INSULIN RESISTANCE

This study tests whether taking a supplement (alpha-lipoic acid) with a drug (mirabegron) can improve how the body handles sugar and insulin in people with obesity. About 60 adults aged 18-65 with a BMI between 30 and 45 will take the combo or a placebo for 4 weeks. The goal is t…

This study looks at whether a type of talk therapy for insomnia (CBT-I) can also improve metabolic health, like blood sugar and insulin resistance. Twenty adults with insomnia and higher body weight will be randomly assigned to CBT-I or basic sleep tips for 5 weeks. Researchers w…

This study tests whether empagliflozin, a medicine used for diabetes, can help reduce depression in people with bipolar disorder who also have insulin resistance. Insulin resistance is common in bipolar disorder and may make mood symptoms worse. The study will include 20 adults a…

This study looks at how artificial sweeteners (saccharin, sucralose) and a natural one (erythritol) affect heart disease risk factors in 80 adults with prediabetes. Participants will be randomly assigned to consume one sweetener or water for two weeks. Researchers will measure ch…

This study measures levels of two proteins, SCUBE-1 and SCUBE-3, in the blood of women with polycystic ovary syndrome (PCOS) and compares them to healthy women. Researchers want to see if these proteins can act as markers of inflammation and help explain the higher risk of heart …

This study looks at how not getting enough sleep and having a messed-up body clock can make it harder for your body to use insulin properly, which can lead to weight gain and type 2 diabetes. Researchers will test 24 healthy adults aged 18-45 in a controlled lab setting to see ho…

This study looks at how changing insulin levels affects the liver's production of sugar and fat in people with insulin resistance, prediabetes, and fatty liver disease. Participants will undergo two procedures where insulin is either kept at a high level or lowered by half, and r…

This study looks for new signs in muscle cells that can help explain why some people's bodies don't respond well to insulin. Researchers will compare muscle tissue from lean, insulin-sensitive adults and those with obesity and insulin resistance. No treatments are tested; the goa…

This study looks at whether a combined exercise program can reduce chronic pain in postmenopausal women. Researchers think insulin resistance might be a key factor. They will measure pain, metabolism, and inflammation in 50 women who are not on hormone therapy or exercising regul…