OBESITY & OVERWEIGHT

This study tests whether a 4-week healthy cooking program for home cooks can help Emirati adults with overweight or obesity lose weight and eat better. The trained cooks prepare nutritious meals for their families over 3 months. Researchers track weight, waist size, blood pressur…

This Phase 2b trial tests whether adding enobosarm (a muscle-preserving drug) to semaglutide (a weight-loss drug) helps older adults lose more fat and keep muscle. About 200 people aged 65 and older who are overweight or obese will take both drugs or semaglutide alone. The goal i…

This study tests whether wearing a continuous glucose monitor (CGM) for 3 months helps adults with prediabetes better control their blood sugar and stick to lifestyle changes compared to standard finger-prick testing. About 80 participants will be randomly assigned to use a CGM o…

This early-stage trial tests whether TIX100, a daily oral pill, is safe and tolerable in healthy adults who are overweight or obese. Over 28 days, participants receive either TIX100 or a placebo, and researchers monitor for side effects and how the drug moves through the body. Th…

This study tests whether a 16:8 time-restricted eating diet (eating only during an 8-hour window each day) helps people with obesity manage their weight, both those who have had bariatric surgery and those who haven't. Researchers will measure changes in body weight, fat mass, an…

This study investigates whether taking spermidine, a natural compound found in wheat germ, can improve blood fat levels and body weight in overweight or obese adults with high cholesterol. Participants take either spermidine capsules or a placebo daily for one month. The goal is …

This study is testing a mobile app called Adhera Caring Digital Program for Obesity (ACDP-O) in 280 families. The app provides personalized education, mental health monitoring, and wearable device integration to support weight management and well-being in adolescents and young ad…

This study tests an experimental oral drug, ERX1000, for weight loss in 80 adults with obesity (BMI 30-50). Participants will take the drug or a placebo daily for 24 weeks. The main goals are to check safety and see how much weight is lost. This is an early-phase trial, so the dr…

This early-stage trial tests a new daily pill called CX11 in 90 adults with obesity or overweight who also have weight-related health problems like high blood pressure or prediabetes. The study aims to see if the pill is safe and helps with weight loss compared to a placebo. Part…

This pilot study tests a device that gently stimulates a nerve in the ear (taVNS) to help overweight or obese people who didn't lose much weight after 12 weeks of diet and exercise. 24 participants will get either real or sham stimulation twice daily for 12 more weeks, while cont…

This study tests whether a 12-week telephone health coaching program, called Support Your Heart, is practical and helpful for young adults aged 18-39 who have at least two heart disease risk factors (like poor sleep, inactivity, or high blood pressure). Twenty participants in the…

This pilot study tests whether a gentle electrical stimulation of the ear (taVNS) can help overweight or obese people lose more weight when they haven't lost enough on the medication tirzepatide alone. 24 participants will receive either active ear stimulation or a sham (fake) st…

This study tests a new magnetic device that creates a shortcut in the gut to help with weight loss and blood sugar control, comparing it to the popular drug semaglutide (Ozempic/Wegovy). Twenty adults with obesity and type 2 diabetes will be randomly assigned to either the one-ti…

This study tests a personalized program to help people who have lost weight keep it off. About 30 adults who lost at least 7% of their body weight in the past 6 months will receive weekly texts, surveys, and possibly health coaching over 26 weeks. The goal is to see if this appro…

This study tests whether a supplement called Xanthigen helps overweight adults lose weight. About 180 people with a BMI between 27 and 30 will take either a low dose, high dose, or placebo for 16 weeks. Researchers will measure weight, BMI, and waist size to see if the supplement…

This study tests a new surgical device (a metal clip) to create a second food pathway in the stomach for people with type 2 diabetes who are overweight or mildly obese (BMI 25-35). The goal is to improve blood sugar control without causing too much weight loss or needing lifelong…

This study tests whether giving free summer day camp vouchers to low-income children with overweight or obesity can help them manage their weight. Eighty children aged 5-11 who are on Medicaid will be randomly assigned to either receive a voucher for an 8-week summer day camp or …

This study tests two experimental drugs, AZD6234 and AZD9550, given as weekly injections to Chinese adults with obesity or overweight. About 871 participants will receive the drugs alone, together, or a placebo. The main goal is to check safety and how well the drugs work for wei…

This study looks at whether adding a structured exercise program to the weight-loss drug tirzepatide can help overweight and obese women maintain muscle mass and physical function. Sixty women aged 25-50 will take tirzepatide for 20 weeks; half will also follow a progressive resi…

This study tests whether giving adults with obesity and food insecurity free healthy groceries or grocery vouchers, plus behavioral weight loss counseling, helps them lose more weight than counseling alone. Researchers will enroll 300 adults and track weight loss at 24 and 52 wee…

This study tests whether offering personalized financial incentives can help 80 adults with obesity stick to a weight-loss program. Participants attend virtual group classes, log their calories, and weigh themselves regularly. The goal is to see if tailored rewards improve diet t…

This study tests whether taking a combination of Akkermansia muciniphila (a beneficial gut bacterium) and berberine (a plant compound) can improve insulin sensitivity in night-shift workers. 200 participants from healthcare and industry in Austria and Denmark will receive either …

This study tests whether a 12-month personalized exercise and diet program can reduce the amount of time spent in atrial fibrillation (an irregular heartbeat) and decrease fat around the heart in overweight or obese adults. About 158 participants will either follow the lifestyle …

This study tests a special bed scale that automatically weighs wheelchair users when they get in and out of bed. The goal is to help them lose weight by providing daily feedback, combined with a lifestyle program. About 92 adults who use wheelchairs and are overweight or obese wi…

This small pilot study is testing whether eating Greek bottarga (grey mullet fish roe) every day can improve blood sugar, cholesterol, and inflammation in adults with prediabetes, diabetes, or obesity. About 20 participants will compare the effects of bottarga against a dairy pro…

This study looks at whether increasing physical activity helps teens with obesity lower high blood fats and improve how well their blood vessels work. About 110 participants aged 10–20 who are already in a structured weight loss program will wear fitness trackers and have their b…

This study tests whether adding semaglutide (a drug used for diabetes and weight loss) to a standard topical cream can improve psoriasis symptoms and reduce body-wide inflammation. About 62 adults with plaque psoriasis who are overweight or have type 2 diabetes will receive eithe…

This study tests whether powerful weight loss drugs (like semaglutide or tirzepatide) can lower blood pressure enough for young adults (ages 18-40) with obesity and early-stage hypertension to stop taking daily blood pressure pills. Sixty participants will either receive the weig…

This study tests a 24-week church-based program called FELLAship for Black men at risk of heart disease, diabetes, and obesity. Participants attend weekly sessions with exercise and health education, get coaching, and use a smartwatch to track progress. The goal is to see if the …

This study tests whether empagliflozin, a diabetes drug, can help people with HIV who are overweight or obese lose weight and improve metabolic health. Researchers will enroll 66 adults with HIV who are on a specific antiretroviral therapy and have a BMI over 30. Participants wil…

This study tests whether tirzepatide, a drug already used for diabetes and weight loss, can improve irregular periods and ovulation in women with PCOS who are overweight or have obesity. About 198 women will receive either tirzepatide or a placebo for 72 weeks, along with lifesty…

This study is testing a drug called Spartina® (Tirzepatide) to see how well it helps people with obesity or overweight lose weight and if it is safe. About 175 adults with a BMI of 30 or higher (or 27 with a weight-related health issue) will take the drug. There is no placebo gro…

This study tests a new drug called HDM1005, given as a weekly injection, to help people with obesity or overweight lose weight. It includes 825 Chinese adults who do not have diabetes. Participants receive either the drug or a placebo for 52 weeks, along with diet and exercise ad…

This study aims to see if prescribing a specific number of daily steps based on a person's weight and body fat can help overweight and obese adults lose weight and improve heart health. Researchers will develop a formula to predict weight loss from step counts, then test it in an…

This study is testing whether a breath test can identify metabolic syndrome and metabolically healthy obesity without needles or blood work. Researchers will analyze the air exhaled by 300 adults using a special mass spectrometry technique and teach a computer to recognize diseas…

This study tests a program called PINPOINT that helps women with obesity or diabetes get screened for cervical cancer. About 20 women who are behind on screening will be offered options like self-collection or a Pap smear. The goal is to see if the program is practical and well-l…

This study looks at whether offering free center-based childcare during the summer can help prevent unhealthy weight gain in preschoolers from low-income households. Researchers will enroll 300 children who attend needs-based pre-K programs. The goal is to see if the structure an…

This study looks at whether taking a daily supplement made from artichoke by-products, combined with a calorie-controlled Mediterranean diet, can help prevent type 2 diabetes in people who are overweight or obese. Researchers will measure changes in insulin resistance and weight …

This study tests a 9-session group program for parents of children aged 6 months to 3 years, focusing on healthy eating, physical activity, and sleep. About 526 families from Spain will take part, with half receiving the program and half getting usual care. The goal is to see if …

This study tests a 6-month lifestyle program designed to prevent obesity and eating disorders in transgender and gender-diverse adolescents aged 10-14. Participants attend monthly group sessions and receive weekly supportive messages. The goal is to improve quality of life and bo…

This study tests different types of weekly feedback to help people lose weight. 300 adults with overweight or obesity will receive feedback on their calorie intake, diet quality, or physical activity. The goal is to find which feedback works best for improving weight loss.

This study tests whether a 16-week hydration program can reduce side effects like nausea and dehydration in people starting GLP-1 medications (such as Ozempic or Wegovy). Researchers will track 30 adults aged 18-60 who recently started the drug, measuring hydration levels and sid…

This study tests whether a 5-week program of aerobic and resistance exercises can improve muscle quality, body composition, and quality of life in 84 adults who recently had bariatric surgery. Participants are split into an exercise group and a usual-care group. The goal is to se…

This study looks at whether adding peanuts to daily meals for 12 weeks can help adults on GLP-1 medications (like semaglutide or tirzepatide) feel fuller, have more energy, and improve their diet quality. About 64 adults who have been on these meds for at least 6 months will part…

This study looks at whether special breathing exercises (inspiratory muscle training) can improve lung function and reduce inflammation in people with obesity. Researchers will measure breathing, muscle strength, and blood markers in 40 adults aged 30-60 with a BMI of 30 or highe…

This study tests whether a single 40-minute infrared sauna session, done before a meal, can lower blood sugar spikes in overweight adults. Fifteen participants at risk for metabolic issues will wear a continuous glucose monitor and compare sauna versus rest. The goal is to see if…

This study tests two ways of giving feedback to people in a weight loss program: one that only praises progress, and another that mixes praise with tips for improvement. Researchers want to see which style helps people lose more weight. About 127 adults with overweight or obesity…

This study tests whether a special food drink can help adults on popular weight loss drugs like Wegovy or Mounjaro keep their muscle while losing weight. About 144 overweight or obese adults will take the drink or a placebo for 24 weeks. Researchers will measure changes in muscle…

This study tests whether eating 2 ounces of pistachios daily for 12 weeks helps people on GLP-1 medications (like semaglutide or tirzepatide) feel fuller, have more energy, and improve their diet quality. Researchers will track satiety, fatigue, mood, and body composition in 108 …

This study tests whether a cold water extract from saffron tepals (the flower petals) can improve blood sugar and metabolism after a meal in 20 adults with obesity or prediabetes. Participants drink either the extract or plain water before eating white bread, then have blood test…

This study tests whether a home-use device that sends a mild electrical current to the brain can help breast cancer survivors with memory and attention problems (often called 'chemo brain'). Forty women who finished cancer treatment will use either the active device or a sham ver…

This study looks at how a person's genetics, gut microbiome, and behaviors influence how well they tolerate and respond to the weight-loss drug tirzepatide. Researchers will follow 200 overweight or obese adults for up to 12 months, tracking weight changes, side effects, and whet…

This study looks at how a six-month hybrid training program (combining cardio and strength exercises) affects muscle cells in 30 overweight or obese adults. Researchers will measure changes in mitochondria, blood vessels, and other muscle components. The goal is to understand the…

This study is tracking 10,000 adults with obesity to see how well integrated traditional Chinese medicine and Western medicine work in real-world settings. Researchers will collect health records, lab results, and lifestyle data to compare different treatment approaches. The goal…

This study follows 30 people aged 16–80 with obesity who are starting weight-loss medication. Researchers will track changes in hunger, fullness, cravings, and portion size using questionnaires and interviews at 0, 3, 12, and 18 months. The goal is to understand how eating behavi…

This study compares two common anesthetics—propofol and sevoflurane—in 70 obese patients undergoing back surgery. Researchers will measure inflammation markers in blood samples taken before and after surgery to see which anesthetic causes less immune system disruption. The goal i…

This study looks at whether a special type of high-intensity interval training can help overweight adults maintain healthy vitamin D levels during winter. Thirty participants will either exercise three times a week for 12 weeks or just follow a balanced diet. Researchers will mea…

This study is testing whether taking a sirtuin activator supplement every day for six months can improve how the body processes fats and sugars, and possibly slow cell aging. Researchers will compare the supplement to a placebo in 120 women aged 40-65 who are overweight or obese.…

This study is recruiting 100 adults with obesity to find out what factors predict weight loss after taking weight-loss drugs or having bariatric surgery. Researchers will track participants over time, measuring things like eating behaviors, thinking skills, and biological markers…

This study looks at how semaglutide, a drug used for diabetes and weight loss, changes fat tissue around the kidneys, heart, and liver in people with type 2 diabetes and chronic kidney disease. Researchers will compare patients taking semaglutide to those not taking it. The goal …

This study looks at how weight loss (using tirzepatide) and a biologic drug (ixekizumab) affect the body in people with psoriatic arthritis who are overweight or obese. About 45 adults will receive one or both treatments. Researchers will take samples of skin, joint tissue, and f…

This study tests whether people with prediabetes and obesity change their eating and activity habits when they can see their glucose levels in real time versus when the data is hidden. Thirty-four adults will wear a continuous glucose monitor during both an open and a blinded pha…

This study looks back at medical records of 150 adults aged 18-60 who took GLP-1 drugs like semaglutide for weight loss. Researchers want to understand how these drugs change taste perception, food preferences, and eating behaviors. The goal is to learn more about why these medic…

This study looks at how different types of exercise—moderate, vigorous, or short bursts—change inflammation levels in the body. Researchers want to see if exercise can help reduce the low-grade inflammation linked to obesity and heart disease. The study is recruiting 33 overweigh…

This study looks at whether a community program rooted in Native Hawaiian values can improve the well-being of young people aged 12-25 who have health issues like asthma, obesity, or mental health concerns. About 100 youth from the Wai'anae area will take part in cultural activit…

This study looks at 150 adults with obesity to see if there are differences in fat, muscle, and metabolism between those who were obese as children and those who became obese as adults. Participants will provide tissue samples, blood, and urine, and undergo a weight loss program.…

This study looks at how two natural hormones—amylin and pancreatic polypeptide—work together to control appetite and food intake. Eighteen healthy men will receive infusions of these hormones, alone or combined, and then eat a meal to see how much they consume. The goal is to bet…

This early-stage study looks at how taking a new tablet called CX11 with or without food changes the amount of drug in the blood. It involves 32 healthy adults and does not aim to treat any disease. The results will help researchers decide how to give the drug in future studies f…

This study aims to find out how many adults in rural Bangladesh have metabolic fatty liver disease (MAFLD) and how it relates to their diet and metabolic health. Researchers will check 1,000 participants with physical exams, blood tests, and ultrasound. The goal is to gather basi…

This study will compare two methods—the El Ganzouri Risk Index and airway ultrasound—to predict difficult intubation in 52 adults undergoing bariatric surgery. Researchers will measure how well each method identifies patients who may have trouble with breathing tube placement. Th…

This study tests a new, radiation-free ultrasound technology called REMS to measure bone density in children aged 5 to 18 who have conditions that weaken bones, such as brittle bone disease or osteoporosis. The goal is to see if REMS can work as well as the standard X-ray method …

This study looks at 500 people who are offered prescription weight-loss drugs like Wegovy or Mounjaro. Researchers want to understand what makes someone accept or refuse these medications. They will also track those who start treatment for up to 5 years to see how well the drugs …

This study looks at how severe obesity and weight-loss surgery change natural chemicals in scalp hair. Researchers will track 60 adults—some with severe obesity scheduled for bariatric surgery and some healthy-weight controls—to see if hair chemistry can signal poor metabolic hea…

This study tests different ways of tracking food and weight during a 24-week online weight loss program. Participants will be randomly assigned to one of five self-monitoring strategies, such as tracking calories every day or only a few days a week. The goal is to see which metho…

This study looks at how the tongue changes in children and teens with obesity after a 30-week weight loss program. Researchers use ultrasound to measure tongue fat, stiffness, and shape, and see how these relate to sleep apnea. About 100 participants aged 6 to 18 will be scanned …

This study tests five different group programs, all delivered remotely, to help adults with higher body weight eat healthy and be active. Some groups also include mindful eating, body image support, or finding enjoyable physical activities. The goal is to see which program people…

This study tests whether a ketone supplement can improve how the body uses insulin and burns energy. Ten overweight adults aged 55-70 will receive different combinations of growth hormone, a ketone drink, or placebos on separate days. Using advanced PET scans and tissue samples, …

This study looks at how digestion works in people who have had bariatric surgery (like gastric bypass or sleeve gastrectomy) and in people living with obesity. Researchers will collect fluid samples from the stomach and small intestine, and also use a swallowable capsule that mea…

This study at Stanford University will enroll 120 children and teens with severe obesity to develop a simple index that measures how well their bodies use insulin and their overall heart and metabolic health. Participants will wear fitness trackers and continuous glucose monitors…

This study looks at how exercise affects blood components and physical fitness in overweight or obese adults. Researchers will measure things like body fat, strength, and heart health, along with tiny particles in the blood. The goal is to learn more about how exercise helps the …

This study is collecting and analyzing genetic, metabolic, and microbiome data from over 6,000 people with and without metabolic syndrome. The goal is to find biological markers that predict disease progression and help create personalized prevention and treatment plans. Particip…

This early-stage study tests a single dose of the drug GZR18 in 32 adults who are overweight or obese, some with mild to severe kidney problems and some with normal kidneys. Researchers want to see how kidney function affects drug levels and safety. The goal is to find the right …

This study is creating new questionnaires to better understand how overweight and obesity affect people's lives, their quality of life, and the costs involved. Researchers will gather information from 500 adults with a BMI over 25 and from healthcare professionals. No treatments …

This study follows 52 teens (ages 12–17) getting braces to see if having a higher body weight leads to more gum inflammation, white spots on teeth, and higher levels of certain mouth bacteria. Researchers will compare overweight and normal-weight participants by checking saliva, …