University Of Missouri-columbia

This study is investigating whether clavulanic acid, a component of some antibiotics, can help adult smokers reduce their cigarette use. Researchers will use brain imaging (fMRI) to see how the substance affects brain activity related to smoking cues. The study involves 30 partic…

This study is testing a family-based group program to help teens with overweight or obesity. It will see if the program improves their weight, eating habits, activity levels, and thinking skills like focus and planning. The study will enroll 10 teens and a parent for six months o…

This study is testing a new type of bone graft material called Fibergraft Aeridyan for severe open ankle fractures. It aims to see if this material helps the bone heal better and reduces complications like infection compared to standard bone grafts. Researchers will observe 45 ad…

This study is testing if a medication called empagliflozin, usually used for diabetes, can make stiff arteries more flexible in healthy older adults. It will involve 80 men and women aged 60-80 who already have some artery stiffening but do not have diabetes. Participants will ta…

This study aims to find out if patients who continue taking their GLP-1 weight loss and diabetes medications (like Wegovy or Ozempic) after bariatric surgery have better results than those who stop. Researchers will compare weight loss, blood sugar control, and gut health in 150 …

This study is testing if a very powerful 7T MRI scanner can detect tiny brain tumors earlier than standard MRI scanners in people with small-cell lung cancer. It involves 20 patients who have chosen not to receive preventive brain radiation. Researchers will compare the 7T scan r…

This study aims to find out if the standard 5-day antibiotic course is necessary to prevent infections from cat bites to the hand or forearm. Researchers are comparing a 5-day antibiotic course, a 1-day course, and a placebo (a pill with no medicine) in adults who seek care withi…

This study is testing a thinking-skills training program to help breast cancer survivors who are struggling with memory, focus, and concentration problems after treatment. Researchers will work with 50 participants to see if this training is practical to deliver and if it helps i…

This study is testing a special type of exercise for people with neuromuscular diseases (like ALS or muscular dystrophy) who often can't do regular workouts. It uses a suit that sends mild electrical signals to make muscles contract, aiming to improve strength, walking, balance, …

This study is testing whether a program of low-impact group exercise, combined with diet advice and mental health support, can help reduce pain for people with osteoarthritis in their knees, hips, or ankles. It will enroll up to 10,000 adults who can commit to attending classes t…

This study is testing whether a 10-week video therapy program can help teenagers with PKU manage anxiety and depression. Researchers will enroll 30 adolescents aged 10-17 who have PKU and experience these symptoms. Half will start therapy immediately, while the other half will wa…

This study aims to understand why people with type 1 diabetes have a higher risk of heart disease. Researchers will compare how the body processes certain fats and proteins in the blood between 30 adults with type 1 diabetes and healthy volunteers. The goal is to gather knowledge…

This study aims to understand if adults who carry the gene for PKU (phenylketonuria) experience changes in brain chemistry, thinking skills, or brain activity after consuming protein. Researchers will compare 18 PKU carriers to 18 non-carriers. Participants will take a protein or…

This study aims to understand how getting less sleep than usual affects a person's blood pressure. Researchers are recruiting 45 healthy adults, both normal weight and with obesity, to measure their blood pressure after periods of restricted sleep. The goal is to gather knowledge…

This study aims to learn more about how blood flow and the body's nervous system change in women as they get older. Researchers will measure blood flow in the arms of 64 women aged 18 to 70. The goal is to gather basic knowledge about these early changes, not to test a treatment.

This study aims to understand why women have a higher risk of heart disease after menopause. Researchers will measure nerve activity and blood flow in 75 women at different stages of menopause. The goal is to gather basic knowledge, not to test a treatment.

This study aims to understand how the brain uses a fuel called lactate, especially in people with obesity. Researchers will compare brain blood flow and lactate levels during exercise in 24 adults with and without obesity. They also want to see if a short exercise program changes…

This study aims to learn if finding cancer cells or cancer DNA in a person's blood, urine, or bone marrow can help doctors better understand how cancer spreads. Researchers will collect samples from 100 people with cancer and 200 people at high risk for lung cancer to see if thes…

This study aims to better understand leukemia and other blood cancers by collecting blood and bone marrow samples from patients. Researchers will study a specific protein (DPP4) found in cancer cells to learn how it affects the disease. The goal is to use this knowledge to help d…

This study aims to better understand rare genetic disorders that affect brain development, such as Baker Gordon Syndrome and Syt-1 Disorder. Researchers will collect information from 100 participants with these conditions to track how symptoms change over time and identify marker…

This study aims to better understand how stress fractures in the lower back heal in adolescents and young adults. Researchers will use a series of MRI scans over one year to watch the bone repair itself in 40 participants with these injuries. The goal is to gather information tha…

This study aims to understand how blood vessels in the arm respond to low oxygen levels in healthy women at different stages of menopause. Researchers will compare younger premenopausal women, perimenopausal women, and older postmenopausal women to see how aging and menopause aff…

This small pilot study is exploring whether combining electrical muscle stimulation with light exercise can help older adults activate their muscles more effectively, as this ability often declines with age. Researchers will test if this approach improves measures of strength, ba…

This study aims to understand how growth hormone affects the cells that produce insulin in women who had high blood sugar during pregnancy (gestational diabetes). Researchers will compare 30 women with a past history of gestational diabetes to a control group without that history…

This study is looking to see if eating freeze-dried grape powder for 4 weeks can improve gut bacteria, reduce body-wide inflammation, and lower stress in adults with obesity. 50 participants will try both the grape powder and a placebo powder in a random order to compare the effe…