Could a simple gel boost gum healing in diabetes?

NCT ID NCT07631273

Not yet recruiting Disease control Sponsor: Marmara University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether adding hyaluronic acid gel to standard deep cleaning (scaling and root planing) improves gum healing in people with both diabetes and advanced gum disease. Twenty-three participants will receive the standard cleaning on all teeth, and then two gum pockets will also get the gel. Researchers will measure gum attachment, pocket depth, bleeding, and markers of inflammation and bone breakdown over six months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: hyaluronic acid gel
What this could lead to: If it works, this could point toward a simple, low-cost addition to standard gum treatment for people with diabetes.
What could go wrong: This is a very small, early study (23 people) that hasn't started yet. The benefit may be small or not show up at all, and results may not apply to everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cerebrotendinous xanthomatosis diabetes mellitus periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DIABETES MELLITUS HYALURONIC ACID IL-34 ORAL MICROBIOTA PERIODONTITIS Β-CTX

Contacts and locations

Locations

Department of Periodontology, Faculty of Dentistry, Marmara University

Istanbul, Turkey (Türkiye)

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