INFLAMMATION

This phase 3 trial tests whether the anti-inflammatory drug ketorolac can improve outcomes in 360 people undergoing emergency surgery for a life-threatening aortic dissection. Participants receive either ketorolac or a placebo before and after surgery, alongside standard care. Re…

Most older Americans eat too much salt, which can raise blood pressure and harm the kidneys. This study tests whether a ketone supplement (a substance the body makes during fasting or exercise) can block those harmful effects. Thirty-five adults aged 60-85 will follow a high-salt…

This study looks at whether royal jelly, a substance made by bees, can reduce inflammation and oxidative stress in people with high blood pressure. Researchers will give 34 participants royal jelly or a placebo for two months and measure changes in blood markers. The goal is to s…

This study tests whether giving patients electrical muscle stimulation and high-protein shakes soon after a type of stroke (aneurysmal subarachnoid hemorrhage) can prevent muscle loss and improve recovery. Thirty adults will receive the combo therapy or standard care. The main go…

This study tests whether a natural substance called red propolis can lower inflammation and oxidative stress in people with chronic kidney disease (stages 3-5) who are not yet on dialysis. Researchers will measure changes in inflammatory markers like IL-6 and TNF-α. The goal is t…

This study tests whether taking propolis and royal jelly supplements for two months can reduce inflammation and oxidative stress in people with high blood pressure. Researchers will measure inflammatory markers in blood samples from 48 participants. The goal is to see if these na…

This study is testing whether nattokinase, an enzyme from fermented soy, can reduce inflammation and improve cholesterol levels in people with high cholesterol. Researchers will measure blood markers of inflammation and heart risk in 48 adults over two months. The goal is to see …

This study tests whether a drug called icosapent ethyl (Vascepa) can reduce inflammation in the arteries of people hospitalized with pneumonia. Pneumonia can trigger body-wide inflammation that may harm blood vessels. Researchers will give 168 adults either Vascepa or a placebo t…

This study is testing whether a healthy diet centered around beef can reduce inflammation and improve metabolic health better than a standard U.S.-style diet based on USDA guidelines. Researchers will enroll 56 adults with metabolic syndrome or pre-diabetes and assign them to one…

This study tests whether eating grape powder daily for 3 weeks can improve gut health, reduce inflammation, and improve blood vessel function in 40 overweight adults aged 45-70. Participants will drink grape or placebo powder twice a day and provide blood and stool samples. The g…

This study looks at whether eating wild blueberries can improve heart health, thinking skills, and gut bacteria in Black and White adults aged 45-65 with high blood pressure. Participants will eat blueberries daily and have their blood pressure, artery stiffness, and cognitive fu…

This study tests whether a daily dose of freeze-dried wild blueberry powder can improve blood sugar, blood pressure, and brain function in women with prediabetes. Thirty overweight women aged 20-65 will take either the blueberry powder or a placebo for six weeks. Researchers will…

This study tests whether a daily low dose of colchicine, an anti-inflammatory drug, can prevent heart attacks, strokes, and severe leg complications in people with peripheral artery disease (PAD). About 6,150 participants with symptomatic PAD will receive either colchicine or a p…

This study tests a special medical food containing probiotics and prebiotics to see if it can help slow or reverse bone loss in older women. Researchers will measure changes in bone density and strength over 18 months. The goal is to find a safe, dietary approach to manage osteop…

This study tests a blood filter called HA380 in 40 critically ill adults (ages 18-65) who need dialysis or ECMO due to severe infection, injury, or major surgery. The filter is added to their life-support circuit to remove inflammatory substances from the blood. Researchers want …

This study tests whether a non-invasive device that gently stimulates a nerve in the ear can lower inflammation and pain after major spine surgery. About 50 adults having long-segment spinal fusion will be randomly assigned to receive the stimulation or standard care. Researchers…

This study looks at whether eating a mango every day for 4 weeks, instead of high-calorie snacks, can improve gut health, reduce inflammation, and boost heart health in Hispanic/Latino teens. Researchers will measure blood markers and blood vessel function in 25 participants. The…

This study tests a drug called orticumab in 240 people who had a heart attack and still have high inflammation in their heart arteries. Participants receive either orticumab or a placebo for 24 weeks. The main goal is to see if orticumab lowers inflammation measured by a special …

This study tests whether a 6-month diet change can reduce inflammation and improve metabolism in obese adults who have had colon polyps. Participants and their household partners will follow a special eating plan. The goal is to see if diet can lower the risk of developing colore…

This study tests whether omega-3 fatty acids from fish oil or camelina oil can reduce inflammation and improve heart health in 324 adults over 55 at moderate to high cardiovascular risk. Participants take daily supplements for 12 weeks, and researchers measure changes in blood ma…

This study is for very premature babies (born between 24 and 29 weeks) to find the safest and most effective dose of a medicine called anakinra, which helps reduce inflammation. About 24 infants will receive anakinra through an IV or a shot under the skin. Researchers will measur…

This study tests whether a comprehensive treatment plan can reduce heart attacks and other serious events in people with rapidly-progressive coronary artery disease tied to inflammation. Researchers will compare each participant's outcomes before and after treatment. The study en…

This phase 3 trial tests whether ziltivekimab, a drug that targets inflammation, can reduce swelling in the arteries of 40 people with coronary artery disease. Participants receive either the drug or a placebo, and researchers use advanced imaging and blood tests to measure chang…

This early-stage study tests a new imaging agent called 18F-4FN for PET scans to safely detect inflammation in the body. It involves 55 adults with cancer who are on immunotherapy or have suspected inflammation. The goal is to see if this agent can highlight areas of inflammation…

This study is testing whether two simple, non-invasive tests—a breath test (FeNO) and a blood test (eosinophil count)—can accurately diagnose asthma in children aged 6 to 17. Currently, diagnosing asthma often requires complex hospital-based breathing tests. The researchers aim t…

This study looks at whether measuring inflammation in the breath and blood can help doctors prioritize who gets lung tests first when asthma is suspected. About 1,500 people aged 6 and older will take part. The goal is to see if this approach reduces delays for those most at risk…

This study collects blood samples from 20,000 adults with conditions like infections, heart disease, or kidney issues. Researchers will use these samples to develop and fine-tune new diagnostic tests that can deliver results quickly at the point of care. The goal is to make disea…

This study compares low-glycemic index (GI) bakery foods like pasta and pizza to standard wholegrain versions in 40 adults with high triglycerides. The goal is to see if low-GI carbs improve a key marker of metabolic and heart risk more than wholegrain carbs. Participants follow …

This study is testing whether lifestyle changes—like following a Mediterranean diet, exercising regularly, or doing cognitive training—can prevent cognitive decline and improve mood in people aged 50 to 80 who have depressive symptoms or major depression but no current memory pro…

This study looks at whether drinking beetroot juice every day for 12 weeks can help postmenopausal women get more heart and blood vessel benefits from exercise. The researchers will compare two groups of women doing the same exercise program—one group gets real beetroot juice, th…

This pilot study looks at whether an 8-week stress reduction program can reduce inflammation in the arteries of adults aged 30-65 who feel stressed. Researchers will use special PET scans to measure changes in artery inflammation before and after the program. The goal is to see i…

This study tests whether sports bras designed for full-busted women can reduce chronic pain in the neck, shoulders, arms, and back. Researchers will also look at how hormones, inflammation, and brain changes may contribute to this pain. About 140 women aged 18-60 will wear a spec…

This study tests whether a daily probiotic drink can improve immune function and reduce skin inflammation in women aged 40-60 going through menopause. Participants will drink either a probiotic or a plain milk drink for 8 weeks. Researchers will measure immune aging, inflammation…

This study tests whether high-dose aerobic exercise (over 150 minutes per week at a safe intensity) helps teens aged 13–18 recover faster from a concussion compared to standard care. Researchers will track symptom resolution, brain inflammation markers, and changes in anxiety and…

This study looks at whether giving L-Citrulline, tetrahydrobiopterin (BH4), and atorvastatin can improve blood vessel function and physical ability in veterans with a type of heart failure called HFpEF. About 90 participants will take these medications and be tested on how well t…

This study looks at whether special breathing exercises (inspiratory muscle training) can improve lung function and reduce inflammation in people with obesity. Researchers will measure breathing, muscle strength, and blood markers in 40 adults aged 30-60 with a BMI of 30 or highe…

This study tests whether a low dose of colchicine, an anti-inflammatory drug, can improve exercise capacity in people with heart failure and chronic inflammation. Sixty participants will be randomly assigned to receive either colchicine or a placebo for three months. Researchers …

This study tests whether a neuroscience-based computer program can improve memory and thinking in older adults who have had cognitive problems for at least 12 weeks after a COVID-19 infection. Researchers will compare the brain-training program to other computer activities in 75 …

This study looks at whether using the Calm meditation app for 10 minutes a day can help blood cancer patients who have trouble sleeping. Researchers will track sleep, mood, and inflammation in 276 participants over 20 weeks. The goal is to find a simple, drug-free way to improve …

This study looks at whether drinking haskap berry juice helps reduce inflammation and muscle damage after an intense leg workout. Thirty adults who regularly squat will drink either haskap juice or a placebo and follow a special diet. Researchers will measure strength, soreness, …

This study looks at two different exercise programs—using flexi bands or whole-body electrical stimulation—for people with cancer. The goal is to see which one better helps maintain muscle strength, reduce inflammation, and improve quality of life during treatment. About 100 part…

This study tests whether a special type of artificial light that changes throughout the day can improve sleep, body clock function, and overall well-being in frail older adults. Researchers will enroll 300 people over age 65 who are staying in hospital rooms equipped with this dy…

This study tests whether supplements made from agar-agar (a seaweed extract) and undenatured type II collagen can reduce knee pain in people with osteoarthritis. Eighty adults aged 40 to 70 with mild to moderate knee pain will take capsules daily for several weeks. The goal is to…

This pilot study tests whether taking a seaweed supplement called fucoidan for 8 to 16 weeks can reduce fatigue and inflammation in cancer survivors. Researchers will enroll 40 adults who have completed cancer treatment within the last 10 years and still feel tired. The main goal…

This study looks at whether giving lidocaine or ketamine during colorectal cancer surgery can lower inflammation (measured by a substance called IL-6) and help patients feel better after the operation. About 50 adults having open colorectal surgery will receive one of the two dru…

This study looks at whether minocycline, an antibiotic that reduces inflammation, can help people who have both obesity and depression that hasn't improved with other treatments. Researchers will test if this approach is practical and acceptable for 35 participants. The goal is t…

This study compares a 6-week mindfulness program to a sleep education class to see which better improves sleep in first- and second-year college students. About 240 students aged 18-22 who have trouble sleeping will participate. Researchers will track sleep quality, mood, and inf…

This study tests a program called RiSE that helps African American women cope with race-based stress. Researchers want to see if it improves well-being, reduces inflammation, and changes DNA markers. 300 post-menopausal women aged 50-75 with heart or metabolic risk factors will j…

This study enrolls up to 400 people with known or suspected infections or inflammatory diseases that are not covered by other research protocols. The goal is to evaluate patients using standard medical practices, generate new ideas for future studies, and train doctors. No experi…

This study tests whether taking a broccoli sprout extract (sulforaphane) for four days, doing high-intensity interval running, or combining both can improve how immune cells use energy and reduce inflammation. Twenty healthy adults aged 18-35 will try each approach in random orde…

This study will test whether using essential oils (by smelling, applying to skin, or swallowing capsules) can improve immune health in healthy adults aged 18 to 45. Forty participants will use either the oils or a placebo for 30 days. Researchers will measure changes in blood, sa…

This study looks at how certain white blood cells (neutrophils and monocytes) sense signals in the body and what substances they release, especially when they might cause inflammation. Healthy adults aged 18 to 65 who weigh at least 110 pounds can join by donating blood up to six…

This study tests whether a supplement called BioToxin Binder, made from humic and fulvic acid, can affect markers of biological age, detoxification, inflammation, and oxidative stress. Researchers will enroll 60 generally healthy adults aged 40 and older. Participants take the su…

This study tests whether morning bright light therapy can improve sleep in 300 veterans with traumatic brain injury. Researchers will measure changes in inflammation, energy production in cells, and brain cleaning systems. The goal is to understand how better sleep might support …

This study looks at how stress and social support might influence preterm birth in 200 pregnant women, especially among Black and Hispanic women who face higher risks. Researchers will measure stress levels, immune responses, and cellular energy (mitochondria) to understand why s…

This study looks at two blood inflammation markers, SII and SIRI, to see if they can help predict metabolic problems like insulin resistance and fatty liver in people who are overweight or have obesity. Researchers will follow 200 adults for up to 3 years, tracking their diet, la…

This study tests whether a device called the CoreSys monitor can help reduce the body's stress response during abdominal hysterectomy. Thirty women having the surgery will be randomly assigned to standard anesthesia or anesthesia guided by the monitor. Researchers will measure st…

This study follows 2,500 adults aged 30-75 in Puerto Rico to track chronic diseases like heart disease, diabetes, and obesity. Researchers will collect data on diet, stress, and lifestyle over two years to identify trends and risk factors. The goal is to guide public health prior…

This study is looking at 150 women having breast cancer surgery to see if their sleep quality in the month before surgery can predict how much pain and inflammation they have afterward. Participants fill out a sleep questionnaire before surgery, and their pain and painkiller use …

This study looks at how different types of exercise—moderate, vigorous, or short bursts—change inflammation levels in the body. Researchers want to see if exercise can help reduce the low-grade inflammation linked to obesity and heart disease. The study is recruiting 33 overweigh…

This study looks at whether giving mothers in Brazil an extra $40 per month (compared to just $2) can protect their children's brain development and mental health. About 450 children aged 7-10 from low-income families will be followed for 2 years. Researchers will measure stress,…

This study aims to understand how environmental factors like pollution, diet, and stress contribute to human disease. Researchers will collect samples such as blood, urine, and skin from 2,000 healthy adults aged 18 and older. Participants may also complete surveys and provide ho…

This study is looking at whether early signs of inflammation in the blood can help identify which patients with infections are at risk for serious complications like sepsis. Researchers will follow 4,200 adults with confirmed or suspected infections, as well as healthy controls, …

This study looks at inflammatory genes in people with psoriasis to better understand the disease. Researchers will take skin samples from 13 adults with psoriasis and measure genes linked to inflammation. The goal is to find markers that could help manage psoriasis in the future.

This observational study follows 30 women undergoing DIEP flap breast reconstruction after mastectomy. Researchers will measure inflammation and oxidative stress markers in blood samples taken before and after surgery. The goal is to understand how the body responds to the tempor…

This study looks at how chronic marijuana use changes brain inflammation and thinking abilities in people with HIV. Researchers will use brain scans and blood tests to measure brain health in 220 adults. The goal is to understand the effects, not to test a new treatment.

This study is testing whether a simple finger-prick blood spot can measure inflammatory markers as accurately as a standard blood draw from a vein. Researchers will collect both types of samples from 50 adults before and after a planned stressor, like a vaccine, which temporarily…

This study looks at how well young women with overweight or obesity absorb iron from their diet compared to women at a healthy weight. Researchers will track iron levels and losses over time in 70 South African women. The goal is to understand why obesity raises the risk of iron …

This study is looking at new blood markers that measure inflammation and oxidative stress in people with Gaucher disease type 1. Researchers want to see if these markers can give more information than the tests currently used. The study involves 34 adults who are stable on their …

This study looks at whether an 8-week stress reduction program can lower inflammation in the arteries of people with stable heart disease. About 36 adults who feel stressed will take part. Researchers will use special PET/MRI scans to measure changes in artery and brain activity …

This study looks at why having low 'bad' cholesterol (LDL) might actually increase the risk of type 2 diabetes. Researchers think LDL entering fat tissue may cause problems that lead to diabetes. They will test if taking omega-3 fish oil supplements for 6 months can reduce that r…

This study is observing 42 postoperative patients in the intensive care unit to see if levels of a protein called IL-6 and other inflammation scores can predict who will die or have serious complications. Researchers will measure these markers at ICU arrival and 24 hours later, t…

This pilot study tests whether applying over-the-counter moisturizers (CeraVe or Vaseline) daily for 4 weeks can reduce inflammation in adults aged 70 and older with dry skin. Researchers will measure skin barrier function, blood markers of inflammation, and skin microbes. The ma…

This study is looking at whether certain substances in the blood can help predict postoperative delirium—a state of confusion that can occur after surgery in older adults. Researchers will measure specific biomarkers before and after surgery in 1,170 patients aged 65 and older un…

This study looks at whether eating beef every day as part of a heart-healthy diet helps older adults (ages 55-70) absorb zinc better and improves how their blood vessels work. Researchers will measure zinc levels in cells and blood vessel function in 20 participants. The goal is …

This study looks at how a type of talk therapy for depression changes the gut microbiome, immune system, and brain function in people living with HIV. Researchers will enroll 150 adults with HIV and depression to understand these connections. The goal is to learn more about how t…

This study looks at how moderate wine consumption changes tiny particles called extracellular vesicles, which help cells communicate. Eight healthy adults aged 35-65 will drink red wine, white wine, or water, and researchers will analyze their blood for changes in these particles…

This study looks at whether breathing pure oxygen in a pressurized chamber (hyperbaric oxygen therapy) at a specific pressure can improve cardiovascular fitness and lower inflammation in healthy adults. Researchers will measure fitness with a treadmill test and check blood for si…

This study collects white blood cells from up to 10 healthy volunteers and patients with autoimmune diseases, inflammation, or liver transplant. The goal is to analyze these cells to help develop engineered regulatory T cell (Treg) therapies. No treatment is given; it is a resear…

This study looks at the genes of 2,750 people in French Polynesia to find out why gout, inflammation, and metabolic diseases like diabetes are common there. Participants must be of Polynesian ancestry and either have gout or be part of the general population. The goal is to disco…

This early-phase study at Queen Mary University of London aims to understand why men and women respond differently to inflammation, which may affect heart disease risk. Researchers will apply a small amount of cantharidin (a blister-inducing chemical) to the skin of 34 healthy vo…

This study looks at whether platelets—small blood cells that help with clotting—are found inside brain and spinal cord tumors. Researchers want to see if the presence of platelets in these tumors is linked to how long patients survive. The study will involve 50 adults who are hav…

This study looks at how being overweight or having early signs of type 2 diabetes affects the brains of teenagers aged 12 to 17. Researchers will use brain scans and memory tests to see which factors—like insulin resistance or inflammation—are most linked to changes in brain stru…

This study looks at whether inflammation caused by e-cigarette use harms blood vessel function in young adults aged 18-24. Researchers will compare chronic vapers to non-users, measuring blood vessel responses after giving an anti-inflammatory drug or placebo. The goal is to unde…

This study looks at how difficult childhood experiences and poor sleep might harm blood vessel function in young adults aged 18-29. Researchers will monitor sleep at home and test blood vessel health. Some participants will receive a 6-week sleep therapy program (CBT-i) to see if…

This study in Kyrgyzstan is testing whether using a rapid C-reactive protein (CRP) blood test and giving patients an information leaflet can help doctors prescribe fewer antibiotics for respiratory infections like coughs and sore throats. About 1050 adults will be randomly assign…

This study looks at a fast-progressing type of coronary artery disease that may be driven by inflammation. Researchers will compare 20 patients with this condition to 10 patients with typical heart disease, using lab tests, imaging, and physical assessments. The goal is to better…

This study aims to learn more about heart disease that is linked to inflammation but does not progress quickly. Researchers will follow 120 adults with this condition to track their treatments and health outcomes, such as heart attacks or the need for procedures. The goal is to b…

This study will follow 80 people with advanced chronic kidney disease who are waiting for a kidney transplant. Researchers will use PET scans and echocardiograms to measure blood flow and heart function before and after transplant. The goal is to see if improving kidney function …

This study is observing 1,000 critically ill ICU patients to learn how their bodies respond to life-threatening infections and injuries. Researchers will collect blood and lung fluid samples to identify biological factors that could lead to earlier diagnosis and new treatments fo…

This study looks at whether fungi moving from the gut into the blood can cause inflammation and worsen lung function in people with HIV. Researchers will measure a fungal marker called BDG in blood and urine, and track lung health over three years. The goal is to better understan…

This study aims to understand why heart disease develops differently in women compared to men. Researchers will measure inflammation markers and hormone levels in 6,000 women with chest pain. They hope to uncover how female sex hormones and inflammation interact to influence hear…