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Combining GLP-1 drugs with Weight-Loss surgery: better results or just more pills?

NCT ID NCT06132477

Recruiting now Disease control Sponsor: University of Missouri-Columbia Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at whether people who take GLP-1 receptor agonists (like Ozempic or Wegovy) should continue them after having bariatric surgery. Researchers will compare weight loss, blood sugar control, gut health, and hunger in 150 adults who either keep taking the drug or stop before surgery. The goal is to see if combining both treatments leads to better outcomes than surgery alone.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
GLP-1 receptor agonists (drugs like semaglutide or liraglutide)
What this could lead to
If it works, this could show that staying on GLP-1 drugs after bariatric surgery leads to greater weight loss and better blood sugar control, helping patients and doctors make informed treatment decisions.
What could go wrong
This is a single-center Phase 4 trial with 150 participants, so results may not apply to everyone. The study is still recruiting, and it's possible that continuing the drugs offers no extra benefit or causes more side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

abdominal obesity-metabolic syndrome diabetes mellitus hypertensive disorder metabolic syndrome X morbid obesity obesity disorder obstructive sleep apnea syndrome type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DIABETES MELLITUS HYPERTENSION METABOLIC SYNDROME MORBID OBESITY OBSTRUCTIVE SLEEP APNEA OF ADULT

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • University of Missouri Hospital

    RECRUITING

    Columbia, Missouri, 65201, United States

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