DIABETES MELLITUS

This large study is testing whether aiming for a lower blood pressure target can better protect people with diabetes from serious heart problems and memory decline. It involves nearly 9,500 participants who have type 2 diabetes and are at high risk for heart disease. Participants…

This study is testing whether transplanting insulin-producing islet cells into adults with hard-to-control type 1 diabetes is safe and can help them become less dependent on insulin injections. Participants receive the transplant and must take lifelong anti-rejection drugs to pre…

This study is testing a medical device procedure called renal denervation for people whose high blood pressure remains uncontrolled despite medications. The procedure uses a catheter to deliver energy to nerves around the kidney arteries, aiming to lower blood pressure long-term.…

This study compares two ways of performing a delicate eye membrane peel during surgery for advanced diabetic eye disease. Researchers want to see if leaving a tiny, central area of the membrane untouched (foveal sparing) leads to better vision and eye structure recovery after sur…

This study is testing a new, automated insulin pump system designed to help adults with type 2 diabetes manage their blood sugar more easily. Up to 48 participants will use the system, which automatically adjusts insulin delivery based on continuous glucose monitor readings. The …

This study tests a new program designed to improve teamwork between cancer specialists and primary care doctors (PCPs) for patients who have both cancer and a heart-related condition like high blood pressure or diabetes. The goal is to see if better coordination helps manage the …

This study tests a telehealth training program for primary care teams in New Mexico. The program connects local clinic staff with specialist mentors to improve care for patients with diabetes and other ongoing health issues like high blood pressure or depression. Researchers will…

This pilot study is testing whether adding a trained community health worker to the healthcare team can help children newly diagnosed with type 1 diabetes and their families. The community health worker provides personalized support for one year, helping families navigate challen…

This study is testing if people with type 2 diabetes can safely keep taking their usual diabetes pills while in the hospital, instead of switching to insulin shots. It will compare blood sugar control and safety between the two approaches in 255 hospitalized patients. The goal is…

This study is testing a new snack bar called 'GlycoBite,' made from red beans and tomatoes, to see if it can help people with type 2 diabetes manage their blood sugar. About 100 participants will eat the bar daily for three weeks while researchers check their blood sugar and HbA1…

This study is testing whether switching to a plant-based diet can improve heart health and reduce inflammation in people who have received a kidney transplant. Researchers are helping 25 participants follow the diet for at least 16 weeks, with training and support. They will meas…

This study is testing a wearable device called the iCan O3 Continuous Glucose Monitoring (CGM) System. It aims to see if using the device for 60 days helps adults with type 1 or type 2 diabetes better manage their blood sugar levels. The study will measure if people spend more ti…

This study is testing whether adding short, easy-to-watch educational videos on a smartphone helps pregnant women with diabetes better manage their condition. Over 500 women will be randomly assigned to receive either the standard education from their doctor or the standard educa…

This study is testing whether a short, two-day course of a compound called fisetin can help people with advanced chronic kidney disease. Researchers want to see if fisetin can reduce body-wide inflammation, improve the function of certain repair cells, and help with physical stre…

This study is testing whether sending text message reminders and educational tips helps pregnant women with diabetes better follow their recommended care plan. Researchers enrolled 185 pregnant women with diabetes and randomly assigned some to receive the text messages. The goal …

This study aimed to test whether a combination of four drugs could help people recently diagnosed with type 1 diabetes keep making their own insulin. The goal was to see if this treatment could protect the body's remaining insulin-producing cells better than a placebo. The trial …

This study aims to check if a wearable glucose monitor (Dexcom G7) gives accurate readings for people with diabetes when they are in situations that strain their circulation, like major surgery or being in the intensive care unit. Researchers will compare the monitor's readings t…

This study is testing a specific screening method to find undiagnosed heart failure in people with diabetes who are at high risk. About 700 participants are being randomly assigned to either receive this new screening or continue with their usual care. The screening involves a bl…

This study is testing a new method to find pancreatic cancer sooner. It focuses on adults aged 50-85 who have recently developed high blood sugar or diabetes, as this can sometimes be an early sign of the cancer. The research uses a computer model to identify which of these patie…

This study is testing if the BCG vaccine, commonly used against tuberculosis, can help prevent type 2 diabetes in people with pre-diabetes. Researchers in Guinea-Bissau are giving 200 adults either the BCG vaccine or a placebo and following them for three years. They will check i…

This VA study aims to improve how 20 VA medical centers provide virtual health programs to women Veterans. It's testing two different support strategies to help these facilities successfully offer proven programs for preventing heart disease, diabetes, and depression. The goal is…

This study aimed to see if training and paying residents as Community Health Ambassadors could help more people in Boston public housing get primary care visits and screenings for diabetes and high blood pressure. The ambassadors would run workshops and connect their neighbors to…

This small pilot study is testing a new program in a primary care clinic to help prevent low blood sugar (hypoglycemia) in people with diabetes who take medications that can cause it. The main goal is to see if the program is practical and acceptable to patients, doctors, and cli…

This study tests a 12-week program called 'Black Girls Move' designed to prevent obesity in Black teenage girls. The program involves both the girls and their mothers, focusing on setting goals for better physical activity and healthier eating. Researchers want to see if this fam…

This study is testing a culturally-appropriate education program designed to help Native American men reduce their consumption of sugary drinks like soda and juice. The program involves group classes and text message support over six months. The goal is to see if this approach ca…

This study tests whether a free 12-week program of nutrition education, cooking demonstrations, and exercise sessions can help reduce the risk of cancer and chronic diseases like diabetes. The program is designed specifically for underserved communities and is offered in English …

This research study aims to develop better MRI scanning methods to examine the pancreas in people with type 1 diabetes. Researchers will scan 250 participants, including those recently diagnosed with diabetes, to understand how the pancreas changes during disease development. The…

This study aims to understand the long-term health of people who have been cured of chronic Hepatitis C. Researchers will follow 121 participants for up to 10 years to see if cured patients still develop liver complications, cancer, or other health problems. The goal is to learn …

This study aims to understand why some people with diabetes develop serious heart and kidney problems while others do not. Researchers are collecting detailed health information and blood samples from 48,000 people with diabetes in Hong Kong to look for genetic and other biologic…

This long-term study followed nearly 5,900 adults aged 65 and older to identify what factors predict heart disease and stroke in the elderly. Researchers tracked participants' health over decades, using exams and tests to understand how risk factors like high blood pressure and c…

This is a long-term observational study that aims to understand how heart and blood vessel diseases develop in people before they show symptoms. It follows over 6,400 healthy men and women from four different ethnic backgrounds, aged 45-84, using regular scans and tests over many…

This study aims to see if special MRI scans can help doctors better understand and predict complications from pancreatitis in children. Researchers will compare MRI results with other tests to see if the scans can spot early signs of diabetes or digestive problems. The goal is to…

This study aims to collect and store biological samples from 500 people with obesity. The goal is to build a repository of blood, urine, and tissue to help researchers understand why weight loss treatments sometimes work or fail, and why weight is often regained. This is an obser…

This study aimed to understand how doctors in France use a heart calcium scan to assess heart disease risk in people with diabetes. It planned to observe how test results influence decisions for further heart tests or treatments. The study was withdrawn before any participants we…

This study aims to understand why Black people living with HIV are at higher risk for serious health problems like kidney disease, diabetes, and heart disease. Researchers collected health information and genetic samples from over 3,000 Black participants with HIV across the UK. …

This is a long-term observational study that began in 1985 to understand how heart disease risk factors develop in young adulthood. It follows over 5,000 Black and White men and women who were 18-30 years old when they joined. The goal is to identify which lifestyle habits and ch…

This study aims to understand how genetics, lifestyle, and other factors influence the progression and severity of many common chronic diseases. Researchers will collect health records, genetic data, and samples from 120,000 participants with conditions like diabetes, arthritis, …

This study looked back at the medical records of 22,000 Danish patients with diabetes who had major surgery. The goal was to see how often hospitals correctly followed established guidelines for managing blood sugar before, during, and after surgery. Researchers specifically chec…