Sleep apnea syndrome

This study investigates whether two medications—acetazolamide and eszopiclone—can improve sleep apnea outcomes when taken after soft palate surgery. The trial includes adults with moderate to severe obstructive sleep apnea who cannot use CPAP or oral appliances. Researchers will …

This study investigates whether oxygen and the drug acetazolamide can help stabilize breathing during sleep in people who take prescription opioids and have sleep apnea. Researchers will measure breathing patterns and sleep quality in 150 veterans. The goal is to find new ways to…

This study tests a once-weekly injection called NNC0487-0111 in 300 adults with overweight or obesity and moderate-to-severe obstructive sleep apnea who use a breathing device. The goal is to see if the drug helps with weight loss and reduces breathing pauses during sleep. Partic…

This study tests a once-weekly injection called NNC0487-0111 in 300 adults with overweight or obesity and moderate-to-severe obstructive sleep apnea who do not use a CPAP machine. The goal is to see if the drug helps with weight loss and reduces breathing pauses during sleep. Par…

This phase 3 trial tests a weekly injection called eloralintide in 800 adults with moderate-to-severe obstructive sleep apnea who are also overweight or have obesity. The study looks at whether the drug can improve sleep apnea symptoms and help with weight loss. Participants are …

This study is testing a device called the Genio® System for people with moderate to severe obstructive sleep apnea who cannot use CPAP machines. The device is implanted and stimulates the tongue to keep the airway open during sleep. Researchers will track how well it reduces brea…

This study looks at whether using a CPAP machine for sleep apnea after a heart procedure (catheter ablation) can help prevent atrial fibrillation from coming back. About 658 adults with both conditions will be randomly assigned to use CPAP for a year or receive usual care. The go…

This study tests a program called MiWeigh that helps people with obesity and related conditions like diabetes or high blood pressure lose weight. Participants get a personalized plan from a doctor, access to a website, and weekly check-ins. The goal is to see if this approach lea…

This study tests a new medicine, maridebart cafraglutide, for adults with obstructive sleep apnea who are overweight or obese and already use a CPAP machine. The goal is to see if the drug can reduce breathing pauses during sleep and help with weight loss over 52 weeks. About 250…

This phase 3 trial tests whether maridebart cafraglutide, a drug that may help with weight loss, can reduce sleep apnea episodes in 250 adults who are overweight or obese and not using a breathing machine. Participants receive either the drug or a placebo for 52 weeks. The main g…

This study tests whether a non-invasive ventilator (NIV) or a CPAP machine is better at preventing severe COPD flare-ups and death in people who also have sleep apnea. About 386 adults who recently survived a life-threatening breathing crisis will use one of the two machines at h…

This study looks at whether using a positive airway pressure (PAP) machine at night can improve thinking, sleepiness, and quality of life in older veterans (age 60+) who have both COPD and obstructive sleep apnea—a combination called Overlap Syndrome. About 668 participants will …

This study tests a culturally tailored sleep program for Latino couples where one partner has sleep apnea and is starting CPAP therapy. The program includes three telehealth sessions teaching sleep skills and support strategies. Researchers want to see if it improves CPAP use and…

This study tests a non-surgical laser treatment for people with obstructive sleep apnea who still have breathing problems even after using a dental mouthpiece. The laser aims to stiffen the soft palate and tongue to keep the airway open during sleep. Researchers will enroll 528 a…

This study tests whether removing the tonsils and adenoids can slow or stop the progression of scoliosis (curved spine) in children aged 6 to 15 who also have mild sleep-disordered breathing. Half of the 160 participants will have surgery within 4 weeks, while the other half will…

This study tests whether acetazolamide, a cheap and well-tolerated diuretic, can help people with obstructive sleep apnea who cannot use a CPAP mask. Sixty adults with moderate to severe sleep apnea will receive either the drug or a placebo for 4 weeks each. Researchers will meas…

This study looks at whether a structured program to find and treat obstructive sleep apnea can reduce the amount of time people with atrial fibrillation have an irregular heartbeat. About 209 adults with AF will use a home sleep test device and a Fitbit smartwatch to track their …

This study tests a new device that uses freezing (cryotherapy) to treat obstructive sleep apnea in adults who cannot use standard treatments like CPAP machines. About 25 people with moderate to severe sleep apnea will receive the procedure. The main goal is to check safety and se…

This phase 3 trial tests an injectable drug called XW003 (Ecnoglutide) in 140 obese adults with obstructive sleep apnea who do not use CPAP machines. The goal is to see if the drug reduces breathing pauses during sleep and helps with weight loss. Participants receive either the d…

This study compares two alternative treatments for moderate-to-severe obstructive sleep apnea in people who cannot use a CPAP machine: a custom mouthpiece (mandibular advancement device) and a surgically implanted nerve stimulator (hypoglossal nerve stimulation). Researchers will…

This study tests an injection called XW003 in 140 obese adults with obstructive sleep apnea who already use a breathing machine (PAP). The goal is to see if the drug reduces breathing pauses during sleep and helps with weight loss. Participants will receive either the drug or a p…

This study tests whether matching sleep apnea treatment to the specific cause in each person with Down syndrome works better than a one-size-fits-all approach. 200 children and adults will receive either a combination of two drugs (ato-oxy) or oxygen therapy based on their indivi…

This study tests whether a custom mouthpiece (mandibular advancement device) can help people with obstructive sleep apnea when they temporarily stop using their CPAP machine. Forty adults who normally use CPAP will either use the mouthpiece or nothing during a two-week CPAP break…

This study looks at whether using a CPAP machine during pregnancy can reduce the chance of developing high blood pressure disorders like preeclampsia. About 1,500 pregnant women with mild to moderate sleep apnea will be randomly assigned to use CPAP or not. The goal is to see if …

This study is testing a device called Inspire, which is implanted in the body to treat obstructive sleep apnea. It is being studied in people with more severe sleep apnea (higher AHI) and higher body weight (higher BMI) who cannot use CPAP machines. The study will follow 70 parti…

This study tests whether a custom mouthpiece called EVO can safely treat severe obstructive sleep apnea. About 49 adults with severe sleep apnea will use the device, which moves the jaw forward to keep the airway open. The goal is to see if it reduces breathing pauses by at least…

This study tests a custom mouthpiece (mandibular advancement device) for people with moderate to severe obstructive sleep apnea who cannot tolerate CPAP and have not improved with a nerve stimulation implant. Researchers will measure if the device reduces breathing pauses during …

This study tests a flexible silicone tube that people insert into one nostril before sleep to keep their airway open. It's for adults with moderate to severe obstructive sleep apnea who cannot tolerate CPAP machines. Twenty participants will use the device for 30 days to see if i…

This study looks at whether lifestyle changes (diet and exercise) plus CPAP therapy can reduce eye pressure in people with glaucoma, sleep apnea, and obesity. Forty participants will be split into two groups: one gets CPAP alone, the other gets CPAP plus lifestyle changes. The ma…

This study tests a jaw surgery called maxillomandibular advancement for people with moderate to severe obstructive sleep apnea who cannot use standard treatments like CPAP machines. The surgery moves the jaw forward to open the airway, and researchers will track breathing, sleepi…

This study compares personalized surgery guided by a special camera during sleep (DISE) to standard tonsil and adenoid removal for treating obstructive sleep apnea in 303 children with Down syndrome, ages 2 to 17. Sleep apnea is very common in these children and standard surgery …

This study tests a custom mouthpiece called OrthoApnea NOA for obstructive sleep apnea, a condition where breathing stops and starts during sleep. Researchers want to see if it can reduce breathing pauses by at least half, to fewer than 5 per hour. They will compare new patients …

This phase 3 trial tests an injectable drug called HRS9531 in 140 obese adults with moderate-to-severe obstructive sleep apnea who already use a breathing machine (PAP). The study aims to see if the drug reduces the number of breathing pauses during sleep and helps with weight lo…

This study tests a lung-protective technique during surgery for women with obstructive sleep apnea (OSA) undergoing total laparoscopic hysterectomy. The approach uses ultrasound to guide lung recruitment maneuvers, aiming to reduce postoperative lung complications like collapsed …

This study looks at whether people who take GLP-1 receptor agonists (like Ozempic or Wegovy) should continue them after having bariatric surgery. Researchers will compare weight loss, blood sugar control, gut health, and hunger in 150 adults who either keep taking the drug or sto…

This study looks at whether using a CPAP machine, sometimes with a mild sleep aid, can help lower blood pressure in people with both sleep apnea and high blood pressure. About 200 adults aged 18-70 will use CPAP every night for 3 months. Those with insomnia can also take trazodon…

This early study tests a new device called MAGNAP for people with moderate to severe obstructive sleep apnea who cannot tolerate CPAP machines. The device is surgically implanted in the neck and works with an external magnetic brace to keep the airway open during sleep. The study…

This study works with 300 Native American elders aged 50 and older who have sleep apnea and a PAP machine. It tests if adding motivational interviews and text messages to usual care helps them use their machine more often. The goal is to improve sleep apnea control and possibly l…

This study tests a device called the Restora Serene System, which uses mild electrical pulses to stimulate nerves in the neck during sleep. The goal is to keep the airway open in people with obstructive sleep apnea who cannot use a CPAP machine. Twenty adults will be enrolled to …

This study compares a standard smartphone app with a more interactive version to see which helps people better follow their care plan after weight-loss surgery. About 200 adults having bariatric surgery will participate. Researchers will measure weight loss, quality of life, and …

This study looks at whether a weight-loss procedure called Endoscopic Sleeve Gastroplasty (ESG), combined with healthy eating and exercise, can improve obstructive sleep apnea (OSA) in people with obesity. About 74 adults with moderate to severe OSA will be randomly assigned to r…

This study tests whether using a CPAP machine at night can help people with severe uncontrolled asthma who also have obstructive sleep apnea. Researchers will compare asthma control, lung function, and quality of life between those who receive CPAP plus lifestyle advice and those…

This study is testing a new, smarter algorithm for CPAP machines used to treat obstructive sleep apnea. The algorithm automatically adjusts air pressure to keep the airway open during sleep. Researchers will compare the new algorithm to the current one in 80 adults who already us…

This study tests whether artificial intelligence can predict the best treatment for each person with obstructive sleep apnea (OSA). It also checks if a smartphone app helps people stick with mouth and throat exercises. About 300 adults with OSA will be assigned to CPAP, surgery, …

This study tests a device called the Lunair Alpha System, a neurostimulator implant that aims to treat moderate to severe sleep disordered breathing. It is for people who cannot use or do not tolerate other treatments like CPAP machines. The trial will check if the device is safe…

This pilot study tests a device implanted in the neck that stimulates nerves to keep the airway open during sleep. It is for adults with moderate to severe obstructive sleep apnea who cannot use a CPAP machine. The study will check if the device is safe and improves sleep quality…

This study tests whether telehealth care, including a human sleep navigator, works as well as private sector care for obstructive sleep apnea in 160 military members aged 18-64. Participants will receive education, support, and troubleshooting via telehealth. The goal is to see i…

This study follows 20 people who have already used a flexible silicone tube device (NPA-OSA) for obstructive sleep apnea. Participants will continue using the device at night for up to 12 months. Researchers will check if the device keeps working well by measuring sleep apnea eve…

This study looks at whether treating obstructive sleep apnea (OSA) early with a positive airway pressure (PAP) device can improve outcomes for veterans with both PTSD and substance use disorder. About 194 veterans in a residential treatment program will either receive PAP therapy…

This study is testing a new implantable device called the Remede Dual Channel System for people with severe sleep apnea. The device is designed to stimulate nerves to keep the airway open during sleep. Researchers will check if the implant is safe and if it can reduce breathing p…

This study compares a personalized surgical approach using sleep endoscopy to standard tonsil removal in 240 children aged 2-17 with small tonsils and moderate-to-severe obstructive sleep apnea. The goal is to see if tailoring surgery to each child's specific airway blockages imp…

This study tests whether oxygen, acetazolamide, or finasteride can help treat sleep apnea in people aged 60 and older. Researchers will measure how these treatments affect breathing stability during sleep. The goal is to find better, more personalized options for elderly veterans…

This study tests whether using a CPAP machine at night can reduce high red blood cell counts (polycythemia) in people with moderate to severe sleep apnea. Researchers will compare 182 adults who use CPAP plus standard care to those who receive only standard care over 12 months. T…

This study looks at whether screening for and treating sleep apnea can reduce the burden of atrial fibrillation (AFib) in patients who are candidates for heart ablation. Fifty adults with paroxysmal or persistent AFib that hasn't responded to medication will be screened for sleep…

This registry follows 225 adults with moderate-to-severe obstructive sleep apnea who receive the Inspire hypoglossal nerve stimulation implant. The device is for people who cannot use CPAP, the standard treatment. Researchers will measure how well it reduces breathing pauses duri…

This early-phase trial is testing whether dronabinol, a synthetic form of THC, can reduce the severity of obstructive sleep apnea. 120 adults with moderate to severe sleep apnea will take the drug for two weeks. Sleep studies before and after treatment will measure changes in bre…

This registry follows 1,000 people with obstructive sleep apnea who have received the Inspire implant, a device that stimulates nerves to keep the airway open during sleep. Researchers will track how well the device works over time and how consistently patients use it, using rout…

This study looks at whether using a positive airway pressure (PAP) machine to treat obstructive sleep apnea can help people recover better after an ischemic stroke. About 360 participants who have had a stroke and have moderate to severe sleep apnea will be randomly assigned to r…

This early-phase study will test whether a device that stimulates the phrenic nerve can help treat moderate-to-severe obstructive sleep apnea in 50 Latin American adults. Participants will undergo sleep studies and a procedure to map their airway collapse. The goal is to see if t…

This study aims to see if a French version of the OSA-18 questionnaire can accurately identify obstructive sleep apnea in children. Parents of children aged 4 to 17 who are already scheduled for a sleep test (polysomnography) will fill out the questionnaire. The results will be c…

This study is testing a wearable sensor that measures oxygen levels in the brain and limbs of children with and without obstructive sleep apnea (OSA). The sensor, called near-infrared spectroscopy (NIRS), is compared to standard sleep study techniques. Researchers hope it could l…

This study is testing whether simple wearable devices can accurately screen for sleep disorders in children with cerebral palsy. About 140 children aged 6 to 15 will wear the devices at home and then undergo a standard hospital sleep test. The goal is to see if the wearable metho…

This study tests whether a smartphone app called Apneal can help screen for obstructive sleep apnea in people with head and neck cancer. Sleep apnea is common but often missed in these patients, and current diagnosis requires expensive equipment. Participants use the app at home …

This study tests whether a small, single-use home monitor called Sunrise can help doctors decide how to adjust CPAP therapy for people with obstructive sleep apnea who are not getting enough benefit. About 105 adults will use the Sunrise device at home and also undergo a standard…

This study looks at whether a simple questionnaire given during a dental checkup can identify children at risk for sleep-disordered breathing (like sleep apnea). Sixty children aged 8-13 will fill out the questionnaire and then wear a home sleep monitor for one night to measure t…

This study is testing whether simple measurements like facial scans, videos of blinking and swallowing, and heart rate changes can help doctors diagnose obstructive sleep apnea (OSA). Researchers will collect this data from 800 adults who do not already have an OSA diagnosis. The…

This study looks at whether a home sleep apnea test is as accurate as the standard overnight sleep lab test for children ages 5 to 12. Researchers will compare results from both tests and see how they affect treatment choices. The goal is to find a more comfortable and convenient…

This study tests whether a combination of noninvasive sensors—listening to breathing sounds, measuring oxygen levels, and tracking body movement—can accurately estimate the severity of obstructive sleep apnea. Researchers will enroll 150 adults suspected of having sleep apnea and…

This study is testing whether a portable sleep monitor can accurately detect obstructive sleep apnea in children with autism spectrum disorder. Twenty children aged 6 to 18 will wear the portable device at the same time as their standard in-hospital sleep test. Researchers will c…

This study tests if a computer algorithm called BodySleep can accurately diagnose obstructive sleep apnea in children using fewer sensors than the standard hospital test. About 90 children aged 2 to 18 who are already scheduled for a sleep study will take part. If successful, thi…

This study is testing a new device that measures how sensitive the throat is to help diagnose obstructive sleep apnea (OSA). Researchers will compare the results of this test with standard sleep studies in 117 adults. The goal is to see if this simpler, quicker test can accuratel…

This study is testing whether short video clips recorded by parents on their smartphones can help screen for moderate-to-severe obstructive sleep apnea (OSA) in children. OSA affects 1-4% of kids and can lead to serious health issues if untreated, but getting a sleep study is oft…

This study tests a wearable device called Sunrise that tracks small jaw movements during sleep to diagnose obstructive sleep apnea (OSA). About 100 adults referred to a sleep clinic will use Sunrise alongside standard tests like oximetry or WatchPAT. Researchers want to see if Su…

This study checks if wearable devices like movement sensors, headbands, and pulse oximeters can accurately track sleep stages in children and teens aged 3 to 18. Results will be compared with standard sleep lab tests to see if these gadgets can help diagnose sleep problems more e…

This study is testing whether wearable devices like activity trackers, EEG headbands, and smartphones can accurately measure sleep stages. Researchers will compare these devices to standard sleep lab tests (polysomnography) in 96 healthy volunteers and people with sleep disorders…

This study is testing whether a smartphone app called Apneal can accurately diagnose sleep apnea in adults who already need an overnight sleep test. About 500 participants will wear the app on their chest while also undergoing standard polysomnography at home. The goal is to see …

This study tests two simple ways to prevent bite changes in people using a mouthpiece for sleep apnea or snoring. Some participants will use a special aligner each morning to gently guide their jaw back into place, while others will do daily jaw exercises. The goal is to see whic…

This study tests three approaches—oxygen therapy, the drug trazodone, and brief low-oxygen episodes—to see if they can improve sleep apnea in people with chronic cervical spinal cord injury. Researchers will measure changes in breathing and sleep quality in 100 participants. The …

This study tests whether a silicone mouth tape worn during sleep can reduce snoring and improve sleep quality in people with mild sleep apnea or simple snoring. About 100 adults with a bed partner will use the tape for a period, and both the snorer and partner will report on snor…

This study tests whether acetazolamide, a drug used for other types of sleep apnea, can help people on methadone or buprenorphine who develop central sleep apnea. Forty participants will take either the drug or a placebo for 7 days, then have an overnight sleep study. Researchers…

This study tests whether a sleep medication called eszopiclone can help people with obstructive sleep apnea use their CPAP machine more consistently and improve their thinking skills. About 250 adults with a new sleep apnea diagnosis will receive either eszopiclone or a placebo f…

This study tests whether a type of light therapy called photobiomodulation can help people with obstructive sleep apnea tolerate their CPAP machine better. About 30 adults who currently use CPAP but have trouble with it will receive the light treatment. The goal is to see if it l…

This study looks at whether children with medical complexity (ages 5-17) can safely start using a nighttime breathing machine at home instead of in a hospital sleep lab. The machine helps them breathe better at night, improving quality of life. Researchers will compare home start…

This study looks at whether endoscopic sinus surgery can improve sleep in people with chronic sinusitis and nasal polyps. Researchers will measure sleep quality before and after surgery in 30 participants. The goal is to see if removing polyps and opening blocked sinuses helps wi…

This study tests whether a nasal spray of oxytocin, a natural hormone, can lower the air pressure needed from a CPAP machine in people with obstructive sleep apnea. Forty adults who already use CPAP will take the spray or a placebo before bed for 14 days. Researchers will measure…

This study tests whether extra support—like a health pamphlet, a video, and motivational counseling—helps people with obstructive sleep apnea use their mandibular advancement appliance (a mouth guard) more consistently. Fifty-six adults (age 40+) with sleep apnea will be randomly…

This study tests whether a high-flow nasal cannula (a device that delivers warm, moist oxygen) can prevent low oxygen levels during sedated gastrointestinal endoscopy in people at high risk for obstructive sleep apnea. About 600 adults with a STOP-Bang score of 5 or higher will b…

This study tests whether doing specific mouth and tongue exercises can help people with obstructive sleep apnea who cannot use a CPAP machine. Forty-five adults will be randomly assigned to real exercises, sham exercises, or unsupervised exercises for 10 weeks. The main goal is t…

This study looks at whether interval exercise (short bursts of activity with rest) can improve daily steps, daytime sleepiness, and heart health in veterans who have both COPD and obstructive sleep apnea (called Overlap Syndrome). About 28 veterans will take part for 12 weeks. Th…

This study looks at whether using a CPAP machine in a personalized way can reduce the amount of time people with atrial fibrillation (AFib) spend in an irregular heart rhythm. Twenty adults with both moderate-to-severe sleep apnea and AFib will alternate two weeks on and two week…

This study tests whether a nose spray containing two drugs, dexmedetomidine and esketamine, can reduce pain after tonsil and adenoid surgery in children aged 3 to 7. About 160 kids will receive either the drug combo or a placebo spray right after anesthesia. Researchers will trac…

This study tests whether daily treatments with slightly elevated carbon dioxide (hypercapnia) can improve breathing and reduce sleep apnea in Veterans with spinal cord injury. About 30 adults with chronic spinal cord injury or able-bodied people with sleep apnea will receive the …

This study tests whether eating a whole food plant-based diet for 8 weeks can reduce daytime sleepiness and improve sleep apnea severity. Researchers will measure changes using a sleepiness questionnaire and a home sleep test. The study involves 40 adults with sleep apnea who are…

This study tests whether taking melatonin before bed can help adults with obstructive sleep apnea and insomnia sleep through the night and restore a healthy nighttime blood pressure dip. Fifty participants will take 3 mg of melatonin daily for 30 days. Researchers will measure ch…

This study follows 1,000 adults in Canada who are authorized to use medical cannabis for pain, sleep issues, anxiety, depression, or epilepsy. Researchers will track changes in symptoms using standard questionnaires over 24 weeks. The goal is to see how well medical cannabis work…

This study tests whether extra support—like personalized mask fitting, monthly phone calls, and a tracking app—helps stroke patients with sleep apnea use their CPAP machine more consistently during rehab. About 250 participants will be randomly assigned to either this intensive s…

This study tests the MedCline Sleep System, a device placed on the bed to keep people sleeping on their side. It aims to reduce breathing pauses and snoring in adults with mild obstructive sleep apnea. Researchers will measure changes in apnea and oxygen levels during sleep. The …

This study tests whether remote monitoring of CPAP machines helps people with severe sleep apnea use their therapy more regularly. About 200 adults who are new to CPAP will either get standard care or have their device tracked remotely via an app. The goal is to see if digital su…

This pilot study tests a digital program that uses facial recognition and guided exercises to strengthen throat muscles in people with mild-to-moderate obstructive sleep apnea. Sixty adults who cannot or will not use a CPAP machine will either receive the 3-month app-based therap…

This study tests a special nasal airway device (ssNPA) in 40 children with weak throat muscles and obstructive sleep apnea, including those with Down syndrome. The device is designed to keep the airway open during sleep without needing surgery. Researchers will measure how well i…

This early-phase study tests whether a combination of two drugs—atomoxetine and DAW2022—can reduce the severity of obstructive sleep apnea (OSA) in 18 adults with moderate-to-severe OSA. The goal is to find a better-tolerated alternative to current treatments by measuring breathi…

This study tests whether adding a quick stitching step (lateral pharyngoplasty) to standard tonsillectomy helps children recover better. About 160 kids aged 3-17 will be randomly assigned to get tonsillectomy with or without the extra stitch. Parents will track pain, eating, and …

This study tests whether simple exercises (like drinking water and breathing in a certain way) can improve sleep quality in 60 U.S. service members with obstructive sleep apnea. Some participants have also had a traumatic brain injury. The goal is to see if these exercises reduce…

This study tests whether a non-invasive electrical stimulation device can help people with obstructive sleep apnoea breathe easier during sleep. Fifteen adults with moderate to severe sleep apnoea will wear sticky electrodes under their chin while sleeping. The goal is to see if …

This study tests a mobile app called OurSleepKit that coaches couples to work together on CPAP therapy for obstructive sleep apnea. 360 newly diagnosed patients and their partners will use the app for 6 months. Researchers will measure how many hours per night the patient uses CP…

This study tests a 4-week online course designed to help adults who experience parasomnias—unwanted sleep events like sleep terrors, sleepwalking, and nightmares. The course teaches safety planning, relaxation, and therapy techniques. Researchers will measure whether it reduces h…

This study tests whether a dental mouthpiece (MAD) works as well as a CPAP machine to improve thinking and memory in people with sleep apnea who also have mild memory problems. About 260 adults aged 45 and older will be randomly assigned to use either device for one year. Researc…

This study tests a new device called DidgeriTU, which works like a didgeridoo to strengthen breathing muscles, in 76 adults with mild-to-moderate obstructive sleep apnea. Participants will use the device or a sham (fake) device for 3 months and take sleep tests to see if it reduc…

Many people with obstructive sleep apnea still feel very sleepy during the day even after using a CPAP machine. This study tests a device called tPBM, which shines red and near-infrared light on the scalp to change brain activity. Researchers will measure brain blood flow and sle…

This study tests whether wearing bright light therapy glasses can reduce daytime sleepiness and depressive symptoms in people with obstructive sleep apnea who still feel tired despite using their CPAP machine. Sixty participants will wear the glasses for four weeks of active trea…

This study compares two methods of delivering oxygen during sleep in children aged 5-17 with Down syndrome and moderate to severe obstructive sleep apnea. Ten participants will have two sleep studies—one with continuous oxygen flow and one with pulse flow from a portable concentr…

This Mayo Clinic study tests a smartphone app called SleepWell24 to help people with obstructive sleep apnea use their CPAP machine for at least 6 hours a night, 6 nights a week. The app connects to a smart plug and a Fitbit to track CPAP usage, sleep time, and activity. Research…

This study tests whether a breathing exercise program can reduce daytime sleepiness in adults with obstructive sleep apnea who already use a CPAP machine. Participants will do 12-20 minute sessions of inhaling against resistance three times a week. The goal is to see if strengthe…

This study looks at whether trained community health workers can motivate people with moderate-to-severe sleep apnea to use their breathing machines (PAP) more regularly. About 48 adults who have never used PAP before will receive either motivational coaching or standard care. Th…

This study compares a single dose of methadone (a long-acting opioid) given during surgery to standard short-acting opioids for pain relief after tonsillectomy in children ages 3 to 17. The goal is to see if methadone reduces the need for extra pain medication in the recovery roo…

This study tests whether brief, mild low-oxygen breathing sessions can improve blood vessel function, lower blood pressure, and reduce tiredness in people with obstructive sleep apnea. Researchers will enroll 60 adults aged 30-60 who are newly diagnosed and not yet using CPAP. Th…

This study tests whether a special memory support program can help people aged 50 and older remember and stick to their sleep treatment. The program uses simple memory strategies alongside standard sleep therapy. Researchers will track sleep quality, daily functioning, and life s…

This study tests whether taking nattokinase, a supplement made from fermented soybeans, can improve sleep quality, thinking skills, and heart health in people at risk for metabolic syndrome. About 80 adults will take either the supplement or a placebo for 12 weeks, then switch af…

This study tests an injection called HRS9531 in 140 adults with obstructive sleep apnea and obesity who do not use a CPAP machine. The goal is to see if it improves breathing during sleep and reduces weight over 52 weeks. Participants are randomly assigned to receive the drug or …

This study tests whether taking branched chain amino acids (BCAAs) twice a day for three weeks can improve sleep in people with traumatic brain injury. Researchers will also check if the supplement is easy to take and if participants stick with it. The study involves 300 veterans…

This study compares how satisfied people with moderate to severe obstructive sleep apnea are with a standard CPAP machine (Airsense 10) versus a portable one (Air-Mini). Fifty adults who are new to CPAP will try both devices and rate their satisfaction. The goal is to see if the …

This study tests whether bexagliflozin, a drug used for diabetes, can reduce the severity of obstructive sleep apnea in overweight or obese adults. Over 6 months, participants will take either the drug or a placebo and undergo sleep tests and body scans. The goal is to see if the…

This study tests a 12-month telehealth program that combines healthy eating, exercise coaching, and remote pulmonary rehab for 400 overweight veterans with both COPD and obstructive sleep apnea. Participants use a Fitbit and app to track progress, with the goal of improving physi…

This study tests a device called FreeO2 that automatically adjusts oxygen levels during noninvasive breathing support. It includes 10 patients with COPD flare-ups or after weight-loss surgery. The goal is to see if the device keeps oxygen in a safe range better than manual adjust…

This study investigates a technique called drug-induced sleep endoscopy (DISE) to examine the upper airway in adults with obstructive sleep apnea (OSA) who are considering surgery. Participants receive a mild sedative (propofol) to induce sleep, then a thin camera is passed throu…

This study looks at whether special mouth and throat exercises can improve sleep apnea by strengthening the muscles that keep the airway open. Thirty adults with sleep apnea will use myofunctional therapy devices for three months. Researchers will measure muscle pressure in the t…

This study will test new methods to measure how sleep apnea affects the heart. Researchers will follow 270 adults with moderate to severe sleep apnea who use CPAP, mouth devices, or nerve stimulation. The goal is to see if these new metrics can better predict heart problems than …

This study looks at whether stimulating two nerves in the neck (the ansa cervicalis and hypoglossal nerve) can help people with obstructive sleep apnea. Researchers will measure how the airway changes during sleep in 100 adults. The goal is to understand if combining these stimul…

This pilot study at Tulane University is testing whether obstructive sleep apnea (OSA) can cause scarring (fibrosis) in the heart's upper chambers, even in people without atrial fibrillation. Researchers will use a special MRI with contrast dye to measure scarring in 60 adults wi…

This study looks at how often sleep apnea occurs in people with peripheral artery disease (blocked leg arteries). Researchers will monitor 295 adults with leg artery disease using a sleep test. The goal is to better understand the connection between these two conditions, which ma…

This trial tests whether mailing a sleep apnea home-testing device to people with atrial fibrillation can improve their quality of life. About 936 participants will either receive the device and possible treatment, or no test at all. Researchers will track symptoms, activity, and…

This study looks at how having both sleep apnea and COPD (called overlap syndrome) affects the heart. Researchers will compare people with one or both conditions and test two breathing treatments—a special mask that helps breathing at night and extra oxygen—to see which may impro…

This study looks at whether a quality-of-life questionnaire (OSA-18) can help parents of children with mild obstructive sleep apnea make treatment decisions. About 130 parents of children aged 3-12 with mild sleep apnea will take the survey. The goal is to see if the survey reduc…

This study looks at older veterans who have both sleep apnea and COPD, a combination called 'overlap syndrome.' Researchers want to see if having both conditions worsens thinking and memory more than having just one. They will also test whether using a breathing machine (CPAP) pl…

This study looks at whether treating obstructive sleep apnea (OSA) with a CPAP machine can improve asthma control in people with difficult-to-treat asthma. Eighty adults will be randomly assigned to receive CPAP, no OSA treatment, or serve as a reference group without OSA. The go…

This observational study looks at whether removing excess fluid from the body (diuresis) can reduce sleep apnea severity in adults hospitalized with heart failure. Fifty participants will wear a sleep monitor before and after fluid removal, and researchers will track changes in n…

This study looks at the connection between high blood pressure and obstructive sleep apnea (OSA) using heart rate variability (HRV), a simple heart monitoring method. Researchers will track 100 adults with high blood pressure who are at risk for OSA, using heart monitors and slee…

This study follows 320 people with small-to-moderate thoracic aortic aneurysms for up to 5 years. Researchers will track major complications like rupture or need for surgery, and look for factors such as high blood pressure or sleep problems that might speed up aneurysm growth. T…

This study looks at two different sedative drugs used during a sleep endoscopy procedure in children with obstructive sleep apnea. The goal is to see if one drug causes more airway collapse than the other, and whether the collapse patterns can predict if sleep apnea will continue…

This study explores whether practicing breathing exercises while awake and then replaying them during sleep can change how people breathe at night and boost their thinking skills. Researchers will recruit 18 adults with untreated obstructive sleep apnea. Participants will train a…

This pilot study tests whether a drug called aprepitant (currently used for nausea) can lower a hormone called aldosterone in people with severe sleep apnea and high blood pressure. The study will enroll 24 adults and measure aldosterone levels before and after taking the drug or…

This study looks at sleep problems like sleep apnea and insomnia in 226 people who have had a stroke. Researchers want to see how these sleep issues affect recovery, daily activities, and quality of life. Participants will use a home sleep test and a smartwatch to track sleep and…

This study will explore whether sleep apnea makes multiple sclerosis worse. Researchers will collect sleep studies, MRIs, and lab results from 800 adults with MS to see if there is a link. The goal is to better understand how sleep problems might affect the brain and overall heal…

This study aims to see if analyzing the chemicals in a child's breath can help diagnose and monitor diseases like asthma, neurological disorders, and type 1 diabetes. Researchers will collect breath samples from up to 3,600 children and teens to find patterns linked to these cond…

This study explores whether simple tongue motor tests can predict where and how severely a child's airway is blocked during sleep. Researchers will assess tongue strength, mobility, and frenulum tightness in 48 children aged 6-17 who are scheduled for surgery to treat obstructive…

This study looks at how changes in brain blood flow affect breathing control during sleep in healthy adults. Researchers will expose participants to normal oxygen and low oxygen levels to see how the brain responds. The goal is to better understand sleep apnea and related conditi…

This study is testing new ResMed mask systems in 500 adults who already use CPAP for obstructive sleep apnea. Researchers will track how often the mask is used, how well it seals, and how comfortable it feels. The goal is to confirm the masks work well in everyday life.

This study looks at whether having obstructive sleep apnea (OSA) might help protect the body from damage during surgery to fix a large blood vessel (aortic aneurysm). The idea is that the short, repeated drops in oxygen from sleep apnea might train the body to handle the stress o…

This study is following 1,000 people in Korea who have symptoms of sleep apnea, like loud snoring or feeling very tired during the day. The goal is to learn more about the condition and how well patients stick with breathing machine therapy. Participants will have sleep tests and…

This study looks at how sleep apnea changes pressure in the brain and belly during sleep in people with normal-pressure hydrocephalus. Researchers want to see if these pressure changes affect how well a surgically placed shunt (a tube that drains fluid from the brain) works. The …

This study looks at whether simple equations can accurately predict the right CPAP pressure for Thai people with obstructive sleep apnea, compared to the standard overnight lab test. About 150 participants will have a sleep study to check which equation works best. The goal is to…

This study is testing a small, wireless wearable device that tracks breathing in children. It aims to see if the device works well for kids who have trouble with standard sleep or breathing tests, including premature infants, children with sleep apnea, and those with epilepsy at …

This study watches 150 adults with heart valve problems who are getting a procedure (TAVI or M-TEER) to see if it helps their sleep-disordered breathing. Participants take a sleep test before the procedure and again 6 months later. The goal is to learn how fixing heart valves mig…

This study aims to learn more about PFAPA, a condition that causes repeated fevers, sore throats, and mouth sores in children. Researchers will collect blood, saliva, stool, and tonsil tissue from 1,500 people with PFAPA or other tonsil problems. No treatment is given; the goal i…

This study looks at 30 six-month-old infants with Down syndrome to see if their sucking patterns are linked to the severity of obstructive sleep apnea (OSA). Researchers will measure sucking bursts and compare them to sleep study results. The goal is to find a simple way to scree…

This study looks at 1,200 children and young adults (ages 1-20) with suspected sleep-disordered breathing to see if their sleep test results match up with problems in thinking, mood, and behavior. Participants will complete sleep studies, questionnaires, and thinking tests. The g…

This study looks at whether children with a narrow upper jaw (transverse orthodontic deficiency) are more likely to have obstructive sleep apnea. Researchers will compare sleep test results from 102 children aged 6 to 16, some with and some without this jaw issue. The goal is to …

This study checks tongue strength in 78 children with suspected obstructive sleep apnea. Researchers use a device to measure tongue pressure during pushing and swallowing. They compare results to healthy kids to see if weak tongue muscles are linked to sleep problems.

This study looks at how the immune system influences disease control in people with inflammatory airway diseases like asthma, COPD, and bronchiectasis. Researchers will analyze blood and sputum samples from 200 participants to find links between immune cell patterns and disease s…

This study looks at whether obstructive sleep apnea (OSA) changes how the body processes fat. Researchers will compare fat metabolism in 100 adults with and without sleep apnea using glucose tests. No treatment is given; the goal is to better understand how OSA might affect energ…

This study looks at adults having dental procedures under general anesthesia to see if undiagnosed sleep apnea raises the risk of breathing problems after surgery. Researchers will use two common screening tools (STOP-BANG and ASA criteria) to identify high-risk patients and refe…

This study looks at how reliable the Maintenance of Wakefulness Test (MWT) is for people who feel very sleepy during the day. Researchers will test 100 participants twice to see if the results are consistent. If the test proves reliable, it could help doctors decide who is safe t…

This study looks at whether orthodontic treatments like Twin Block and Hyrax appliances can improve breathing in children aged 8-14 with small jaws and narrow upper airways. Researchers will use 3D scans to measure changes in airway shape and airflow. The goal is to understand if…

This study looks at why central sleep apnea happens and how to treat it better. Researchers will test a combination of a drug (acetazolamide), extra oxygen, and a breathing machine (PAP therapy) in 200 veterans with this condition. The goal is to understand the body's breathing c…

This study looks at whether breathing through the nose or mouth changes how the airway collapses in people with sleep apnea. About 50 adults will have a sleep endoscopy while lightly sedated. The goal is to see if the breathing route during the test matches natural sleep and affe…

This study tests how different frequencies of electrical stimulation affect tongue muscles in 28 adults at high risk for sleep apnea. During a single visit, participants receive five different stimulation frequencies in random order. Researchers measure changes in tongue muscle t…

This study will follow 1,000 adults in Spain who are suspected of having obstructive sleep apnea (OSA) and daytime sleepiness. Participants will undergo standard sleep tests, blood pressure monitoring, and fill out questionnaires about their quality of life and sleepiness. Resear…

This study follows 35 people with severe obesity who are having mini-gastric bypass surgery. Researchers want to see how the surgery changes body composition and improves related health issues like type 2 diabetes, sleep apnea, high blood pressure, and fatty liver disease. The go…

This study looks at how sleep apnea changes fat tissue in adults. Researchers will take small fat samples from the belly and thigh to check for signs of cell damage. They hope to understand why sleep apnea raises the risk of heart disease. The study is currently recruiting 120 pa…

This study looks at whether taking atorvastatin (a statin) for 4 weeks can lower inflammation in the blood vessels of adults with obstructive sleep apnea who are already using CPAP therapy. Researchers will measure specific markers of inflammation and blood clotting. The goal is …

This study looks at people with interstitial lung disease (ILD) and obstructive sleep apnea (OSA) to learn more about these conditions. Researchers will collect medical data, lung samples, and sleep test results from 70 participants. The goal is to find better ways to diagnose an…

This study tests a program called REPOSE, where a patient navigator helps families overcome barriers to getting specialist care for children with sleep-disordered breathing. The navigator provides support, resources, and coordinates care between doctors and parents. The goal is t…

This study uses ultrasound to measure diaphragm function in children aged 1-12 with suspected obstructive sleep apnea who are having surgery. Researchers will compare these children to those without sleep apnea to see if diaphragm movement differs. The goal is to better understan…

This study tests if a special pad placed under the mattress can help doctors better adjust a mouthpiece used to treat obstructive sleep apnea. About 70 adults with sleep apnea will use the device at home while their treatment is fine-tuned. The goal is to see if the device accura…

This study looks at how the tongue changes in children and teens with obesity after a 30-week weight loss program. Researchers use ultrasound to measure tongue fat, stiffness, and shape, and see how these relate to sleep apnea. About 100 participants aged 6 to 18 will be scanned …

This study tests whether a tongue-stimulating device (hypoglossal nerve stimulation) for obstructive sleep apnea can improve how the body handles blood sugar and lower heart risks. About 30 overweight or obese adults who cannot use a CPAP machine will wear a continuous glucose mo…

This study looks at how obstructive sleep apnea (OSA) affects thinking skills and empathy in children aged 3 to 12. Researchers will compare surgery versus medication for mild OSA and track changes over 12 months. They will also use EEG to find brain signals linked to sleep apnea…

This study looks at whether a night of disrupted sleep can lead to extra heartbeats or atrial fibrillation the next day. Researchers will ask 100 adults with sleep apnea to either use or not use their sleep device on different nights, then monitor their heart rhythms. The goal is…

This study looks at how obstructive sleep apnea (OSA) affects thinking, memory, and other brain functions in adults. Researchers will follow 30 people with newly diagnosed OSA for 12 months to see if using a breathing device (positive airway pressure therapy) helps protect the br…

This study looks at how sleep issues and sleep apnea might affect thinking, memory, and daily life in people who had COVID-19. Researchers will follow 200 veterans for up to a year, testing their brain function, sleep quality, and exercise ability. The goal is to find out if trea…

This study looks at how sleep apnea (pauses in breathing during sleep) affects blood sugar levels in adults with type 1 diabetes. Researchers will track blood sugar patterns using continuous glucose monitors in 40 participants. The goal is to understand the link between sleep apn…

This study looks at how doctors currently screen and treat obstructive sleep apnea in children with Down syndrome at one hospital. By reviewing past records of 30 children, researchers hope to create a standard care plan that can be used across France. The goal is to improve brea…

This study looks at whether men and women with untreated obstructive sleep apnea (OSA) have different blood pressure control systems. Researchers will measure blood pressure, artery stiffness, and nerve activity in 60 adults aged 20-70. The goal is to understand sex-specific risk…

This study aims to create a computer tool that uses MRI scans to predict which surgery will work best for children with obstructive sleep apnea (OSA). About 120 children with persistent OSA after tonsil and adenoid removal will be enrolled. The tool simulates airflow in the airwa…

This study looks at oxygen levels in adults over 65 after hip fracture surgery, comparing regional (spinal) anesthesia to general anesthesia. Researchers will measure oxygen saturation and track complications like sleep apnea, delirium, and hospital stay length. The study is obse…

This study looks at 60 people with moderate to severe sleep apnea who are being evaluated for a nerve stimulator implant (Inspire). During a routine sleep endoscopy, researchers will measure how the airway responds to direct muscle stimulation. They want to see if these measureme…

This study reviews medical records of 200 children with obstructive sleep apnea who had tonsil surgery. Researchers want to find out how often breathing problems happen after surgery, especially in children with obesity, Down syndrome, or other health issues. The goal is to bette…

This study will follow 7,000 people with obstructive sleep apnea to see how different forms of the condition relate to long-term health. Researchers will use sleep tests, health records, and additional lab work to find patterns. The goal is to better understand sleep apnea and it…

This study looks at a new system for classifying obstructive sleep apnea (OSA) based on how sleepy patients feel and their heart health. Researchers will follow 1,800 adults newly diagnosed with OSA to see if this classification helps predict long-term improvements. The goal is t…

This study aims to uncover the clinical features and molecular mechanisms behind obstructive sleep apnea (OSA). Researchers will analyze blood, saliva, and urine samples from 500 participants to build a multi-omics database. The goal is to identify biomarkers and treatment target…

This study uses brain scans (fMRI) to see if people with severe sleep apnea have unusual brain activity while awake, and whether CPAP treatment changes that. Researchers will compare 70 participants—some with sleep apnea and some without—to understand how the brain compensates fo…

This study looks at how a device that stimulates the nerve to the tongue (hypoglossal nerve) changes the way the upper airway collapses during sleep in people with obstructive sleep apnea. Researchers will use a sleep endoscopy and sleep study data to compare collapse patterns be…

This study looks at sleep quality in 100 people with atrial fibrillation (AFib) who are scheduled for a heart procedure called pulmonary vein isolation. Participants will have four non-invasive sleep tests—two before and two after the procedure—to measure breathing, heart rate, a…

This study looks at whether the way people make decisions about effort can predict how well they stick with CPAP therapy for obstructive sleep apnea. Researchers will test memory, planning, and decision-making in 64 adults before and after starting CPAP. The goal is to understand…

This study looks at how common sleep apnea is in people with chronic kidney disease and whether it makes kidney function worse over time. Researchers will follow 356 adults with moderate kidney disease for several years, tracking their health and sleep patterns. The goal is to fi…

This study looks at whether successfully treating moderate-to-severe sleep apnea can improve memory and reduce biological markers linked to Alzheimer's disease in older adults. About 200 cognitively healthy people aged 55-85 will either receive immediate sleep apnea treatment or …

This study looks at how the amount of air in your lungs affects throat collapse during sleep in people with obstructive sleep apnea (OSA). Researchers will use a special camera to watch the throat while patients are sedated, and try changing lung volume with a chest device or nec…

This study looks at whether using a CPAP machine for obstructive sleep apnea can also help people with chronic pain. Researchers will follow 80 adults newly diagnosed with sleep apnea who are starting CPAP therapy. Participants will fill out pain and sleep questionnaires at the s…

This study looks at how common sleep apnea is in people hospitalized with schizophrenia and whether it affects their mental health. Researchers will use a special ring and a fiber-optic mat to track breathing during sleep without any wires or uncomfortable equipment. The goal is …

This study looks at how insomnia affects how often children and teens use their positive airway pressure (PAP) machines for obstructive sleep apnea. Researchers will track 82 kids aged 8-18 who are starting PAP therapy and measure their machine use over 90 days. The goal is to un…

Researchers at Mayo Clinic are studying 600 Somali-American adults to understand how common obstructive sleep apnea is and how it affects heart health. Participants will have sleep tests, blood pressure monitoring, and glucose testing. The goal is to learn about unique risk facto…

This study compares two ways of adjusting a nerve stimulator implant (Inspire system) for obstructive sleep apnea. Currently, patients need an overnight sleep study to fine-tune the device. Researchers want to see if a daytime sleep study works just as well. The trial will enroll…

This study follows 65 adults with obstructive sleep apnea to see how three weeks of CPAP therapy changes their thinking skills, blood markers of brain health, and emotional well-being. Participants complete memory and attention tests, give blood samples, and fill out questionnair…