OBESITY & OVERWEIGHT

This small pilot study is testing whether eating Greek bottarga, a type of fish roe, can improve markers of metabolic health like cholesterol and blood sugar. It will involve 20 adults in Massachusetts who have conditions like prediabetes, high cholesterol, or obesity. Participan…

This study is testing whether a special medical food can help people keep their muscle while they lose weight using medications like Ozempic or Mounjaro. About 144 adults starting these weight-loss drugs will take either the nutritional supplement or a placebo for 24 weeks. Resea…

This study is testing whether a personalized 12-month program of exercise and dietary changes can help reduce episodes of atrial fibrillation (AFib) in overweight and obese adults who have this common heart rhythm disorder. Researchers will compare the program to usual medical ca…

This study aims to create a personalized walking plan to help manage weight and improve heart health. Researchers will recruit 200 overweight or obese adults to first find the link between daily steps, body fat, and health markers. Then, they will test if a custom step goal, base…

This study is testing whether a six-month course of a dietary supplement called a sirtuin activator can improve metabolic health and affect markers of cell aging in women. It will involve 120 women aged 40-65 who are overweight or obese. Participants will take either the suppleme…

This study is testing five different online group programs designed to help adults with higher body weight improve their health without focusing on weight loss. The programs combine healthy eating and physical activity education with optional components like mindful eating, body …

This study aims to find the easiest and most effective way for people to track their diet and weight during an online weight loss program. Over 275 adults with overweight or obesity will try different tracking methods, like using a smartwatch or logging food just a few days a wee…

This study is testing if a doctor's referral for free summer day camp can help treat obesity in children from low-income families. It will enroll 80 children with Medicaid insurance who are overweight or obese. The goal is to see if this accessible, fun approach is feasible and c…

This study is testing two new investigational drugs, AZD6234 and AZD9550, to see if they are safe and can help with weight loss in Chinese adults who have obesity or are overweight. Researchers will give the drugs separately and together to about 871 participants to compare their…

This study is testing whether a new, less invasive surgery using magnets to reroute the intestines works better than the medication semaglutide (like Ozempic) for controlling type 2 diabetes and weight in adults with obesity. It will enroll 20 adults with a BMI between 30-40 and …

This study is testing if a drug called empagliflozin, commonly used for diabetes, can help control weight gain and related metabolic problems in people living with HIV. It will involve 66 adults with HIV who are overweight and on a specific antiviral treatment known to cause weig…

This pilot study compares two approaches for treating high blood pressure in young adults who are overweight or obese. Researchers will test whether new weight loss medications (like tirzepatide) can lower blood pressure more effectively than standard treatments that use blood pr…

This study is testing a special scale built into a bed to help people who use wheelchairs track their weight. The goal is to see if having easy, daily weight checks helps participants stick to a diet and exercise program and lose weight. Researchers will compare weight loss over …

This study is collecting real-world information on how well and how safely the medication Tirzepatide (brand name Spartina®) works for weight loss. It will follow 175 adults with obesity or overweight who are prescribed the medication as part of their regular care. The main goal …

This study is testing a new weekly injection called HDM1005 to see if it helps people lose weight and improve related health conditions like high blood pressure. About 825 Chinese adults who have obesity or are overweight with other health issues will receive the injection or a p…

This study aims to find the most effective way to give weekly feedback to people in a weight loss program. Researchers will enroll 300 adults with overweight or obesity and provide them with education and tools to track their diet, activity, and weight. Each week, participants wi…

This large study is observing how well combining traditional Chinese medicine with standard Western treatments works for people with obesity. Researchers will follow 10,000 adults to see which approaches help them lose weight and improve their health. The goal is to gather real-w…

This study is testing if tirzepatide, a medication already approved for weight loss and diabetes, can improve ovarian function and regulate menstrual cycles in women with PCOS who are overweight or have obesity. About 200 premenopausal women in Germany will be randomly assigned t…

This study is testing whether providing easier access to healthy foods helps people with obesity and food insecurity lose weight. 300 adults will receive weight loss counseling and be randomly assigned to also get either free home-delivered groceries, grocery store vouchers, or n…

This study is testing whether a combination of a specific gut bacteria (Akkermansia muciniphila) and a plant compound called berberine can improve how the body handles blood sugar in night shift workers. It involves 200 participants who will take either the supplement or a placeb…

This study is testing whether eating pistachios daily for 12 weeks can help people feel fuller, have more energy, and improve their diet quality while they are taking prescription weight-loss medications like Ozempic or Mounjaro. It will involve 108 adults who have been on these …

This study is testing a 24-week church-based program called FELLAship, designed to help Black men at risk for heart disease, diabetes, and obesity improve their health. Participants attend weekly sessions for exercise and health education, receive personal support, and track thei…

This study is testing whether an AI system can learn to give personalized financial rewards to help people stick with a weight loss program. For 24 weeks, 80 adults with obesity will join a virtual group program, log their meals, and weigh themselves on a smart scale. The AI will…

This study is testing if adding the drug semaglutide, which is used for diabetes and weight loss, to standard psoriasis skin cream can better control the skin disease. It will involve 62 adults with plaque psoriasis who are also overweight or have type 2 diabetes. Researchers wil…

This study is testing whether a strength training program can help women keep their muscle mass while they lose weight using the medication tirzepatide. Researchers will recruit 60 overweight or obese women aged 25-50 and give them tirzepatide. Half will also follow a supervised,…

This study is looking at how adding exercise to a weight loss program affects the health of young people with obesity. It focuses on two things: the level of fats in their blood and how well their blood vessels work. About 110 participants, aged 10 to 20, will wear an activity tr…

This study aims to create a new, non-invasive way to diagnose metabolic health issues by analyzing a person's exhaled breath. Researchers will use a special machine to measure chemicals in the breath of 300 people, including those with metabolic syndrome, those who are obese but …

This study aims to find the best way to predict if placing a breathing tube will be difficult for obese patients undergoing weight-loss surgery. Researchers will compare a standard checklist (the El Ganzouri Risk Index) with neck ultrasound measurements taken before surgery. The …

This study is testing whether a daily supplement made from artichoke by-products, when combined with a calorie-controlled Mediterranean diet, can help prevent type 2 diabetes in overweight adults who already show signs of insulin resistance. Researchers will follow 150 participan…

This study is looking at whether a 5-week supervised exercise program can help people recover better after weight-loss surgery. Researchers will measure changes in muscle quality, body fat, and physical function in 68 participants before and after the program. The goal is to see …

This study is testing whether a safe, at-home brain stimulation treatment can help improve memory, attention, and thinking speed in breast cancer survivors who experience 'chemo brain' or cancer-related cognitive impairment. Researchers will compare a real stimulation device to a…

This study aims to understand if taking ketone supplements can improve how the body processes sugar and uses energy, particularly for people who are overweight. Ten healthy overweight adults aged 55-70 will test different combinations of a ketone drink and a hormone infusion duri…

This study aims to find out if the natural chemicals in a person's scalp hair can serve as a new sign of poor metabolic health in people with severe obesity. Researchers will compare 60 people—30 with severe obesity scheduled for weight-loss surgery and 30 healthy-weight individu…

This study aims to understand if having a higher body weight increases the risk of gum inflammation, tooth discoloration, and harmful mouth bacteria in teenagers getting braces. Researchers will observe 52 adolescents over 6 months, comparing those with higher and normal weight. …

This study aims to understand how the stomach and intestines work after weight loss surgery. Researchers will enroll 51 adults who have had surgery or are living with obesity. Participants will have two visits: one to collect fluid samples from their gut and another to swallow a …

This early-stage study aims to understand how eating food affects how the body absorbs an experimental medication called CX11, which is being developed for obesity and type 2 diabetes. Researchers will test 32 healthy volunteers to see if taking the pill with or without food chan…

This study is creating a global registry to better understand the full impact of being overweight or obese. It will collect information from 500 adults with a BMI over 25 about their symptoms, quality of life, and associated costs. The goal is to develop better tools to measure h…

This early study is testing whether a water extract made from saffron flower petals can help improve blood sugar and metabolism right after a meal. Twenty adults with obesity or prediabetes will drink either the saffron extract or plain water before eating bread, and researchers …

This study is investigating whether a specific type of high-intensity interval training can help the body release Vitamin D that is stored in fat tissue. It will involve 30 adults with overweight or obesity who will either follow the exercise program or maintain their usual routi…

This large research study aims to understand why some people develop serious health problems related to metabolic syndrome, like heart disease and fatty liver. Researchers will collect blood, urine, and stool samples from over 6,000 participants, both with and without metabolic s…

This study is testing a new, radiation-free ultrasound technology called REMS to measure bone density in children aged 5-18. It aims to see how well this method works for kids with various conditions that can weaken bones, like osteoporosis or growth hormone deficiency. The goal …

This study aims to understand which patients accept a prescription for weight-loss drugs and why. It will follow 500 people aged 12 and older for up to 5 years to see how well the medications work and how long people stick with them in everyday life. The goal is to gather real-wo…

This study aims to understand how exercise changes the blood and physical fitness of overweight adults. Researchers will measure fitness levels and analyze blood components in 20 participants before and after an exercise program. The goal is to gather new knowledge that could hel…

This study aims to see if ultrasound can reliably measure the tongue's size, fat, and stiffness in children and teens with obesity. Researchers will scan participants' tongues at the start and end of a 30-week inpatient weight-loss program. The goal is to learn if tongue characte…

This early-stage study aims to understand how a new injectable drug called GZR18 is processed by the body in people with normal and impaired kidney function. It will enroll 32 adults with overweight or obesity to measure drug levels and safety after a single dose. The goal is to …

This study aims to create a simple score to measure heart and metabolic health in children and teens with obesity. Researchers will use data from wearable fitness trackers and glucose monitors, along with lab tests, to understand how physical activity and blood sugar relate to he…