INFLAMMATION

This study tests whether a low dose of colchicine, an anti-inflammatory drug, can reduce the risk of serious heart problems and limb complications in people with peripheral artery disease (PAD). About 6,150 adults with symptomatic PAD will take either colchicine or a placebo dail…

This study tests a blood filter called HA380 in 40 very ill adults (ages 18–65) who are on dialysis or a heart-lung machine (ECMO) due to severe infection, injury, or major surgery. The filter aims to remove inflammatory substances from the blood, potentially reducing time on lif…

This study tests whether the anti-inflammatory drug ketorolac can improve outcomes for 360 people undergoing emergency surgery for a severe aortic tear (Stanford Type A aortic dissection). Participants receive either ketorolac or a placebo before and after surgery, alongside stan…

This study tests whether nattokinase, an enzyme from fermented soy (natto), can reduce inflammation and improve heart health markers in people with high cholesterol. About 48 adults with dyslipidemia will take nattokinase or a placebo for two months. Researchers will measure chan…

This study tests a drug called orticumab in 240 people who had a heart attack and still have high inflammation in their heart arteries. The goal is to see if orticumab can lower that inflammation better than a placebo over 6 months, using special CT scans to measure changes. Part…

This study tests whether a comprehensive treatment can reduce heart attacks and other serious events in people with rapidly-progressive coronary artery disease caused by inflammation. About 39 adults who have already had heart procedures like stents or bypass surgery will receive…

This study tests whether the drug ziltivekimab can lower inflammation in the arteries of people with heart disease. About 40 adults aged 50 and older with multiple blocked arteries and high inflammation levels will receive either the drug or a placebo. Researchers will use specia…

This study looks at whether a daily dose of freeze-dried wild blueberry powder can improve blood sugar, blood pressure, and thinking skills in women aged 20-65 who have prediabetes and are overweight. Researchers will also check if it changes gut bacteria. The goal is to see if t…

This study looks at whether taking ketone supplements can help older adults (ages 60-85) avoid the negative effects of a high-salt diet, such as higher blood pressure, blood vessel problems, and kidney stress. Researchers will give 30 healthy volunteers a high-salt diet with or w…

This study tests different doses and ways of giving the anti-inflammatory drug anakinra to very premature infants (born between 24 and 29 weeks). The goal is to find the safest and most effective dose to reduce inflammation and prevent lung problems. About 24 babies will take par…

This study looks at whether eating wild blueberries can improve heart health, thinking skills, and gut bacteria in adults aged 45-65 with high blood pressure. Researchers will measure blood pressure, artery stiffness, and memory over time. The goal is to see if a simple diet chan…

This study tests whether adding omega-3 fatty acids from fish oil or camelina oil to the diet can improve a blood-based risk score for heart disease. About 324 adults over 55 at moderate to high cardiovascular risk will take one of three diets for 12 weeks: fish oil, plant oil, o…

This study compares two healthy diets—one centered on lean beef and one following a standard US pattern—to see which better lowers inflammation in adults with metabolic syndrome or pre-diabetes. Over 5 weeks, researchers will measure changes in blood markers of inflammation and o…

This study tests whether a special food containing probiotics and prebiotics can help manage bone loss in women aged 60 and older. Over 18 months, researchers will measure bone density and strength in 220 participants. The goal is to see if this dietary approach can slow or impro…

This study tests whether a daily probiotic drink can improve immune function and reduce skin inflammation in women aged 40-60 going through menopause. Participants will drink either a probiotic or a plain milk drink for 8 weeks. Researchers will measure immune aging, inflammation…

This study tests if a drug called icosapent ethyl (Vascepa) can reduce inflammation in the arteries of adults hospitalized with community-acquired pneumonia. Inflammation from pneumonia can harm blood vessels, raising heart risks. Over 6 months, 168 participants will take either …

This study tests whether eating grapes every day can improve gut health, reduce inflammation, and help blood vessels work better in healthy overweight adults aged 45 to 70. Participants will drink a grape powder or placebo drink twice daily for three weeks. Researchers will measu…

This study looks at whether two easy, non-invasive tests—a breath test (FeNO) and a blood test (eosinophils)—can accurately diagnose asthma in children aged 6 to 17. Currently, diagnosing asthma often requires complex hospital-based tests. The goal is to see if these simpler test…

This study looks at whether measuring inflammation in the breath and blood can help prioritize who gets lung tests first when asthma is suspected. Researchers will include 1,500 people aged 6 and older who were referred by their primary care doctor. The goal is to see if this app…

This study looks at whether lifestyle changes—like regular exercise, cognitive training, and a Mediterranean diet—can help prevent memory and thinking problems in people aged 50 to 80 who have depression or depressive symptoms but no current cognitive decline. Researchers will co…

This study compares low-glycemic index (GI) carbohydrates to standard whole grains in a Mediterranean diet for 40 adults with high triglycerides. The goal is to see if low-GI carbs improve a key marker of metabolic and cardiovascular risk. Participants will try both types of carb…

This study tests whether a 6-week mindfulness program (MAPs) or a sleep education class can improve sleep quality in first- and second-year UCLA students who have trouble sleeping. About 240 participants will wear sleep trackers, answer surveys, and give blood samples to measure …

This study tests whether adding the antibiotic minocycline to usual antidepressants can help people who have both obesity and treatment-resistant depression. Researchers believe that inflammation may play a role in these conditions, and minocycline can reduce inflammation. The st…

This study tests whether using the Calm meditation app for 10 minutes a day can help blood cancer patients who have trouble sleeping. Researchers will track sleep quality, anxiety, depression, fatigue, and inflammation in 276 participants over 20 weeks. The goal is to see if a si…

This study tests if a non-invasive device that gently stimulates a nerve in the ear can help reduce inflammation and pain after major spine surgery. Researchers will measure inflammatory markers and pain scores in 50 adults undergoing long-segment spinal fusion. The goal is to se…

This study tests whether a low dose of colchicine, a drug usually used for gout, can help people with a certain type of heart failure (HFpEF) and inflammation exercise more easily. About 60 adults aged 50 and older will take either colchicine or a placebo for 3 months. Researcher…

This study compares two drugs, lidocaine and ketamine, given through an IV during and after colorectal cancer surgery. The goal is to see which one better lowers inflammation (measured by a substance called Interleukin-6) and helps with pain and recovery. About 50 adults having o…

This study tests whether an 8-week stress reduction program can reduce inflammation in the arteries of adults aged 30-65 who feel stressed. Researchers will use special scans to measure changes in artery inflammation. The goal is to see if managing stress can improve heart health…

This study looks at whether drinking haskap berry juice helps people who lift weights recover faster after an intense leg workout. Thirty adults with at least 2 years of squatting experience will drink either haskap juice or a placebo and follow a low-polyphenol diet. Researchers…

This study looks at whether giving L-Citrulline, tetrahydrobiopterin (BH4), and atorvastatin can improve blood vessel function and physical ability in veterans with a type of heart failure called HFpEF. About 90 veterans will take part. The goal is to see if these treatments help…

This study tests whether a neuroscience-based computer brain training program can improve memory and thinking in older adults (60+) who have had cognitive problems for at least 12 weeks after a confirmed COVID-19 infection. Researchers will compare the brain training to other com…

This study tests whether a supplement made from seaweed, called fucoidan, can help reduce fatigue and inflammation in people who have finished cancer treatment. About 40 adult cancer survivors with ongoing fatigue will take the supplement for 8 weeks. The goal is to see if it's p…

This study tests whether a higher amount of aerobic exercise, started within two weeks of a concussion, helps teenagers recover faster. Researchers will measure symptom relief, brain inflammation markers, and changes in anxiety or depression. The goal is to create better, more pr…

This study looks at two different exercise programs—flexi band resistance training and whole-body electrical muscle stimulation—for people with cancer. The goal is to see which one better improves muscle strength, body composition, and quality of life. About 100 participants will…

This study tests whether a special type of dynamic lighting can improve sleep, daily rhythms, and overall well-being in frail older adults (65+) who are in the hospital. Researchers will measure changes in melatonin levels and sleep patterns. The goal is to find a simple, non-dru…

This study tests whether supplements made from agar (a seaweed extract) and collagen can reduce knee pain in people with osteoarthritis. Researchers will enroll 80 adults aged 40 to 70 who have mild to moderate knee pain. Participants will take the supplements or a placebo for a …

This study tests whether a compound found in green tea, called EGCG, can reduce frailty and inflammation in older adults who have survived cancer. About 118 people aged 65 and older who have completed cancer treatment will take EGCG or a placebo for 12 weeks. The goal is to see i…

This study looks at how well young women with overweight or obesity absorb iron from their diet compared to women at a healthy weight. Researchers will track iron levels and losses over two years in 70 South African women. The goal is to understand why obesity raises the risk of …

This study looks at how difficult childhood experiences and sleep problems may harm blood vessel function in young adults aged 18-29. Researchers will measure sleep quality and blood vessel health in 70 participants. Some will then join a 6-week sleep improvement program to see i…

This study looks at people with known or suspected inflammatory or infectious diseases that aren't covered by other research protocols. The goal is to evaluate and treat these patients using standard medical practices while gathering information to help train doctors and design f…

This study follows 120 adults with coronary artery disease and signs of chronic inflammation to understand their symptoms, current treatments, and health outcomes over time. Researchers will track major heart events like heart attacks, need for procedures, or death. The goal is t…

This study is looking at whether early signs of inflammation in the blood can help identify which patients with infections are at risk for serious problems like sepsis. Researchers will follow 4,200 adults with confirmed or suspected infections for 28 days to see how well these e…

This study will follow 200 adults with overweight or obesity for up to 3 years to see if two blood inflammation markers (SII and SIRI) can predict metabolic problems like insulin resistance and fatty liver, and how well people respond to weight-loss treatments. Participants will …

This study looks at whether fungi moving from the gut into the blood can cause inflammation and worsen lung function in people with HIV. Researchers will measure a fungal marker called BDG in blood and urine, and track lung health over three years. The goal is to better understan…

This study looks at whether eating mangoes every day for 4 weeks, instead of high-calorie snacks like cookies and chips, can improve gut health, reduce inflammation, and boost heart health in Hispanic/Latino teens. About 25 teens aged 12-19 with a higher BMI will participate. Res…

This study looks at how obesity affects breathing and inflammation, and whether special breathing exercises (inspiratory muscle training) can help. Researchers will measure lung function, inflammation markers, and body composition in 40 adults with obesity. The goal is to see if …

This study will follow 80 people with advanced chronic kidney disease who are waiting for a kidney transplant. Researchers want to see if getting a new kidney improves blood flow to the heart and reduces inflammation. Participants will have heart scans and blood tests before and …

This study looks at why having low 'bad' cholesterol might actually increase the risk of type 2 diabetes. Researchers think it may be due to how cholesterol enters fat tissue. They will test if taking omega-3 (fish oil) for 6 months can reduce this risk in 48 adults aged 45-74 wi…

This study is following 2,500 adults aged 30-75 in Puerto Rico to learn how stress, diet, and where they live affect chronic diseases like heart disease, diabetes, and obesity. Researchers will collect health data and survey participants over two years, including before and after…

This study aims to understand how environmental factors like pollution, diet, and stress contribute to human diseases. Researchers will collect blood, urine, hair, and other samples from 2,000 healthy adults aged 18 and older. Participants may also complete surveys and provide sa…

This study looks at why heart disease affects women differently than men, especially after menopause. Researchers will measure inflammation and hormone levels in 6,000 women with chest pain. The goal is to understand how these factors influence heart attack risk and recovery, lea…

This study checks if a simple finger prick (dried blood spot) can measure inflammation markers as well as a standard blood draw from a vein. About 50 adults who are getting a vaccine or have a planned stressor will give both types of samples. The goal is to see if the finger-pric…

This study looks at why some people with heart disease get worse much faster due to inflammation. Researchers will compare 20 patients with inflammation-related rapid coronary artery disease to 10 patients with typical disease. The goal is to find patterns in their health history…

This study looks at how being overweight or having early signs of type 2 diabetes affects the brains of teenagers aged 12 to 17. Researchers will use brain scans and thinking tests to see if factors like insulin resistance or inflammation are linked to changes in memory, processi…

This study looks at how one serving of red or white wine changes tiny particles called extracellular vesicles in the blood. These particles help cells talk to each other and may influence heart and brain health. Researchers will compare blood samples from 8 healthy adults before …

This study looks at whether inflammation from e-cigarette use harms blood vessel function in young adults aged 18-24. Researchers will compare vapers and non-vapers by measuring skin blood flow after a mild heat test, with and without an anti-inflammatory drug. The goal is to und…

This study looks at platelets (small blood cells) found in brain and spinal cord tumors. Researchers want to see if platelets help tumors grow or spread, and if their presence is linked to patient survival. About 50 adults having tumor surgery will donate a small piece of their t…

This study looks at whether giving mothers in Brazil a little extra money each month can help protect their children's brain development and mental health. About 450 families already receiving a government cash program will be randomly assigned to get either $40 or $2 extra per m…

This study looks at white blood cells from healthy volunteers and people with autoimmune diseases, inflammation, or liver transplant rejection. The goal is to understand these cells better so scientists can create new engineered regulatory T cell (Treg) therapies. The study invol…

This study looks at how stress and childhood trauma might increase the risk of preterm birth by affecting tiny energy-producing parts of cells called mitochondria. Researchers will follow 200 pregnant women, mostly Black and Hispanic, to understand these connections and why prete…

This study collects blood samples from 20,000 adults with infections, heart disease, blood clots, or kidney disease. Researchers use the samples to develop and fine-tune new diagnostic tests that can give results quickly at the point of care. No treatment or experimental therapy …

This study looks at whether an 8-week stress reduction program can lower inflammation in the arteries of people with stable heart disease. About 36 adults who feel stressed will learn mindfulness techniques and get special PET/MRI scans to measure changes. The goal is to see if c…

This study looks at how chronic marijuana use impacts brain inflammation and thinking skills in people with HIV. Researchers will use brain scans and cognitive tests to compare marijuana users and non-users. The goal is to understand whether marijuana helps or harms brain health …

This study aims to understand which inflammatory genes are active in psoriasis, a chronic skin condition. Researchers will measure specific genes from skin samples of 13 adults with psoriasis. The goal is to find better ways to track and manage the disease, not to test a new trea…

This study tests whether a device called CoreSys can help doctors manage stress during abdominal hysterectomy. The monitor tracks consciousness, pain, and stress levels during surgery. 30 women having the procedure will be split into two groups: one with standard anesthesia care,…

This study tests a program called RiSE that teaches African American women ways to handle stress from racism. Researchers want to see if it lowers inflammation and improves well-being. About 300 women aged 50-75 with heart or metabolic risks will join online classes for 8 weeks a…

This early-phase study aims to understand why healthy women seem to resolve inflammation better than men, which may help explain sex differences in heart disease. Researchers will create small blisters on the skin of 34 healthy volunteers aged 18-45 and compare blister size, flui…

This study looks at how a type of talk therapy for depression changes the gut microbiome, immune system, and brain function in people living with HIV. Researchers will enroll 150 adults with HIV and depression to understand these connections. The goal is to learn more about how t…

This study looks at new blood markers for inflammation and oxidative stress in adults with Gaucher disease type I. Researchers want to see if these markers give extra information beyond the usual tests. The goal is to better understand the disease, not to test a new treatment.

This study looks at how different exercise routines—moderate, vigorous, or short and intense—affect inflammation and the immune system in overweight but otherwise healthy adults. Researchers want to see if exercise can help reduce chronic low-grade inflammation, which is linked t…

This study is for adults aged 65 and older having major surgery. Researchers want to see if certain substances in the blood, measured right after surgery, can predict whether a patient will experience postoperative delirium—a state of sudden confusion. The goal is to find a relia…

This study looks at whether daily use of simple moisturizers like Vaseline or CeraVe can lower inflammation in older adults with dry skin. Researchers will measure skin barrier function, blood markers of inflammation, and skin microbes. The goal is to see if a larger trial is pos…

This study looks at how white blood cells from healthy adults respond to different signals in a lab. The goal is to understand how these cells sense threats and may cause inflammation. Participants donate blood up to six times a year, which is used to test cell reactions and meas…

This study is watching 42 adults who had surgery and then went to the intensive care unit (ICU). Researchers want to see if a blood marker called IL-6 and other inflammation scores can help predict who might die or have serious problems in the hospital. The goal is to learn if th…

This study tests whether an attachment-based parenting program (ABC) can improve health outcomes like common illnesses, sleep, and weight in low-income Latino children. 260 mothers and their 9-month-old babies will be randomly assigned to either the ABC program or a home reading …

This study follows 30 women aged 18-70 who are having DIEP flap breast reconstruction after breast cancer surgery. Researchers will take blood samples before and after surgery to measure markers of inflammation and stress. The goal is to learn more about how the body heals and to…

This study looks at whether measuring CRP levels (a sign of inflammation) and giving patients an information leaflet can help doctors prescribe fewer antibiotics for respiratory infections. About 1050 adults in Kyrgyzstan will take part. The goal is to find the best CRP cutoff to…

This study looks at whether breathing pure oxygen in a pressurized chamber (hyperbaric oxygen therapy) at a specific pressure can improve cardiovascular fitness and reduce inflammation in healthy adults. Researchers will measure fitness levels and blood markers of inflammation be…

This study looks at the genes of 2,750 adults in French Polynesia to find links between inherited traits and diseases like gout, inflammation, and diabetes. Participants include both healthy volunteers and people with gout. The goal is to better understand why these conditions oc…

This study is observing 1,000 adults in the intensive care unit (ICU) to learn more about why some people get very sick from infections or injuries. Researchers will collect blood samples and health data to find early signs that could help diagnose serious conditions like sepsis …

This study looks at whether the quality of sleep before breast cancer surgery affects pain and inflammation after the operation. Researchers will track 150 women, measuring their sleep quality, blood markers of inflammation, and pain levels. The goal is to see if poor sleepers ha…

This study looks at whether eating beef every day as part of a heart-healthy diet helps older adults (ages 55-70) absorb zinc better and improve blood vessel function. Researchers will measure zinc levels inside cells and how well blood vessels work. The goal is to understand how…

This study looks at whether a 6-month diet change can reduce inflammation and improve metabolism in obese adults who have had colon polyps (a risk factor for colon cancer). It also includes their overweight partner living in the same home. The goal is to understand how diet affec…