OBESITY; OVERWEIGHT

This study tests a special bed scale called FIT that automatically tracks weight when a person gets in or out of bed. It aims to help 92 wheelchair users who are overweight or obese lose weight by giving them daily feedback, along with a diet and exercise program. Participants mu…

This study tests whether giving adults with obesity and food insecurity access to healthy groceries or grocery vouchers, along with behavioral weight loss coaching, leads to more weight loss than coaching alone. About 300 adults will be randomly assigned to one of three groups fo…

This study looks at whether a structured exercise program can help overweight and obese women aged 25-50 maintain muscle mass and physical function while taking the weight-loss drug tirzepatide. Participants will be split into two groups: one taking tirzepatide alone, and the oth…

This study tests whether a 12-month program of tailored exercise and dietary changes can reduce the amount of time spent in atrial fibrillation (an irregular heart rhythm) and decrease fat around the heart in overweight and obese adults. About 158 participants with atrial fibrill…

This study tests whether powerful weight loss drugs (like semaglutide or tirzepatide) can lower blood pressure enough for young adults (ages 18-40) with obesity and mild hypertension to stop taking daily blood pressure pills. About 60 participants will either receive the weight l…

This study looks at how adding exercise to a weight loss program affects blood fats and blood vessel function in young people ages 10-20 with obesity. Participants will follow a structured weight loss program and have their blood vessel health and triglyceride levels measured ove…

This study tests whether a supplement containing a beneficial gut bacterium (Akkermansia muciniphila) and a plant compound (berberine) can improve how night-shift workers process sugar. Two hundred healthcare and industrial workers will take either the supplement or a placebo for…

This study tests whether empagliflozin, a diabetes drug, can help people with HIV who are overweight or obese lose weight and improve their metabolism. About 66 adults with HIV on a specific antiretroviral therapy will receive either the drug or a placebo for 6 months. The main g…

This study tests whether tirzepatide, a drug already approved for diabetes and obesity, can improve irregular periods in overweight women with PCOS. About 198 women will receive either tirzepatide or a placebo for 72 weeks. The goal is to see if the drug helps restore normal mens…

This study tests whether adding a drug called enobosarm to a common weight-loss medication (semaglutide) helps people aged 65 and older lose more weight while preserving muscle and physical function. About 200 participants will receive either the combination or semaglutide alone.…

This study tests whether a supplement called Xanthigen helps overweight adults lose weight. About 180 people with a BMI between 27 and 30 will take either a low dose, high dose, or placebo for 16 weeks. Researchers will measure changes in weight, BMI, and waist size.

This study is testing a drug called Spartina® (Tirzepatide) to see if it helps people with obesity or overweight lose weight safely. About 175 adults will take the drug and be monitored for weight loss and side effects. There is no placebo group — everyone gets the treatment.

This study tests whether offering personalized financial incentives can help people with obesity stick to a weight-loss program. Eighty adults with a BMI of 30 or higher will attend virtual group classes and track their diet and weight. The goal is to see if tailored rewards impr…

This study is testing whether semaglutide (a drug used for diabetes and weight loss) can improve psoriasis when added to a standard topical cream. About 62 adults with plaque psoriasis who are overweight or have type 2 diabetes will take either semaglutide or a placebo pill for 1…

This study looks at whether wearing a continuous glucose monitor (CGM) that shows real-time blood sugar levels can help people with prediabetes and obesity change their eating habits, reduce blood sugar swings, and lose weight. About 34 adults will try both an open (visible data)…

This study compares a new magnetic procedure to the medication semaglutide for controlling obesity and type 2 diabetes. About 20 adults with a BMI between 30 and 40 and type 2 diabetes will be randomly assigned to either the magnetic surgery or the drug. The goal is to see which …

This study tests a new medicine called HDM1005, given as a weekly injection, to help Chinese adults with obesity or overweight lose weight. About 825 participants will receive either the drug or a placebo for 52 weeks, along with diet and exercise advice. The main goal is to see …

This study tests a new surgical device (a clip) to treat type 2 diabetes and obesity in people with a BMI of 25-35. The surgery creates a second food pathway to help control blood sugar, similar to popular diabetes drugs. About 90 adults will be randomly assigned to different gro…

This study looks at whether giving free summer day camp vouchers to low-income children with overweight or obesity can help them manage their weight. About 80 children aged 5 to 11 who are on Medicaid will either receive a camp voucher or continue with standard care. The goal is …

This study aims to see if giving overweight adults a specific daily step count, based on their body fat, can help them lose weight and lower risks for heart disease and diabetes. Researchers will track 200 adults aged 20 and older over 8 months as they walk while eating normally.…

This study tests two experimental drugs, AZD6234 and AZD9550, alone or together, for weight loss in Chinese adults who are overweight or have obesity. About 871 participants aged 18 to 55 with a BMI of 27 or higher will receive the drugs or a placebo to check safety and effective…

This study tests whether connecting youth (ages 12-25) to community programs rooted in Native Hawaiian culture can improve their mental and chronic health. Participants will take part in cultural activities and complete surveys about their well-being. The goal is to see if this a…

This study aims to see how well a mix of traditional Chinese medicine and Western medicine works for people with obesity. Researchers will track at least 10,000 adults with a BMI of 28 or higher over 24 weeks, measuring weight loss and other health changes. The goal is to find be…

This study tests a 24-week church-based program for Black men aged 18 and older who are at risk for heart disease, diabetes, and obesity. Participants attend weekly sessions with exercise and health education, get one-on-one support from a community health worker, and use smart d…

This pilot study explores whether eating Greek bottarga (grey mullet fish roe) daily can improve markers of metabolic health in adults with prediabetes, diabetes, high cholesterol, or obesity. Twenty participants will compare the effects of bottarga versus a calorie-matched dairy…

This study explores whether analyzing the chemicals in your breath can help doctors identify metabolic syndrome and metabolically healthy obesity without blood draws or invasive tests. Researchers will collect breath samples from 300 adults and use machine learning to find unique…

This study tests whether a daily supplement made from artichoke by-products, combined with a low-calorie Mediterranean diet, can help prevent type 2 diabetes in 150 overweight or obese adults with insulin resistance. Researchers will measure changes in blood sugar control, insuli…

This study tests a program designed to prevent childhood obesity in vulnerable families with children aged 6 months to 3 years. About 526 families with at least one parent who has overweight or obesity will take part. The program includes group sessions on healthy eating, physica…

This study tests a 6-month lifestyle program for transgender and gender-diverse adolescents aged 10-14 to prevent obesity and eating disorders. Participants attend monthly group sessions and receive supportive messages, while a control group gets standard care. The goal is to imp…

This study tests a special food drink designed to help adults keep their muscle mass while losing weight with popular GLP-1 drugs like Wegovy or Mounjaro. About 144 overweight or obese adults will take either the drink or a placebo for 24 weeks. The goal is to see if the drink ca…

This study looks at whether eating pistachios every day for 12 weeks can help people on GLP-1 medications (like semaglutide or tirzepatide) feel fuller, have more energy, and improve their overall diet quality. Researchers will track changes in hunger, fatigue, mood, and body com…

This study looks at whether adding peanuts to daily meals helps people on GLP-1 medications (like semaglutide or tirzepatide) feel fuller, have more energy, and improve their diet quality. Researchers will follow 64 adults who have been on these meds for at least 6 months. Over 1…

This study tests whether a safe, home-use brain stimulation technique called tDCS can improve memory and thinking in breast cancer survivors who struggle with 'chemo brain.' Forty women who finished cancer treatment at least 3 months ago will receive either real or fake (placebo)…

This study looks at whether a 5-week program combining aerobic and strength training can improve muscle health, body fat, physical function, and quality of life in adults who recently had weight-loss surgery. About 84 people aged 18-60 will either join the supervised exercise gro…

This study tests whether a cold water extract from saffron flower tepals, taken just before a meal, can improve blood sugar and metabolism in 20 adults with obesity or prediabetes. Participants will drink either the extract or plain water before eating white bread, and researcher…

This study is testing different ways to give weekly feedback to help people lose weight. Researchers want to see which type of message helps participants stay on track with their goals. About 300 adults with a BMI of 25 or higher will take part. The study uses a smartphone app an…

This study looks at how semaglutide (a diabetes and weight-loss drug) changes fat deposits around the kidneys, heart, and liver in people with type 2 diabetes and chronic kidney disease. Researchers want to understand if these fat changes help slow kidney damage. About 52 adults …

This study looks at how obesity affects breathing and inflammation, and whether special breathing exercises (inspiratory muscle training) can help. Researchers will measure lung function, inflammation markers, and body composition in 40 adults with obesity. The goal is to see if …

This study looks at whether a single 40-minute sauna session before a meal can lower blood sugar spikes in overweight adults aged 30-55. Participants will wear a continuous glucose monitor and visit the lab twice—once for sauna, once for rest. The goal is to see if heat exposure …

This study tests whether taking a daily sirtuin activator supplement for six months can improve metabolism and reduce signs of cell aging in women aged 40 to 65 who are overweight or obese. Researchers will compare the supplement to a placebo and measure changes in blood fats, bl…

This study examines how GLP-1 receptor agonists (like semaglutide) affect taste perception, food preferences, and eating behaviors in adults with obesity. Researchers will review medical records and surveys from 150 participants treated at Italian clinics for at least 12 weeks. T…

This study aims to find out how many adults in rural Bangladesh have metabolic fatty liver disease (MAFLD) and how it relates to their diet, weight, and other health markers. Researchers will check 1000 participants using body measurements, blood tests, and ultrasound. The result…

This study follows 52 teens (ages 12–17) getting braces to see if those with a higher body mass index (BMI) have worse gum health, more white spots on teeth, and higher levels of certain mouth bacteria and inflammation markers compared to teens with normal weight. Participants wi…

This study looks at 52 adults having weight-loss surgery to see which method better predicts a difficult breathing tube placement: a standard checklist or an ultrasound. Participants get both checks before surgery, and doctors record how the tube goes in. The goal is to find a mo…

This study looks at how the tongue changes in children and teens with obesity after a 30-week weight loss program. Researchers use ultrasound to measure tongue fat, size, and stiffness, and see how these relate to sleep apnea. About 100 participants aged 6 to 18 will be scanned a…

This study aims to find the most effective way to give weekly feedback to people trying to lose weight. Researchers will test different types of messages to see which helps participants lose more weight. The study involves 127 adults who are overweight or obese and will use a sma…

This study looks at how exercise affects blood components and physical fitness in overweight or obese adults. Researchers will measure things like body fat, strength, and heart health, as well as tiny particles in the blood called extracellular vesicles. The goal is to learn more…

This study watches 500 people who are offered weight-loss drugs like Wegovy or Mounjaro. It aims to understand who accepts the prescription and why, based on their health history and lifestyle. For those who start the drugs, researchers will track how well the treatment works and…

This early-stage study looks at how taking CX11 tablets with or without food changes the drug's levels in the body. It involves 32 healthy adults and is not meant to treat any condition. The results will help design future studies for obesity and type 2 diabetes.

This study looks at how weight loss (using tirzepatide) and the biologic drug ixekizumab affect joint, fat, and skin tissues in people with psoriatic arthritis who are overweight or obese. 45 participants will receive one or both treatments, and tissue samples will be taken at th…

This study is creating new questionnaires to better understand how overweight and obesity affect people's daily lives, health, and finances. Researchers will gather information from 500 adults with a BMI over 25 and from healthcare professionals. The goal is to develop tools that…

This study looks at different ways to track eating and weight during a 24-week online weight loss program. About 275 adults with overweight or obesity will try a new tracking method every two weeks, like recording all foods, only slip-ups, or using a smartwatch. The goal is to se…

This study aims to find the best combination of support strategies to help adults with higher body weight eat well and stay active. Researchers will test five different group programs delivered online, each with unique features like mindful eating, body image support, or enjoyabl…

This study is creating a simple tool to measure how well the body uses insulin and overall heart health in children and teens with severe obesity. Researchers will use data from fitness trackers and glucose monitors, along with blood tests, to understand how activity and blood su…

This study looks at how ketone bodies—chemicals your liver makes when you fast or exercise—affect energy use and insulin sensitivity. Ten overweight adults aged 55-70 will receive different combinations of ketone supplements, growth hormone, or placebo on four separate days. Rese…

This study looks at how body weight and weight-loss surgery change natural chemicals in scalp hair. Researchers will track 60 adults with severe obesity who are scheduled for bariatric surgery, plus healthy-weight controls. They aim to understand hair thinning and muscle loss in …

This study is collecting and analyzing genetic, metabolic, and microbiome data from over 6,000 adults with and without metabolic syndrome. The goal is to find biological markers that predict disease progression and help design personalized prevention or treatment strategies. Part…

This study looks at how different exercise routines—moderate, vigorous, or short and intense—affect inflammation and the immune system in overweight but otherwise healthy adults. Researchers want to see if exercise can help reduce chronic low-grade inflammation, which is linked t…

This study tests a new, safe ultrasound technology called REMS to measure bone density in children aged 5 to 18 who have conditions that weaken bones, like brittle bone disease or osteoporosis. Unlike standard X-ray methods, REMS uses no radiation. The goal is to see how well REM…

This study looks at 150 adults with obesity to see if there are differences in fat, muscle, and metabolism between those who were overweight as children versus those who became overweight as adults. Participants will provide tissue samples, blood, and urine, and undergo scans and…

This study looks at how the stomach and intestines digest food after bariatric surgery (like gastric bypass or sleeve gastrectomy) in people with obesity. Researchers will collect gut samples and have participants swallow a small capsule that measures things like pH and transit t…

This study looks at how two natural hormones, amylin and pancreatic polypeptide, affect hunger and food intake in healthy men. Over four separate days, 18 participants will receive different combinations of these hormones or a placebo. Researchers will measure how much they eat a…

This study looks at how the drug GZR18 behaves in people with different levels of kidney function, from normal to severe impairment. About 32 overweight or obese adults will receive a single dose and be monitored for up to 50 days. The goal is to find the right dose for patients …

This study aims to understand if a specific type of high-intensity interval training can help release vitamin D that is stored in body fat. Researchers will enroll 30 adults who are overweight or obese and do not take vitamin D supplements. The goal is to see if this exercise can…