Peking University First Hospital

This study tests a cream called benvitimod (tapinarof) for people with cutaneous T-cell lymphoma, a rare skin cancer that causes red patches and itching. The cream is non-steroidal and works by targeting a specific receptor in skin cells. About 35 adults with the disease will app…

This study tests whether a nasal spray containing esketamine and dexmedetomidine, given twice after childbirth, can lower the chance of postpartum depression in women who already had mild depressive symptoms during pregnancy. Esketamine is a fast-acting antidepressant, and dexmed…

This study tests a kidney-sparing approach for people with high-risk upper tract urothelial carcinoma, a cancer in the kidney or ureter. Instead of removing the whole kidney, participants get endoscopic surgery, targeted radiotherapy, and two drugs (disitamab vedotin and toripali…

This study tests whether giving a bile acid pill (TUDCA) to breastfeeding mothers with fatty liver disease can make their breast milk healthier for their babies. Eighty mother-infant pairs will be randomly assigned to receive TUDCA or a placebo for a short time after birth. The g…

This study tests a new treatment for people with a rare cancer of the upper urinary tract (UTUC) that has spread beyond the kidney. Participants must have had surgery and cannot take standard chemo due to health reasons. They will receive either a targeted drug (disitamab vedotin…

This study tests a new treatment for diabetes using lab-grown cells that produce insulin. About 30 adults with diabetes who have used insulin for over 5 years will receive an infusion of these cells. The goal is to see if the cells are safe and can improve blood sugar control, po…

This phase 2 trial tests whether adding darolutamide (a pill that blocks male hormones) to standard hormone therapy after prostate removal can keep cancer from coming back in high-risk patients. About 40 men will take the combination for 12 months and be followed for 2 years. The…

This study tests whether a single sample of used dialysis fluid can accurately predict how well the treatment is cleaning the blood. Currently, patients must collect all fluid drained over 24 hours, which is cumbersome and error-prone. Researchers will develop and validate a pred…

This study tests a new radioactive tracer for PET/CT scans that targets a protein called GPRC5D found on multiple myeloma cells. About 50 adults with plasma cell disorders, including multiple myeloma, will receive the tracer and then undergo imaging. The goal is to see if this me…

This study will follow 1,000 men with suspicious prostate lesions using yearly MRI scans and regular PSA blood tests. The goal is to see if changes in MRI images can help decide when a biopsy is truly needed, potentially avoiding unnecessary procedures. Researchers will track how…

This long-term study follows older adults (65-90) who are having non-cardiac surgery to see if a combination of two drugs (dexmedetomidine and esketamine) plus a gentle brain stimulation technique (tDCS) can prevent memory and thinking problems that sometimes occur after surgery.…

This study tests two approaches—a combination of medicines (dexmedetomidine and esketamine) and a gentle brain stimulation technique (tDCS)—to prevent confusion and memory problems after surgery in older adults. About 1,160 patients aged 65-90 with mild cognitive issues will be e…

This study tests whether keeping older patients (65+) at a slightly higher body temperature (36.8°C) during major cancer surgery can reduce the risk of delayed neurocognitive recovery—a kind of short-term confusion or memory decline that can happen after surgery. About 1,500 part…

This study tests whether a single injection of a slow-release painkiller (liposomal bupivacaine) into a nerve block can control pain for up to 72 hours after hip fracture surgery in older adults. The standard drug only lasts about 12 hours, often leading to more pain and opioid u…

This study tests whether a nasal spray containing two medicines, dexmedetomidine and esketamine, can improve sleep quality and thinking abilities in older adults with mild-to-moderate Alzheimer's-related cognitive impairment and sleep problems. Sixty participants will receive eit…

This study tests whether giving a combination of two drugs, dexmedetomidine and esketamine, during and after spinal surgery can reduce moderate-to-severe pain in the first three days after the operation. About 274 adults aged 40 to 80 having spine surgery will be randomly assigne…

This study tests whether giving a combination of two drugs (dexmedetomidine and esketamine) before and after spine surgery can lower the risk of long-term pain. About 274 adults aged 40-79 having spine surgery will take part. The goal is to see if this approach reduces pain that …

This study tests whether a drug called esketamine can help prevent confusion and memory problems that sometimes happen after surgery in older adults. The trial will involve 120 people aged 65 to 90 who are having major non-cardiac surgery. Researchers will compare three different…

This study tests whether taking tamsulosin, a drug often used for enlarged prostate, can prevent difficulty urinating after a prostate biopsy. About 1,844 men will either take the drug for a few days around the biopsy or receive no preventive medication. The goal is to see if the…

This study looks at how deep anesthesia affects memory and thinking in older adults (65+) after non-heart surgery. Researchers will give a fixed mix of two anesthetic drugs to 200 participants and check their brain function with a simple test. The goal is to find the best anesthe…

This study will follow about 2,500 adults with liver cirrhosis to learn who gets dangerous blood clots in the liver's main vein, how these clots affect survival, and whether blood-thinner medications are safe and helpful. Participants receive no experimental treatment—just routin…

This study looks at 50 adults with AL amyloidosis who achieved complete remission after initial chemotherapy. It checks if tiny amounts of remaining disease (called minimal residual disease, or MRD) affect organ recovery and survival. Researchers also test whether a stem cell tra…