Queen Mary University Of London

This study tests if a less invasive needle-based treatment (thermal ablation) works as well as surgery to cure a hormone disorder called primary aldosteronism, which causes high blood pressure. About 122 adults with the condition will be randomly assigned to one of the two treatm…

This study is for women with a type of advanced breast cancer called triple-negative breast cancer that does not have the PDL1 protein. It tests whether adding an immunotherapy drug (durvalumab) to a targeted chemotherapy (datopotamab deruxtecan) works better than the chemotherap…

This study compares 3 versus 6 cycles of platinum-based chemotherapy followed by the immunotherapy drug avelumab in 320 people with advanced bladder cancer. The goal is to see if fewer chemo cycles improve quality of life without harming cancer control. Participants receive eithe…

This study tests whether a new gel containing hyaluronic acid and octenidine can improve gum healing after standard deep cleaning for periodontitis. About 26 adults with advanced gum disease will receive either cleaning alone or cleaning plus the gel. Researchers will measure hea…

This study tests whether giving the drug natalizumab (Tyruko) within two weeks of first MS symptoms can help repair nerve damage. Forty adults with a first episode of MS-like inflammation will receive either the drug or a placebo. The main goal is to see if early treatment improv…

This phase 2 trial tests whether the drug atezolizumab can shrink tumors in people with urothelial cancer before they have surgery. Participants receive two doses of atezolizumab, then undergo standard surgery to remove the tumor. Researchers will compare tissue and blood samples…

This phase 1b trial is testing whether ixazomib, a drug already used for multiple myeloma, is safe for people with multiple sclerosis. The study will enroll 72 adults with relapsing-remitting or progressive MS. Participants will receive either ixazomib or a placebo for up to 24 m…

This study looks at whether doing a CT scan of the heart's arteries before the usual catheter procedure can lower the risk of death, heart attack, stroke, or hospital stays in people who have had bypass surgery. About 1000 participants will be randomly assigned to get the CT scan…

This study trains non-expert staff in GP practices to perform quick heart ultrasounds on people 65 and older. The goal is to find hidden heart valve disease or heart failure early, especially in diverse communities. Researchers hope this approach can reduce emergency hospital vis…

This study offers free genetic testing to 5,000 women, trans men, and non-binary people with female reproductive organs, regardless of family history. The goal is to find hidden gene changes that raise the risk of breast, ovarian, bowel, and womb cancers. Participants use a smart…

This study looks at the best way to prevent blood clots in people who have a leg cast or splint after an injury. For those at high risk of clots, it compares pills to standard injections. For low-risk people, it checks if any medication is better than just advice. Over 10,000 par…

This study tests whether extra support—like a health pamphlet, a video, and motivational counseling—helps people with obstructive sleep apnea use their mandibular advancement appliance (a mouth guard) more consistently. Fifty-six adults (age 40+) with sleep apnea will be randomly…

This study tests a community program for young adults aged 20-40 in London who feel lonely. The program offers free or low-cost social events like walks, bingo, board games, and pub quizzes. Researchers will check if the program is practical and liked by participants, and if it h…

This study tests whether encouraging people with asthma to join an online support group can improve their symptoms and quality of life. 600 adults with poorly controlled asthma will be recruited. Their doctors will introduce them to a private online community where they can read …

This 18-month study tests whether a smartphone app with game-like features can help adults aged 40+ with a reduced sense of smell become more active. 110 participants will be randomly assigned to either a full-dose programme aiming to double their daily steps or a low-dose contro…

This observational study is looking at whether people with primary aldosteronism (a cause of high blood pressure) have hormone levels that vary in cycles or differ between day and night. Researchers will collect urine samples over 24 hours from 100 participants to see if this met…

This study looks at how short-term exposure to air pollution affects children's breathing. Around 330 children from London schools will either take a science lesson or do physical education outdoors. Researchers will measure lung function and immune responses to see if exercising…

This study compares people with non-alcoholic fatty liver disease (NAFLD) to healthy controls to understand how the immune system, metabolism, and gut bacteria differ. Researchers will also track what happens to liver health in NAFLD patients who undergo weight loss surgery. The …

This study is figuring out what normal PSA levels are for trans women and non-binary people who have a prostate. Researchers will measure PSA in 500 volunteers aged 40 and older who are on hormones or have had lower surgery. The goal is to help doctors better detect prostate canc…

This study tests whether adding a safe amount of nitrate—a natural compound found in leafy greens and beetroot—to common oat-based foods like biscuits, cereal bars, and porridge can improve nitric oxide levels and lower blood pressure. Thirty healthy adults will try each fortifie…

This study is testing whether two non-invasive tools—ultrasound and electrical impedance tomography (EIT)—can help doctors monitor breathing muscles in patients with acute respiratory failure who are using non-invasive breathing support. Up to 100 adults will be enrolled, with me…

This study is tracking over 25,000 people with inflammatory bowel disease (IBD) to understand why many continue to have abdominal pain even when their disease is in remission. Researchers will use questionnaires, blood and stool samples, heart rate recordings, and genetic data to…

This study is testing whether a Fitbit can accurately measure heart electrical activity (QT interval) in 80 adults with Long QT Syndrome, a condition that can cause dangerous heart rhythms. Participants will use a Fitbit to take weekly ECG readings at home, which will be compared…

This study is tracking 1,500 people who either have a blood clot in the heart's main pumping chamber (left ventricular thrombus) or are at high risk for one. Researchers will collect blood samples, scan results, and quality-of-life data over 12 months to learn why clots form and …

This study looks at 1,500 people with a common skin cancer called cutaneous squamous cell carcinoma. Most cases are cured with surgery, but a small number can spread and become dangerous. Researchers will compare current staging systems to see which best predicts poor outcomes, a…

This observational study follows 60 adults undergoing thoraco-abdominal aorta repair to understand why some develop persistent pain. Researchers will use sensory tests, pain scores, and blood/spinal fluid analysis to identify risk factors. The goal is to better predict and preven…

This study is testing whether giving less treatment (de-escalation) to men with stage II seminoma testicular cancer is safe and improves quality of life. Researchers will enroll 30 men at two UK hospitals to see if patients are willing to join and how their cancer and well-being …

This study tests whether a balloon device, called REBOA, can be safely used by emergency teams outside a hospital to improve blood flow in people whose heart has stopped (cardiac arrest). The balloon is inserted into the main artery and inflated to redirect blood to the heart and…

This observational study will enroll 120 people who have had a stent placed in their heart artery to see if blood flow patterns can predict dangerous clots. Researchers will use advanced imaging and computer models to compare blood flow in those who had a clot versus those who di…

This study follows 20,000 heart attack patients who are discharged early from the hospital after a minimally invasive procedure. Researchers want to see how well medications are adjusted, track major heart events, and measure quality of life over one year. No new treatment is giv…

This study looks at how small genetic changes influence molecules that naturally resolve inflammation. Researchers will analyze blood samples from 200 volunteers of Bangladeshi and Pakistani origin to understand why some people develop chronic inflammatory diseases like arthritis…

This early-phase study at Queen Mary University of London aims to understand why men and women respond differently to inflammation, which may affect heart disease risk. Researchers will apply a small amount of cantharidin (a blister-inducing chemical) to the skin of 34 healthy vo…

This study is a large registry that will collect health information from up to 60,000 people with both heart and kidney disease. The goal is to better understand how these conditions interact and to find ways to predict and improve patient outcomes. No new treatments or procedure…

This study will use artificial intelligence to analyze health records from 200,000 pregnant women in London, combined with air pollution data, to predict the risk of preterm birth. The goal is to understand when and how pollution exposure is most harmful during pregnancy. Researc…

This study aims to collect tissue and blood samples from 3,000 adults with solid tumors to learn why cancers spread and become resistant to treatments. Researchers will use advanced lab tests to find molecular defects that drive cancer growth. The goal is to use this knowledge to…

This pilot study compares immediate versus delayed dental implant placement after tooth extraction. Researchers will measure healing-related molecules in saliva and gum fluid over 30 days in 24 adults. The goal is to understand how timing affects early healing, which could guide …

This study is a registry that will follow 3000 people who had a heart attack but no blocked arteries (MINOCA). The goal is to learn more about this condition, improve diagnosis, and understand long-term outcomes. Participants will be tracked over time to see how they are doing an…

This study aims to understand why heart disease develops differently in women compared to men. Researchers will measure inflammation markers and hormone levels in 6,000 women with chest pain. They hope to uncover how female sex hormones and inflammation interact to influence hear…