Could a common diabetes drug protect aging brains?
NCT ID NCT07395960
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether metformin, a diabetes drug, can improve memory and thinking in overweight adults aged 60-75 with mild cognitive impairment. Half of the 54 participants will take metformin daily for 26 weeks, while the other half will receive lifestyle advice only. Researchers will use brain scans and memory tests to see if metformin helps.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- metformin
- What this could lead to
- If it works, this could point toward a way to slow cognitive decline in elderly people who are overweight, potentially reducing dementia risk.
- What could go wrong
- This is a small, early-phase trial with only 54 people. Metformin has shown mixed results in past studies, and the improvement may be small or not happen at all.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Huadong Hospital, Fudan University
RECRUITINGShanghai, 200040, China
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