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Gut bacteria byproducts may tame inflammation and shield the brain

NCT ID NCT07713641

Recruiting now Knowledge-focused Sponsor: Universitaire Ziekenhuizen KU Leuven Source: ClinicalTrials.gov ↗

First seen Jul 20, 2026 · Last updated Jul 21, 2026 · Updated 1 time

Summary

This study tests whether short-chain fatty acids (SCFAs) — substances naturally produced by gut bacteria — can reduce inflammation and protect thinking skills. Healthy adults receive either SCFA capsules or a placebo, then a low dose of a bacterial substance that briefly activates the immune system, causing mild flu-like symptoms. Researchers measure inflammation in the blood and test memory, inhibition, and mental flexibility to see if SCFAs help.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
short-chain fatty acid colon-delivery capsules (sodium acetate, sodium butyrate, sodium propionate)
What this could lead to
If it works, this could point toward a dietary supplement that reduces inflammation and protects mental performance during immune challenges.
What could go wrong
This is a small, early-phase trial in healthy people using a temporary lab-induced inflammation, so results may not apply to real infections or chronic conditions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Endotoxemia Inflammation inflammatory disease Inhibition, Psychological van der Woude syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ENDOTOXEMIA EXECUTIVE FUNCTION (COGNITION) INFLAMMATION

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • University Hospital Leuven (UZ Leuven)

    RECRUITING

    Leuven, 3000, Belgium

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact Phone: •••-•••-•••• Email: •••••@•••••

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