New needle treatment could replace surgery for curing Hormone-Driven high blood pressure

NCT ID NCT05405101

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests if a less invasive needle-based treatment (thermal ablation) works as well as surgery to cure a hormone disorder called primary aldosteronism, which causes high blood pressure. About 122 adults with the condition will be randomly assigned to one of the two treatments. The goal is to see if the needle treatment can normalize blood pressure and hormone levels without the need for long-term medication.

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Conditions

The condition(s) this trial relates to.

hyperaldosteronism primary aldosteronism

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Cambridge University Hospitals NHS Foundation Trust

    RECRUITING

    Cambridge, SMLG, CB2 0QQ, United Kingdom

    Contact Email: •••••@•••••

  • Guy's and St Thomas' NHS Foundation Trust

    RECRUITING

    London, SE1 9RT, United Kingdom

    Contact Email: •••••@•••••

  • Imperial College Healthcare NHS Trust

    RECRUITING

    London, W12 0HS, United Kingdom

    Contact Email: •••••@•••••

  • Sheffield Teaching Hospitals NHS Foundation Trust

    RECRUITING

    Sheffield, S10 2JF, United Kingdom

    Contact Email: •••••@•••••

  • St Bartholomew's Hospital

    RECRUITING

    London, EC1A 7BE, United Kingdom

    Contact Email: •••••@•••••

  • University College London Hospital NHS Foundation Trust

    RECRUITING

    London, NW1 2PG, United Kingdom

    Contact Email: •••••@•••••