OBESITY & OVERWEIGHT

This study tests whether adding enobosarm to the weight-loss drug semaglutide helps people aged 65 and older lose more weight while keeping their muscle strength and physical function. About 200 participants will receive either the combination or semaglutide alone. The goal is to…

This study aims to see if prescribing a specific number of daily steps based on a person's weight and body fat can help overweight and obese adults lose weight and improve heart health. Researchers will track 200 adults aged 20 and older over 8 months using simple pedometers. Par…

This study tests a new medicine called HDM1005, given as a weekly injection, to help people with obesity or overweight lose weight. About 825 Chinese adults who do not have diabetes will receive either the drug or a placebo for 52 weeks, along with diet and exercise advice. The m…

This study tests a 24-week church-based program called FELLAShip to help Black men aged 18 and older improve their heart health. Participants will attend weekly sessions with exercise and health education, get support from a community health worker, and use devices like a smartwa…

This study looks at whether adding exercise to a structured weight loss program helps teens with obesity lower unhealthy blood fats and improve how well their blood vessels work. About 110 young people aged 10 to 20 who are already in a weight loss program will take part. Researc…

This study tests whether empagliflozin, a drug used for diabetes, can help people with HIV who are overweight or obese lose weight and improve their metabolism. About 66 adults with HIV on a specific type of antiretroviral therapy will take either the drug or a placebo for 6 mont…

This study tests whether tirzepatide, a drug already used for diabetes and weight loss, can improve irregular periods in women with PCOS who are overweight or have obesity. About 198 premenopausal women in Germany will receive either tirzepatide or a placebo for 72 weeks. The mai…

This study tests two experimental drugs, AZD6234 and AZD9550, alone or together, for weight loss in Chinese adults who are overweight or obese. About 871 participants aged 18 to 55 with a BMI of 27 or higher will receive injections and be monitored for safety and effectiveness. T…

This study tests whether powerful weight loss drugs can lower blood pressure enough to let young adults (ages 18-40) with obesity and early-stage hypertension stop taking daily blood pressure pills. About 60 participants will either receive standard care (medication and lifestyle…

This study tests whether giving adults with obesity and food insecurity access to healthy groceries or vouchers, along with behavioral weight loss coaching, leads to greater weight loss than coaching alone. About 300 adults will be randomly assigned to one of three groups for 24 …

This study tests whether a supplement called Xanthigen, made from seaweed and pomegranate seed oil, can help overweight adults lose weight. About 180 people with a BMI between 27 and 30 will take either a low dose, high dose, or placebo for 16 weeks. Researchers will measure chan…

This study tests whether a 12-month program of tailored exercise and dietary changes can reduce the amount of time spent in atrial fibrillation (an irregular heart rhythm) and decrease fat around the heart in overweight and obese adults. About 158 participants with atrial fibrill…

This study tests whether a supplement containing a beneficial gut bacterium (Akkermansia muciniphila) and a plant compound (berberine) can improve how night-shift workers process sugar. Two hundred healthcare and industrial workers will take either the supplement or a placebo for…

This study is testing a drug called Spartina® (Tirzepatide) to see how well it helps people with obesity or overweight lose weight and if it is safe. About 175 adults will take the drug and be monitored for weight changes and side effects. The goal is to see if at least 5% weight…

This study looks at whether connecting youth (ages 12-25) with community programs rooted in Native Hawaiian culture can improve their mental and physical health. Participants will take part in activities that strengthen their connection to the land and culture, and complete surve…

This small pilot study is testing whether eating bottarga (a type of fish roe) every day for 8 weeks can improve cholesterol, blood sugar, and inflammation in adults with prediabetes, diabetes, or obesity. About 20 adults from Massachusetts will take part. The goal is to see if t…

This study is testing whether giving free summer day camp vouchers to low-income children with overweight or obesity can help them manage their weight. The camps provide physical activity, healthy meals, and regular sleep. The study will enroll 80 children aged 5-11 who are on Me…

This study tests a special bed scale called FIT that automatically tracks weight when a person gets in or out of bed. It aims to help 92 wheelchair users who are overweight or obese lose weight by giving them daily feedback, along with a diet and exercise program. Participants mu…

This study looks at whether a structured exercise program can help overweight and obese women aged 25-50 maintain muscle mass and physical function while taking the weight-loss drug tirzepatide. Participants will be split into two groups: one taking tirzepatide alone, and the oth…

This study is testing whether semaglutide (a drug used for diabetes and weight loss) can improve psoriasis when added to a standard topical cream. About 62 adults with plaque psoriasis who are overweight or have type 2 diabetes will take either semaglutide or a placebo pill for 1…

This study looks at whether wearing a continuous glucose monitor (CGM) that shows real-time blood sugar levels can help people with prediabetes and obesity change their eating habits, reduce blood sugar swings, and lose weight. About 34 adults will try both an open (visible data)…

This study compares a new magnetic procedure to the medication semaglutide for controlling obesity and type 2 diabetes. About 20 adults with a BMI between 30 and 40 and type 2 diabetes will be randomly assigned to either the magnetic surgery or the drug. The goal is to see which …

This study tests a new surgical device (a clip) to treat type 2 diabetes and obesity in people with a BMI of 25-35. The surgery creates a second food pathway to help control blood sugar, similar to popular diabetes drugs. About 90 adults will be randomly assigned to different gro…

This study aims to see how well a mix of traditional Chinese medicine and Western medicine works for people with obesity. Researchers will track at least 10,000 adults with a BMI of 28 or higher over 24 weeks, measuring weight loss and other health changes. The goal is to find be…

This study explores whether analyzing the chemicals in your breath can help doctors identify metabolic syndrome and metabolically healthy obesity without blood draws or invasive tests. Researchers will collect breath samples from 300 adults and use machine learning to find unique…

This study tests whether a daily supplement made from artichoke by-products, combined with a calorie-controlled Mediterranean diet, can improve blood sugar control and reduce insulin resistance in 150 overweight or obese adults at risk for type 2 diabetes. Researchers will also u…

This study tests a 6-month lifestyle program for transgender and gender-diverse teens aged 10-14. The program includes monthly group sessions and weekly messages to help prevent obesity and eating disorders. Researchers will measure quality of life, eating habits, and body change…

This study tests a program designed to prevent childhood obesity in vulnerable families with children aged 6 months to 3 years. About 526 families with at least one parent who has overweight or obesity will take part. The program includes group sessions on healthy eating, physica…

This study looks at whether special breathing exercises (inspiratory muscle training) can improve lung function and reduce inflammation in people with obesity. About 40 adults aged 30-60 with a BMI of 30 or higher will be enrolled. Researchers will measure breathing capacity, mus…

This early study tests whether a cold water extract from saffron tepals (the flower petals) can improve blood sugar and metabolism after a meal in 20 adults with obesity or prediabetes. Participants will drink the extract or plain water before eating white bread, and researchers …

This study tests whether a special food drink can help adults on popular weight loss drugs (like Wegovy or Mounjaro) keep their muscle while losing weight. About 144 overweight or obese adults will take the drink or a placebo for 24 weeks. The goal is to see if the drink preserve…

This study looks at whether a 5-week exercise program (a mix of cardio and strength training) can improve muscle health, body composition, and quality of life in adults who have had bariatric surgery. About 84 people aged 18 to 60 will either join the supervised exercise group or…

This study looks at whether eating pistachios every day for 12 weeks can help people on GLP-1 medications (like semaglutide or tirzepatide) feel fuller, have more energy, and improve their overall diet quality. Researchers will track changes in hunger, fatigue, mood, and body com…

This study looks at whether adding peanuts to daily meals helps people on GLP-1 medications (like semaglutide or tirzepatide) feel fuller, have more energy, and improve their diet quality. Researchers will follow 64 adults who have been on these meds for at least 6 months. Over 1…

This study tests whether a safe, home-use brain stimulation technique called tDCS can improve memory and thinking in breast cancer survivors who struggle with 'chemo brain.' Forty women who finished cancer treatment at least 3 months ago will receive either real or fake (placebo)…

This study looks at whether a single 40-minute sauna session can lower blood sugar spikes after meals in adults who are overweight or obese. Fifteen participants will have their blood sugar tracked with a monitor while they try both a sauna session and a rest session. The goal is…

This study is creating new questionnaires to better understand how overweight and obesity affect people's daily lives, well-being, and finances. Researchers will gather information from 500 adults with a BMI over 25 and from healthcare professionals. No treatments or medications …

This study looks at how GLP-1 weight loss drugs (like semaglutide) change taste, eating habits, and behavior in adults with obesity. Researchers will review medical records and surveys from 150 people aged 18-60 in Italy. The goal is to understand why these drugs help people eat …

This study aims to find out how common metabolic dysfunction-associated fatty liver disease (MAFLD) is among adults in rural Bangladesh. Researchers will check 1,000 participants using physical exams, blood tests, and ultrasound scans. The goal is to understand how diet, weight, …

This study is collecting and analyzing genetic, metabolic, and gut bacteria data from over 6,000 adults with and without metabolic syndrome. The goal is to find biological markers that can predict who will develop related conditions like heart disease, kidney disease, or fatty li…

This study tests whether offering personalized financial rewards can help people with obesity stick to tracking their diet and losing weight. About 80 adults will join a 25-week program with group classes and rewards for logging calories and weighing themselves. The goal is to se…

This study looks at how the drug GZR18 behaves in people with normal kidneys versus those with mild, moderate, or severe kidney problems. Researchers will give a single dose to 32 adults and track the drug levels and safety over 50 days. The goal is to learn how to properly dose …

This study aims to find out why some people lose more weight than others after obesity treatments like surgery or medication. Researchers will look at eating behaviors, thinking patterns, and biological markers in 100 adults with obesity. The goal is to better personalize care an…

This study looks at how ketone bodies—chemicals your liver makes when you fast or exercise—affect how your body uses energy and responds to insulin. Ten overweight adults aged 55–70 will each try four different treatments (including a ketone drink and a placebo) on separate days.…

This study looks at how the tongue changes in children and teens with obesity after a 30-week weight loss program. Researchers will use ultrasound to measure tongue fat, shape, and stiffness, and see how these relate to sleep apnea. About 100 participants aged 6 to 18 will be sca…

This study looks at how the drug semaglutide affects fat tissue around the kidneys, heart, and liver in people with type 2 diabetes and chronic kidney disease. Researchers want to understand if changes in fat can help slow kidney disease. About 52 adults will join, and the goal i…

This study looks at 52 obese adults having weight-loss surgery to see which method better predicts a difficult breathing tube placement: a standard checklist (El Ganzouri Risk Index) or an ultrasound of the airway. Researchers will measure the neck and throat with ultrasound befo…

This study follows 52 teens (ages 12–17) getting braces to see if those with a higher body mass index (BMI) have worse gum health, more white spots on teeth, and higher levels of certain mouth bacteria and inflammation markers compared to teens with normal weight. Participants wi…

This study aims to find the most effective way to give weekly feedback to people trying to lose weight. Researchers will test different types of messages to see which helps participants lose more weight. The study involves 127 adults who are overweight or obese and will use a sma…

This study looks at how different exercise routines—moderate, vigorous, or short bursts—affect inflammation in overweight but otherwise healthy adults aged 18 to 45. Participants will do one of three exercise programs, and researchers will measure changes in blood markers of infl…

This study looks at how to give the most helpful weekly feedback to people trying to lose weight. About 300 adults with overweight or obesity will track their weight using a special scale. Researchers will test different ways of sending feedback to see which helps people lose mor…

This study tests whether taking a daily sirtuin activator supplement for six months can improve metabolism and reduce signs of cell aging in women aged 40 to 65 who are overweight or obese. Researchers will compare the supplement to a placebo and measure changes in blood fats, bl…

This study looks at how exercise affects blood components and physical fitness in overweight or obese adults. Researchers will measure things like body fat, strength, and heart health, as well as tiny particles in the blood called extracellular vesicles. The goal is to learn more…

This study watches 500 people who are offered weight-loss drugs like Wegovy or Mounjaro. It aims to understand who accepts the prescription and why, based on their health history and lifestyle. For those who start the drugs, researchers will track how well the treatment works and…

This early-stage study looks at how taking CX11 tablets with or without food changes the drug's levels in the body. It involves 32 healthy adults and is not meant to treat any condition. The results will help design future studies for obesity and type 2 diabetes.

This study looks at how weight loss (using tirzepatide) and the biologic drug ixekizumab affect joint, fat, and skin tissues in people with psoriatic arthritis who are overweight or obese. 45 participants will receive one or both treatments, and tissue samples will be taken at th…

This study looks at different ways to track eating and weight during a 24-week online weight loss program. About 275 adults with overweight or obesity will try a new tracking method every two weeks, like recording all foods, only slip-ups, or using a smartwatch. The goal is to se…

This study aims to find the best combination of support strategies to help adults with higher body weight eat well and stay active. Researchers will test five different group programs delivered online, each with unique features like mindful eating, body image support, or enjoyabl…

This study is creating a simple tool to measure how well the body uses insulin and overall heart health in children and teens with severe obesity. Researchers will use data from fitness trackers and glucose monitors, along with blood tests, to understand how activity and blood su…

This study looks at how body weight and weight-loss surgery change natural chemicals in scalp hair. Researchers will track 60 adults with severe obesity who are scheduled for bariatric surgery, plus healthy-weight controls. They aim to understand hair thinning and muscle loss in …

This study tests a new, safe ultrasound technology called REMS to measure bone density in children aged 5 to 18 who have conditions that weaken bones, like brittle bone disease or osteoporosis. Unlike standard X-ray methods, REMS uses no radiation. The goal is to see how well REM…

This study looks at 150 adults with obesity to see if there are differences in fat, muscle, and metabolism between those who were overweight as children versus those who became overweight as adults. Participants will provide tissue samples, blood, and urine, and undergo scans and…

This study looks at how the stomach and intestines digest food after bariatric surgery (like gastric bypass or sleeve gastrectomy) in people with obesity. Researchers will collect gut samples and have participants swallow a small capsule that measures things like pH and transit t…

This study looks at how two natural hormones, amylin and pancreatic polypeptide, affect hunger and food intake in healthy men. Over four separate days, 18 participants will receive different combinations of these hormones or a placebo. Researchers will measure how much they eat a…

This study aims to understand if a specific type of high-intensity interval training can help release vitamin D that is stored in body fat. Researchers will enroll 30 adults who are overweight or obese and do not take vitamin D supplements. The goal is to see if this exercise can…