ELDERLY

This study compares an adjuvanted (boosted) flu vaccine to a standard flu vaccine in 200 adults aged 65 and older who have chronic medical conditions like diabetes or heart disease. Researchers will measure immune response and safety over one year. The goal is to see if the adjuv…

This study looks at whether using a positive airway pressure (PAP) machine at night can improve thinking, sleepiness, and quality of life in older veterans (age 60+) who have both COPD and obstructive sleep apnea—a combination called Overlap Syndrome. About 668 participants will …

This study looks at two ways to treat a specific type of neck fracture (odontoid fracture) in people aged 70 and older. Participants will be randomly assigned to either surgery or wearing a rigid neck collar. The goal is to see which treatment helps them recover better in daily a…

This study tests whether a team of specialists—including surgeons, oncologists, and geriatricians—can create better treatment plans for elderly lung cancer patients. 2,000 people aged 60-90 will receive personalized care based on their overall health and cancer type. The goal is …

This study looks at two ways to prevent another stroke in older adults who have a hole in the heart (PFO) and had a stroke from an unknown cause. One option is a procedure to close the hole, plus lifelong blood thinners. The other is taking blood thinners alone. Researchers will …

This study tests whether metformin, a diabetes drug, can improve memory and thinking in overweight adults aged 60-75 with mild cognitive impairment. Half of the 54 participants will take metformin daily for 26 weeks, while the other half will receive lifestyle advice only. Resear…

This early-phase trial is testing whether a combination of a drug (GI-102) and a probiotic supplement (GIB-7) can improve markers of aging in the immune system. The study includes 15 healthy adults and cancer survivors aged 18 to 80. Participants will receive either the active co…

This study tests whether using a lung water monitor to tailor fluid intake can prevent acute kidney injury in elderly patients with kidney disease who are undergoing coronary angiography. 320 participants will receive hydration rates adjusted based on their lung water levels. The…

This study looks at whether singing—alone or in a group—can improve heart health in older adults with coronary artery disease. Researchers will test if people stick with the program and if it's practical to run a larger trial. The study involves 32 participants who will sing thre…

This study tests an AI chatbot called Aurora that guides people through creating a personal life story to improve emotional well-being and identity. It includes healthy adults, adults with mental health conditions in residential care, and older adults aged 65+. The chatbot is not…

This study looks at whether adding local muscle vibration to standard rehabilitation can help elderly patients (75+) recover strength and mobility after a hip fracture. The vibration is applied to the leg muscles for 30 minutes, five times a week, for four weeks. The main goal is…

This study tests whether having a general practitioner and pharmacist work together can help people aged 65 and older safely stop or reduce benzodiazepines (drugs for sleep or anxiety). These medications raise the risk of falls, confusion, and dementia in older adults. The trial …

This study looks at how well people digest and use protein from peas, comparing young and older adults who are either vegetarians or omnivores. Researchers will measure protein absorption after a pea-based meal using special tracers. The goal is to understand if age or diet affec…

This study is watching 1,200 older adults (65+) before, during, and after surgery to learn why some get complications like confusion (delirium). Researchers will collect blood samples and health information to build a tool that predicts these risks. The goal is to better understa…

This study looks at whether it is safe to stop antibiotics early in elderly patients (65+) hospitalized for a viral lung infection. Many patients get antibiotics even when they have a virus, which can cause side effects and lead to antibiotic resistance. Researchers will compare …

This study looks at whether a blood test for a protein called p-tau181 and brain scans can predict which elderly patients with dementia, frailty, and loss of independence will need to visit the emergency room within six months. Researchers will follow 110 participants and track E…

This study looks at why some older adults improve more with exercise than others. Researchers will track 900 people aged 60 and older, measuring muscle power, blood markers, and physical function before and after a 12-week activity program. The goal is to find biological and phys…

This study looks at whether elderly men (70+) with prostate cancer who have been on hormone therapy for over 3 years can safely stop it. Researchers will check if their testosterone stays at castrate levels without ongoing treatment. The goal is to see if stopping is feasible and…