INSULIN RESISTANCE

This phase 2 trial tests whether a low dose of everolimus, a drug used in cancer, can safely improve signs of aging in 106 adults aged 55-80 who have insulin resistance or prediabetes. Participants take the drug daily or weekly for 24 weeks, and researchers measure changes in met…

This study tests whether giving children a sugary drink one hour before elective surgery can prevent insulin resistance afterward. Fifty children will be randomly assigned to receive either a carbohydrate drink or plain water. The goal is to see if this simple step can help their…

This study looks at whether adding less sitting time to regular exercise improves heart and metabolic health more than exercise alone. About 30 adults with desk jobs who sit over 9 hours a day will either follow an exercise plan or do the same exercise plus reduce sitting. Resear…

This 16-week study tests whether an avocado-based dietary supplement (Metavo) can help overweight adults manage their weight and blood sugar. Sixty participants will take either the supplement or a placebo daily, and researchers will track changes in body weight, glucose levels, …

This pilot study tests whether taking a daily probiotic supplement for 12 weeks can improve insulin resistance and asthma control in obese adults with asthma. Researchers will measure changes in gut and airway bacteria, blood markers, and asthma symptoms. Only 7 people are enroll…

This early-phase trial tests whether metformin, a widely used diabetes drug, can prevent muscle loss and insulin resistance in healthy older adults during five days of bed rest. Researchers will measure changes in muscle size and insulin sensitivity. The study involves 64 partici…

This study tests whether eating 1.5 cups of fresh mango daily for 12 weeks can improve blood sugar, cholesterol, and inflammation in people with prediabetes. Thirty-one participants will eat mango for 12 weeks, then take a break, and then avoid mango for another 12 weeks. Researc…

This study tests whether a 12-week program of exercise and diet counseling can improve insulin sensitivity and heart function in people with pulmonary arterial hypertension (PAH). The 34 participants have stable PAH and are already on standard medications. The goal is to see if l…

This study is testing a digital health platform called STELA that creates personalized lifestyle plans to reduce risk factors for heart disease, like obesity, high cholesterol, and insulin resistance. About 100 adults without existing heart disease will use the platform for a yea…

This study tests whether a combination of aerobic exercise, cognitive training, and turmeric (with black pepper) can prevent memory decline in adults aged 55-70 who have insulin resistance and self-reported memory concerns. Participants will follow a 24-week program, repeated aft…

This study looks at how aging changes the way older adults respond to exercise. Researchers will have 26 people who previously completed a structured exercise program do a 6-month aerobic workout. They will measure changes in insulin sensitivity and heart fitness to see if age af…

This study looks at how immune cells in different types of body fat (belly fat vs. fat under the skin) are linked to insulin resistance, a condition where the body doesn't use insulin well. Researchers will analyze fat samples from 50 people having weight-loss surgery to see if c…

This study looks at medical records from over 1,200 psoriasis patients to find who is most likely to develop insulin resistance, a condition that can lead to diabetes. Researchers will use machine learning to build a simple tool that helps doctors estimate this risk. No new treat…

This pilot study compares the effects of daily erythritol (a sugar substitute) versus regular sugar on insulin resistance and blood clotting in 30 healthy adolescents aged 14-18. Participants consume either erythritol or sucrose for 5 weeks, and researchers measure changes in glu…

This study checks if insulin resistance (when your body doesn't use insulin well) can predict whether a heart procedure called pulsed field ablation will work for people with atrial fibrillation (an irregular heartbeat). About 120 non-diabetic patients having their first ablation…

This study looks at how fructose in meals influences fat production and blood sugar levels in people with prediabetes or insulin resistance. Researchers will give participants special labeled fructose or pyruvate in liquid meals to track these processes. The goal is to better und…

This study is testing whether a Mediterranean-style low-carb diet that reduces calories can lower insulin and testosterone levels in overweight or obese women with insulin resistance. Eight premenopausal women aged 21-45 will follow the diet to lose about 5% of their body weight.…

This study follows 50 obese patients who are having weight-loss surgery (laparoscopic sleeve gastrectomy). Researchers use MRI scans and blood tests before surgery and at 1, 3, and 6 months after to measure changes in pancreatic fat and insulin function. The goal is to see if los…

This study aims to learn more about blood sugar patterns in women with Polycystic Ovary Syndrome (PCOS) using a continuous glucose monitor (CGM). Researchers will compare women with and without PCOS to see how their blood sugar differs in daily life. They will also test whether w…

This study looks at how eating chestnuts affects blood sugar and insulin levels after a meal in healthy adults. Researchers want to see if chestnuts, which are high in fiber and starch, can help manage blood sugar better than other foods. Fifteen healthy adults will participate i…

This early-phase study at Vanderbilt University Medical Center is looking at how certain nerve signals (called sympathetic vasoconstriction) might interfere with insulin's ability to widen blood vessels and take up sugar. The researchers will give a drug called phentolamine into …

This study looks at why some people with obesity develop conditions like type 2 diabetes while others don't. Researchers are comparing three popular diets—Mediterranean, low-carb, and very-low-fat plant-based—in 180 participants to see how they affect insulin sensitivity and over…

This study aims to understand how bariatric surgery affects the body's tissues, like fat, muscle, and liver, and how it improves insulin sensitivity. Researchers will collect tissue and blood samples from 500 adults undergoing surgery or other procedures. The goal is to learn the…

This study looks at how insulin in the brain changes blood flow and nerve signals in healthy adults aged 18-45. Researchers will measure blood flow in the brain and legs, as well as nerve activity. The goal is to understand basic body functions, not to treat any disease.

This study looks at how a gene called Caveolin-1 affects blood vessel function in people with mild to moderate high blood pressure. Researchers will measure kidney blood flow, artery flexibility, and blood pressure after low- and high-salt diets, as well as after an infusion of a…

This study looks at how a substance made by gut bacteria, called TMAO, might affect insulin resistance (a step toward diabetes). Researchers will give 40 healthy adults L-carnitine supplements and also have them do a simulated night-shift to see how these factors change blood mar…

This study planned to test whether an 8-week course of a flavored drink containing essential amino acids plus arginine could reduce liver fat and improve metabolism in obese children aged 7-10. The researchers intended to measure changes in liver fat, blood fats, insulin sensitiv…

This pilot study aimed to see if taking fish oil supplements could improve gut bacteria and make exercise more effective at reducing inflammation in people with obesity. The study was withdrawn before any participants were enrolled, so no results or conclusions are available.