DIABETES MELLITUS

This study tests a new gel called GM-XANTHO on bedsores (pressure ulcers) that are stage 2 or 3. About 58 adults, including those with diabetes, will receive either a low or high dose of the gel or a placebo, along with standard wound care. The goal is to see if the gel helps the…

This study looks at whether eating proteins and vegetables before carbohydrates can improve blood sugar control in adults with diabetes or prediabetes who also experience food insecurity. Participants will receive free produce boxes and either standard nutrition advice or extra c…

This trial tests if islet cells made from stem cells can safely help people with diabetes. About 30 adults who have had diabetes for over 5 years and use insulin will receive an infusion of these cells. The goal is to see if the cells can improve blood sugar control and reduce th…

This study looks at how well a special type of tooth-colored filling (Giomer) works in people with diabetes compared to those without. Researchers will check the fillings at 6, 12, and 18 months to see if they stay in place and prevent new cavities. The goal is to understand if d…

This study tests a new care package for adults aged 65 and older who have two or more chronic conditions like high blood pressure, diabetes, or arthritis. The package includes digital tools, personalized guidance, and ongoing support. Researchers will compare this approach to usu…

This study tests a program called Primary Care Connect (PC2) for cancer survivors who also have heart-related conditions like high blood pressure, diabetes, or high cholesterol. The goal is to see if the program helps them stay connected to their primary care doctor and better ma…

This study tests a community-based exercise program for adults aged 50 and older who have at least two chronic conditions, such as heart disease, diabetes, or arthritis. The goal is to see if personalized exercise can improve heart and muscle fitness, mobility, and overall well-b…

This study will test whether using a real-time continuous glucose monitor (CGM) helps manage blood sugar better than standard finger-stick testing in people with type 2 diabetes who are hospitalized for heart failure. Researchers will follow 140 adults for 3 months after discharg…

This study checks if a cheap thermal camera (about 200 euros) works as well as a professional one for spotting foot problems in people with diabetes. 130 adults with diabetes will have both cameras take pictures of their feet. The goal is to see if the low-cost camera can reliabl…

This study tests whether a simple, non-invasive facial scan using a smartphone can accurately estimate blood sugar and HbA1c levels. Researchers will compare the scan results with standard blood tests in 300 adults in Jakarta, with or without diabetes. If successful, this technol…

This study aims to see if a single-lead electrocardiogram (ECG) analyzed by machine learning can accurately screen for heart conditions and related diseases like high blood pressure, diabetes, and kidney disease. Researchers will enroll at least 5,000 adults who have already had …

This study tests whether using artificial intelligence (AI) to screen for diabetic eye disease during a regular primary care visit can help more people get the follow-up eye care they need. About 4,000 adults with diabetes who have not had an eye exam in the past year will take p…

This study compares several non-invasive methods to measure the hardness of foot calluses in healthy people and those with diabetes. Researchers will use pressure plates, a hardness meter, ultrasound, and infrared cameras during a single session. The goal is to find the most reli…

This study tests whether an oral supplement called DLBS1033 can reduce nerve damage and inflammation in adults with diabetic polyneuropathy—a common complication of type 2 diabetes causing pain and numbness. Thirty-four participants will take either the supplement plus standard c…

This study looks at whether having a root canal done in one visit causes less pain afterward than spreading it over multiple visits, specifically for people with diabetes. About 200 diabetic patients needing root canal on a single-rooted tooth will be randomly assigned to one of …

This study tests whether acupressure (a gentle pressure technique) can lower blood sugar and reduce anxiety in people aged 65 and older with diabetes. About 48 participants will be randomly assigned to receive acupressure or a sham procedure. Researchers will measure fasting and …

This study tests whether laser acupuncture can improve arterial stiffness in people with cardiorenal metabolic syndrome (CRMS), a condition linking heart, kidney, and metabolic problems. 35 adults with at least two related conditions (like high blood pressure, diabetes, or chroni…

This study will follow 100 adults with diabetes and foot ulcers to see how non-vascular factors like nerve damage, infection, and poor blood sugar control affect ulcer severity and healing. Researchers will track ulcer size and recurrence over one year. The goal is to identify mo…

This study looks at whether a custom toe divider can help people with diabetes who have had a small toe amputated. Researchers want to see if it improves walking and reduces the risk of new foot sores. The study is small and aims to find out if a larger trial is possible. Partici…

This study looks at how fear of low blood sugar (hypoglycemia) affects how well people with diabetes follow their diet and take their medication. Researchers will survey 100 adults with diabetes who have had at least one low blood sugar episode. The goal is to understand how this…

This study looks at how the mouth heals after gum surgery in people with and without diabetes. About 40 adults with gum recession will take part. Researchers will measure wound size and healing over 12 weeks to see if diabetes makes a difference.

This early-stage study will test a new combination diabetes medicine (AD-123) in 50 healthy adults. Researchers want to see how the body processes the drug when given as a single pill versus taking two separate pills. The study is not yet recruiting and focuses on safety and drug…

This observational study will follow 100,000 elderly Chinese adults to see how conditions like diabetes, high blood pressure, and high cholesterol impact the development and progression of chronic kidney disease (CKD). Participants will provide health data through clinic visits a…

This study looks at how well the gums heal after a common gum surgery in people with and without diabetes. Researchers want to see if diabetes slows healing and what factors, like mouth bacteria or inflammation, play a role. About 40 adults with gum recession will join, providing…

This study looks at whether the way health information is presented can help people with diabetes better understand their risk of developing foot ulcers. Researchers will compare two types of messages—one focusing on the benefits of good foot care, and another on the dangers of n…

This study aims to find better ways to deliver health services to women Veterans, especially those in midlife. Researchers will test two different strategies at 18 VA sites to see which one helps more women get the care they need. The study focuses on improving engagement with pr…

This study will use ultrasound to measure the amount of fluid and food left in the stomach before surgery in 220 adults, comparing those with and without diabetes. The goal is to see if standard fasting guidelines (no clear liquids for 2 hours, no solid food for 6-8 hours) work e…

This early-stage study looks at how the body processes HRS9531, a drug for diabetes and weight loss, in people with mild or moderate liver issues compared to those with healthy livers. About 24 adults will receive a single dose to measure drug levels and check for side effects. T…

This study explores whether advanced eye and brain imaging can detect early damage to nerves and blood vessels caused by diabetes. Researchers will also test a Chinese herbal medicine, Tangshen'an Granule, to see if it can prevent or treat this damage. About 160 adults with diabe…

This study looks at how diabetes affects a type of numbing shot called an ankle block, used during foot or ankle surgery. Researchers will compare 46 diabetic and non-diabetic adults to see how quickly the block works and how much pain medicine they need afterward. The goal is to…

This study tests a program called SPARK-CGM that helps primary care doctors learn about and prescribe continuous glucose monitors (CGMs) for people with diabetes. CGMs track blood sugar in real-time, helping patients avoid dangerous lows and improve their quality of life. The stu…

This study will follow 500 Beijing residents aged 60 and older to see how urinary function (like bladder and kidney health) is linked to multiple chronic conditions such as high blood pressure, diabetes, and heart disease. Participants will have regular health check-ups, blood an…

This study is testing a new computer-based decision aid designed to help cancer survivors and their heart doctors. The tool, accessed through electronic health records, aims to improve decisions about heart-protective medications and monitoring tests. Researchers want to see if b…