METABOLIC DYSFUNCTION ASSOCIATED STEATOTIC LIVER DISEASE
Clinical trials for METABOLIC DYSFUNCTION ASSOCIATED STEATOTIC LIVER DISEASE explained in plain language.
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Can these diabetes drugs stop liver failure? major trial launches
Disease control Recruiting nowThis large phase 3 study is testing whether two drugs, tirzepatide and retatrutide, can prevent major liver complications in 4,500 adults with high-risk metabolic fatty liver disease (MASLD). Participants are randomly assigned to receive one of the drugs or a placebo for about 4 …
Matched conditions: METABOLIC DYSFUNCTION ASSOCIATED STEATOTIC LIVER DISEASE
Phase: PHASE3 • Sponsor: Eli Lilly and Company • Aim: Disease control
Last updated Jun 27, 2026 14:03 UTC
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Could a stomach tuck reverse fatty liver?
Disease control Recruiting nowThis study tests whether a minimally invasive procedure called endoscopic sleeve gastroplasty (ESG), which reduces stomach size by 70%, can help reverse fatty liver disease (MASH) in people with obesity. Researchers will compare ESG plus lifestyle changes to lifestyle changes alo…
Matched conditions: METABOLIC DYSFUNCTION ASSOCIATED STEATOTIC LIVER DISEASE
Phase: NA • Sponsor: Pichamol Jirapinyo, MD, MPH • Aim: Disease control
Last updated Jun 27, 2026 14:02 UTC
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New drug targets liver fat and weight in obesity trial
Disease control Recruiting nowThis study tests whether the drug maridebart cafraglutide can reduce liver fat and body weight in adults who are overweight or obese and have high liver fat. Participants will also follow a reduced-calorie diet and increase physical activity. The trial involves 180 adults and las…
Matched conditions: METABOLIC DYSFUNCTION ASSOCIATED STEATOTIC LIVER DISEASE
Phase: PHASE2 • Sponsor: Amgen • Aim: Disease control
Last updated Jun 27, 2026 14:00 UTC
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New study tests tailored Weight-Loss program for obesity
Disease control Recruiting nowThis study tests a program called MiWeigh that helps people with obesity and related conditions like diabetes or high blood pressure lose weight. Participants get a personalized plan from a doctor, access to a website, and weekly check-ins. The goal is to see if this approach lea…
Matched conditions: METABOLIC DYSFUNCTION ASSOCIATED STEATOTIC LIVER DISEASE
Phase: NA • Sponsor: University of Michigan • Aim: Disease control
Last updated Jun 27, 2026 13:07 UTC
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Teen liver crisis: diet trial offers hope
Disease control Recruiting nowThis study tests two diet approaches—essential amino acids and a low-sugar diet—in teens aged 11-17 with fatty liver disease and heart risk. The goal is to reduce liver fat and improve health. Participants will be assigned to one or both diets over time to find the best treatment…
Matched conditions: METABOLIC DYSFUNCTION ASSOCIATED STEATOTIC LIVER DISEASE
Phase: PHASE2 • Sponsor: Michigan State University • Aim: Disease control
Last updated Jun 27, 2026 13:00 UTC
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Experimental drug ALN-CIDEB targets fatty liver in early trial
Disease control Recruiting nowThis study tests an experimental drug called ALN-CIDEB in adults with fatty liver conditions (MASLD or MASH). The main goal is to check safety and tolerability, and also to see if the drug can reduce liver fat. About 132 participants will receive either the drug or a placebo. Thi…
Matched conditions: METABOLIC DYSFUNCTION ASSOCIATED STEATOTIC LIVER DISEASE
Phase: PHASE1, PHASE2 • Sponsor: Regeneron Pharmaceuticals • Aim: Disease control
Last updated Jun 27, 2026 12:24 UTC
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Gut bacteria boost may help fight fatty liver
Disease control Recruiting nowThis study is testing whether a multi-strain probiotic supplement, taken alongside standard lifestyle advice, can improve liver health in people with Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD). The trial will enroll 80 adults with elevated liver enzymes and …
Matched conditions: METABOLIC DYSFUNCTION ASSOCIATED STEATOTIC LIVER DISEASE
Phase: NA • Sponsor: Fu Jen Catholic University Hospital • Aim: Disease control
Last updated Jun 27, 2026 12:04 UTC
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Could a gut bug help heal fatty liver? new trial begins
Disease control Recruiting nowThis early-stage trial is testing whether a pasteurized gut bacterium called Akkermansia muciniphila can help people with metabolic dysfunction-associated steatotic liver disease (MASLD), a common fatty liver condition. About 40 adults will take either a low, medium, or high dose…
Matched conditions: METABOLIC DYSFUNCTION ASSOCIATED STEATOTIC LIVER DISEASE
Phase: PHASE1 • Sponsor: Leeuwenhoek Laboratories Co. Ltd. • Aim: Disease control
Last updated Jun 27, 2026 12:00 UTC
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Could an antibiotic help reverse fatty liver? new trial launches
Disease control Recruiting nowThis study tests whether a gut-acting antibiotic called rifaximin-α can reduce liver fat in people with metabolic fatty liver disease (MASLD). About 60 adults will take either the drug or just follow diet and exercise advice for 24 weeks. The goal is to see if the drug safely low…
Matched conditions: METABOLIC DYSFUNCTION ASSOCIATED STEATOTIC LIVER DISEASE
Phase: EARLY_PHASE1 • Sponsor: Shanghai Changzheng Hospital • Aim: Disease control
Last updated Jun 27, 2026 09:02 UTC
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Can a menopause-mimicking drug fight fatty liver in endometriosis patients?
Disease control Recruiting nowThis study tests whether goserelin acetate, a drug that temporarily stops menstruation (like a short-term menopause), can reduce liver fat in women with endometriosis who also have fatty liver disease. Researchers will measure liver fat and stiffness using ultrasound in 62 women …
Matched conditions: METABOLIC DYSFUNCTION ASSOCIATED STEATOTIC LIVER DISEASE
Phase: PHASE4 • Sponsor: Aristotle University Of Thessaloniki • Aim: Disease control
Last updated Jun 27, 2026 09:01 UTC
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Indianized mediterranean diet takes on fatty liver in kids
Disease control Recruiting nowThis study compares an Indianized version of the Mediterranean diet to a standard low-fat diet for reducing liver fat in overweight children and teens with a fatty liver condition called MASLD. About 134 participants aged 8 to 18 will follow one of the two diets for 180 days. The…
Matched conditions: METABOLIC DYSFUNCTION ASSOCIATED STEATOTIC LIVER DISEASE
Phase: NA • Sponsor: Institute of Liver and Biliary Sciences, India • Aim: Disease control
Last updated Jun 27, 2026 08:08 UTC
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Automated blood test strategy could spot hidden liver disease in routine checkups
Diagnosis Recruiting nowLiverSeek is a study testing an automated screening program for advanced liver fibrosis in people aged 50-75 with risk factors like diabetes or obesity. When a routine blood test is done, the lab system automatically calculates a fibrosis score and, if needed, orders additional t…
Matched conditions: METABOLIC DYSFUNCTION ASSOCIATED STEATOTIC LIVER DISEASE
Sponsor: Hospital General Universitario Gregorio Marañon • Aim: Diagnosis
Last updated Jun 27, 2026 14:01 UTC
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Could a simple ultrasound replace costly MRIs for fatty liver diagnosis?
Diagnosis Recruiting nowThis study is testing a new ultrasound technology called DeepUSFF to measure fat in the liver of people with metabolic fatty liver disease (MASLD). Researchers will compare the ultrasound results to MRI scans, which are the current gold standard. If the ultrasound works well, it …
Matched conditions: METABOLIC DYSFUNCTION ASSOCIATED STEATOTIC LIVER DISEASE
Phase: NA • Sponsor: Seoul National University Hospital • Aim: Diagnosis
Last updated Jun 27, 2026 07:51 UTC
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Can eating only during an 8-10 hour window help liver cancer patients?
Symptom relief Recruiting nowThis study is testing whether a time-restricted eating plan (eating only during an 8-10 hour window each day) combined with a healthy plant-based diet is safe and doable for people with liver cancer, cirrhosis, or fatty liver disease. Fifty overweight or obese adults will either …
Matched conditions: METABOLIC DYSFUNCTION ASSOCIATED STEATOTIC LIVER DISEASE
Phase: NA • Sponsor: University of California, San Diego • Aim: Symptom relief
Last updated Jun 27, 2026 14:03 UTC
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AI chatbot aims to curb drinking in liver disease patients
Symptom relief Recruiting nowThis study tests whether a chatbot powered by large language models can help people with metabolic alcohol-related liver disease (MetALD) reduce their alcohol intake. About 50 adults in Hong Kong will use the chatbot for counseling. The main goal is to see if the approach is prac…
Matched conditions: METABOLIC DYSFUNCTION ASSOCIATED STEATOTIC LIVER DISEASE
Phase: NA • Sponsor: The University of Hong Kong • Aim: Symptom relief
Last updated Jun 27, 2026 12:00 UTC
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Fatty liver frailty: do men and women differ?
Knowledge-focused Recruiting nowThis observational study aims to see if frailty—a state of increased weakness and vulnerability—differs between men and women with MASLD (fatty liver disease). Researchers will track 140 participants over time using physical tests and questionnaires. No drugs or treatments are be…
Matched conditions: METABOLIC DYSFUNCTION ASSOCIATED STEATOTIC LIVER DISEASE
Sponsor: Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:00 UTC
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New EHR alert aims to catch silent liver damage in primary care
Knowledge-focused Recruiting nowThis study tests whether a simple electronic health record alert can help primary care doctors identify patients with fatty liver disease who may have advanced liver scarring. The alert prompts doctors to calculate a risk score and, if needed, order a special ultrasound to check …
Matched conditions: METABOLIC DYSFUNCTION ASSOCIATED STEATOTIC LIVER DISEASE
Phase: NA • Sponsor: Medical University of South Carolina • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:01 UTC
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New study aims to uncover hidden liver risks in diabetes patients
Knowledge-focused Recruiting nowThis study will follow 1,000 adults in Hong Kong who have both type 2 diabetes and a common fatty liver condition called MASLD. Researchers will collect health data and blood samples over time to see how the liver disease progresses and to find early markers of serious liver scar…
Matched conditions: METABOLIC DYSFUNCTION ASSOCIATED STEATOTIC LIVER DISEASE
Sponsor: Chinese University of Hong Kong • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:08 UTC
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Fatty liver secrets revealed: bariatric surgery study probes cell talk
Knowledge-focused Recruiting nowThis study looks at how tiny communication points inside liver cells (called MAMs) change in people with a fatty liver disease called MASH. Researchers will collect liver and blood samples from 20 adults having weight-loss surgery. The goal is to understand what goes wrong in the…
Matched conditions: METABOLIC DYSFUNCTION ASSOCIATED STEATOTIC LIVER DISEASE
Sponsor: Hospices Civils de Lyon • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:11 UTC
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Fatty liver gene hunt: could your DNA raise your risk?
Knowledge-focused Recruiting nowThis study is looking at a specific gene, PNPLA3, in 600 adults with a type of fatty liver disease called MASLD. Participants are from Guadeloupe, French Guiana, and Réunion Island. Researchers want to see how common certain gene variants are and if they are linked to more severe…
Matched conditions: METABOLIC DYSFUNCTION ASSOCIATED STEATOTIC LIVER DISEASE
Sponsor: Centre Hospitalier Universitaire de la Guadeloupe • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:09 UTC
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Hidden liver danger: new study scans cancer survivors for fatty liver disease
Knowledge-focused Recruiting nowThis study is checking how common liver disease (MASLD) is in people who survived breast or colorectal cancer. Researchers will use painless scans and blood tests instead of a liver biopsy. The goal is to find better ways to catch liver problems early in cancer survivors.
Matched conditions: METABOLIC DYSFUNCTION ASSOCIATED STEATOTIC LIVER DISEASE
Sponsor: University of Bern • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:03 UTC