful inflammation from the blood, which might help patients get off life support faster and spend le…

This study aims to find the safest and most effective dose of a medication called anakinra for very premature babies. It will involve 24 infants born between 24 and 28 weeks of pregnancy. Researchers will test three different doses given by IV and also explore giving it as a shot…

This study is testing whether an 8-week mindfulness and stress reduction program can reduce inflammation in the arteries of people with stable heart disease. Researchers will use PET and MRI scans to measure artery inflammation before and after the program in 36 adults who report…

This study is testing whether eating freeze-dried wild blueberry powder every day for six months can help control high blood pressure, improve gut bacteria, and enhance memory and thinking skills. It will involve 40 Black and White adults aged 45-65 who have elevated blood pressu…

This study is testing if adding the anti-inflammatory drug celecoxib to standard depression treatment works better than a placebo for a specific group of patients. It focuses on people with 'Immuno-Metabolic Depression,' a type linked to inflammation, weight gain, and extreme fat…

This study is testing a comprehensive treatment plan for a specific, fast-worsening type of coronary artery disease believed to be driven by inflammation. It will enroll about 39 patients who have this condition. Researchers will compare each patient's health outcomes before and …

This study is testing whether an experimental drug called ziltivekimab can reduce inflammation in the arteries of people with heart disease. Researchers will give the drug or a placebo to 40 patients for 20 weeks and use advanced scans and blood tests to see if it lowers inflamma…

This study is testing a special mobile app designed for Black pregnant women. The app provides culturally relevant tools to build self-advocacy skills, improve communication with doctors, and create a support network. Researchers want to see if using the app can help reduce depre…

This study is testing whether a ketone supplement drink can protect older adults from the negative health effects of eating too much salt. Researchers want to see if the supplement can prevent high salt from raising blood pressure, harming blood vessels, or causing kidney stress.…

This study is testing if a new drug called orticumab can reduce harmful inflammation in the heart arteries of people who have had a heart attack. Researchers will compare the drug's effects against a placebo in 240 participants over 6 months, using special heart scans to measure …

This large, late-stage trial is testing whether a low daily dose of an existing anti-inflammatory drug (colchicine) can prevent serious complications in people with symptomatic peripheral artery disease (PAD). It aims to see if the drug reduces the combined risk of heart attacks,…

This small pilot study is testing whether an 8-week stress reduction program can reduce inflammation in the arteries of adults who feel highly stressed. About 30 participants will be randomly assigned to either learn mindfulness and relaxation techniques or receive no interventio…

This study aims to fight antibiotic resistance by helping doctors in Kyrgyzstan prescribe antibiotics more wisely for common respiratory infections like coughs and colds. It will test if giving patients an information leaflet about when antibiotics are needed, and using a simple …

This study is testing if adding the anti-inflammatory drug ketorolac to standard emergency care helps patients recover better from a life-threatening tear in their main heart artery (Type A aortic dissection). 360 patients scheduled for emergency surgery will receive either ketor…

This study aims to develop and improve new portable blood testing devices. Researchers will collect small blood samples from up to 20,000 adults with various health conditions to see if the new portable tests are as accurate as standard lab tests. The goal is to create faster, ea…

This study is testing whether a 6-month anti-inflammatory diet can reduce body inflammation and improve gut health in obese adults who have had colon polyps, a risk factor for early colon cancer. Researchers are also enrolling an overweight partner or child from the same househol…

This study is testing whether adding specific omega-3 fats to your diet can help reduce chronic inflammation, a key driver of heart disease. Researchers will enroll 324 adults over 55 who are at moderate to high risk for heart problems. Participants will follow one of three diets…

This study is testing whether lifestyle changes can help prevent memory and thinking problems in adults aged 50-80 who have depression or depressive symptoms. Participants will try different 12-week programs involving supervised exercise, brain training games, or Mediterranean di…

This study is testing whether a 10-week parenting support program can help prevent common health problems in low-income Latino infants. Researchers will enroll 260 mothers and their 9-month-old babies to compare the parenting program against a book-sharing program. They will trac…

This study explores a surprising link: having low 'bad' cholesterol (LDL) might actually increase the risk for type 2 diabetes. Researchers believe this happens when LDL enters fat tissue too easily. They are testing if a 6-month supplement of fish oil (omega-3 fatty acids) can t…

This study is testing if a low dose of an anti-inflammatory drug called colchicine can help people with a specific type of chronic heart failure (HFpEF) who also have body-wide inflammation. For 3 months, 60 participants will take either the drug or a placebo pill to see if it im…

This small pilot study is testing whether taking a supplement made from seaweed, called fucoidan, for 8 weeks can help reduce fatigue and inflammation in people who have finished cancer treatment. The researchers will enroll 40 adult cancer survivors who report significant fatigu…

This study is testing whether a compound found in green tea, called EGCG, can help older adults who have survived cancer feel less frail and reduce body inflammation. About 118 participants aged 65+ who have finished cancer treatment will take either EGCG or a placebo pill daily …

This study is testing whether using the Calm meditation app for 10 minutes a day can help people with blood cancers who have trouble sleeping. Researchers will enroll 276 patients to see if the app improves sleep quality, reduces fatigue and anxiety, and lowers body inflammation …

This study is testing whether a gentle, non-invasive stimulation of the ear nerve can help control inflammation and pain after major spinal fusion surgery. Fifty patients undergoing long spinal fusions will be randomly assigned to receive either the real ear stimulation or a sham…

This study compares two programs to help college students sleep better. Researchers want to see if a 6-week mindfulness training course is more effective than a standard sleep education program. They will enroll about 240 UCLA students who report poor sleep and measure changes in…

This study is testing whether special 'dynamic' lighting in hospital rooms can help improve sleep and daily rhythms for elderly patients. It will involve 300 patients over age 65 who are hospitalized. Researchers will compare patients in rooms with the special lighting to those i…

This study is testing two different exercise programs to help people with cancer feel better during treatment. Researchers will compare traditional flexi band resistance training to whole-body electrical muscle stimulation (EMS) over 12 weeks. They want to see which method better…

This study is testing whether drinking haskap berry juice helps people recover faster from intense weightlifting. Researchers will compare the juice to a placebo drink in 30 adults with at least 2 years of squatting experience. They will measure muscle soreness, strength, and blo…

This study is testing whether daily supplements made from agar (a type of seaweed) and/or collagen can help reduce knee pain and stiffness. It will involve 80 adults aged 40-70 who have mild to moderate knee discomfort but do not have a formal osteoarthritis diagnosis. Participan…

This study is testing whether two commonly used anesthetic drugs, lidocaine or ketamine, given through an IV during and after surgery, can better reduce inflammation and improve recovery for people having open surgery for colorectal cancer. Researchers will measure a key inflamma…

This study aims to understand how drinking a single glass of red or white wine might affect tiny particles in the blood called extracellular vesicles, which carry signals between cells. Researchers will enroll 8 healthy adults to drink wine and have their blood tested before and …

This study aims to understand if platelets, tiny blood cells, are present inside brain tumors and if their presence is linked to how long patients live. Researchers will collect and analyze tumor tissue and blood samples from 50 adults undergoing surgery for brain or spinal cord …

This study aims to better understand inflammation and stress in adults with Gaucher disease type 1 by measuring specific markers in their blood. Researchers will collect blood samples from 34 participants over three visits during three months to analyze these markers. The study d…

This study aims to understand how cognitive-behavioral therapy (a type of talk therapy) for depression affects the gut microbiome, immune system, and brain function in people living with HIV. Researchers will enroll 150 adults with HIV and depression to measure changes in their g…

This study aims to understand how everyday environmental factors like pollution, diet, and stress contribute to disease and inflammation. Researchers will collect various samples—such as blood, saliva, urine, and even household dust—from up to 2,000 healthy adults. The goal is to…

This study aims to better understand a specific type of coronary artery disease (CAD) that is linked to chronic inflammation, often affects younger women, and doesn't respond well to standard heart treatments. Researchers will observe 120 patients with this condition over two yea…

This study is investigating whether eating beef daily as part of a healthy diet helps the body absorb zinc better, which might improve blood vessel function. Researchers are recruiting 20 adults aged 55-70 to compare two healthy diets—one with beef and one with other protein sour…

This study aims to understand how poor sleep might connect difficult childhood experiences to early signs of blood vessel problems in young adults. Researchers will first observe 70 young adults, measuring their sleep and blood vessel health. Then, some participants with poor sle…

This study aims to understand how being overweight and having blood sugar problems might affect brain development in teenagers. Researchers will follow 117 teens aged 12-17 for nearly two years, comparing brain scans and thinking tests across three groups: normal weight, overweig…

This study aims to find out if simple blood tests taken right after surgery can predict which older patients will develop sudden confusion, known as delirium. Researchers will observe 1,170 patients aged 65+ having major surgery, checking their blood for specific markers and asse…

This study aims to understand why heart disease develops differently in women and men, focusing on the roles of hormones and inflammation. Researchers will collect blood samples and survey 6000 patients with chest pain to analyze hormone levels and inflammatory markers. The goal …

This study aims to see if certain markers of inflammation in the blood can help predict which patients are at higher risk of complications or death after major surgery. Researchers will observe 42 adults admitted to the intensive care unit (ICU) after an operation, using only dat…

This study aims to understand why gout and related metabolic diseases are so common in French Polynesia. Researchers will collect genetic and health data from 2,750 adults of Polynesian ancestry to identify the biological and genetic factors involved. The goal is to gather knowle…

This study aims to understand how using e-cigarettes (vaping) affects blood vessel health and causes inflammation in young adults. Researchers will compare young people who vape regularly with those who don't, measuring blood vessel function before and after taking an anti-inflam…

This study aims to understand why men and women experience heart disease differently by comparing how their bodies resolve inflammation. Researchers will create small, temporary skin blisters on healthy volunteers to measure healing responses over three days. The goal is to gathe…

This study aims to understand how a mother's stress and life experiences might affect tiny energy centers in her cells (mitochondria) and inflammation, potentially increasing the risk of preterm birth. Researchers will follow 180 pregnant women to see if different stress profiles…

This study aims to better understand a specific, fast-progressing type of heart disease linked to inflammation. Researchers will compare 20 patients with this inflammation-linked disease to 10 patients with the more common type of heart disease. They will look at medical historie…

This study aims to understand how obesity affects iron absorption and loss in young women. Researchers will track 70 South African women with and without obesity over two years, measuring how their bodies process iron from their normal diets. The goal is to learn whether women wi…

This study aims to find out if a simple finger-prick blood spot test can measure inflammation markers as accurately as a traditional blood draw from the arm. Researchers will compare both methods in 50 adults after they experience a planned, temporary stressor like getting a vacc…

This study aims to collect and analyze white blood cells from healthy volunteers and patients to support the development of new engineered cell therapies. Researchers will examine the number, type, and function of these cells to better understand how they might be used to treat a…

This study is exploring whether applying common over-the-counter moisturizers can reduce body-wide inflammation in older adults with dry skin. Researchers will enroll 32 participants aged 70+ to apply either Vaseline or CeraVe cream daily for four weeks, comparing it to a period …

This study is testing whether breathing pure oxygen in a pressurized chamber can improve heart fitness and reduce inflammation in healthy, active adults. Researchers want to see if a specific, moderate pressure setting works better than others. The goal is to gather information a…

This study is looking at whether eating mangos daily for 4 weeks, instead of typical high-calorie snacks like chips and cookies, can improve gut health and markers for heart health in Hispanic/Latino teenagers. Researchers will enroll 25 teens to compare their health before and a…

This study aims to understand how kidney transplant affects heart health in people with advanced kidney disease. Researchers will measure heart blood flow and function in 80 patients before and after transplant to see if improved kidney function reduces inflammation and helps the…

This is the first study in people to test the safety of avenanthramide, a natural compound found in oats that may have anti-inflammatory properties. Researchers will give single and multiple doses to healthy volunteers and to people with a larger waist size and low-grade inflamma…

This long-running National Institutes of Health (NIH) study aims to better understand infectious and inflammatory diseases by evaluating patients with these conditions. It enrolls people aged 3 and older who have symptoms or a suspected exposure. The main goal is to gather medica…

This study aims to understand how the body's white blood cells sense and respond to signals that trigger inflammation. Researchers will collect blood from healthy volunteers and test how different immune cells react to various substances in the lab. The goal is to map the interna…

This study aims to understand how fungi from the gut might move into the bloodstream and affect lung health in people living with HIV. Researchers will enroll 100 adults with HIV to measure markers of fungal movement, gut health, and lung function over three years. The goal is to…

This study aims to understand the biology of life-threatening conditions like sepsis and ARDS by observing 1,000 critically ill patients in the ICU. Researchers will collect blood and fluid samples to identify early biological signs that could lead to faster diagnosis and better …