INSULIN RESISTANCE

This study tests whether wearing a continuous glucose monitor (CGM) for 3 months helps adults with prediabetes better control their blood sugar and stick to lifestyle changes compared to standard finger-prick testing. About 80 participants will be randomly assigned to use a CGM o…

This study looks at whether eating avocados regularly can improve how the body handles fats and sugar in people with prediabetes and insulin resistance. About 82 adults aged 40-70 with high triglycerides and insulin resistance will eat avocados as part of their daily diet. Resear…

This study tests whether a minimally invasive procedure called endoscopic sleeve gastroplasty (ESG), which reduces stomach size by 70%, can help reverse fatty liver disease (MASH) in people with obesity. Researchers will compare ESG plus lifestyle changes to lifestyle changes alo…

This study investigates whether reducing calories to lower fat in the liver and muscles can improve how the body responds to insulin. Researchers will measure changes in insulin sensitivity and fat levels in 250 healthy but insulin-resistant adults with a family history of type 2…

This study tests whether an internet-based depression treatment called cognitive behavioral therapy (iCBT-D) can prevent insulin resistance from getting worse in adults with HIV who are on antiretroviral therapy and have depression. Researchers will compare the online therapy pro…

This early-phase study aims to see if a natural substance called angiotensin-(1-7) can improve how the body uses insulin in people with obesity, insulin resistance, and high blood pressure. About 26 adults aged 18-60 will receive the peptide or a placebo infusion, and researchers…

This study tests whether taking sodium bicarbonate (baking soda) daily can improve muscle energy and physical endurance in people with chronic kidney disease and metabolic acidosis. About 80 adults with moderate-to-severe kidney disease will receive either sodium bicarbonate or a…

This study tests whether electro-acupuncture can improve insulin resistance in people with obesity. 60 participants will be randomly assigned to receive either real electro-acupuncture or a sham (fake) version. The main goal is to see if the treatment lowers a key measure of insu…

This study is testing whether a multi-strain probiotic supplement, taken alongside standard lifestyle advice, can improve liver health in people with Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD). The trial will enroll 80 adults with elevated liver enzymes and …

This study tests an investigational drug called MOTS-c in 120 adults with prediabetes and overweight or obesity. The goal is to see if 12 weeks of treatment can improve how the body uses insulin, compared to a placebo. All participants also receive standard lifestyle advice. The …

This study tests a physical activity program called ActiveGirls in 40 girls ages 8-12 who are at higher risk for PCOS and insulin resistance. Some girls get health coaching plus text messages, while others get only texts. Researchers will see if the program is acceptable and if i…

This study looks at whether drinking cranberry juice for 12 weeks can help overweight or obese adults improve blood sugar, insulin levels, cholesterol, and gut health. About 73 participants will be randomly assigned to receive either a cranberry drink or a placebo, then switch af…

This study tests whether taking glutamine, an amino acid, for 8 weeks can improve insulin resistance and reduce irritable bowel syndrome (IBS) symptoms in obese patients. 110 participants will receive either glutamine or a protein powder placebo. Researchers will measure changes …

This study tests whether metformin, a drug already used for diabetes, can help obese but non-diabetic Black Nigerians lose weight and lower their heart disease risk. Researchers will give 220 participants either metformin or a placebo for several months, tracking changes in weigh…

This study tests whether taking a daily oil rich in linoleic acid (a type of omega-6 fat) for 8 weeks can improve insulin resistance in adults aged 20-60 who have this condition plus at least one other cardiometabolic risk factor (like abdominal obesity or high blood pressure). P…

This study tests whether adding a daily fiber supplement to metformin helps improve insulin resistance and weight loss in teenagers aged 12-18 with severe obesity and a family history of type 2 diabetes. 90 participants will be randomly assigned to receive metformin alone, fiber …

This study looks at whether cognitive-behavioral therapy (CBT), exercise training, or both can help prevent type 2 diabetes in teenage girls who are at risk. The researchers want to see if these approaches lower stress, improve mood, boost physical activity, and reduce insulin re…

This 8-week study tests whether a daily supplement called Sabroxy® (made from Oroxylum indicum bark) can improve insulin resistance and memory in adults aged 40-80 with mild cognitive impairment and insulin resistance. About 140 participants will receive either Sabroxy® or a plac…

This study compares two simple physical activity strategies—short walks after meals and brief activity snacks—to standard 30-minute exercise sessions in breast and prostate cancer survivors. The goal is to see which approach best controls blood sugar and is easiest to fit into da…

This study tests whether replacing sugary sodas with unsweetened sparkling water can reduce added sugar intake and improve health in Black/African American and Latine adolescents with obesity who love sweet drinks. For 4 weeks, participants swap their sodas for one of three optio…

This trial tests whether a 10-week telemedicine exercise program can improve cardiorespiratory fitness and insulin resistance in Asian children aged 12-17 with low fitness levels. Participants will either join weekly online exercise sessions or follow standard activity advice. Re…

This study investigates how muscle fiber type and protein makeup relate to early insulin resistance, a key step before type 2 diabetes develops. Researchers will follow 250 healthy adults aged 20-30 for up to 20 years, using muscle biopsies, scans, and wearable sensors. The goal …

This study looks at how the body's innate immune system responds to certain environmental exposures by measuring inflammation markers in blood. Researchers will collect blood samples from up to 725 healthy volunteers aged 18-45 to analyze how specific genes and proteins react. Th…

This study investigates how exercise affects the structure and function of fat tissue in adults aged 18-40 with obesity or metabolic syndrome. Participants are randomly assigned to either an exercise program or a sedentary control group. All undergo a 10% weight loss phase, then …

This study looks at how certain immune cells, called meta-inflammatory monocytes, along with body composition and diet, may contribute to insulin resistance in adolescents. Researchers will collect blood samples and health information from 175 teens aged 14-18, including those wi…

This study aims to understand how the hormone insulin controls blood sugar in different people. Researchers will test a new procedure called the graded insulin suppression test (GIST) in 15 healthy volunteers and those at higher risk for type 2 diabetes. Participants receive medi…

This study looks at how losing weight changes the fat stored inside your muscles, called intermuscular adipose tissue (IMAT). Researchers want to see if weight loss reduces inflammation and improves how your muscles respond to insulin. Seventy adults with obesity will follow a 12…

This study collects blood and tissue samples from 270 severely obese patients during bariatric surgery to uncover new biological factors that lead to type 2 diabetes. Participants are grouped by their metabolic status: those with diabetes, insulin resistance, or normal insulin se…

This study looks at how a pregnant person's metabolism—specifically insulin resistance and fat burning—may be linked to placenta health and pregnancy complications like preeclampsia and gestational diabetes. Researchers will follow 50 pregnant women at high or moderate risk for p…

This study looks at how fasting insulin and insulin resistance differ based on age, sex, race/ethnicity, body weight, and PCOS diagnosis. Researchers will analyze data from 150 adults to find patterns that may explain why some groups face higher metabolic risks. The goal is to be…

This study looks at what happens inside your fat tissue when you lose weight with or without exercise. 68 adults with obesity will lose 10% of their body weight through diet, with some also doing moderate exercise. Researchers will measure insulin sensitivity, fat breakdown, and …

This early-stage trial is testing whether a one-week course of diazoxide can reduce the production of new fat in the liver. The study involves 25 adults with obesity, insulin resistance, and fatty liver disease. Participants will take either the drug or a placebo and undergo bloo…

This study looks at how the hormone insulin controls blood sugar and fat in healthy adults and those at risk for type 2 diabetes. Researchers will give participants a single dose of a drug called alpelisib, which blocks some of insulin's effects, to see if the liver can still mak…

This study looks at how antipsychotic drugs might cause metabolic problems in women by affecting how the brain responds to insulin. Researchers will give 15 healthy women a single dose of the antipsychotic olanzapine and insulin nasal spray, then use brain scans to see changes. T…

Polycystic ovary syndrome (PCOS) affects many women and raises the risk of type 2 diabetes. This study will use a continuous glucose monitor worn for 14 days to track blood sugar patterns in 80 women with different PCOS subtypes. The goal is to see which subtypes have the worst g…

This study looks at why diabetes can damage the heart even without clogged arteries. Researchers will examine heart tissue and use advanced imaging in 500 adults with heart failure, with or without type 2 diabetes. The goal is to find early warning signs and new treatment targets…

This study looks at whether eating more slowly digestible starch and resistant starch can help control blood sugar and improve health in people with insulin resistance. Forty adults will follow a special diet for two months, with regular blood, urine, and stool tests to track cha…

This study looks at how different types of insulin resistance (in fat or muscle) affect the liver's production of fats called triglycerides. Researchers will measure fat production after a meal, with and without exercise beforehand. The goal is to understand why some people have …

This study looks at how the fermentation of food in the gut affects metabolism in young people aged 15–22 with obesity. Researchers will give participants a sugar called lactulose to trigger fermentation and measure changes in fat breakdown and sugar production. The goal is to un…

This study tests whether a ketone supplement can improve how the body uses insulin and burns energy. Ten overweight adults aged 55-70 will receive different combinations of growth hormone, a ketone drink, or placebos on separate days. Using advanced PET scans and tissue samples, …

This study looks at how different types of fat affect how muscles respond to insulin. Healthy adults will receive infusions of palm oil or a fat emulsion through a tube into the intestine overnight. Researchers will then take small muscle samples to see how the fats are stored an…

This study is testing a new, safe imaging technique called photoacoustic imaging to look at brown adipose tissue (BAT), a type of body fat that burns energy. Researchers will compare BAT in healthy adults and people with metabolic syndrome to see if the imaging can spot differenc…

This study looks at how being overweight or having early signs of type 2 diabetes affects the brains of teenagers aged 12 to 17. Researchers will use brain scans and memory tests to see which factors—like insulin resistance or inflammation—are most linked to changes in brain stru…

This study aims to understand how much insulin the body actually needs to keep blood sugar normal. Ten adults with obesity and high insulin levels will take a drug called diazoxide, which stops the pancreas from making insulin. Researchers will then measure their fasting blood su…

This study from the University of Minnesota is looking at what happens to your body when you fast for up to 60 hours, drinking only water. Researchers want to see if the changes in your blood can make cancer cells more sensitive to chemotherapy in lab tests. Fifteen healthy adult…

This study looks at what happens to muscle size, strength, and insulin sensitivity after 5 days of strict bedrest in healthy young adults. Twelve volunteers will undergo tests before and after the bedrest period, including MRI scans, strength tests, and muscle biopsies. The goal …