DIABETES MELLITUS

This study is testing whether two types of algae supplements can improve markers of heart health and change gut bacteria in people with conditions like heart disease, diabetes, or kidney disease. 150 participants aged 50+ will take either spirulina, another seaweed supplement, or…

This study is testing whether a wearable glucose monitor that alerts nurses to blood sugar problems helps diabetic patients recover better after surgery. It compares this new monitoring method to the standard finger-prick checks. About 200 patients having certain types of surgery…

This study is testing if an automated insulin pump system can help people who have both diabetes and advanced kidney disease. The system continuously monitors blood sugar and automatically delivers insulin, aiming to keep levels in a safe range. Researchers will compare this auto…

This study is testing a new digital tool called P3-EX, designed to help doctors create personalized exercise plans for their patients. The researchers want to see if the tool is easy for doctors to use and if patients find it helpful. They will also check if using the tool leads …

This study is testing whether an 8-session nutrition education program is practical and helpful for people with diabetes or prediabetes. The program teaches participants how to eat more fiber-rich foods like fruits, vegetables, and whole grains. Researchers will enroll 48 people …

This study is testing whether letting hospital staff monitor data from patients' personal continuous glucose monitors (CGMs) leads to better blood sugar control during hospital stays. 150 adults with diabetes who use CGMs at home will be randomly assigned to either have their CGM…

This study is testing a digital tool called a 'Smart Family Doctor' to see if it helps people better manage their health after heart procedures like bypass surgery or stents. The app uses AI to assist with controlling blood pressure, blood sugar, and cholesterol. About 536 adults…

This study is testing a special soft cast wrap to see if it helps heal foot ulcers in people with diabetes as well as common methods. It will check how well it works, how safe it is, and if patients find it comfortable and easy to use. The goal is to control the wound and prevent…

This study is observing how well the Omnipod 5 automated insulin delivery system works for people with type 1 diabetes in their everyday lives. It will follow 304 adults and children in France for one year to see how the system affects blood sugar control, quality of life, and sa…

This study is testing whether performing a procedure to open blocked leg arteries within 48 hours helps diabetic foot ulcers heal better than waiting for a standard scheduled procedure. It will involve 200 adults with type 2 diabetes and a foot ulcer. Researchers will use a 3D ca…

This study is testing if giving diabetes doctors specific care recommendations when their patients have diabetic eye disease helps improve blood sugar control. It involves 336 adults in Bangladesh with both diabetes and diabetic retinopathy. Researchers will compare if sharing ey…

This study is testing whether sending supportive text messages can help adults experiencing homelessness manage their type 2 diabetes better. It will involve 100 people in New York City shelter clinics who have uncontrolled diabetes. Researchers will compare a group receiving tex…

This study is testing whether giving people with type 2 diabetes vouchers to buy fruits and vegetables helps them manage their condition. It will involve 120 low-income adults with diabetes and compare different approaches to using these food vouchers. The goal is to see if this …

This study is testing whether a structured care program led by community pharmacists can help people with type 2 diabetes manage their condition better than their usual doctor's care. It will involve 600 Albertans whose blood sugar is not yet at a healthy target. The goal is to s…

This study is testing the safety and early effectiveness of a new medical procedure that targets nerves in both the kidney and liver to help lower blood pressure. It is for adults with uncontrolled high blood pressure, including those with other heart or kidney risks. The goal is…

This study is testing whether a program using an AI chatbot health coach and remote vital sign monitoring can help people better manage their interconnected chronic conditions. It aims to reduce serious health events like heart attacks, kidney failure, and hospitalizations. The t…

This study is testing if adding regular exercise to standard vitamin D treatment helps diabetic men who have erectile dysfunction. Forty men with type 2 diabetes, low vitamin D, and long-term erectile problems will take vitamin D pills. Half of them will also do supervised treadm…

This study is testing whether using two different artery-opening devices together is better than using just one for people with diabetes and blocked heart arteries. It will involve 120 participants across four hospitals in Ireland. Patients will be randomly assigned to receive ei…

This study is testing if automated voice message reminders, which warn about the risk of vision loss from diabetes, help people in Bangladesh keep their scheduled diabetes and eye check-up appointments. It will also provide free reading glasses to participants. Researchers want t…

This study is testing a smartphone app designed to help older adults with multiple chronic conditions like heart failure, diabetes, and kidney disease manage their care after leaving the hospital. The goal is to see if the app can reduce complications and readmissions by providin…

This early-stage study is testing the safety of a new cell therapy for advanced stomach and esophageal cancers that have spread to the abdominal lining. Doctors collect a patient's own immune cells, modify them in a lab to better target cancer cells, and then infuse them directly…

This study is testing if a temporary spinal cord stimulator can help people with type 2 diabetes who have painful nerve damage in their legs. Researchers want to see if the device not only reduces pain but also improves blood circulation and artery health in the lower limbs. The …

This study is testing a new drug, Tegoprubart, combined with standard medications to see if it can safely help transplanted islet cells survive and produce insulin in people with severe type 1 diabetes. The goal is to reduce or eliminate the need for insulin injections and preven…

This study is testing whether using smart insulin pens with continuous glucose monitors and remote doctor visits works better than standard insulin pens with the same monitors and remote visits. It aims to help veterans with type 2 diabetes who take multiple daily insulin injecti…

This is an early safety study testing a new islet cell injection called RGB-5088 for adults with Type 1 diabetes. The main goal is to see if the treatment is safe and if it can help patients achieve better blood sugar control without severe low blood sugar events. Researchers wil…

This study is observing how well the medication dapagliflozin works for people who have both type 2 diabetes and high blood pressure. It will follow 9,000 patients in real-world settings to see how effectively it controls their blood sugar and blood pressure, and to monitor for a…

This study is testing whether an online training and peer support platform can help teenagers with type 1 diabetes better manage their health as they prepare to move from pediatric to adult healthcare. Researchers will compare the online platform plus usual care against usual car…

This study is testing if a new gel called ENERGI-F703 can help heal diabetic foot ulcers better than a placebo gel. About 230 adults with a specific type of foot sore will apply the gel for 16 weeks. Researchers will check if the sores fully close and heal, and monitor for any si…

This study aims to find out if patients who continue taking their GLP-1 weight loss and diabetes medications (like Wegovy or Ozempic) after bariatric surgery have better results than those who stop. Researchers will compare weight loss, blood sugar control, and gut health in 150 …

This study aims to understand why some people diagnosed with diabetes in the emergency room don't get follow-up care. Researchers will interview patients and review records to identify barriers. They will also test if a telehealth visit right after the ER helps connect people to …

This study is testing whether a device called the iLet Bionic Pancreas can help adults with type 1 or type 2 diabetes better manage their blood sugar when it is prescribed and monitored by their regular primary care doctor. Researchers will compare 13 weeks of using the automated…

This study is testing whether repeat doses of the BCG vaccine, typically used against tuberculosis, can help children recently diagnosed with type 1 diabetes. Researchers want to see if the vaccine can improve long-term blood sugar control and help the body preserve its own insul…

This study is testing if a faster version of a kidney nerve-calming procedure works as well as the older, longer method to lower high blood pressure. It will involve about 130 adults whose blood pressure remains high despite treatment. Researchers aim to see if simplifying where …

This early-stage study is testing a new drug called retatrutide to see how it affects the body's ability to produce and respond to insulin in people with type 2 diabetes. It will involve about 95 adults and compare the new drug against a placebo and another existing diabetes medi…

This study is testing how accurate and reliable a new continuous glucose monitoring system is for critically ill patients in intensive care. Researchers will place small sensors on patients' arms to measure blood sugar continuously, then compare these readings to standard blood t…

This study is testing a new computer tool designed to help general practice doctors more accurately identify the specific type of diabetes a patient has. The tool will scan patient records to find adults diagnosed with diabetes under age 50 who might have been given the wrong cla…

This study is testing if people with diabetes can collect their own blood samples at home and mail them in, instead of going to a clinic for a blood draw. Researchers want to see if the home test results for blood sugar, cholesterol, and thyroid are as accurate as the standard cl…

This study is testing a new device that scans fingernails to check for signs of type 2 diabetes. Researchers will compare the scan results to standard blood sugar tests in 100 adults, some with and some without known diabetes. The goal is to see if this non-invasive scan can accu…

This study is testing a new, faster diagnostic tool called MinION for identifying the bacteria and fungi in serious bone infections of the foot in people with diabetes. It will compare the results from this new tool to the standard, slower lab culture methods. The goal is to see …

This study is testing a new blood test called Avantect to see if it can find pancreatic cancer early in people who were recently diagnosed with type 2 diabetes, as they have a higher risk. About 15,000 participants will be randomly assigned to either get the test now or later, an…

This study is testing if home visits can help prevent diabetes in women who had diabetes during pregnancy. Nearly 1,000 participants will receive either healthy lifestyle coaching or coaching plus free, healthy meals. Researchers will check if these supports help keep blood sugar…

This study tests whether diabetes specialists can help patients manage a common but bothersome side effect: dry mouth. Doctors will be trained to screen for dry mouth, offer simple advice, and provide basic treatments during regular diabetes appointments. The goal is to see if th…

This study is testing two new walking training programs designed to help Veterans with leg amputation from diabetes or poor circulation walk more evenly. Researchers want to see if these training methods, which give specific feedback about walking patterns, can improve balance, r…

This study is testing if a special hospital discharge program that provides a continuous glucose monitor (CGM) can improve patient satisfaction and quality of life. It involves about 37 adults with Type 1 or Type 2 diabetes who use insulin and have not used a CGM recently. Resear…

This study is testing whether real-time visual and audio feedback can help people with diabetic nerve damage walk better. Participants will walk on a special treadmill while seeing projections of their foot pressure and push-off force, with the goal of training safer walking patt…

This study is testing two different online group therapy programs to help reduce the emotional distress that often comes with managing type 1 diabetes. Researchers will enroll 200 adults with type 1 diabetes who report significant distress. If the initial group program doesn't wo…

This study is creating a worldwide registry of people with Wolfram syndrome, a rare genetic disorder that causes childhood diabetes, vision loss, deafness, and other serious problems. Researchers will collect health information and blood/urine samples from up to 5,000 participant…

This study aims to see if a detailed, non-invasive scan of the blood vessels in the back of the eye can reveal information about a person's overall heart and blood vessel health. Researchers will follow 300 people with high blood pressure, diabetes, or high cholesterol for five y…

This study aims to understand how a mother's health, weight, and blood sugar during pregnancy affect her child's growth and risk for obesity, diabetes, and fatty liver disease later in life. Researchers will follow 1,500 Hispanic and American Indian/Alaska Native mothers and thei…

This study aims to understand how and why fatty plaque builds up in the heart arteries of people with diabetes over many years. Researchers will follow a group of over 500 Korean patients who had a special heart CT scan years ago, and see how their scans have changed. The goal is…

This study aims to understand the step-by-step process that leads to type 1 diabetes. Researchers will follow 4,000 participants, including families affected by the disease and healthy volunteers, for up to 10 years. They will collect blood samples and health information to learn…

This study aims to understand if the chemicals in a person's breath change throughout the day and if those patterns differ between people without diabetes and those with type 1 or type 2 diabetes. Researchers will recruit 60 people across these three groups to collect breath samp…

This study aims to collect hair follicles from participants to grow and study different types of cells in the lab. Researchers want to see if cells from hair can be turned into other cell types that might one day help treat conditions like diabetes or injuries. The study involves…

This study aims to understand how rare genetic changes cause problems with the body's insulin-producing cells, leading to conditions like diabetes or very low blood sugar. Researchers will compare detailed blood samples and optional body scans from 50 people who have these geneti…

This study aims to understand how chronic diseases like high blood pressure, diabetes, and frailty develop and progress in a rural Chinese county. Researchers will follow 20,000 adult residents for three years, collecting health data and samples to build a detailed picture of com…

This study aims to understand the many real-life reasons why adults with diabetes find it hard to take their medications correctly. Researchers will observe 220 patients to look at factors like cost, family support, doctor communication, and personal beliefs. The goal is to gathe…

This study aims to understand how long-term blood sugar control in diabetic patients affects brain oxygen levels during surgery and recovery afterward. Researchers will observe 80 adults having planned urologic surgery, grouping them by their recent blood sugar history. They will…

This study aims to understand how certain substances in the blood relate to changes seen in detailed eye scans for people with diabetic macular edema (DME), a vision-threatening condition. Researchers will observe 150 patients who are either receiving standard eye injections/impl…

This study aims to understand how a specific diabetes measurement, called the Hemoglobin Glycation Index (HGI), naturally varies over time. It will observe 750 adults with diabetes who already use continuous glucose monitors. The goal is to gather knowledge, not to test a new tre…

This study aims to find the genes that make some people with diabetes more likely to develop serious kidney disease. Researchers are recruiting 100,000 people, focusing on families where one member already has diabetic kidney disease, to compare their DNA. The goal is to understa…

This study aims to understand why some people develop insulin resistance, a condition that can lead to diabetes and other health problems. Researchers will collect blood and sometimes skin samples from about 1,200 people, including those with severe insulin resistance, their fami…

This study aims to understand why people with type 2 diabetes have a higher risk of heart attacks. Researchers will collect red blood cells from 500 people—including those with diabetes, those who have had a heart attack, and healthy individuals—to test how these cells function i…