Nose spray could replace needles for Post-Surgery pain in children

NCT ID NCT07479602

Recruiting now Symptom relief Sponsor: Peking University First Hospital Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a nose spray containing two drugs, dexmedetomidine and esketamine, can reduce pain after tonsil and adenoid surgery in children aged 3 to 7. About 160 kids will receive either the drug combo or a placebo spray right after anesthesia. Researchers will track pain scores and sleep quality for two days after surgery to see if the spray helps.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: dexmedetomidine and esketamine (intranasal)
What this could lead to: If it works, this could offer a safe, needle-free way to manage pain after tonsil surgery in young children.
What could go wrong: This is a single, mid-sized trial. The drugs may not work better than placebo, and side effects like drowsiness or nausea are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

obstructive sleep apnea syndrome Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADENOTONSILLECTOMY CHILDREN DEXMEDETOMIDINE ESKETAMINE INTRANASAL ADMINISTRATION POSTOPERATIVE PAIN

Contacts and locations

Locations

Peking University First Hospital
RECRUITING

Beijing, Beijing Municipality, 100034, China

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