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A national multicenter prospective cohort study on the incidence characteristics and risk associations of metabolic and multi-system comorbidities in overweight and obese populations stratified by body mass index

NCT ID NCT07884903

NEW Sponsor: Shanxi Bethune Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Oct 21, 2026 · Last updated Oct 21, 2026

Summary

This is a nationwide, multi-center, long-term follow-up study of overweight and obese adults in China. The study aims to recruit approximately 26,000 participants across 39 hospitals to better understand how body weight affects the development of obesity-related diseases over a 3-year period. Eligible participants are adults aged 18 to 79 years with a body mass index (BMI) of 23 kg/m² or higher. Participants will be grouped into four categories based on their BMI: overweight, mild obesity, moderate obesity, and severe obesity. At the beginning of the study, all participants will undergo a comprehensive health assessment, including physical measurements, body composition analysis, blood tests, and lifestyle questionnaires. Participants will then be followed for 3 years with annual check-ins to track any new health conditions. The main goal is to identify the 3-year risk of developing conditions such as type 2 diabetes, fatty liver disease, high blood pressure, and heart disease in different weight groups. This information will help doctors better predict and prevent obesity-related health problems in the future. Participation is voluntary, and all personal information will be kept confidential.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 25,974 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Nov 2026

An estimate. Start dates often move.

Expected to finish

Sep 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Overweight and obese adults (BMI ≥23.0 kg/m²) aged 18-79 years from 39 centers across China, stratified into four BMI groups: overweight, mild obesity, moderate obesity, and severe obesity.

Ages

18 to 79 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults aged 18 to 79 years * BMI ≥23.0 kg/m² (overweight or obese per 2026 ADA criteria) * Able to provide written informed consent * Capable of completing baseline assessment and 3-year follow-up * Local residency for ≥3 years * Willing to provide fasting blood samples for storage Exclusion Criteria: * Secondary obesity (Cushing's syndrome, hypothyroidism, drug-induced or genetic obesity) * End-stage severe chronic diseases (refractory heart failure, advanced malignancy, AIDS) * Severe psychiatric disorders or cognitive impairment * Pregnancy or lactation * Concurrent participation in other weight-loss or metabolic intervention trials

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Conditions

The condition(s) this trial relates to.

cardiovascular disorder Dyslipidemias hyperlipidemia hypertensive disorder Hyperuricemia metabolic dysfunction-associated steatotic liver disease Obesity obesity disorder Overweight polycystic ovary syndrome sleep apnea syndrome type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cardiovascular diseases Diabetes mellitus, type 2 Dyslipidemias Hypertension Hyperuricemia Non-alcoholic fatty liver disease (masld) Obesity / overweight Polycystic ovary syndrome Sleep apnea, obstructives

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Department of Endocrinology, Shanxi Bethune Hospital

    Taiyuan, Shanxi, 030032, China

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