Queen Mary University Of London

This study tests a special stent valve (TRICENTO) in 15 people with carcinoid heart disease who have a leaky tricuspid valve and cannot have open-heart surgery. The goal is to see if the implant reduces the leak and improves symptoms and quality of life. Participants will be foll…

This study is for people in Pakistan with hepatitis C whose first treatment didn't work. It compares two different drug combinations to see which one clears the virus better. About 318 adults will take part, and the goal is to find the safest and most effective second-line option…

This study tests whether giving an antimicrobial (infection-fighting) treatment after hospital discharge can prevent death, re-hospitalization, or poor recovery in children aged 6-59 months with complicated severe acute malnutrition. About 674 children will be randomly assigned t…

This study tests whether adding a drug called ATRA (a form of vitamin A) to standard chemotherapy can help people with locally advanced pancreatic cancer live longer without their disease getting worse. About 170 participants will receive either chemo alone or chemo plus ATRA. Th…

This study tests whether cladribine tablets, already used for relapsing MS, can protect hand function in people with advanced MS (EDSS 6.5-8.5). About 204 participants will receive either cladribine or a placebo over two years. The main goal is to see if the drug slows the loss o…

This study tests a new blood test that uses DNA sequencing to identify the bacteria causing infective endocarditis, a serious heart infection. The test aims to be faster than current methods, which can take up to 5 days. Researchers will compare the new test's accuracy to standar…

This study is testing a new blood test that looks for the TB bacteria themselves, not just the body's immune response. Current tests can't tell if dormant TB treatment worked or who will get sick later. Researchers will test 100 people with and without dormant TB to see if this n…

This study is developing a test using urine and blood samples to detect pancreatic cancer earlier. Researchers are collecting samples from 3,500 people with and without pancreatic disease to see how accurate the test is. The goal is to create a simple, non-invasive way to diagnos…

This study tests whether an oral bacterial lysate (Broncho-Vaxom) can reduce wheezing episodes in infants who were hospitalized for severe bronchiolitis. About 173 infants will receive either the lysate or a placebo for up to 24 months. The goal is to see if this approach can pre…

This study looks at whether a 'Learning Health System' can help clinics in Thailand better manage high blood pressure, diabetes, and kidney disease. About 419 people from 16 primary care units will take part. The approach uses electronic health records to give care teams real-tim…

This study tests a new, non-invasive sensor that measures lactate levels through the skin, compared to standard blood tests. Twenty adults undergoing elective heart bypass or valve surgery will wear the sensor for up to 14 hours after surgery. The goal is to see if the sensor wor…

This study tests a computer model that uses artificial intelligence to analyze tissue samples from people with a type of skin cancer called squamous cell carcinoma. The goal is to see if the AI can better predict whether the cancer will spread. 300 participants with confirmed dia…

This study looks at how common high-risk HPV is in transgender people by having them collect their own samples from the vagina, anus, urine, and mouth. Transgender men will also have a clinician-collected cervical swab to compare accuracy. The goal is to make HPV screening more c…

This study looks at whether a drug called Racecadotril can reduce fluid leakage in skin blisters. The blisters are a safe model for what happens in the lungs of patients with Acute Respiratory Distress Syndrome (ARDS), a severe lung injury with no effective treatments. Healthy vo…

This study analyzed data from 3,350 men with early-stage prostate cancer who chose watchful waiting (no immediate treatment). Researchers looked at biological, pathological, and clinical markers to find which factors best predict how the disease will progress. The goal is to help…