INSULIN RESISTANCE

This study is testing whether empagliflozin, a medication approved for type 2 diabetes, might help reduce depression symptoms in people with bipolar disorder who also have insulin resistance. Twenty adults with bipolar depression will take empagliflozin alongside their current me…

This study is testing if treating depression can help prevent a worsening of insulin resistance, a condition that can lead to diabetes, in adults with HIV. Researchers will compare a 9-week online cognitive behavioral therapy program to an educational program about depression. Th…

This study is testing whether combining a dietary supplement (alpha-lipoic acid) with an existing medication (mirabegron) can help the body process sugar and burn fat more effectively in people with obesity. Researchers will enroll 60 adults with obesity to take the combination f…

This study is testing whether a specific blend of probiotic bacteria can help people with fatty liver disease when taken alongside recommended diet and exercise changes. Researchers will enroll 80 adults with fatty liver and related metabolic issues to see if the supplement reduc…

This study is testing whether a talk therapy for insomnia can improve metabolic health in people with obesity and sleep problems. Twenty adults will receive either the sleep therapy or basic sleep education for five weeks. Researchers will measure changes in insulin resistance, b…

This study is testing whether a combined exercise program can reduce chronic pain in postmenopausal women. Researchers will look at how exercise might work by improving the body's insulin sensitivity and reducing inflammation. The goal is to provide evidence for exercise as a non…

This study aims to understand how consuming different artificial and natural sweeteners affects people with prediabetes, a condition of high blood sugar that increases the risk of type 2 diabetes and heart disease. Researchers will enroll 80 participants with prediabetes and have…

This study aims to understand if two specific proteins (SCUBE-1 and SCUBE-3) in the blood could serve as markers for inflammation and heart disease risk in women with polycystic ovary syndrome (PCOS). Researchers will compare protein levels in 56 women with PCOS—some with normal …

This study aims to understand exactly how poor sleep and night shift work can lead to insulin resistance, a key factor in developing type 2 diabetes. Researchers will study 24 healthy adults in a controlled lab setting, manipulating their sleep schedules and measuring changes in …

This early-stage study aims to understand if lowering high insulin levels for one week can reduce the liver's production of new fat, a key driver of fatty liver disease. Researchers will compare a drug called diazoxide against a placebo in 25 adults with obesity, insulin resistan…

This study aims to understand how high insulin levels contribute to fatty liver disease in people who are overweight and insulin resistant. Researchers will temporarily control insulin levels in 36 participants to measure how the liver produces fat and sugar. The goal is to gathe…