Night-Shift workers test gut bug and herb combo to beat diabetes risk

NCT ID NCT07440147

Recruiting now Disease control Sponsor: FH Joanneum Gesellschaft mbH Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether taking a combination of Akkermansia muciniphila (a beneficial gut bacterium) and berberine (a plant compound) can improve insulin sensitivity in night-shift workers. 200 participants from healthcare and industry in Austria and Denmark will receive either the supplements or a placebo for 12 weeks, then switch after a break. The main goal is to see if this approach lowers insulin resistance, a key risk factor for type 2 diabetes.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Akkermansia muciniphila (a gut bacterium) and berberine (a plant compound) taken as dietary supplements
What this could lead to: If it works, this could point toward a simple supplement combination to help night-shift workers improve insulin sensitivity and reduce their risk of type 2 diabetes.
What could go wrong: This is an early-stage trial with no phase designation, and the supplements may not improve insulin sensitivity more than placebo. Results may not apply to non-shift workers or other populations.

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Conditions

The condition(s) this trial relates to.

Chronobiology Disorders circadian rhythm sleep disorder glucose intolerance Insulin Resistance Obesity obesity disorder Overweight prediabetes syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CIRCADIAN RHYTHM DISORDERS GUT MICROBIOTA MODULATION OBESITY & OVERWEIGHT PREDIABETES (INSULIN RESISTANCE, IMPAIRED GLUCOSE TOLERANCE)

Contacts and locations

Locations

FH JOANNEUM University of Applied Sciences
RECRUITING

Graz, Styria, 8020, Austria

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