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Exercise may fight fatty liver by targeting hidden muscle fat

NCT ID NCT06506513

Disease control Sponsor: Cliniques universitaires Saint-Luc- Université Catholique de Louvain Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 14, 2026 · Last updated Jul 15, 2026 · Updated 1 time

Summary

This trial investigates whether different intensities of physical exercise can reduce fat stored in muscles (myosteatosis) and improve liver health in people with metabolic dysfunction-associated steatotic liver disease (MASLD). Researchers will compare high-intensity interval training, moderate intensity exercise, and low intensity exercise over several weeks. The goal is to see if reducing muscle fat can help treat the liver condition.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
exercise training (high-intensity interval training, moderate intensity, or low intensity)
What this could lead to
If successful, this could show that tailored exercise programs are an effective way to treat fatty liver disease by targeting muscle fat.
What could go wrong
This is a small, early-stage trial with 60 participants, so results may not apply to everyone. It is also unclear which exercise intensity works best or if benefits last long-term.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 60 people

The number the study aims to enrol. It can still change while the study runs.

Started

Sep 2025

Expected to finish

Sep 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 70 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * confirmed MASLD at abdominal imaging * confirmed excessive muscle lipid content at imaging * stable weight Exclusion Criteria: * severe comorbidities including active malignancies, neuromuscular degenerative diseases * contraindications to physical activity * excessive alcohol consumption

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Conditions

The condition(s) this trial relates to.

metabolic dysfunction-associated steatotic liver disease Motor Activity

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Metabolic dysfunction-associated steatotic liver disease

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    2 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Centre d'investigation clinique en nutrition

    RECRUITING

    Louvain-la-Neuve, 1348, Belgium

  • Cliniques universitaires Saint-Luc

    RECRUITING

    Brussels, 1200, Belgium

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