University Of Missouri-columbia

This trial compares two types of stitches used to close the joint capsule during hip arthroscopy, a key step in treating hip injuries like labral tears and femoroacetabular impingement. One type dissolves over time, while the other remains permanently. The study will measure pati…

This study tests whether eating freeze-dried grape powder every day for 4 weeks can improve gut bacteria, reduce inflammation, and lower stress in adults with obesity. Fifty participants aged 30-45 will be randomly assigned to receive grape powder or a placebo, then switch after …

This study tests whether injecting N-acetylcysteine (NAC), an antioxidant, into the ankle right after a severe pilon fracture can keep cartilage cells alive and reduce the chance of developing post-traumatic arthritis. Thirty adults with closed high-energy pilon fractures will re…

This study tests whether adding a pre-surgery scrub with isopropyl alcohol and chlorhexidine soap to the standard cleaning routine can lower the number of germs on the skin and reduce infections after elective foot and ankle surgery. About 100 adults having planned foot or ankle …

This study is testing two different surgical devices used to fix a broken bone near the knee (distal femur fracture). The goal is to see which device leads to better bone healing and fewer repeat surgeries. About 100 adults who need surgery for this type of break will be randomly…

This study tests whether empagliflozin, a drug currently used for diabetes, can reverse the natural stiffening of arteries that happens with age. Researchers will give 80 healthy adults aged 60-80 either the drug or a placebo daily for 12 weeks. The main goal is to see if artery …

This study looks at whether people who take GLP-1 receptor agonists (like Ozempic or Wegovy) should continue them after having bariatric surgery. Researchers will compare weight loss, blood sugar control, gut health, and hunger in 150 adults who either keep taking the drug or sto…

This study looks at a new bone graft material called Fibergraft Aeridyan Matrix for treating open pilon fractures, which are severe breaks in the lower leg that often get infected or don't heal well. Researchers will follow 45 adults who need bone grafting as part of their standa…

This study is testing whether a very powerful 7 Tesla MRI can detect tiny brain metastases earlier than standard 1.5 or 3 Tesla MRIs in people with small-cell lung cancer who choose not to have preventive brain radiation. Twenty participants will get a 7T brain scan followed by u…

This study looks at whether taking antibiotics for just one day after a cat bite to the hand or forearm works as well as the usual five-day course, or even a placebo. About 72 adults who are bitten and seek care within 24 hours will be randomly assigned to one of three groups. Th…

This early-phase trial tests whether propranolol, a drug typically used for high blood pressure, can improve language abilities and reduce anxiety in older adults with primary progressive aphasia (PPA). PPA is a type of dementia that gradually impairs speech and language, and the…

This study tests whether applying a steroid (dexamethasone) directly to the surgical site during herniated disc surgery can lower pain and disability afterward. About 200 adults with a single-level lumbar disc herniation who have not improved with rest or therapy will be randomly…

This study is testing whether cognitive behavioral therapy for insomnia (CBT-I) can improve sleep and daily function in 15 people with mild traumatic brain injury (mTBI) who have trouble sleeping. Participants will learn techniques like sleep scheduling and changing unhelpful tho…

This study tests a group-based self-management program delivered via telehealth for people who had a mild or moderate stroke within the last 6 months. The program teaches problem-solving and goal-setting skills to improve daily activities and community participation. Researchers …

This study tests whether whole-body electrical muscle stimulation (WB-EMS) can help adults with neuromuscular diseases like ALS, SMA, and muscular dystrophy exercise safely. Because these conditions weaken the nerves that control muscles, traditional exercise is often too hard. W…

This study tests a training program that teaches breast cancer survivors with memory and concentration problems (brain fog) strategies to improve daily tasks and quality of life. About 50 women who finished cancer treatment 6 months to 3 years ago will participate. The goal is to…

This pilot study tests whether whole-body electrical muscle stimulation (WB-EMS) combined with exercise can improve muscle activation and physical function in healthy older adults aged 65 and older. Participants will use a special suit with electrodes that stimulate major muscle …

This study is testing whether low-impact group exercise classes can help reduce pain in people with knee, hip, or ankle osteoarthritis. Participants attend one-hour group sessions three times a week for six months, led by a physical therapist or trainer. The study also includes s…

This study tests a short-term behavioral program called Show Me FIRST to help teens with PKU manage anxiety and depression. Thirty adolescents will be randomly assigned to receive the program right away or after a wait period. The researchers will also check if new phone-based te…

This study tests whether clavulanic acid, a drug used to boost antibiotics, can help people smoke less. Thirty adult smokers will take either the drug or a placebo for several weeks. Researchers will measure smoking levels and use brain scans to see if the drug changes how the br…

This pilot study will use a very small camera, called a nano-arthroscope, to look inside the ankle joint of 25 people who have a severe type of ankle fracture (pilon fracture). The goal is to find out how often hidden cartilage injuries occur and whether seeing them changes the s…

This study examines whether sex and obesity influence how blood vessels widen in response to low oxygen levels. Researchers will infuse several drugs into the forearm artery of 72 healthy volunteers to block or stimulate specific nerve signals, measuring changes in blood flow. Th…

This study looks at what happens to blood pressure when healthy adults sleep only 4 hours a night. Researchers will compare normal-weight and obese participants to see if lack of sleep affects their blood pressure differently. The goal is to better understand the link between sle…

This study follows 40 adolescents and young adults with back stress fractures to see how these injuries heal naturally over a year. Participants get several MRI scans and answer pain questionnaires. The goal is to learn when it's safe to return to sports by watching the bone brid…

This study follows 50 children and adults with Baker Gordon Syndrome, a rare genetic disorder, to track how the condition changes over time. Participants will undergo brain scans, EEGs, and genetic testing, and complete developmental assessments. The goal is to create better tool…

This study investigates whether high-protein meals, especially from animal sources, activate immune cells in a way that could worsen atherosclerosis (hardening of the arteries). Researchers will give 24 adults different protein-rich meals and measure changes in blood cells. The g…

This study looks at how growth hormone affects beta-cells, which make insulin, in people with a family history of type 2 diabetes. Researchers will compare 30 obese adults with and without a family history of diabetes. The goal is to better understand why some people develop diab…

This study looks at how growth hormone affects beta-cells, which make insulin to control blood sugar, in women who had gestational diabetes. Researchers will compare women with and without a history of gestational diabetes to better understand risk factors. The goal is to learn m…

This study looks at how different sources of protein (animal vs. plant, and whole foods vs. protein powders) affect blood sugar control and insulin sensitivity in people with metabolic syndrome. Researchers will measure blood sugar levels over 24 hours and use a special test to s…

This study looks at whether showering 48 hours after breast reconstruction surgery, while drain tubes are still in place, raises the chance of infection. It will follow 100 women for 90 days to check for infections and how showering affects their quality of life. The goal is to h…

This study collects blood, urine, and bone marrow samples from 620 people with solid cancers like lung, colorectal, and pancreatic cancer. Researchers will look for tumor cells and DNA in these samples to understand how cancer spreads and why it sometimes comes back after surgery…

This study tests a remote training program for autistic teens and young adults (ages 13-21) and their primary caregiver. The program teaches strategies to improve thinking and daily life skills. The goal is to see if the program is practical and helpful for participants.

This study examines how adults who carry the gene for phenylketonuria (PKU) but do not have the disease handle phenylalanine, a common amino acid. Researchers will give participants phenylalanine or a placebo and then use MRI scans and cognitive tests to measure brain activity, t…

This small study looks at how a 6-month family-focused program of healthy eating and activity affects thinking skills (like focus and planning) in teens ages 13-17 who are overweight or have obesity. Ten teens and a parent or guardian will attend group sessions and complete tests…

This study aims to understand why people with type 1 diabetes have a higher risk of heart attacks and strokes. Researchers will compare fat and protein processing in 30 adults—some with type 1 diabetes and some healthy—using special tracer infusions and blood tests. The goal is t…

This study observes 100 people with rare genetic neurodevelopmental disorders like Baker Gordon Syndrome and Syt-1 disorder. Researchers will track symptoms, collect genetic and imaging data, and create cell models to better understand these conditions. The goal is to improve dia…

This study collects blood and bone marrow samples from 50 adults with blood cancers like leukemia. Researchers want to learn how a protein called DPP4 affects these cancers, which could lead to better treatments in the future. Participants provide samples during regular clinic vi…

This study looks at how a substance called lactate affects blood flow to the brain in people with and without obesity. Researchers will measure brain blood flow and lactate levels during rest and exercise. The goal is to understand if short-term exercise training can improve lact…

This study looks at how blood flow and the nervous system adapt early in aging women. Researchers will measure forearm blood flow in 64 women aged 18-70. The goal is to better understand these changes, not to test a treatment.

This study collects samples from 320 people, including those with solid cancers (like lung, colon, or pancreatic cancer) and those undergoing lung cancer screening, to look for cancer cells and DNA in blood, urine, and bone marrow. The goal is to learn how cancer spreads and find…

This study looks at how the nervous system controls blood flow in women going through menopause. Researchers will measure nerve activity and blood vessel responses in 75 women aged 18-70. They will also test how two drugs (propranolol and phentolamine) affect these responses. The…

This study examines how aging and menopause change the way blood vessels widen in response to low oxygen. Researchers will give healthy women either a placebo, a beta-blocker (propranolol), or a bladder medication (gemtesa) to see how these drugs affect blood flow in the forearm.…