Nasal insulin study aims to uncover Obesity's hidden effects on brain and blood flow

NCT ID NCT07653464

Not yet recruiting Knowledge-focused Sponsor: University of Missouri-Columbia Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 29, 2026 · Updated 2 times

Summary

This early-phase study will test how insulin given as a nasal spray affects nerve activity and blood flow in the brain and legs. Researchers will compare 64 adults with obesity and insulin resistance to healthy-weight individuals. The goal is to understand how obesity changes the body's response to insulin beyond blood sugar control.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: human insulin (given as a nasal spray)
What this could lead to: If successful, this study could reveal how obesity-related insulin resistance alters brain and blood vessel responses, pointing toward new ways to manage metabolic health.
What could go wrong: This is a very early, small study (64 people) that only measures short-term nerve and blood flow changes, not health outcomes. It may not lead to any treatment.

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Conditions

The condition(s) this trial relates to.

Insulin Resistance Obesity obesity disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

INSULIN RESISTANCE OBESITY (BMI>30)

Contacts and locations

Locations

University of Missouri

Columbia, Missouri, 65211, United States

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