INSULIN RESISTANCE

This study looks at whether a healthy diet and exercise program can improve symptoms for people with pulmonary arterial hypertension (PAH), a serious lung condition. The idea is that better diet and exercise may help the body use insulin more effectively, which could in turn impr…

This study looks at whether adding less sitting time to regular exercise can improve heart and metabolic health more than exercise alone. About 30 adults with desk jobs who sit over 9 hours a day will either exercise only or exercise and reduce sitting. Researchers will measure b…

This small pilot study tests whether taking oral probiotics for 12 weeks can improve asthma symptoms, lower insulin resistance, and reduce inflammation in obese adults with asthma. Researchers will measure changes in gut and airway bacteria, blood markers, and lung function. The …

This study tests whether a low dose of everolimus, a drug that targets a key aging pathway, can safely improve how the body ages in people aged 55-80 with insulin resistance or prediabetes. Participants take the drug daily or weekly for 24 weeks, and researchers measure changes i…

This study tests whether a daily avocado supplement (Metavo) can help overweight adults manage their weight and blood sugar. Over 16 weeks, 60 participants will take either the supplement or a placebo, and researchers will track changes in body weight, blood glucose, and other he…

This study tests if giving children a carbohydrate drink before elective surgery can prevent a temporary condition called insulin resistance, where the body doesn't use sugar properly. About 50 healthy children having surgery under general anesthesia will be randomly assigned to …

This study looks at whether eating 1.5 cups of fresh mango every day for 12 weeks can improve blood sugar, cholesterol, and inflammation in adults with prediabetes. Participants will eat mango for 12 weeks, then avoid it for another 12 weeks, so researchers can compare the effect…

This study tests whether a combination of aerobic exercise, cognitive training on a mat, and turmeric (with black pepper) can prevent memory decline in people aged 55-70 who have insulin resistance and notice their thinking skills slipping. Participants will be followed for 24 we…

This study tests whether metformin, a standard diabetes medication, can prevent muscle loss and insulin resistance in healthy older adults during 5 days of bed rest. Researchers will measure changes in muscle size and insulin sensitivity. The goal is to find a simple preventive s…

This study is testing a digital health system called STELA that helps adults without heart disease lower their risk factors like obesity, high cholesterol, and insulin resistance. About 100 participants will get a full health check, a personalized prevention plan, and support thr…

This study looks at how the tightening of blood vessels (called sympathetic vasoconstriction) may reduce the ability of insulin to widen blood vessels and take up sugar. Researchers will test this by temporarily blocking the tightening signal in the forearm of 36 adults with obes…

This study tracks 50 obese adults (BMI over 32) who are having weight-loss surgery. Researchers use MRI scans and blood tests before and up to 6 months after surgery to measure fat in the pancreas and check how well the pancreas makes insulin. The goal is to see if losing pancrea…

This study looks at how immune cells in fat tissue are linked to insulin resistance in people with obesity. Researchers will collect fat samples from 50 adults undergoing bariatric surgery to measure different types of immune cells and fat cell size. The goal is to understand why…

This study looks at how losing a small amount of weight (5% of body weight) changes insulin and testosterone levels in overweight women with insulin resistance. Researchers will measure these hormones before and after a weight loss diet. The goal is to understand the link between…

This study looks at how increasing insulin in the brain changes blood flow and nerve activity in healthy adults aged 18-45. Researchers will measure blood flow in the brain and legs, and nerve signals to muscles. The goal is to understand basic body processes, not to treat any di…

This study looks at why some people with obesity develop conditions like type 2 diabetes and heart disease while others do not. Researchers will compare three popular weight loss diets—Mediterranean, low-carb, and very-low-fat plant-based—in 180 adults with obesity. The goal is t…

This study looks at how eating chestnuts affects blood sugar and insulin levels after a meal in healthy adults. Researchers want to see if chestnuts, which are high in fiber and starch, can help manage blood sugar. The study involves 15 healthy adults who will eat chestnuts and t…

This study looks at how a specific gene (Caveolin-1) and salt intake affect blood vessel function in people with high blood pressure. About 120 adults with mild to moderate hypertension will follow low- and high-salt diets while researchers measure heart and blood vessel response…

This study was designed to test whether taking essential amino acids plus arginine for eight weeks could improve liver fat, body composition, and metabolism in obese children aged 7-10. However, the study was withdrawn before enrolling any participants, so no results are availabl…

This study looks at medical records from over 1,200 adults with psoriasis to find who is most likely to develop insulin resistance, a condition that can lead to diabetes and heart disease. Researchers will use machine learning to build a simple tool that helps doctors estimate a …

This study looks at how bariatric surgery affects the way the body handles sugar and fat. Researchers will collect tissue and blood samples from 500 people having weight-loss surgery or other procedures. The goal is to learn more about how the intestines signal other organs, whic…

This study planned to see if taking fish oil before starting an exercise program could boost the anti-inflammatory benefits of exercise in people with obesity. Researchers wanted to measure changes in blood markers of inflammation and gut bacteria over 6 weeks. However, the study…

This study looks at how a substance called TMAO, made by gut bacteria from L-carnitine, might affect insulin resistance—a key step toward diabetes. Researchers will give 40 healthy adults L-carnitine supplements and also have them do simulated night-shift work to see how these fa…

This study looks at how fructose (a type of sugar) contributes to fat production and high blood sugar in people with prediabetes or insulin resistance. Researchers will measure these effects in 35 adults after they eat meals containing fructose. The goal is to better understand t…

This study looks at whether insulin resistance (when the body doesn't respond well to insulin) can predict how well a heart procedure called pulsed field ablation works for people with atrial fibrillation (an irregular heartbeat). About 120 non-diabetic patients having their firs…

This study aims to learn more about blood sugar patterns in women with PCOS using continuous glucose monitors (CGMs). Researchers will compare women with and without PCOS to see if CGMs can reveal unique glucose problems. They will also test whether wearing a CGM for 90 days can …