Could a common anesthetic prevent post-surgery brain fog in seniors?

NCT ID NCT07523334

Not yet recruiting Symptom relief Sponsor: Peking University First Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a drug called esketamine can help prevent confusion and memory problems that sometimes happen after surgery in older adults. The trial will involve 120 people aged 65 to 90 who are having major non-cardiac surgery. Researchers will compare three different doses of esketamine to find the best balance between protecting the brain and avoiding side effects like feeling detached.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Esketamine (a type of ketamine anesthetic)
What this could lead to: If it works, this could point toward a way to prevent or reduce confusion and memory problems after surgery in older adults.
What could go wrong: This is a small, early pilot trial with only 120 people, so results may not apply to everyone. Esketamine can cause dissociative symptoms (feeling detached) and other side effects.

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Conditions

The condition(s) this trial relates to.

Emergence Delirium

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DELAYED NEUROCOGNITIVE RECOVERY ELDERLY ESKETAMINE NONCARDIAC SURGERY POSTOPERATIVE DELIRIUM

Could a common anesthetic prevent post-surgery brain fog in seniors?

Summary

What this could mean

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Conditions

As listed by the trial registrant

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