Peking University First Hospital

This study looks at whether a lower dose of aspirin (50 mg daily) works as well as the standard dose (100 mg) to prevent heart attacks and strokes in people aged 60 and older with heart disease. It involves over 5,400 Chinese participants who will be followed for about 6 years. T…

This study looks at whether carefully managing body temperature during major cancer surgery can lower the risk of postoperative delirium (sudden confusion) and improve long-term survival in older adults. About 4,000 patients aged 65 and older having cancer surgery will be randoml…

This study tests a new, minimally invasive brain stimulation technique for people with cerebellar cognitive affective syndrome (CCAS) caused by Cushing's syndrome. The treatment uses a device placed near the cerebellum to improve both thinking and movement. The trial will enroll …

This study looks at whether combining radiation and immunotherapy works better than standard chemotherapy for people with high-risk upper urinary tract cancer. The goal is to prevent the cancer from coming back after surgery. About 178 adults with certain high-risk features will …

This study tests whether a portable, AI-enhanced ECG device can help people with moderate-to-advanced chronic kidney disease avoid dangerously high potassium levels (hyperkalemia). Participants will measure their potassium at home at least twice a week using the device and receiv…

This study tests whether combining a special PET/CT scan (CAIX-targeted) with standard imaging can better find and treat cancer spots in people with advanced kidney cancer. About 70 adults with recurrent or metastatic clear cell renal cell carcinoma will receive standard drug the…

This study tests whether adding rezvilutamide to standard hormone therapy can stop high-risk salivary duct cancer from returning after surgery. About 37 people with a specific type of this rare cancer will take the drug combination for up to 2 years. The goal is to see if it impr…

This study tests a simpler treatment for Helicobacter pylori infection, a bacteria that can cause stomach ulcers. Researchers will use a stool test to check if the bacteria have a gene that makes them resistant to the antibiotic clarithromycin. If no resistance is found, patients…

This study looks at adding a precise type of radiation called SABR to standard drug therapy (targeted therapy and immunotherapy) for people with kidney cancer that has come back or spread. The goal is to see if this combination can help control the cancer longer than drugs alone.…

This study tests whether combining the drug disitamab vedotin with radiation therapy can help prevent upper urinary tract cancer from returning after surgery. It includes 60 patients whose tumors have high HER2 levels and who are at high risk for recurrence. Participants choose t…

This study is testing whether artificial intelligence can help doctors find adrenal nodules (small growths on the adrenal glands) in low-dose chest CT scans taken during routine checkups. Researchers will collect 600 chest CT images and train an AI algorithm to detect these nodul…

This study tests a new imaging probe called 68Ga-PFA2 for PET scans to see if it can better detect cancer that has spread (metastasis) in people with lung, breast, or pancreatic cancer. The probe targets a protein called annexin A2, which is often found in high levels on these ca…

This study is testing a new type of PET/CT scan that uses a special tracer called 18F-T2 to find cancers that have high levels of a protein called CAIX. About 200 adults with cancers like kidney, bladder, lung, or breast cancer will get this scan to see if it works better than th…

This study is testing whether a computer program (deep learning) can accurately tell early-stage (T1-T2) from more advanced (T3) kidney cancer using standard CT scans. Researchers will train the AI on 1,000 patients' scans and check its accuracy against the actual stage found aft…

This study tests a new radioactive probe called PFD3 that targets a protein (DLL3) found on small cell lung cancer cells. Using PET/CT scans, doctors hope to see tumors more clearly and assess the cancer's spread. About 30 adults with confirmed small cell lung cancer will receive…

This early-phase study tests a new PET imaging probe called 68Ga-NB381 that targets a protein (CD38) found on multiple myeloma cancer cells. The goal is to see if this scan can detect the disease more accurately than current methods, potentially reducing the need for invasive bon…

This study compares two ways of taking prostate biopsies to see which finds dangerous cancers more accurately while avoiding unnecessary detection of harmless ones. About 592 men with a suspicious MRI finding will get either targeted plus perilesional biopsies or a combination th…

This study tests whether a new pain medicine called anrikefon can better control deep internal pain after laparoscopic (keyhole) surgery. About 140 adults having colorectal surgery will receive either anrikefon or a standard painkiller through a pump they control. The goal is to …

This study tests whether a nasal spray containing two medicines (dexmedetomidine and esketamine) can safely reduce pain in children aged 3-7 after tonsil and adenoid surgery. About 160 children will receive either the spray or a placebo, and their pain levels will be tracked for …

This study tests whether giving dexmedetomidine and esketamine during and after surgery helps patients feel better and recover faster. About 316 adults having surgery under general anesthesia will take part. The goal is to see if these drugs improve pain, comfort, and emotional w…

This study tests whether a personalized form of transcranial magnetic stimulation (rTMS) can improve movement and non-movement symptoms in people with Parkinson's disease, multiple system atrophy, or progressive supranuclear palsy. Fifty adults aged 30-80 will receive 10 daily se…

This study tests whether combining two sedatives (dexmedetomidine and esketamine) can lower the risk of delirium—sudden confusion—in older patients (60+) after surgery in the ICU. Delirium can lead to worse outcomes, and each drug alone has side effects. The trial will involve 10…

This study aims to create a better way to screen for prostate and bladder cancer using artificial intelligence (AI). Researchers will test this new screening system in 3,000 men aged 50 and older who live in Beijing. The goal is to catch cancer earlier and improve the entire proc…

This study is testing a new, advanced ultrasound technique that can see the smallest blood vessels in the legs. Researchers want to know if images of these tiny vessels can help predict future problems like limb pain or amputation in people with peripheral artery disease (PAD). T…

This study is creating a system to identify people at high risk for type 1 diabetes (T1D) before symptoms appear. Researchers will follow 340 participants—including T1D patients, their close relatives, and healthy volunteers—for up to 4 years. They will collect blood, urine, and …

This study is testing whether a structured education course can help adults with type 1 diabetes improve their self-management skills and blood sugar levels. Researchers will enroll 150 participants who will attend classes covering diet, exercise, insulin use, and more, followed …

This study aims to develop a computer model that uses MRI scans and patient information to predict whether a man has clinically significant prostate cancer (csPCa). Researchers will analyze data from 3,000 men who had an MRI and a prostate biopsy. The goal is to create a tool tha…

This study is for people who have had a severe allergic reaction (anaphylaxis) during surgery. Researchers want to better diagnose these reactions and find out what caused them by using blood tests and skin tests. The goal is to help doctors avoid giving the same allergy-causing …

This study looks at whether new biological markers can predict acute kidney injury and long-term kidney disease in 60 adults who have a kidney removed due to cancer. Current tests are slow and not always accurate. Researchers will measure these markers in blood and urine before, …

This study looks at whether taking out the breathing tube after robot-assisted surgery in the recovery room instead of the operating room can free up the operating room faster. About 218 adults having robot-assisted laparoscopic surgery will be randomly assigned to one of two gro…

Inflammatory bowel disease (IBD) is a lifelong condition with no cure. Biologic drugs are a common treatment, but they don't work for 30-50% of patients and are very expensive. This study will collect data from 200 IBD patients to build a model that predicts who will benefit from…

This study aims to find new ways to detect primary aldosteronism, a common cause of high blood pressure that is often missed. Researchers will analyze blood, urine, and adrenal tissue samples from 400 people, including patients and healthy volunteers. The goal is to identify biom…