Could a common sugar fuel liver damage?

NCT ID NCT07013916

Recruiting now Knowledge-focused Sponsor: Queen Mary University of London Source: ClinicalTrials.gov ↗

First seen Jul 31, 2026 · Last updated Jul 31, 2026

Summary

This trial asks whether fructose, a sugar found in fruit and processed foods, causes more liver inflammation in people with MASH (a serious fatty liver disease) than in those with milder fatty liver or no liver disease. Over four weeks, participants follow a low-sugar diet and then add either fructose or glucose supplements. Researchers compare blood, urine, and stool samples to see if fructose triggers inflammation and affects liver fat and gut bacteria.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: fructose (a type of sugar) compared with glucose (another type of sugar)
What this could lead to: If fructose is shown to trigger more inflammation in MASH, this could point toward dietary advice or treatments that limit fructose to slow liver damage.
What could go wrong: This is a small, short-term study, so results may not apply to everyone. It looks at markers of inflammation, not long-term outcomes like cirrhosis or liver cancer.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

fatty liver disease Inflammation metabolic dysfunction-associated steatohepatitis metabolic dysfunction-associated steatotic liver disease visceral steatosis, congenital

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MASH - METABOLIC DYSFUNCTION-ASSOCIATED STEATOHEPATITIS MASH WITH FIBROSIS STEATOSIS OF LIVER

Contacts and locations

Locations

Blizard Institute, Faculty of Medicine and Dentistry, Queen Mary University of London
RECRUITING

London, E1 2AT, United Kingdom
Royal London Hospital
RECRUITING

London, E1 1FR, United Kingdom

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