INSULIN RESISTANCE

This study looks at whether taking fiber supplements along with the diabetes drug metformin can help teenagers with severe obesity and insulin resistance. The goal is to see if the combination works better than either treatment alone for improving blood sugar control, reducing in…

This study looks at whether an online depression treatment program can improve how the body uses insulin to control blood sugar in people with HIV who are on HIV medication. Researchers will compare the online therapy to standard depression education. The goal is to see if treati…

This study tests whether metformin, a drug used for diabetes, can help obese, non-diabetic people in Nigeria lose weight and lower their heart disease risk. Researchers will give 220 participants either metformin or a placebo for several months. The goal is to see if this afforda…

This study tests an investigational drug called MOTS-c in 120 adults with prediabetes and overweight or obesity. Participants receive either MOTS-c or a placebo for 12 weeks, along with lifestyle advice. The main goal is to see if MOTS-c improves how the body uses insulin, which …

This study tests if replacing sugary sodas with unsweetened flavored sparkling water can help Black and Latine teens with obesity reduce their sugar intake and improve health. Over 8 weeks, 63 participants will swap their usual drinks for study beverages and complete taste tests,…

This study tests whether electro-acupuncture can improve insulin resistance in people with obesity. Sixty adults aged 21-65 with a BMI of 25 or higher and signs of insulin resistance will be randomly assigned to receive either real electro-acupuncture or a sham (fake) version. Re…

This study looks at whether taking a multi-strain probiotic alongside healthy lifestyle changes can improve liver health in people with Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), a common fatty liver condition. About 80 adults with signs of liver damage wil…

This study tests whether taking a daily oil rich in linoleic acid (a type of omega-6 fat) can improve insulin resistance and other metabolic health markers in adults. 120 participants with insulin resistance will receive either the linoleic acid oil or a control oil for 8 weeks. …

This study tests whether taking oral glutamine, an amino acid, for 8 weeks can improve insulin resistance and irritable bowel syndrome (IBS) symptoms in people with severe obesity. About 110 participants will receive either glutamine or a placebo protein powder. Researchers will …

This study looks at whether drinking cranberry juice can help improve blood sugar, insulin levels, and gut health in people who are overweight or have early signs of metabolic problems. About 73 adults will drink either a cranberry beverage or a placebo for 12 weeks, then switch …

This study tests whether a minimally invasive stomach-shrinking procedure (endoscopic sleeve gastroplasty) combined with lifestyle changes is better than lifestyle changes alone for treating a serious liver condition called MASH in people with obesity. The procedure reduces stoma…

This study looks at whether cognitive-behavioral therapy, exercise training, or both can lower the risk of type 2 diabetes in teenage girls. Participants are 300 girls aged 12-17 who are at higher risk due to family history, weight, and mood symptoms. The goal is to see if these …

This study looks at whether eating more slowly digestible and resistant starch can help people with insulin resistance better manage their blood sugar. Forty adults will follow a special diet for two months, with regular blood, urine, and stool tests to track changes in glucose l…

This study tests whether a 10-week telemedicine exercise program can improve cardiorespiratory fitness and insulin sensitivity in Asian children aged 12-17 who have low fitness levels. Participants will either join weekly online exercise sessions or follow standard activity recom…

This study looks at whether short bursts of physical activity after meals can help breast cancer survivors on hormone therapy manage their blood sugar better than a standard 30-minute walk. Researchers will compare different activity patterns in 24 women, including cancer survivo…

This study looks at whether taking sodium bicarbonate (baking soda) can improve muscle energy and physical endurance in people with chronic kidney disease and metabolic acidosis. About 80 adults with moderate-to-severe kidney disease will take part. Researchers will measure muscl…

This study tests a dietary supplement called Sabroxy® in 140 adults aged 40-80 who have both mild cognitive impairment (early memory loss) and insulin resistance (a pre-diabetic condition). Participants will take either the supplement or a placebo daily for 8 weeks. The goal is t…

This study looks at how being overweight or having early signs of type 2 diabetes affects the brains of teenagers aged 12 to 17. Researchers will use brain scans and thinking tests to see if factors like insulin resistance or inflammation are linked to changes in memory, processi…

This study aims to understand how insulin controls sugar and fat production in the liver, comparing healthy adults to those at risk for type 2 diabetes. Participants will receive a single dose of the drug alpelisib or a placebo during two overnight hospital stays. Researchers wil…

This study looks at how the gut's fermentation process affects insulin resistance in teenagers and young adults with obesity. Researchers will give a sugar drink (lactulose) to see how it changes fat breakdown and sugar production in the body. The goal is to better understand the…

This study looks at how fasting insulin and insulin resistance (HOMA-IR) differ based on age, sex, race/ethnicity, body mass index (BMI), and whether someone has polycystic ovary syndrome (PCOS). Researchers will analyze data from 150 adults who recently had metabolic blood tests…

This study looks at how losing weight affects the fat stored inside your muscles, called IMAT. Researchers want to see if this fat makes muscles less responsive to insulin and causes inflammation, and if weight loss can reverse that. About 70 adults with obesity will follow a 12-…

This study is testing a new, radiation-free imaging technique called photoacoustic imaging to look at brown adipose tissue (brown fat), which helps burn energy. Researchers will compare brown fat activity in 100 healthy adults and people with metabolic syndrome, both at rest and …

This study looks at how diabetes changes the way heart cells use energy, which may lead to heart failure. Researchers will examine heart tissue and use imaging tests in 500 adults with heart failure, with or without type 2 diabetes. The goal is to better understand the disease an…

This study looks at how a pregnant woman's metabolism—specifically insulin resistance and fat burning—relates to the health of the placenta and the risk of conditions like preeclampsia and gestational diabetes. Researchers will follow 50 pregnant women at high risk for these comp…

This study looks at whether a one-week course of the drug diazoxide can reduce how much fat the liver makes in people with obesity, insulin resistance, and a type of fatty liver disease called MASLD. About 25 adults will take either the drug or a placebo, and researchers will mea…

This study aims to learn how the hormone insulin controls blood sugar in different people. Researchers will test a new procedure called the graded insulin suppression test (GIST) in 15 volunteers, including healthy individuals and those at higher risk for type 2 diabetes. Partici…

This study looks at whether a physical activity program can help improve hormone health and reduce diabetes risk in girls ages 8 to 12 who are at higher risk for PCOS. About 40 girls will either get a full program with coaching and messages, or a lighter version with just message…

This study looks at how quickly muscle loss and changes in metabolism happen when healthy young adults stay in bed for 5 days. Researchers will measure muscle size, strength, and how the body uses sugar before and after bedrest. The goal is to understand the early effects of inac…

This study looks at how adding exercise to a weight loss plan changes belly fat and metabolism in ways that may keep you healthier even if you regain some weight. Researchers will compare two groups of adults with obesity: one that loses weight through diet and exercise, and anot…

This study looks at how blood sugar levels change throughout the day in women with polycystic ovary syndrome (PCOS). Using a small sensor that tracks glucose continuously, researchers will compare sugar patterns across four different PCOS types. The goal is to better understand w…

This study looks at how ketone bodies—chemicals your liver makes when you fast or exercise—affect energy use and insulin sensitivity. Ten overweight adults aged 55-70 will receive different combinations of ketone supplements, growth hormone, or placebo on four separate days. Rese…

This study looks at how aging changes the way our bodies respond to exercise. Researchers will have 26 older adults who previously completed an exercise program do another 6 months of aerobic training. They will measure insulin sensitivity, fitness, and overall health to understa…

This study aims to understand how much insulin the body actually needs to keep blood sugar normal. Ten adults with obesity and high insulin levels will take a drug called diazoxide for eight days to temporarily stop the pancreas from making insulin. Researchers will measure fasti…

This study looks at how different types of insulin resistance affect the liver's fat production in people with high triglycerides. About 40 overweight adults will have their fat metabolism measured after a meal, with and without prior exercise. The goal is to understand the link …

This study looks at what happens in the body during a long fast (no food for several days). Researchers will take blood samples from 15 healthy adults before, during, and after fasting to measure changes in metabolism and cell markers. They will then test how the fasting blood af…

This study looks at how antipsychotic drugs might disrupt insulin action in the brains of healthy young women, and how this changes across the menstrual cycle. Fifteen participants will receive olanzapine or a placebo, plus intranasal insulin, and undergo MRI scans. The goal is t…

This study aims to find new biological clues that explain why some people with severe obesity develop type 2 diabetes while others do not. Researchers will collect tissue samples (fat, muscle, liver, blood) from 270 adults during planned weight-loss surgery. By comparing samples …

This study looks at how different types of fat affect muscle insulin resistance, a key factor in obesity and type 2 diabetes. Healthy adults receive a special fat infusion through a tube into the small intestine overnight, then undergo tests to measure how their muscles process f…

This study looks at how the immune system's first response (innate immunity) reacts to certain environmental triggers. Researchers want to understand if these reactions are linked to long-term illnesses like asthma, heart disease, and cancer. Healthy volunteers aged 18 to 45 will…