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Strawberries as medicine? trial tests whether the fruit can calm inflammation and boost insulin response
NCT ID NCT06173765
First seen Aug 28, 2026 · Last updated Aug 28, 2026
Summary
This trial tests whether eating freeze-dried strawberry powder daily for four weeks can lower chronic inflammation and improve blood vessel function and insulin sensitivity in adults with prediabetes. Participants will be randomly assigned to receive either a low dose, a high dose, or a placebo drink. Researchers will measure blood markers of inflammation, blood vessel dilation, and blood sugar control before and after the intervention.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- freeze-dried whole strawberry powder
- What this could lead to
- If it works, this could point toward a simple dietary way to reduce chronic inflammation and improve blood sugar and blood vessel health in people at risk for diabetes.
- What could go wrong
- This is a small, early-stage trial, so results may not apply broadly. The effect may be modest, and the study does not measure long-term health outcomes.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
-
68 people
The number who actually took part.
- Started
-
Aug 2022
- Finished
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Apr 2023
- Lead sponsor
-
A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
20 to 60 years
- Sex
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Anyone
- Healthy volunteers
-
Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria * Men or women 20-60 years of age * High sensitivity C-Reactive Protein (hs-CRP), a global marker of inflammation, \>1.0 and ≤10 ng/L * BMI ≥ 25 kg/m2 * Nonsmokers (Past smokers can be allowed if they have abstinence for minimum of 1 years). Occasional smoker may be allowed at investigator discretion * Judged to be in good health on the basis of the medical history ie., no clinical evidence of cardiovascular, metabolic, respiratory, renal, gastrointestinal or hepatic disease * Not taking any medications that would interfere with outcomes of the study, i.e. lipid lowering medications, anti-inflammatory drugs, dietary supplements, etc. * Able to provide informed consent * Able to comply and perform the procedures requested by the protocol (including dietary restrictions, consumption of study treatments, records of food diary and study visit schedule) * Able to maintain usual physical activity pattern * Able to abstain from alcohol consumption and avoid vigorous physical activity for 24 hours prior to and during study visit Exclusion Criteria: * Men and women who smoke regularly * Men and women with known or suspected intolerance, allergies or hypersensitivity to study foods or treatments * Men and women who have blood pressure \>160 mmHg (systolic)/100 mmHg (diastolic) at screening visit * Men and women who have fasting blood glucose concentration \>125 mg/dL at screening visit * Men and women with documented vascular disease, e.g., heart failure, myocardial infarction, stroke, angina, related surgeries, etc. that, in the opinion of the investigator, could interfere with the interpretation of the study results * Men and women with cancer other than non-melanoma skin cancer in previous 5 years * Men and women diagnosed with chronic constipation, diarrhea or other chronic gastrointestinal complaint (e.g. irritable bowel syndrome) * Women who are known to be pregnant or who are intending to become pregnant over the course of the study * Women who are lactating * Taking medication or dietary supplements that may interfere with the outcomes of the study; e.g., antioxidant supplement, anti-inflammation, lipid lowering medication, blood pressure lowering medication, etc... Subjects may choose to go off dietary supplements (requires 30-day washout); e.g., fish oil, probiotics, etc... * Men and women who has participated in prebiotics or laxative trial within 3 months prior to enrollment or any other clinical trial within 1 month * Major trauma or a surgical event within 2 months or longer depending on trauma or event and after consultation with PI. * Vegan or other extreme dietary regimens (e.g., Atkins diet, etc.) as judged by the investigator. * Has a known intolerance or sensitivity to any ingredients in the study products * Has used antibiotics within the previous 2 months * History of an eating disorder (e.g., anorexia nervosa, bulimia nervosa, or binge eating) diagnosed by a health professional * Substance (alcohol or drug) abuse within the last 2 years * Excessive coffee and tea consumers (\> 4 cups/d) * Donated blood within last 3 months * Men and women who do excessive exercise regularly or are an athlete * Unstable weight: gained or lost weight +/- 5 kg (11 lbs) in previous 2 months * Women who are taking unstable dose and brand of hormonal contraceptives and/or stable dose and brand less than 6 months * Unusual working hours i.e., working overnight (e.g. 3rd shift)
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Clinical Nutrition Research Center
Chicago, Illinois, 60616, United States
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Other studies related to the condition(s) this trial covers.
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