DIABETES MELLITUS

This study is testing whether giving the BCG vaccine (normally used for tuberculosis) twice, four weeks apart, can improve blood sugar control and reduce insulin needs in children aged 8 to 17 who were recently diagnosed with type 1 diabetes. The trial involves 100 participants a…

This study looks at whether eating proteins and vegetables before carbohydrates (meal sequencing) can improve blood sugar control in 70 adults with diabetes or prediabetes who also experience food insecurity. Participants will receive free produce boxes and either standard nutrit…

This study tests a nurse-led program that uses home monitoring devices to help older adults with conditions like heart failure, diabetes, and depression manage their health after leaving the hospital. The goal is to improve care coordination and reduce hospital readmissions. Abou…

This study looks at whether switching to a plant-based diet can improve heart health and reduce inflammation in people who have had a kidney transplant. Twenty-five participants who are at least three months post-transplant will follow a plant-based diet for 16 weeks after a two-…

This study tests whether a short course of two drugs, dasatinib and quercetin, can clear senescent (aging) cells in people with chronic kidney disease. The goal is to see if this reduces frailty and improves stem cell function. Thirty participants aged 40-80 with moderate-to-seve…

This pilot study explores how a 6-month low-carbohydrate diet affects blood sugar control, body composition, and gut-brain interactions in 40 obese adults with or without glucose intolerance or diabetes. Participants follow a low-carb eating plan, and researchers measure changes …

This study tests a device that uses radiofrequency energy to calm overactive kidney nerves, which can drive high blood pressure. About 1,900 adults with uncontrolled hypertension will receive the procedure and be followed for years. The goal is to see if this approach safely and …

This study compares two diabetes medications, semaglutide and sitagliptin, in 58 adults who have had a liver transplant and have poorly controlled diabetes. The goal is to see which drug better lowers blood sugar and body weight. Participants will take the study drug daily for th…

This study tests whether having more frequent checkups with an obstetric provider or a study nurse during the first year after childbirth can help women with high blood pressure or diabetes manage their health better. One hundred women with Medicaid insurance who had these condit…

This large study is testing whether a lower blood pressure target can reduce major heart problems like heart attacks, strokes, and heart failure in people with type 2 diabetes. About 9,500 participants with high blood pressure and high cardiovascular risk are being randomly assig…

This study tests whether a nurse practitioner-led team can improve care for adults with two or more chronic conditions like heart failure, diabetes, or kidney disease. Participants are randomly assigned to either the nurse-led team or usual care. The team reviews medications to e…

This study compares continuing oral diabetes medications (like metformin) versus switching to insulin in hospitalized adults with type 2 diabetes. About 255 participants will be randomly assigned to either stay on their usual pills or receive insulin injections. The goal is to se…

This study tests a gel made from chitosan and chlorhexidine on wound healing after lower molar extraction in diabetic patients. Forty adults with controlled diabetes will receive either the gel or standard care. The goal is to see if the gel reduces pain, swelling, and improves e…

This study tests a new way for cancer doctors and primary care doctors to work together to help cancer survivors manage other health problems like high blood pressure, diabetes, and high cholesterol. About 800 adults with certain cancers and at least one of these conditions will …

This study looks at 1500 people with diabetes who had a heart procedure to open blocked arteries. Researchers are comparing two treatments: a drug-coated balloon and a drug-eluting stent. The goal is to see which one works better over the long term for this specific group of pati…

This pilot study looks at whether adding a community health worker to the diabetes care team helps children recently diagnosed with type 1 diabetes. The health worker will visit the child's home, help set health goals, and address social needs like food or housing. The study will…

This study looks at whether a natural substance called fisetin can help people with advanced chronic kidney disease. Researchers will measure changes in inflammation, stem cell health, and physical frailty after 14 days of treatment. The study involves 30 adults aged 40-80 with m…

This study is testing a new continuous glucose monitor (CGM) called the iCan o3 in 70 adults with type 1 or type 2 diabetes. Participants will wear the device for 60 days to see if it improves their blood sugar control, especially the time spent in a healthy range. The goal is to…

This pilot study aimed to test whether a combination of four drugs—ATG, low-dose IL-2, adalimumab, and exenatide—could help people newly diagnosed with type 1 diabetes keep producing their own insulin. The trial planned to enroll adults aged 18-35 diagnosed within the last 120 da…

This study tests a culturally appropriate education program called Indigenous SIPin to help Native American men reduce their intake of sugary drinks like soda and juice. The program includes classes and text messages, and involves 48 men from Native American athletic communities.…

This study tests whether sending text message reminders and education to pregnant women with diabetes helps them follow their care plan—like keeping appointments, tracking blood sugar, and taking medications. About 185 participants will be randomly assigned to receive texts or st…

This trial compares two surgical methods for diabetic patients with proliferative diabetic retinopathy who need vitrectomy. One method spares the central part of the retina (fovea), while the other removes the entire inner limiting membrane. The study will measure vision and eye …

This early-phase study tests whether transplanting insulin-making islet cells can help people with difficult-to-control type 1 diabetes. Participants receive donor islet cells along with immune-suppressing drugs to prevent rejection. The goal is to reduce or stop insulin injectio…

This study tests a snack bar made from red beans and tomatoes, called GlycoBite, in 100 people with type 2 diabetes. Participants eat one 40-gram bar daily for three weeks. Researchers check if it helps lower fasting blood sugar and HbA1c levels. The goal is to see if this simple…

This study offers voluntary screening for newborns in North Carolina to detect a wide range of rare health conditions early. Using a small blood sample already collected at birth, the program tests for dozens of disorders, including spinal muscular atrophy, cystic fibrosis, and m…

This study tests a new way to screen for type 2 diabetes by measuring sugar levels in fingernails. Researchers will compare results from 100 adults (half with known diabetes, half without) to standard blood tests. The goal is to see if this simple, non-invasive method can accurat…

This study tests whether a blood test for NT-proBNP can spot undiagnosed heart failure in 706 people with diabetes who are at high risk. Those with elevated levels get a heart ultrasound and exam. The goal is to see if this screening strategy leads to more early diagnoses and pro…

This study tests a program where Black mothers and their 9th- or 10th-grade daughters work together to increase physical activity and improve diet, aiming to prevent obesity. About 120 pairs will join, with daughters at higher risk due to weight. The program uses activity tracker…

This study tests whether the BCG vaccine, normally used for tuberculosis, can prevent type 2 diabetes in people with pre-diabetes. Researchers in Guinea-Bissau will give two doses of BCG or a placebo to 200 adults and track their blood sugar levels. The goal is to see if the vacc…

This study tests a free, culturally tailored program called Eat, Move, Live (EML) to help reduce the risk of cancer and chronic diseases like diabetes in underserved communities. About 347 adults will attend nutrition and physical activity sessions over 12 weeks. Researchers will…

This study tests a remote education program called REST, designed to help adults aged 65 and older with insulin-treated diabetes start and keep using continuous glucose monitors (CGMs). The goal is to reduce dangerous low blood sugar episodes and improve overall glucose control. …

This study tests whether an 8-week nutrition education program focused on fiber-rich foods (like fruits, vegetables, and whole grains) is acceptable and helpful for people with diabetes, prediabetes, or obesity. Researchers will track participants' weight and dietary changes over…

This study was designed to compare a tiny steroid insert (Dextenza) placed in the tear duct against standard steroid eye drops (prednisolone) after cataract surgery in people with diabetes. The goal was to see which better controls eye inflammation and swelling. However, the stud…

This study follows 121 adults who have been cured of chronic hepatitis C to understand why some still develop liver complications like scarring or cancer. Participants are monitored for up to 10 years with regular tests, scans, and occasional liver biopsies. The goal is to learn …

This large study is looking at the genes of over 9,000 people with diabetes and kidney disease, along with their family members. The goal is to find which genes make some people more likely to get diabetic kidney disease. By understanding the genetic roots, researchers hope to de…

This study compares two ways of delivering a health and wellness program to people with chronic conditions like diabetes and high blood pressure. One group gets a kit with a tablet and home monitors for blood pressure and blood sugar; the other gets standard phone calls. The goal…

This study looks at whether the adrenaline (epinephrine) commonly added to local anesthesia for tooth extraction raises blood sugar levels. Researchers will measure blood glucose before, during, and after the procedure in 90 adults—half with type 2 diabetes and half without. The …

This study looks at ways to help more adults with type 2 diabetes get screened for colorectal cancer. Researchers are testing a program that works with patients, their care teams, and clinics to make screening easier. The goal is to see if this approach increases the number of pe…

This study looks at how a measure called the hemoglobin glycation index (HGI) changes over time in 750 adults with diabetes who use continuous glucose monitors. HGI compares lab-measured blood sugar levels with estimated levels from a glucose monitor. Researchers will collect dat…

This study tests a 10-week educational program called HomeStyles-China, designed to help Chinese American adults improve their diet, increase physical activity, and reduce risk factors for heart disease and diabetes. Researchers will enroll 400 participants and measure changes in…

This study looks at over 10,000 adults in Ecuador to understand why some people with diabetes develop kidney disease. Researchers will collect health surveys, blood and urine samples, and kidney tissue to study social, environmental, and biological factors. The goal is to find ne…

This study uses a continuous glucose monitor (a small sensor) to track blood sugar levels in 40 adults with diabetes and end-stage kidney disease who are on dialysis. The goal is to see how glucose changes during and between dialysis sessions over two weeks, and whether those pat…

This study will measure nerve signals in 50 adults aged 45 to 76 with diabetic peripheral neuropathy. Researchers will compare these signals with blood sugar levels, diabetes duration, and neuropathy symptom scores. The goal is to find better ways to detect nerve damage early.

This study is testing whether MRI scans can help predict pancreas health and complications like diabetes in children and young adults aged 5 to 21. Researchers will compare MRI images with standard tests like endoscopic pancreas function tests and blood work. The goal is to see i…

This study is building a large biobank of health information and blood samples from 48,000 people with diabetes in Hong Kong. Researchers will analyze genetic and other markers to find better ways to predict serious complications like kidney failure, heart disease, and stroke. Th…

This large study is testing whether a risk-scoring tool (called ENDPAC) can identify people with new-onset diabetes who are at higher risk for pancreatic cancer. About 8,800 participants aged 50-85 will have their medical records checked for age, weight changes, and blood sugar t…

This study looks at how to help VA medical centers offer virtual programs that prevent heart disease, diabetes, and depression in women Veterans. Researchers are testing two different support strategies at 20 VA sites to see which works better. The study does not involve patients…

This study aimed to learn more about using a CT scan to check for calcium buildup in the heart arteries of people with diabetes. The goal was to improve screening and treatment decisions. However, the study was withdrawn before enrolling any participants, so no new information wa…

This study follows over 5,000 Black and White men and women from age 18-30 for many years to see how their lifestyles and health habits affect their risk of heart disease later in life. Researchers measure things like blood pressure, weight, and cholesterol to understand why some…

This study followed nearly 6,000 adults aged 65 and older to learn what factors predict heart disease, stroke, and related health problems. Researchers aimed to identify risks and understand what leads to disability or death after a heart event. The study did not test a new treat…

This study followed over 6,800 adults from different racial and ethnic backgrounds to understand how heart disease develops over time. Participants were healthy at the start and were monitored for risk factors and heart-related events like heart attacks and strokes. The goal is t…

This observational study plans to enroll 120,000 people with various chronic diseases like pancreatitis, diabetes, and arthritis. Researchers will collect blood samples and health data to study how genetics and lifestyle affect disease progression. The goal is to find common dise…

This study collects blood, urine, and tissue samples from 500 obese adults to help researchers understand why people gain weight, lose weight, or regain weight after treatment. Participants must be over 18 with a BMI of 30 or higher. The samples will be stored for up to 10 years …

This study looks at whether a telehealth program called ECHO can help healthcare teams in New Mexico better care for patients with diabetes and other chronic conditions. The program connects primary care providers with specialists through video sessions for training and case disc…

This study uses advanced MRI scans to measure the size and texture of the pancreas in people recently diagnosed with type 1 diabetes. Researchers hope to develop standard methods for assessing the pancreas, which could improve understanding of the disease. About 250 participants …

This study was designed to see if training residents of Boston housing developments as Community Health Ambassadors could help more people get primary care visits and screenings for diabetes and high blood pressure. The ambassadors would have led workshops and connected neighbors…

This observational study tracks 300 adults with diabetes who take SGLT-2 inhibitors and are recovering from surgery in the intensive care unit. Researchers want to find out how often a rare type of diabetic ketoacidosis (called euglycemic DKA) occurs after surgery. The goal is to…

This study follows over 3,000 Black people with HIV in the UK to understand how genes and lifestyle affect their risk for kidney disease, heart disease, diabetes, and obesity. Researchers collect health data and blood/urine samples to find genetic markers that predict these condi…