New combo therapy aims to save kidneys in High-Risk cancer patients
NCT ID NCT07504939
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests a kidney-sparing approach for people with high-risk upper tract urothelial carcinoma, a cancer in the kidney or ureter. Instead of removing the whole kidney, participants get endoscopic surgery, targeted radiotherapy, and two drugs (disitamab vedotin and toripalimab). The goal is to see if this combination can prevent the cancer from coming back while keeping the kidney working. The trial plans to enroll 36 adults with HER2-positive tumors.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- disitamab vedotin and toripalimab
- What this could lead to
- If successful, this could offer a way to treat high-risk upper tract urothelial carcinoma without removing the kidney, preserving kidney function while controlling the cancer.
- What could go wrong
- This is a small, early-phase study with only 36 participants, so results may not apply broadly. The combination of treatments may cause side effects, and the cancer could still return.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Departmeng of Urology, Peking University First Hospital
Beijing, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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