Could a diabetes drug turn back the biological clock in HIV?
NCT ID NCT07707778
First seen Jul 16, 2026 · Last updated Jul 21, 2026 · Updated 3 times
Summary
This study investigates whether tirzepatide, a drug used for diabetes and weight loss, can reverse biological aging in people with HIV who are virally suppressed and have obesity. Participants receive tirzepatide for 25 weeks after a diet program. Researchers measure epigenetic aging using DNA methylation clocks and also track changes in body fat and liver health. The goal is to see if the drug can restore a more youthful biological age and improve metabolism.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- a drug called tirzepatide, which is a GLP-1 and GIP receptor agonist used for diabetes and weight loss
- What this could lead to
- If successful, this could show that tirzepatide slows or reverses biological aging in people with HIV, potentially reducing age-related health risks.
- What could go wrong
- This is a small pilot study with only 60 participants, so results may not apply to everyone. The effect on aging is measured by blood markers, not direct health outcomes, and the drug may cause side effects like nausea or digestive issues.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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National Taiwan University Hospial
Taipei, Taiwan
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