DIABETES MELLITUS

This study tests whether sending text message reminders and education to pregnant women with diabetes helps them follow their care plan, including keeping appointments, tracking blood sugar, and taking medications. About 185 pregnant women with diabetes (either pre-existing or ge…

This study looks at whether a telehealth program called ECHO can help healthcare teams better manage patients with diabetes and multiple chronic conditions. The program connects primary care teams with specialists through video sessions for training and case discussions. Research…

This study tests whether semaglutide (a once-daily pill) works better than sitagliptin (another diabetes drug) at controlling blood sugar and body weight in people who have had a liver transplant and have poorly controlled diabetes. About 58 adults who are at least 3 months post-…

This study tests whether a natural compound called fisetin can reduce inflammation and improve stem cell function in 30 adults with advanced chronic kidney disease, including those with diabetes. Participants will take fisetin or a placebo for 14 days, and researchers will measur…

This study tests a new way to help cancer survivors manage other health problems like high blood pressure, diabetes, and high cholesterol. About 800 adults with certain cancers and at least one heart-related condition will be enrolled. Their primary care doctors will work more cl…

This study is testing a special snack bar made from red beans and tomatoes, called GlycoBite, to see if it helps people with type 2 diabetes control their blood sugar. About 100 adults with type 2 diabetes who are not changing their current medications will eat the bars regularly…

This pilot study looks at whether adding a community health worker to the care team helps children (under 17) with newly diagnosed type 1 diabetes. The goal is to see if it improves blood sugar control, reduces hospital stays, and lowers healthcare costs. The study involves 28 ch…

This study looks at whether switching to a plant-based diet can improve heart health and reduce inflammation in people who have had a kidney transplant. About 25 adults who are at least 3 months post-transplant will follow a plant-based diet for 16 weeks. Researchers will track c…

This study tests a 10-week program called HomeStyles, adapted for Chinese Americans, to help improve eating habits, physical activity, and overall health. About 400 adults of Chinese heritage with a heart or metabolic condition (or living with someone who has one) will take part.…

This study tests a new continuous glucose monitor (iCan O3) in 70 adults with type 1 or type 2 diabetes whose blood sugar is not well controlled. Participants wear the device for 60 days, first with blinded readings and then with real-time data, to see if it helps them spend more…

This large study tests whether a lower blood pressure target can reduce major heart problems like heart attacks, strokes, and heart failure in people with type 2 diabetes. About 9,500 participants with high blood pressure and diabetes are being randomly assigned to either a stand…

This study tests a new automated insulin delivery algorithm in 48 adults aged 16–70 with type 2 diabetes. The goal is to see if the system can keep blood sugar in a safe range and reduce dangerous highs and lows. Participants use a pump and continuous glucose monitor to automate …

This study tests a procedure called renal denervation, which uses a device to calm overactive nerves in the kidneys that can raise blood pressure. About 1,900 adults with uncontrolled high blood pressure will be followed for years to see if the treatment safely and durably lowers…

This study tests whether adding short educational videos to standard care helps pregnant women with diabetes manage their blood sugar and improve their baby's birthweight. About 500 women participated, receiving either usual face-to-face education or extra virtual lessons on diet…

This study looks at whether people with type 2 diabetes can safely keep taking their usual diabetes pills while in the hospital, instead of switching to insulin. About 255 adults aged 18-80 who are admitted to general medical or surgical units will take part. Researchers will com…

This study compares two ways of peeling a thin layer inside the eye during surgery for diabetic patients with severe eye disease. The goal is to see which method better protects vision and eye structure after surgery. About 48 adults with diabetes and certain eye problems will ta…

This study planned to test a combination of four drugs (ATG, low-dose IL-2, adalimumab, and exenatide) in people aged 18-35 newly diagnosed with type 1 diabetes. The goal was to see if the treatment could help the body keep making its own insulin and improve immune regulation. Ho…

This study tests whether transplanting insulin-making cells (islets) can help people with type 1 diabetes who struggle with dangerous blood sugar swings. About 17 participants will receive the transplant along with immune-suppressing drugs to prevent rejection. The goal is to red…

This study tests a targeted screening approach to detect undiagnosed heart failure in 706 adults aged 40+ with type 1 or type 2 diabetes who also have additional heart risk factors. Participants are randomly assigned to receive the screening or usual care, and researchers track h…

This study checks if a new device can screen for type 2 diabetes by measuring sugar levels in fingernails. Researchers will compare results from 100 adults (half with known diabetes, half without) to standard blood tests. The goal is to see if the nail test is accurate and safe e…

This study tests whether the BCG vaccine (used for tuberculosis) can prevent type 2 diabetes in adults with pre-diabetes in Guinea-Bissau. Researchers believe the vaccine may reduce inflammation and insulin resistance. 200 participants will receive BCG and be monitored for diabet…

This study tests a culturally-appropriate education program called Indigenous SIPin for Native American men who are part of athletic communities. The goal is to help them drink fewer sugary beverages like soda and juice, which can lead to obesity, diabetes, heart disease, and som…

This study tests a program called Black Girls Move, designed to prevent obesity in Black teenage girls (9th and 10th grade) who are at risk. The program involves both daughters and their mothers, focusing on increasing physical activity and improving diet. Researchers will track …

This study tests whether a free, culturally tailored program called Eat, Move, Live (EML) can help people in underserved communities lower their risk for cancer and other chronic diseases like diabetes. The program includes nutrition education, physical activity sessions, and pra…

This study tests whether an 8-session nutrition education program is practical and well-liked by patients in a general medicine clinic. The program focuses on eating more fiber-rich foods like fruits, vegetables, and whole grains. It includes 42 adults with prediabetes, diabetes,…

This study tests a program called REST that helps older adults (65+) with type 1 or type 2 diabetes learn to use continuous glucose monitors (CGM). The goal is to reduce dangerous low blood sugar episodes and improve time in range. Participants will receive remote education and s…

This study looks at why Black people with HIV are more likely to develop kidney disease, diabetes, and heart problems. Researchers are analyzing genetic and health data from over 3,000 participants to find risk factors. The goal is to better understand these diseases and improve …

This study uses MRI scans to learn more about pancreatitis (inflammation of the pancreas) and how it can lead to long-term problems like diabetes and digestive issues. About 195 children and young adults will have MRI exams, blood tests, and other procedures to see if MRI measure…

This study follows people who have been cured of chronic hepatitis C to understand why some still develop liver complications like scarring, cancer, or liver failure. About 121 adults will be monitored for up to 10 years with regular tests, scans, and questionnaires. The goal is …

This study is observing 50 adults aged 45-76 with diabetic peripheral neuropathy to see how well their blood sugar is controlled and how it relates to nerve signal speed in the leg. Researchers will use standard tests like nerve conduction studies and foot exams. The goal is to f…

This study is collecting health and genetic information from 120,000 people with chronic diseases like pancreatitis, inflammatory bowel disease, diabetes, and arthritis. Researchers want to understand how genes, lifestyle, and other factors affect disease progression and quality …

This study followed nearly 6,000 adults aged 65 and older to learn what factors predict heart disease, stroke, and related disabilities. Researchers measured known risks like high blood pressure and diabetes to see how they affect older people's health over time. The goal was to …

This study aims to understand why some people with diabetes develop kidney disease, focusing on social, environmental, and biological factors in Ecuador. Researchers will collect data from over 10,000 adults, including those with and without diabetes, to identify early signs and …

This observational study collects blood, urine, and tissue samples from 500 obese adults to learn more about obesity, weight loss, and why some people regain weight after treatment. Participants must be over 18 and have a BMI of 30 or higher. The samples will be stored for up to …

This study looks at how a measure called the Hemoglobin Glycation Index (HGI) changes over time in people with diabetes. Researchers will track 750 adults who already use continuous glucose monitors. The goal is to better understand this blood sugar marker, not to test a new trea…

This study planned to see if training residents of Boston housing developments as Community Health Ambassadors could help more people get regular doctor visits and screenings for high blood pressure and diabetes. The ambassadors would lead workshops and connect neighbors to clini…

This study looked at how closely Danish hospitals followed official guidelines for managing diabetes in patients having major surgery between 2017 and 2023. Researchers reviewed records from 22,000 adults with type 1 or type 2 diabetes who had non-cardiac surgery lasting at least…

This study follows over 5,000 Black and White adults from age 18-30 for decades to see how their lifestyles and risk factors affect heart disease later in life. Researchers measure things like blood pressure, cholesterol, and weight to understand what leads to heart attacks, stro…

This study is creating a large biobank of health information and blood samples from 48,000 people with diabetes in Hong Kong. Researchers will analyze genes and other markers to better predict who is at risk for serious complications like kidney failure, heart disease, and stroke…

This study looks at the genes of over 9,000 people with diabetes and kidney disease, along with their family members. The goal is to find which genes make some people more likely to get kidney damage from diabetes. This knowledge could lead to better treatments or ways to prevent…

This study uses advanced MRI scans to measure the size and texture of the pancreas in people recently diagnosed with type 1 diabetes. Researchers aim to develop standard methods for assessing the pancreas, which may help understand how diabetes affects this organ. Participants mu…

This study was designed to learn more about using a heart scan (coronary artery calcium score) to find hidden heart disease in people with diabetes. It planned to enroll adults with type 1 or type 2 diabetes who had no heart symptoms. The study was withdrawn before any participan…

This study looks at whether a special screening method can find pancreatic cancer earlier in people aged 50-85 who have recently developed diabetes or high blood sugar. About 8,869 participants are being followed to see if the screening helps detect cancer sooner than usual. The …

This study looks at how to help VA medical centers offer virtual programs that prevent heart disease, diabetes, and depression in women Veterans. It involves 20 VA sites across 4 regions, not individual patients. The goal is to see which strategies work best to get women to sign …

This long-term study aims to understand how early, hidden signs of heart disease develop and predict future heart attacks, strokes, and heart failure. It follows over 6,400 adults from four different ethnic groups who started the study with no known heart disease. Researchers use…

Continuous glucose monitoring is a sensor, which monitors glucose levels continuously throughout the day. In people with diabetes, especially those treated with insulin, this sensor helps guide the amount of treatment (such as insulin) required to maintain glucose within target. …