Queen Mary University Of London

This study is testing if a drug called atezolizumab can shrink tumors before surgery for patients with certain cancers of the urinary system (bladder, kidney, or ureter). The drug works by helping the patient's own immune system recognize and attack the cancer cells. Eligible pat…

This study tests if starting a powerful MS medication called Tyruko (natalizumab) within just 14 days of a person's first MS-like symptoms leads to better nerve repair. It will involve 40 UK adults who have recently shown signs of MS. Researchers will use special brain scans to s…

This study is exploring whether milder treatments can effectively control testicular cancer while causing fewer side effects. Researchers will follow 30 patients in the UK who receive either standard treatments or these gentler approaches. The goal is to see if patients are willi…

This study is testing if a small balloon can be placed in a major artery during a cardiac arrest to help improve blood flow to the brain and heart. It will be done by a specialized air ambulance team on 40 patients who have collapsed outside of a hospital. The goal is to see if t…

This study is testing whether a minimally invasive heat treatment (thermal ablation) works as well as surgery to cure a specific hormone disorder that causes severe high blood pressure. Researchers will compare the two procedures in 122 patients who have the condition in one adre…

This study is testing whether a doctor's recommendation to join a dedicated online asthma support community helps adults with troublesome asthma feel better. About 600 UK participants will be randomly assigned to either get this advice and access to the group or to receive their …

This small pilot study is testing if adding a special gel to standard deep cleaning for gum disease helps the gums heal better. The gel contains hyaluronic acid and an antiseptic. Researchers will measure healing signs, bacteria levels, and patient comfort in about 26 people over…

This study is testing if a two-drug combination works better than a single drug for people with a specific, hard-to-treat type of advanced breast cancer that has spread. It will involve about 140 adults with a form of breast cancer that doesn't respond to standard hormone or targ…

This early-stage study is checking if a drug called ixazomib, used for a type of blood cancer, is safe for people with multiple sclerosis (MS). The goal is to see if it can reduce harmful antibodies linked to MS in the fluid around the brain and spine. About 72 participants with …

This study aims to develop a better test to catch pancreatic cancer early. Researchers are collecting urine and blood samples from 3,500 people who have symptoms or are at risk for the disease. They will analyze these samples to see if a new combination of markers can accurately …

This study aims to improve early detection of heart valve disease and heart failure in older adults from diverse communities. Researchers will train non-expert staff at local clinics to perform quick heart ultrasound scans during routine check-ups. The goal is to find these condi…

This study is testing a new wearable sensor that sticks to the arm to continuously measure lactate, a substance in the body that can signal stress. Researchers want to see if the sensor's readings are as accurate as traditional blood tests taken from patients recovering from plan…

This study offers free genetic testing to 5,000 people to check for hidden gene changes that increase the risk of breast, ovarian, bowel, and womb cancers. Participants use a smartphone app to learn about testing and receive a saliva kit by mail if they choose to participate. The…

This large UK study aims to find the best way to prevent dangerous blood clots in people who get a leg cast or splint after an injury. It will test if taking pills is as effective and easier than the standard daily injections for high-risk patients, and if any medication is bette…

This study is testing whether a new community program can help reduce loneliness in young adults. The program offers weekly social activities and online spaces for people aged 20-40 in London who often feel lonely. Researchers want to see if the program is practical, well-liked, …

This study aims to understand if specific patterns of blood flow inside a heart stent can predict the dangerous formation of a blood clot (stent thrombosis). Researchers will analyze detailed imaging scans from 120 patients who have had a stent placed. By comparing patients who d…

This study is creating a large registry to track the health of 60,000 patients who have both chronic kidney disease and heart problems. The goal is to better understand how these conditions interact and affect patient outcomes like hospital readmissions and survival. By analyzing…

This research aims to understand how air pollution affects pregnancy. Scientists will use artificial intelligence to analyze the health records of 18,000 women who gave birth in London, linking them to local air quality data. The goal is to build a computer model that can predict…

This study is creating a long-term registry to learn more about a puzzling type of heart attack where the main heart arteries are not blocked (called MINOCA). It will follow 3,000 patients to understand what causes these events, how they are diagnosed, and what the long-term outc…

This study aims to understand why heart disease develops differently in women and men, focusing on the roles of hormones and inflammation. Researchers will collect blood samples and survey 6000 patients with chest pain to analyze hormone levels and inflammatory markers. The goal …

This study is testing whether adding a natural compound called nitrate to common foods like cereal bars, porridge, and biscuits can help the body produce more nitric oxide, which may lower blood pressure. Thirty healthy volunteers will try all three fortified foods in a random or…

This study aims to understand how a person's genes affect their body's natural ability to stop inflammation. Researchers will analyze blood samples and health records from 200 volunteers of South Asian descent who are already part of a larger genetics program. The goal is to see …

This study aims to understand why men and women experience heart disease differently by comparing how their bodies resolve inflammation. Researchers will create small, temporary skin blisters on healthy volunteers to measure healing responses over three days. The goal is to gathe…

This study aims to understand why cancer spreads and stops responding to treatment. Researchers will collect leftover tumor and blood samples from up to 3,000 patients over time. By analyzing these samples with advanced lab tests, they hope to discover clues that could lead to mo…

This study aims to understand why about half of patients develop long-lasting pain after major chest and abdominal aorta surgery. Researchers will observe 60 patients before and after their operation, measuring pain levels, painkiller use, and body chemistry to identify who is mo…

This study aims to understand if physical activity outdoors on high pollution days is worse for children's lungs than resting outdoors. Researchers will measure lung function and inflammation in 330 children from London schools after they do PE lessons or science lessons in their…

This study is testing if a drug called Racecadotril, which is normally used for diarrhea, can reduce fluid leaks in a safe skin blister model. Researchers are using this model to see if the drug might help strengthen blood vessel barriers, which could be important for treating a …

This study is collecting real-world information on 20,000 heart attack patients in London who were sent home early after a common artery-opening procedure. The goal is to understand how these patients fare after leaving the hospital, what medications they take, and their quality …

This study aims to understand how the timing of placing a dental implant affects the early healing process. Researchers will compare placing an implant immediately after a tooth extraction versus waiting (delayed placement) in about 24 participants. They will measure specific hea…