UPPER TRACT UROTHELIAL CARCINOMA

This early-stage trial tests a personalized cancer vaccine for people with bladder or stomach cancer who still have tiny amounts of cancer DNA in their blood after surgery. The vaccine is made from unique proteins in each person's tumor and aims to train the immune system to find…

This trial tests whether giving two drugs—enfortumab vedotin and pembrolizumab—before surgery can improve outcomes for people with upper tract urothelial cancer (a type of bladder cancer in the kidney or ureter). Participants receive the drugs intravenously, then undergo surgery …

This trial is testing whether adding a template lymph node dissection (removing nearby lymph nodes) to the standard surgery for high-risk upper tract urothelial cancer helps patients live longer without the cancer returning. About 150 participants will be randomly assigned to get…

This early-stage study tests a new treatment for people with advanced bladder cancer that has not responded to standard therapies. The treatment uses specially engineered immune cells (CAR-NK cells) from a healthy donor, designed to target two proteins on cancer cells. Participan…

This study looks at whether a combination of radiation and immunotherapy works better than standard chemotherapy after surgery for a rare type of kidney cancer called upper tract urothelial carcinoma. About 178 patients with high-risk features will be followed to see which treatm…

This phase 2 trial tests whether the immunotherapy drug avelumab can help prevent upper tract urothelial carcinoma from coming back after patients have already received cisplatin-based chemotherapy. About 48 adults with high-risk muscle-invasive or node-positive disease who show …

This study tests if a very thin, single-use camera can be used in a doctor's office to look for cancer in the upper urinary tract, instead of doing it in an operating room under general anesthesia. Ten adults with known or suspected upper tract urothelial carcinoma will undergo t…

This study is testing whether a urine test can accurately detect urothelial carcinoma, a type of cancer that includes bladder cancer. Researchers are comparing the test results to standard tissue biopsies in 800 adults with blood in their urine and suspicious imaging findings. If…

This study tests whether a medication called 5-ALA, already used in brain surgery, can make upper urinary tract tumors glow under blue light during surgery. About 10 adults with known or suspected tumors will take 5-ALA before their procedure. The goal is to see if this technique…

This study looks at whether doing simple exercises at home before bladder or upper tract cancer surgery can help patients feel stronger and recover faster. About 128 adults scheduled for surgery will either receive a personalized home exercise plan via a smartphone app or standar…

This study follows 300 Korean adults with high-grade upper tract urothelial carcinoma (a type of cancer in the kidney or ureter) to monitor for cancer recurrence. Participants will receive standard treatment (chemotherapy before surgery to remove the kidney and ureter) and provid…

This pilot study is testing whether a flexible camera (ureteroscope) can be used under local anesthesia to check for cancer recurrence in the upper urinary tract after kidney-sparing surgery. Ten adults who have had such surgery will undergo the procedure in an outpatient setting…

This study looks at whether removing lymph nodes during standard kidney-ureter surgery helps people with upper tract urothelial carcinoma. About 94 adults with this rare cancer will be randomly assigned to get either the standard surgery alone or the surgery plus lymph node remov…