DIABETES MELLITUS

This study tests whether simple text messages can help homeless adults with uncontrolled diabetes better manage their blood sugar. About 100 participants will receive regular SMS reminders and tips. The goal is to see if this low-cost approach improves HbA1c levels and medication…

This study tests whether an AI-powered smartphone app can help people who have had heart bypass surgery or stents better control their blood pressure, diabetes, and cholesterol. About 536 adults who already have these conditions will use the app or receive standard care. The goal…

This study tests a gel called ENERGI-F703 on diabetic foot ulcers that haven't healed for at least 4 weeks. About 230 adults with diabetes will use either the gel or a placebo for 16 weeks. The main goal is to see if the gel helps the wound close completely and stay closed.

This study tests a new digital tool that helps doctors create personalized exercise plans for people with heart disease risk factors like high blood pressure, diabetes, and obesity. About 24 doctors and 48 patients will take part. The goal is to see if the tool is easy to use and…

This study tests two common diabetes drugs, pioglitazone and empagliflozin, to see which one better controls blood sugar in people whose diabetes is caused by chronic or recurrent acute pancreatitis. About 40 adults aged 18 to 80 will take one of the two medications, and research…

This study compares the iLet Bionic Pancreas, an automated insulin delivery system, to usual care for adults with type 1 or type 2 diabetes who use insulin. About 240 participants will use the device or continue their routine care for 13 weeks to see if it improves blood sugar co…

This study tests whether giving low-income adults with type 2 diabetes vouchers to buy fruits and vegetables helps them attend diabetes education classes and improve their blood sugar control. About 120 participants will be randomly assigned to receive the vouchers or not. The go…

This study tests whether an AI-powered health coach, along with a vital sign monitor, can help 300 adults with heart disease, diabetes, or kidney disease better manage their health. Participants will use a chatbot and tracking tools to improve key health numbers and reduce hospit…

This study is testing a smartphone app designed to help adults aged 55 and older who have multiple chronic conditions like heart failure, diabetes, and kidney disease. The app provides fall prevention tips, a personalized after-hospital care plan, and tools to track symptoms and …

This study is testing how well the Omnipod 5, an automated insulin delivery system, works in real-world conditions for people with type 1 diabetes. About 304 participants aged 2 and older will use the system for the first time. Researchers will measure blood sugar control, qualit…

This study is testing a new device called the Eversense Gemini System, which helps people with diabetes check their blood sugar levels without finger pricks. The study will include 80 adults with type 1 or type 2 diabetes to see how accurate and safe the new system is compared to…

This study tests a new drug called Tegoprubart in people with type 1 diabetes who have dangerous low blood sugar and are getting islet cell transplants. The drug aims to prevent the immune system from attacking the new cells without using standard anti-rejection medicines that ca…

This study looks at whether an automated insulin delivery system (the Medtronic 780G) can help adults with diabetes and advanced kidney disease manage their blood sugar better than their usual insulin injections. Participants will use the system for 8 weeks and then switch to the…

This study tests whether using smart insulin pens along with continuous glucose monitors and telemedicine can help veterans with type 2 diabetes better control their blood sugar compared to traditional insulin pens. About 50 adults on multiple daily insulin injections will take p…

This study tests whether using a patient's own continuous glucose monitor (CGM) during a hospital stay can help doctors and nurses give better insulin doses. About 150 adults with diabetes who already use a CGM at home will be enrolled. The goal is to reduce dangerous high and lo…

This study aims to help people with diabetes living in rural Kentucky by connecting them with community resources for needs like food, housing, and transportation. About 12,000 adults with diabetes will take part. The goal is to see if this approach improves health and well-being…

This study looks at whether opening blocked leg arteries within 48 hours helps heal foot ulcers in people with type 2 diabetes. About 200 adults with diabetic foot ulcers will be randomly assigned to early or standard treatment. Researchers will track wound healing with a 3D came…

This study looks at whether using a drug-coated balloon together with a drug-eluting stent works better than using either device alone to open blocked heart arteries in people with diabetes. About 120 participants will be randomly assigned to one of three treatment groups. The go…

This study tests a faster version of a procedure called renal denervation, which uses energy to calm overactive nerves in the kidneys that can raise blood pressure. The goal is to see if the quicker approach works as well as the standard method for lowering blood pressure in peop…

This study looks at how well the Omnipod 5 automated insulin delivery system works in daily life for people with type 1 diabetes. About 152 participants aged 2 and older will use the system for the first time. The goal is to see if it helps keep blood sugar in a healthy range and…

This study tests whether taking algae supplements (spirulina or seaweed) for 20 weeks can improve markers of heart health and change gut bacteria in 150 adults aged 50+ with conditions like heart disease, diabetes, or kidney disease. Participants are randomly assigned to receive …

This early-stage study is testing a new medicine called NNC0487-0111 in 80 adults with type 2 diabetes. The goal is to see how it affects the body's use of insulin and how well the pancreas works. Participants are randomly assigned to receive either the study drug or a placebo. T…

This study is observing how well the drug dapagliflozin works and how safe it is for people with type 2 diabetes who also have high blood pressure. Researchers will track blood sugar and blood pressure control in 9,000 participants over time. The goal is to see if this medication…

This study tests a new medication for a rare type of diabetes caused by a gene change. About 44 adults with this condition will take the drug or a placebo in two separate periods. The goal is to see if the drug lowers blood sugar levels and improves daily glucose control.

This study tests whether a special pharmacist-led program helps people with type 2 diabetes control their blood sugar better than usual doctor care. About 600 adults with uncontrolled diabetes will join. The goal is to see if easier access to pharmacists can lower A1C levels and …

This early-phase trial tests a new treatment for people with a type of stomach or esophagus cancer that has spread to the lining of the abdomen. The therapy uses the patient's own immune cells, which are modified in a lab to recognize and attack cancer cells. The cells are given …

This study tests whether giving repeated BCG vaccines (a TB vaccine) can improve blood sugar control and reduce insulin needs in children aged 8 to 17 who were diagnosed with type 1 diabetes within the past year. Researchers will measure changes in HbA1c, C-peptide, and insulin u…

This early-stage trial tests a new islet cell injection (RGB-5088) in 10 adults with type 1 diabetes who have severe low blood sugar episodes. The goal is to see if the treatment is safe and can help control blood sugar without insulin. Participants will be monitored for side eff…

This study tests whether automated voice message reminders, along with free reading glasses, can help people with diabetes attend their scheduled eye and diabetes checkups. About 640 adults recently diagnosed with diabetes in Bangladesh will take part. The goal is to see if these…

This study tests a new medicine called retatrutide in adults with type 2 diabetes. The goal is to see if it improves how the body makes and uses insulin after 28 weeks. About 95 people will take part, and the results will be compared to a placebo and another diabetes drug.

This study tests whether an online training and peer support platform (Support-t) helps teenagers with type 1 diabetes prepare for moving from pediatric to adult healthcare. About 200 teens aged 14-16 from four Quebec hospitals will either receive usual care or also get access to…

This study tests a new once-weekly injection called NNC0487-0111 for people who are overweight or obese and have type 2 diabetes. About 630 adults will receive either the active drug or a placebo to see if it safely helps reduce body weight and improve blood sugar control. The go…

This study tests whether a single pill containing three diabetes medicines (empagliflozin, linagliptin, and metformin) can improve blood sugar control, quality of life, and treatment satisfaction in adults with type 2 diabetes. About 800 participants with poorly controlled diabet…

This study tests a new way to help people with diabetes and diabetic retinopathy (an eye complication) in Bangladesh. Doctors will receive eye exam results along with specific tips on how to manage the patient's diabetes. The goal is to see if this extra information helps more pa…

This study looks at whether continuing GLP-1 medications (like Ozempic or Wegovy) after bariatric surgery helps people lose more weight and control blood sugar better than stopping them. About 150 adults with severe obesity, some with diabetes, will be randomly assigned to keep o…

This study tests whether a spinal cord stimulator can reduce pain and improve blood flow in the legs of people with type 2 diabetes who have nerve pain. About 25 adults will receive the device and be monitored for changes in pain, circulation, and vessel stiffness. The goal is to…

This study tests a device that uses energy to calm overactive nerves in the kidney and liver, which may help lower blood pressure. It is for adults aged 18 to 80 with uncontrolled high blood pressure, with or without other health risks like heart or kidney disease. The goal is to…

This study looks at whether continuous glucose monitors (CGMs) can help people with type 2 diabetes who are uninsured or on Medicaid better manage their blood sugar. About 50 adults who take daily insulin will either use a CGM or standard finger-stick testing for 6 months. Resear…

This study tests whether dapagliflozin, a diabetes medication, can reduce the amount of time people with diabetes spend in atrial fibrillation (AF). About 28 adults with paroxysmal AF and diabetes will receive either dapagliflozin or a placebo for 3 months. Researchers will measu…

This study looks at whether a continuous glucose monitor (CGM) that alerts nurses to high or low blood sugar can help surgical patients with diabetes keep their glucose in a healthy range. About 200 adults having abdominal, bone, or other surgeries will wear the Dexcom G7 device …

This study is testing a soft, removable cast wrap designed to help foot ulcers heal in people with diabetes. Researchers want to see if the wrap is effective, safe, comfortable, and easy for patients to use. They will follow 100 adults with diabetic foot ulcers for up to 16 weeks…

This study tests a new blood test called Avantect to see if it can find pancreatic cancer early in people aged 50-84 who were diagnosed with type 2 diabetes in the last 6 months. About 15,000 participants will give blood samples and fill out anxiety questionnaires over a year. Th…

This study tests a new portable DNA tool called MinION to quickly identify all bacteria and fungi in foot wounds of people with diabetes. Standard lab tests can miss some germs and take days, but MinION gives results in hours. The goal is to see if this tool can help doctors choo…

This study looks at whether extra lifestyle coaching plus medically tailored meals can help prevent type 2 diabetes in women who had gestational diabetes. Nearly 1,000 pregnant or recently pregnant women from home visiting programs will take part. One group gets enhanced support …

This study tests two walking training programs to help veterans with leg amputation walk more evenly. The goal is to reduce pain, improve mobility, and protect the skin of the remaining limb. About 54 veterans who have had a leg amputation due to diabetes or artery disease will t…

This study looks at whether adding exercise to standard vitamin D treatment can improve erectile function in men with type 2 diabetes who also have low vitamin D levels. Researchers will measure changes using a questionnaire and blood tests. The goal is to see if a simple lifesty…

This study compares two virtual group programs—one focused on emotions, the other on problem-solving—to help adults with type 1 diabetes reduce diabetes distress. Participants who don't improve may get extra one-on-one sessions. The goal is to find better ways to support emotiona…

This study tests whether a special discharge program for continuous glucose monitors (CGMs) can improve satisfaction and quality of life in adults with diabetes who use insulin. About 37 participants will complete surveys before and after using the device. The goal is to see if b…

This study looks at whether endocrinologists can help diabetes patients with dry mouth, a common problem that affects eating, speaking, and quality of life. About 80 adults with diabetes and dry mouth symptoms will receive simple oral care advice, saliva substitutes, and dental r…

This study tests whether a structured 8-week program of physical and cognitive exercises can improve daily function, thinking skills, and quality of life in adults with Long COVID and chronic conditions like high blood pressure or diabetes. About 374 participants will be randomly…

This study looks at why people with indigestion and diabetes often have stomach issues, like pain or fullness. Researchers are testing if ondansetron, a drug used for nausea, can reduce these symptoms. About 150 adults will take part to see if the drug helps with daily discomfort…

This study is testing whether taking melatonin supplements can improve sleep patterns and daily body rhythms in people with diabetic retinopathy, an eye complication of diabetes. Researchers will monitor sleep, melatonin, and cortisol levels in 42 adults aged 40-65 with type 2 di…

This study looks at why some people diagnosed with diabetes in the emergency room don't get the follow-up care they need. Researchers will review medical records, interview patients, and test whether a telehealth visit can help connect them to a regular doctor. The goal is to imp…

This study looks at how fat buildup in the pancreas (pancreatic steatosis) is connected to diabetes and metabolic syndrome. Researchers will use a special ultrasound technique to measure the fat and compare it with blood sugar and other health markers. The goal is to better predi…

This study measures chemicals in the breath of 60 adults (with type 1 diabetes, type 2 diabetes, or no diabetes) throughout the day. The goal is to see if these breath patterns change with time and blood sugar levels. No treatment is given; it is purely observational to learn mor…

This study compares whole genome sequencing with standard genetic tests to see which better finds the root cause of atypical diabetes. Researchers will follow 1,020 adults for 5 years, looking for genetic changes that explain their condition and may change treatment. The goal is …

This study checks how accurate and safe a new continuous glucose monitor (Syai Tag) is for patients in the intensive care unit. About 100 adults with diabetes, sepsis, or other critical illnesses will wear two small sensors on their arms. The sensor readings will be compared to s…

This study collects plucked hair follicles from 100 healthy adults to see if cells from them can be turned into stem cells. These stem cells could then be used to model diseases like diabetes or to develop cell-based treatments for injuries. The goal is to learn how well these ce…

This study is following 1,000 people who are having weight-loss (bariatric) surgery to see how their bodies change over two years. Researchers will measure weight, body fat, blood sugar, cholesterol, and other health markers before surgery and at several follow-up visits. The goa…

This study will enroll 8,000 adults who are already getting a routine health checkup. Researchers want to learn how a person's environment, genes, and proteins interact to cause conditions like high blood pressure, diabetes, and other metabolic problems. The goal is to create an …

This study looks at how rare genetic changes affect beta cells, which control blood sugar. Researchers will compare people with and without these gene variants using blood tests and optional MRI scans. There is no treatment involved, and participants continue their normal care. T…

This study looks at how certain diabetes medications (semaglutide, liraglutide, tirzepatide) change blood flow and oxygen use in the eyes of people with diabetes. About 20 adults with diabetes will have their eye blood flow and oxygen levels measured before and after starting one…

This early-stage study tests how well different doses of the experimental drug SHR-3167 are absorbed by the body and whether they are safe. It involves 60 healthy adults aged 18 to 55. The goal is to gather information, not to treat any disease.

This study looks at how well blood sugar is controlled in people with diabetes and how it affects brain oxygen levels during surgery. Researchers will use a special light device to measure brain oxygen and track recovery after surgery. The goal is to understand if better blood su…

This study looks at whether showing people with diabetic peripheral neuropathy (nerve damage from diabetes) real-time visual and audio feedback while they walk can improve their step pattern and reduce harmful foot pressure. About 25 participants will walk on a special treadmill …

This study aims to learn the step-by-step process that causes type 1 diabetes. Researchers believe a person's immune system, guided by genes and environment, plays a key role. Participants include families with a history of type 1 diabetes and healthy controls. They provide a blo…

This study looks at how red blood cells from people with type 2 diabetes and heart attacks differ from healthy ones. Researchers will test these cells in lab experiments to understand why they cause heart damage. The goal is to find new treatments that target red blood cells to p…

This study is building a worldwide registry of people with Wolfram syndrome, a rare genetic disorder that causes diabetes, vision loss, hearing loss, and other problems. Researchers will collect medical history and genetic information from up to 5,000 participants to better under…

This study looks at 800 people aged 50+ who recently developed diabetes or whose diabetes got worse. Researchers use MRI scans and blood samples to find early signs of pancreatic cancer. The goal is to see if changes in diabetes can lead to earlier detection of this cancer.

This study looks at why people with chronic conditions like high blood pressure, diabetes, and high cholesterol often struggle to stick with healthy behaviors. Researchers will test a program designed to boost motivation and help patients take charge of their health. The study in…

This study is enrolling 20,000 adults in Taining County, China, to better understand common chronic diseases like high blood pressure, diabetes, and frailty. Researchers will collect health data and samples over three years to find patterns and risk factors. The goal is to create…

This study checks if long-term blood sugar levels (HbA1c) are linked to how fast the stomach empties before surgery. About 134 adults having planned surgery will get a stomach ultrasound after fasting. The goal is to see if poor blood sugar control raises the risk of stomach cont…

This study looks at why some adults with diabetes find it hard to take their medicines regularly. Researchers will survey 220 people to understand factors like knowledge, beliefs, family support, and access to care. The goal is to find the biggest barriers and use that informatio…

This study looks at how many adults with type 2 diabetes experience severe emotional distress related to their condition. Researchers at a French hospital will ask 246 participants to fill out questionnaires about their feelings, quality of life, and diet. The goal is to find out…

This study follows 800 adults with type 2 diabetes to see how their lifestyle choices relate to long-term complications like heart or kidney problems. Researchers will track participants over time and record any complications that develop. The goal is to find early warning signs …

This study looks at how high blood pressure, diabetes, and high cholesterol change the tiny blood vessels in the back of the eye. Researchers will use a special, non-invasive eye scan called OCTA to measure these changes in 300 adults. Participants will be followed for five years…

This study follows over 500 adults with type 2 diabetes who had a heart CT scan years ago. Researchers will repeat the scan to see how plaque builds up in heart arteries over time and identify factors that increase risk. The goal is to better understand heart disease in diabetes,…

This study looks at whether people with diabetes can collect their own blood samples at home (via finger prick or a device on the upper arm) to check blood sugar, cholesterol, and thyroid levels. The results will be compared to standard blood draws done by a nurse in the clinic. …

This study tests whether a machine learning program can detect hidden lumps (lipohypertrophy) under the skin where people with diabetes inject insulin. These lumps can change how insulin is absorbed and raise blood sugar. Researchers will use portable ultrasound images to train t…

This study involves 150 people with diabetic macular edema (DME) who are either starting treatment with anti-VEGF injections or a dexamethasone implant, or have not been treated before. Researchers will measure various substances in the blood and use eye scans to see if these mar…

This study follows 1,500 pregnant women and their children for up to 18 years to understand how a mother's health, lifestyle, and environment during pregnancy affect her child's growth and risk for conditions like obesity, diabetes, and fatty liver. Participants are American Indi…

This study aims to learn more about insulin resistance and diabetes by collecting blood and skin samples from up to 1,200 participants, including patients with severe insulin resistance and their family members. Researchers will study genetics and how insulin works in the body to…

This study tests whether a medication called diazoxide can reduce the liver's overproduction of sugar in people with type 2 diabetes. The liver normally makes sugar to fuel the body, but in diabetes it makes too much, raising blood sugar. Researchers will give diazoxide or a plac…

This study looks at 3,000 people with type 2 diabetes to see if signs of inflammation in the blood can predict complications like heart or kidney problems. Researchers will review medical records from a hospital in China. The goal is to find early warning signs and identify high-…