Queen Mary University Of London

This study tests if a less invasive procedure called thermal ablation (using heat from a needle) works as well as surgery to cure primary aldosteronism, a condition where a small adrenal gland tumor causes high blood pressure. About 122 adults with a tumor in one adrenal gland wi…

This study tests whether adding durvalumab to datopotamab deruxtecan helps people with a type of advanced breast cancer called PDL1-negative triple-negative breast cancer. About 140 women will be randomly assigned to get either the drug combination or the single drug alone. The g…

This study tests whether giving the drug atezolizumab before surgery can shrink tumors in people with certain types of urinary tract cancer. Atezolizumab helps the immune system recognize and attack cancer cells. About 58 adults will receive two cycles of the drug, then undergo s…

This study tests whether starting the MS drug natalizumab within 14 days of first symptoms can help repair nerve damage in the brain. About 40 adults with early signs of multiple sclerosis will receive either the drug or a placebo for 12 weeks. The goal is to see if quick, strong…

This study tests whether a drug called ixazomib, currently used for cancer, is safe for people with multiple sclerosis (MS). About 72 adults with relapsing-remitting or progressive MS will take either ixazomib capsules or a placebo for up to 24 months. Researchers will monitor si…

This study will train non-expert staff at GP clinics to perform quick heart ultrasounds on people 65 and older during routine check-ups. The goal is to find heart valve disease and heart failure early, especially in diverse communities where these conditions are often missed. Res…

This study looks at the best way to prevent blood clots in people with leg casts or splints after an injury. For those at high risk of clots, it compares pills to standard injections. For those at low risk, it checks if any medication is better than just advice. Over 10,000 parti…

This study offers free genetic testing to 5000 women, trans men, and non-binary people with female reproductive organs to find inherited gene changes that raise the risk of breast, ovarian, bowel, and womb cancers. Participants use a smartphone app to decide if they want testing,…

This study tests whether a special gel, made with hyaluronic acid and octenidine, can improve early healing after non-surgical gum treatment for periodontitis. About 26 adults with advanced gum disease will receive either standard deep cleaning alone or deep cleaning plus the gel…

This study looks at whether giving extra support and advice helps people with obstructive sleep apnea use their mouthpiece more regularly. About 56 adults aged 40 and older will be split into two groups: one gets routine care, the other gets additional support. Researchers will t…

This study compares 3 versus 6 cycles of platinum-based chemotherapy before maintenance treatment with avelumab in 320 people with advanced bladder cancer. The goal is to see if fewer chemotherapy cycles improve quality of life without affecting disease control. Participants rece…

This study tests whether a doctor's recommendation to join an online asthma community can help adults with troublesome asthma control their symptoms and feel better. About 600 participants will be followed for 12 months to see if the digital support improves asthma control, anxie…

This study looks at whether being active in high air pollution is worse for children's lungs than just resting in the same polluted air. Researchers will measure airway resistance and immune responses in 330 children from London schools. The goal is to understand how short-term p…

This study collects leftover tissue and blood samples from 3,000 adults with solid tumors during routine care. Researchers will use advanced lab tests to find out why cancer cells spread and become resistant to treatments. The goal is to discover clues that could lead to better t…

This study tests whether a new community program can help reduce loneliness in young adults aged 20 to 40 living in London. The program offers social activities, online spaces, and low-cost events to encourage connections. Researchers will measure how well the program works and i…

This study looks at whether placing a balloon in the main artery (aorta) during CPR can help blood flow to the heart and brain in people who have a cardiac arrest outside the hospital. It involves 40 adults aged 18-80 with no major injuries. The goal is to see if the procedure is…

This study aims to understand how air pollution affects pregnancy and increases the risk of preterm birth. Researchers will use artificial intelligence to analyze health records from 200,000 pregnant women in London, along with pollution data from their neighborhoods. The goal is…

This study looks at 1,500 people with a common skin cancer called cutaneous squamous cell carcinoma. Researchers want to see how well current staging systems predict if the cancer will come back or spread. The goal is to improve how doctors assess risk and manage this cancer.

This study looks at how blood flow patterns inside stented arteries may lead to dangerous clots (stent thrombosis). Researchers will use computer models to analyze blood flow in 120 people who have had a stent placed. The goal is to find flow-related markers that could predict cl…

This study follows 60 adults undergoing thoracoabdominal aorta repair to understand why about half develop persistent pain around the incision. Researchers will use sensory tests, pain scores, and blood/spinal fluid analysis to identify risk factors. The goal is to find ways to p…

This study looks at how small changes in your genes might affect the body's natural ability to control inflammation. Researchers will analyze blood samples from 200 volunteers to measure molecules that help resolve inflammation. The goal is to better understand why some people de…

This study looks at why heart disease affects women differently than men, especially after menopause. Researchers will measure inflammation and hormone levels in 6,000 women with chest pain. The goal is to understand how these factors influence heart attack risk and recovery, lea…

This study looks at whether placing a dental implant right after a tooth is pulled (immediate) or waiting a few months (delayed) changes how the mouth heals. Researchers will measure healing markers in saliva and gum fluid from 24 adults over 30 days. The goal is to understand th…

This study is a large registry that will collect health information from up to 60,000 patients with both heart and kidney disease. The goal is to better understand how these conditions interact and what factors affect patient outcomes. No new treatments are being tested; instead,…

This study tests a small wearable device that measures lactate levels through the skin in 50 patients recovering from heart surgery. Researchers compare the device's readings to standard blood tests to see if it is accurate. If successful, the device could reduce the need for fre…

This study is collecting information from 1500 people who either have a blood clot in the main heart chamber (left ventricular thrombus) or are at high risk for developing one. The goal is to learn what factors lead to clot formation and how to better manage the condition, which …

This study is a registry for people who have had a heart attack but no blocked arteries (MINOCA). It aims to collect data from 3000 patients to better understand the causes, improve diagnosis, and guide future treatments. Participants will be followed over time to track outcomes …

This early-phase study aims to understand why healthy women seem to resolve inflammation better than men, which may help explain sex differences in heart disease. Researchers will create small blisters on the skin of 34 healthy volunteers aged 18-45 and compare blister size, flui…

This study follows 20,000 heart attack patients who are discharged early from the hospital to see how well their medications are adjusted, track major heart events, and measure quality of life over one year. It aims to improve care for future patients by learning from real-world …

This study looks at whether adding nitrate—a natural compound found in leafy greens and beetroot—to common foods like cereal bars, porridge, and biscuits can help the body produce more nitric oxide, which may lower blood pressure. Thirty healthy adults will eat these fortified fo…

This study is gathering information from 30 testicular cancer patients in the UK who are receiving either standard treatments or less intensive options. Researchers want to see if patients are willing to join such studies, how different treatments affect cancer outcomes and quali…